ZA919207B - Process for the reactivation of denatured protein - Google Patents

Process for the reactivation of denatured protein

Info

Publication number: ZA919207B
Authority: ZA; South Africa
Prior art keywords: pct; reactivation; protein; denatured protein; sec
Prior art date: 1990-11-22

Application number

ZA919207A

Other languages

English (en)

Inventor

Dorothea Ambrosius

Ambrosius Dorothea

Rainer Rudolph

Rudolph Rainer

Original Assignee

Boehringer Mannheim Gmbh

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-11-22

Filing date

1991-11-21

Publication date

1992-08-26

1991-11-21 Application filed by Boehringer Mannheim Gmbh filed Critical Boehringer Mannheim Gmbh

1992-08-26 Publication of ZA919207B publication Critical patent/ZA919207B/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6456—Plasminogen activators
- C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
- C07K1/1136—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by reversible modification of the secondary, tertiary or quarternary structure, e.g. using denaturating or stabilising agents
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/53—Colony-stimulating factor [CSF]
- C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21069—Protein C activated (3.4.21.69)

Landscapes

Chemical & Material Sciences (AREA)
Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Life Sciences & Earth Sciences (AREA)
Genetics & Genomics (AREA)
General Health & Medical Sciences (AREA)
Biochemistry (AREA)
Zoology (AREA)
Engineering & Computer Science (AREA)
Medicinal Chemistry (AREA)
Molecular Biology (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biophysics (AREA)
Wood Science & Technology (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
General Engineering & Computer Science (AREA)
Immunology (AREA)
Toxicology (AREA)
Gastroenterology & Hepatology (AREA)
Microbiology (AREA)
Biotechnology (AREA)
Crystallography & Structural Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Analytical Chemistry (AREA)
Peptides Or Proteins (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)
Enzymes And Modification Thereof (AREA)

ZA919207A 1990-11-22 1991-11-21 Process for the reactivation of denatured protein ZA919207B (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DE4037196A DE4037196A1 (de)	1990-11-22	1990-11-22	Verfahren zur reaktivierung von denaturiertem protein

Publications (1)

Publication Number	Publication Date
ZA919207B true ZA919207B (en)	1992-08-26

Family

ID=6418742

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ZA919207A ZA919207B (en)	1990-11-22	1991-11-21	Process for the reactivation of denatured protein

Country Status (17)

Country	Link
US (1)	US5618927A (xx)
EP (1)	EP0512087B1 (xx)
JP (1)	JP2572517B2 (xx)
KR (1)	KR960013385B1 (xx)
AT (1)	ATE149514T1 (xx)
AU (1)	AU8919591A (xx)
CA (1)	CA2074182C (xx)
DE (2)	DE4037196A1 (xx)
DK (1)	DK0512087T3 (xx)
ES (1)	ES2098379T3 (xx)
GR (1)	GR3023110T3 (xx)
HU (1)	HU213589B (xx)
IE (1)	IE62052B1 (xx)
PT (1)	PT99578B (xx)
RU (1)	RU2070888C1 (xx)
WO (1)	WO1992009622A1 (xx)
ZA (1)	ZA919207B (xx)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
WO1994022902A1 (en) *	1993-04-01	1994-10-13	Schering Corporation	IN VITRO REFOLDING OF RECOMBINANT Fv FRAGMENTS
US20030133905A1 (en) *	2001-12-20	2003-07-17	Zhenze Hu	Composition for treating contact lenses in the eye
SI21273A (sl) *	2002-07-31	2004-02-29	LEK farmacevtska dru�ba d.d.	Priprava inkluzijskih teles z visokim deležem pravilno zvitega prekurzorja heterolognega proteina
RU2439076C2 (ru)	2006-07-14	2012-01-10	Дженентек, Инк.	Способ выделения повторно свернутого рекомбинантного белка из культуры прокариотических клеток (варианты)
EP2831089A1 (en) *	2012-03-30	2015-02-04	Krishnan, Archana Rajesh	Process for renaturation of polypeptides
US20160039868A1 (en) *	2013-03-22	2016-02-11	Biogenomics Limited	Process for isolation and stabilisation of key intermediates for high efficiency refolding of recombinant proteins
RU2646103C2 (ru) *	2016-03-30	2018-03-01	Федеральное бюджетное учреждение науки Государственный научный центр прикладной микробиологии и биотехнологии (ФБУН ГНЦ ПМБ)	Способ выделения ренатурированного белка g из маркированного полиакриламидного геля

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
DE3537708A1 (de) *	1985-10-23	1987-04-23	Boehringer Mannheim Gmbh	Verfahren zur aktivierung von t-pa nach expression in prokaryonten
DE3611817A1 (de) *	1986-04-08	1987-10-15	Boehringer Mannheim Gmbh	Verfahren zur renaturierung von proteinen
DE3835350A1 (de) *	1988-10-17	1990-04-19	Boehringer Mannheim Gmbh	Aktivierung von gentechnologisch hergestellten, in prokaryonten exprimierten antikoerpern
DE3903581A1 (de) *	1989-02-07	1990-08-16	Boehringer Mannheim Gmbh	Gewebs-plasminogenaktivator-derivat

