DK0512087T3 - Fremgangsmåde til reaktivering af denaturerede proteiner - Google Patents
Fremgangsmåde til reaktivering af denaturerede proteinerInfo
- Publication number
- DK0512087T3 DK0512087T3 DK91919945.5T DK91919945T DK0512087T3 DK 0512087 T3 DK0512087 T3 DK 0512087T3 DK 91919945 T DK91919945 T DK 91919945T DK 0512087 T3 DK0512087 T3 DK 0512087T3
- Authority
- DK
- Denmark
- Prior art keywords
- pct
- protein
- denatured proteins
- sec
- date
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
- C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
- C12N9/6424—Serine endopeptidases (3.4.21)
- C12N9/6456—Plasminogen activators
- C12N9/6459—Plasminogen activators t-plasminogen activator (3.4.21.68), i.e. tPA
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
- C07K1/1136—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by reversible modification of the secondary, tertiary or quarternary structure, e.g. using denaturating or stabilising agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/52—Cytokines; Lymphokines; Interferons
- C07K14/53—Colony-stimulating factor [CSF]
- C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y304/00—Hydrolases acting on peptide bonds, i.e. peptidases (3.4)
- C12Y304/21—Serine endopeptidases (3.4.21)
- C12Y304/21069—Protein C activated (3.4.21.69)
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Life Sciences & Earth Sciences (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biophysics (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Immunology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Crystallography & Structural Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DE4037196A DE4037196A1 (de) | 1990-11-22 | 1990-11-22 | Verfahren zur reaktivierung von denaturiertem protein |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DK0512087T3 true DK0512087T3 (da) | 1997-08-25 |
Family
ID=6418742
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DK91919945.5T DK0512087T3 (da) | 1990-11-22 | 1991-11-21 | Fremgangsmåde til reaktivering af denaturerede proteiner |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US5618927A (da) |
| EP (1) | EP0512087B1 (da) |
| JP (1) | JP2572517B2 (da) |
| KR (1) | KR960013385B1 (da) |
| AT (1) | ATE149514T1 (da) |
| AU (1) | AU8919591A (da) |
| CA (1) | CA2074182C (da) |
| DE (2) | DE4037196A1 (da) |
| DK (1) | DK0512087T3 (da) |
| ES (1) | ES2098379T3 (da) |
| GR (1) | GR3023110T3 (da) |
| HU (1) | HU213589B (da) |
| IE (1) | IE62052B1 (da) |
| PT (1) | PT99578B (da) |
| RU (1) | RU2070888C1 (da) |
| WO (1) | WO1992009622A1 (da) |
| ZA (1) | ZA919207B (da) |
Families Citing this family (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1994022902A1 (en) * | 1993-04-01 | 1994-10-13 | Schering Corporation | IN VITRO REFOLDING OF RECOMBINANT Fv FRAGMENTS |
| US20030133905A1 (en) * | 2001-12-20 | 2003-07-17 | Zhenze Hu | Composition for treating contact lenses in the eye |
| SI21273A (sl) * | 2002-07-31 | 2004-02-29 | LEK farmacevtska dru�ba d.d. | Priprava inkluzijskih teles z visokim deležem pravilno zvitega prekurzorja heterolognega proteina |
| RU2439076C2 (ru) | 2006-07-14 | 2012-01-10 | Дженентек, Инк. | Способ выделения повторно свернутого рекомбинантного белка из культуры прокариотических клеток (варианты) |
| EP2831089A1 (en) * | 2012-03-30 | 2015-02-04 | Krishnan, Archana Rajesh | Process for renaturation of polypeptides |
