ZA200709266B - Human GLP-1 mimetibodies, compositions, methods and uses - Google Patents
Human GLP-1 mimetibodies, compositions, methods and usesInfo
- Publication number
- ZA200709266B ZA200709266B ZA200709266A ZA200709266A ZA200709266B ZA 200709266 B ZA200709266 B ZA 200709266B ZA 200709266 A ZA200709266 A ZA 200709266A ZA 200709266 A ZA200709266 A ZA 200709266A ZA 200709266 B ZA200709266 B ZA 200709266B
- Authority
- ZA
- South Africa
- Prior art keywords
- mimetibodies
- compositions
- methods
- human glp
- glp
- Prior art date
Links
- 101000788682 Homo sapiens GATA-type zinc finger protein 1 Proteins 0.000 title 1
- 239000000203 mixture Substances 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/605—Glucagons
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/04—Inotropic agents, i.e. stimulants of cardiac contraction; Drugs for heart failure
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
- C07K2319/30—Non-immunoglobulin-derived peptide or protein having an immunoglobulin constant or Fc region, or a fragment thereof, attached thereto
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Genetics & Genomics (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Zoology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Gastroenterology & Hepatology (AREA)
- Animal Behavior & Ethology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Toxicology (AREA)
- Pharmacology & Pharmacy (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Wood Science & Technology (AREA)
- General Engineering & Computer Science (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Cardiology (AREA)
- Biotechnology (AREA)
- Emergency Medicine (AREA)
- Obesity (AREA)
- Physics & Mathematics (AREA)
- Hospice & Palliative Care (AREA)
- Hematology (AREA)
- Plant Pathology (AREA)
- Microbiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US55798304P | 2004-03-31 | 2004-03-31 | |
US61298104P | 2004-09-24 | 2004-09-24 | |
PCT/US2005/010456 WO2005097175A2 (en) | 2004-03-31 | 2005-03-28 | Human glp-1 mimetibodies, compositions, methods and uses |
Publications (1)
Publication Number | Publication Date |
---|---|
ZA200709266B true ZA200709266B (en) | 2009-05-27 |
Family
ID=35125618
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ZA200709266A ZA200709266B (en) | 2004-03-31 | 2007-10-26 | Human GLP-1 mimetibodies, compositions, methods and uses |
Country Status (17)
Country | Link |
---|---|
US (1) | US20070135338A1 (ru) |
EP (1) | EP1750754A4 (ru) |
JP (1) | JP2008537873A (ru) |
KR (1) | KR20070004078A (ru) |
AR (1) | AR049014A1 (ru) |
AU (1) | AU2005231359A1 (ru) |
BR (1) | BRPI0509528A (ru) |
CA (1) | CA2563379A1 (ru) |
CR (1) | CR8706A (ru) |
EA (2) | EA011583B1 (ru) |
IL (1) | IL178432A0 (ru) |
MX (1) | MXPA06011425A (ru) |
NO (1) | NO20064953L (ru) |
SG (1) | SG151315A1 (ru) |
TW (1) | TW200602491A (ru) |
WO (1) | WO2005097175A2 (ru) |
ZA (1) | ZA200709266B (ru) |
Families Citing this family (58)
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JP2008504249A (ja) * | 2004-06-28 | 2008-02-14 | ノボ ノルディスク アクティーゼルスカブ | 糖尿病を治療するための方法 |
US7910101B2 (en) | 2004-10-25 | 2011-03-22 | Centocor, Inc. | Melanocortin receptor binding mimetibodies, compositions, methods and uses |
AU2005299440B2 (en) * | 2004-10-25 | 2011-12-15 | Centocor, Inc. | Melanocortin receptor binding mimetibodies, compositions, methods and uses |
SG158158A1 (en) * | 2004-12-22 | 2010-01-29 | Centocor Inc | Glp-1 agonists, compositions, methods and uses |
TW200643033A (en) * | 2005-03-08 | 2006-12-16 | Chugai Pharmaceutical Co Ltd | Conjugate of water-soluble modified hyaluronic acid and glp-1 analogue |