1990
- 1990-11-22 DE DE4037196A patent/DE4037196A1/de not_active Withdrawn
1991
- 1991-10-02 IE IE347491A patent/IE62052B1/en not_active IP Right Cessation
- 1991-11-21 AU AU89195/91A patent/AU8919591A/en not_active Abandoned
- 1991-11-21 DK DK91919945.5T patent/DK0512087T3/da active
- 1991-11-21 CA CA002074182A patent/CA2074182C/en not_active Expired - Lifetime
- 1991-11-21 KR KR1019920701705A patent/KR960013385B1/ko not_active IP Right Cessation
- 1991-11-21 WO PCT/EP1991/002190 patent/WO1992009622A1/de active IP Right Grant
- 1991-11-21 US US07/867,679 patent/US5618927A/en not_active Expired - Lifetime
- 1991-11-21 ZA ZA919207A patent/ZA919207B/xx unknown
- 1991-11-21 JP JP4500025A patent/JP2572517B2/ja not_active Expired - Fee Related
- 1991-11-21 EP EP91919945A patent/EP0512087B1/de not_active Expired - Lifetime
- 1991-11-21 ES ES91919945T patent/ES2098379T3/es not_active Expired - Lifetime
- 1991-11-21 DE DE59108583T patent/DE59108583D1/de not_active Expired - Lifetime
- 1991-11-21 RU SU915052826A patent/RU2070888C1/ru not_active IP Right Cessation
- 1991-11-21 HU HU9202354A patent/HU213589B/hu unknown
- 1991-11-21 AT AT91919945T patent/ATE149514T1/de not_active IP Right Cessation
- 1991-11-22 PT PT99578A patent/PT99578B/pt not_active IP Right Cessation
1997
- 1997-04-11 GR GR970400772T patent/GR3023110T3/el unknown

Also Published As

Publication number	Publication date
HU9202354D0 (en)	1992-10-28
PT99578B (pt)	1999-04-30
KR960013385B1 (ko)	1996-10-04
HUT63437A (en)	1993-08-30
IE913474A1 (en)	1992-06-03
US5618927A (en)	1997-04-08
WO1992009622A1 (de)	1992-06-11
CA2074182A1 (en)	1992-05-23
JPH05502245A (ja)	1993-04-22
PT99578A (pt)	1992-10-30
KR927003623A (ko)	1992-12-18
EP0512087B1 (de)	1997-03-05
AU8919591A (en)	1992-06-25
DE59108583D1 (de)	1997-04-10
DK0512087T3 (da)	1997-08-25
RU2070888C1 (ru)	1996-12-27
DE4037196A1 (de)	1992-05-27
ATE149514T1 (de)	1997-03-15
CA2074182C (en)	1999-10-05
IE62052B1 (en)	1994-12-14
HU213589B (en)	1997-08-28
EP0512087A1 (de)	1992-11-11
ES2098379T3 (es)	1997-05-01
GR3023110T3 (en)	1997-07-30
JP2572517B2 (ja)	1997-01-16

Publication	Publication Date	Title
ATE89349T1 (de)	1993-05-15	Enzymatische behandlung von wolle.
DK83093D0 (da)	1993-07-09	Fremgangsmaade
DE69117182D1 (de)	1996-03-28	Kontrollierte abgabe von nährmittel für bakterien und verfahren einer biologischen behandlung
ES8603271A1 (es)	1985-12-16	Un metodo de producir una composicion de interleuquina-2
UA6023A1 (uk)	1994-12-29	Спосіб активізації тканевого активатора плазміногена /його варіанти/
DK39693D0 (da)	1993-04-02	Enzym
SE9003122D0 (sv)	1990-10-01	Improvement in solid phase binding assay
ATE198624T1 (de)	2001-01-15	Expression von albumin in hefe
DK126693D0 (da)	1993-11-08	Drikkevare
EP1329461A4 (en)	2004-12-01	PROCESS FOR PREVENTING POLYMERS OF HUMAN SERUM ALBUMIN
ZA919207B (en)	1992-08-26	Process for the reactivation of denatured protein
DE58904713D1 (de)	1993-07-22	Verwendung von zink- oder eisenhydroxid zur adjuvierung von antigenloesungen und auf diese weise adjuvierte antigenloesungen.
GR3007605T3 (xx)	1993-08-31
MXPA02010643A (es)	2004-05-17	Un metodo de tratamiento de proteinas de soya y un producto de proteina de soya producido mediante este metodo.
GR930300084T1 (en)	1993-09-30	Intermediates for chelating agents with prefixed symmetry and process for their preparation.
ES2060202T5 (es)	1998-10-01	Composicion detergente enzimatica liquida.
DE3681008D1 (de)	1991-09-26	Verfahren zum enzymatischen abbau von restbrot und verwendung des erhaltenen abbauprodukts.
GR930300003T1 (en)	1993-04-28	Inhibitor of proliferation of endothelial cells.
GB9304399D0 (en)	1993-04-21	Novel process
DE59611353D1 (de)	2006-07-06	Transketolase-verwandtes protein
DE69319140D1 (de)	1998-07-16	4-guanidinobutyramid zur verbesserung des blutkreislaufs
UA10054A (uk)	1996-09-30	Спосіб одержання білкового гідролізату
ES2066733A1 (es)	1995-03-01	Complejo consistente en un activador del plasminogeno y albumina de suero y procedimiento para prepararlo.