| US20160039868A1 (en) * | 2013-03-22 | 2016-02-11 | Biogenomics Limited | Process for isolation and stabilisation of key intermediates for high efficiency refolding of recombinant proteins |
| RU2646103C2 (ru) * | 2016-03-30 | 2018-03-01 | Федеральное бюджетное учреждение науки Государственный научный центр прикладной микробиологии и биотехнологии (ФБУН ГНЦ ПМБ) | Способ выделения ренатурированного белка g из маркированного полиакриламидного геля |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3537708A1 (de) * | 1985-10-23 | 1987-04-23 | Boehringer Mannheim Gmbh | Verfahren zur aktivierung von t-pa nach expression in prokaryonten |
| DE3611817A1 (de) * | 1986-04-08 | 1987-10-15 | Boehringer Mannheim Gmbh | Verfahren zur renaturierung von proteinen |
| DE3835350A1 (de) * | 1988-10-17 | 1990-04-19 | Boehringer Mannheim Gmbh | Aktivierung von gentechnologisch hergestellten, in prokaryonten exprimierten antikoerpern |
| DE3903581A1 (de) * | 1989-02-07 | 1990-08-16 | Boehringer Mannheim Gmbh | Gewebs-plasminogenaktivator-derivat |
-
1990
- 1990-11-22 DE DE4037196A patent/DE4037196A1/de not_active Withdrawn
-
1991
- 1991-10-02 IE IE347491A patent/IE62052B1/en not_active IP Right Cessation
- 1991-11-21 AU AU89195/91A patent/AU8919591A/en not_active Abandoned
- 1991-11-21 DK DK91919945.5T patent/DK0512087T3/da active
- 1991-11-21 CA CA002074182A patent/CA2074182C/en not_active Expired - Lifetime
- 1991-11-21 KR KR1019920701705A patent/KR960013385B1/ko not_active IP Right Cessation
- 1991-11-21 WO PCT/EP1991/002190 patent/WO1992009622A1/de active IP Right Grant
- 1991-11-21 US US07/867,679 patent/US5618927A/en not_active Expired - Lifetime
- 1991-11-21 ZA ZA919207A patent/ZA919207B/xx unknown
- 1991-11-21 JP JP4500025A patent/JP2572517B2/ja not_active Expired - Fee Related
- 1991-11-21 EP EP91919945A patent/EP0512087B1/de not_active Expired - Lifetime
- 1991-11-21 ES ES91919945T patent/ES2098379T3/es not_active Expired - Lifetime
- 1991-11-21 DE DE59108583T patent/DE59108583D1/de not_active Expired - Lifetime
- 1991-11-21 RU SU915052826A patent/RU2070888C1/ru not_active IP Right Cessation
- 1991-11-21 HU HU9202354A patent/HU213589B/hu unknown
- 1991-11-21 AT AT91919945T patent/ATE149514T1/de not_active IP Right Cessation
- 1991-11-22 PT PT99578A patent/PT99578B/pt not_active IP Right Cessation
-
1997
- 1997-04-11 GR GR970400772T patent/GR3023110T3/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HU9202354D0 (en) | 1992-10-28 |
| PT99578B (pt) | 1999-04-30 |
| KR960013385B1 (ko) | 1996-10-04 |
| HUT63437A (en) | 1993-08-30 |
| IE913474A1 (en) | 1992-06-03 |
| US5618927A (en) | 1997-04-08 |
| WO1992009622A1 (de) | 1992-06-11 |
| CA2074182A1 (en) | 1992-05-23 |
| JPH05502245A (ja) | 1993-04-22 |
| PT99578A (pt) | 1992-10-30 |
| KR927003623A (ko) | 1992-12-18 |
| EP0512087B1 (de) | 1997-03-05 |
| AU8919591A (en) | 1992-06-25 |
| DE59108583D1 (de) | 1997-04-10 |
| RU2070888C1 (ru) | 1996-12-27 |
| DE4037196A1 (de) | 1992-05-27 |
| ATE149514T1 (de) | 1997-03-15 |
| CA2074182C (en) | 1999-10-05 |
| IE62052B1 (en) | 1994-12-14 |
| HU213589B (en) | 1997-08-28 |
| EP0512087A1 (de) | 1992-11-11 |
| ES2098379T3 (es) | 1997-05-01 |
| GR3023110T3 (en) | 1997-07-30 |
| JP2572517B2 (ja) | 1997-01-16 |
| ZA919207B (en) | 1992-08-26 |
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