Alejandra Barreto Grimaldos

INTRODUCTION Microcirculatory alterations characterize septic shock; increased blood lactate level has been described as markers of microcirculation alteration in patients with septic shock. Although useful, this serological analysis is not always feasible in all settings worldwide. OBJECTIVE To determine if a prolonged capillary refilling is a predictor of mortality in patients with septic shock. METHODOLOGY A 10-months prospective cohort study was carried out on 175 patients admitted to the Intensive Care Unit (ICU) with the diagnosis of septic shock. The capillary refilling time (CRT) was evaluated Immediately upon admission and after 6 hours post-resuscitation. Traditional tissue perfusion markers were also used to compare and analyze their predictive value on mortality at 28 days. RESULTS The area under the ROC curve (AUC) to estimate mortality in patients with septic shock with CRT at admission was 0.666 (0.584-0.748), while at 6 hours was 0.819 (0.753-0.885), with a cut-off p...

The new SARS-CoV-2 virus is an RNA virus that belongs to the Coronaviridae family and causes COVID-19 disease. The newly sequenced virus appears to originate in China and rapidly spread throughout the world, becoming a pandemic that, until January 5th, 2021, has caused more than 1,866,000 deaths. Hence, laboratories worldwide are developing an effective vaccine against this disease, which will be essential to reduce morbidity and mortality. Currently, there more than 64 vaccine candidates, most of them aiming to induce neutralizing antibodies against the spike protein (S). These antibodies will prevent uptake through the human ACE-2 receptor, thereby limiting viral entrance. Different vaccine platforms are being used for vaccine development, each one presenting several advantages and disadvantages. Thus far, thirteen vaccine candidates are being tested in Phase 3 clinical trials; therefore, it is closer to receiving approval or authorization for large-scale immunizations.

• Las reacciones de hipersensibilidad son aquellas respuestas inmunes que causan daño a los tejidos y enfermedad. Se producen en condiciones en las que la respuesta inmune está mal regulada y/o dirigida a antígenos que no son peligrosos. En la mayoría de casos, las respuestas no son eficaces en eliminar al antígeno y por lo tanto se produce inflamación crónica.

Anamnesis: Datos de filiación, motivo de consulta, enfermedad actual, antecedentes personales, antecedentes familiares, antecedentes sociales, hábitos, revisión actual por sistemas. Checklist signos vitales, checklist piel, checklist cabeza: cráneo, ojos, oídos, nariz y senos paranasales, boca, faringe, checklist cuello, checklist respiratorio y pulmonar, checklist cardiaco.