CN101389346A (zh) * | 2005-03-28 | 2009-03-18 | 森托科尔公司 | 人glp-1模拟体、组合物、方法和用途 |
US9284375B2 (en) | 2005-04-15 | 2016-03-15 | Macrogenics, Inc. | Covalent diabodies and uses thereof |
US11254748B2 (en) | 2005-04-15 | 2022-02-22 | Macrogenics, Inc. | Covalent diabodies and uses thereof |
US9963510B2 (en) * | 2005-04-15 | 2018-05-08 | Macrogenics, Inc. | Covalent diabodies and uses thereof |
AU2006236439B2 (en) | 2005-04-15 | 2012-05-03 | Macrogenics, Inc. | Covalent diabodies and uses thereof |
CA2658673A1 (en) * | 2005-07-27 | 2008-02-01 | Gerald J. Prud'homme | Composition and method for prevention and treatment of type i and type ii diabetes |
DE602005017628D1 (de) | 2005-09-22 | 2009-12-24 | Biocompatibles Uk Ltd | Fusionspolypeptide vom glp-1 (glucagon-like peptide-1) mit erhöhten peptidaseresistenz |
CA2627444A1 (en) * | 2005-10-24 | 2007-06-14 | Centocor, Inc. | Glp-2 mimetibodies, polypeptides, compositions, methods and uses |
EP1968645A4 (en) * | 2005-12-22 | 2009-11-04 | Centocor Ortho Biotech Inc | HUMAN GLP-1 MIMETIC BODIES AND COMPOSITIONS FOR THE TREATMENT OF ADIPOSITAS AND RELATED DISEASES, METHODS AND APPLICATIONS |
WO2007115148A2 (en) * | 2006-03-31 | 2007-10-11 | Centocor, Inc. | Human mimetic epo hinge core mimetibodies |
ATE444741T1 (de) | 2006-05-10 | 2009-10-15 | Biocompatibles Uk Ltd | Glp-1 peptide enthaltende kugelförmige mikrokapseln, deren produktion und deren verwendung |
MX2009000748A (es) | 2006-07-18 | 2009-03-31 | Centocor Inc | Mimeticuerpos de peptido-1 similar a glucagon de humano, composiciones, metodos y usos. |
EP2076604A4 (en) * | 2006-08-31 | 2009-09-02 | Centocor Ortho Biotech Inc | GLP-2 MIMIC BODIES, POLYPEPTIDES, COMPOSITIONS, PROCESSES AND USES |
AR064623A1 (es) * | 2006-12-21 | 2009-04-15 | Centocor Inc | Uso de agonistas del receptor de glp -1 de accion prolongada para mejorar la sensibilidad a la insulina y los perfiles lipidicos |
EP1975176A1 (en) * | 2007-03-27 | 2008-10-01 | Biocompatibles UK Limited | Novel glp-1 fusion peptides, their production and use |
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EP3228320B1 (de) | 2008-10-17 | 2019-12-18 | Sanofi-Aventis Deutschland GmbH | Kombination von einem insulin und einem glp-1-agonisten |
PL2786762T3 (pl) * | 2008-12-19 | 2019-09-30 | Macrogenics, Inc. | Kowalencyjne diabody i ich zastosowania |
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MA34062B1 (fr) | 2010-03-04 | 2013-03-05 | Macrogenics Inc | Anticorps réagissant avec b7-h3, fragments immunologiquement actifs associés et utilisations associées |
AU2011202239C1 (en) | 2010-05-19 | 2017-03-16 | Sanofi | Long-acting formulations of insulins |
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US9821032B2 (en) | 2011-05-13 | 2017-11-21 | Sanofi-Aventis Deutschland Gmbh | Pharmaceutical combination for improving glycemic control as add-on therapy to basal insulin |
SG195073A1 (en) | 2011-05-21 | 2013-12-30 | Macrogenics Inc | Deimmunized serum-binding domains and their use for extending serum half-life |
ES2550357T3 (es) | 2011-08-29 | 2015-11-06 | Sanofi-Aventis Deutschland Gmbh | Combinación farmacéutica para su uso en el control glucémico en pacientes de diabetes de tipo 2 |
AR087744A1 (es) | 2011-09-01 | 2014-04-16 | Sanofi Aventis Deutschland | Composicion farmaceutica para uso en el tratamiento de una enfermedad neurodegenerativa |
CN104039822A (zh) | 2011-09-06 | 2014-09-10 | 诺沃—诺迪斯克有限公司 | Glp-1衍生物 |
US9487587B2 (en) | 2013-03-05 | 2016-11-08 | Macrogenics, Inc. | Bispecific molecules that are immunoreactive with immune effector cells of a companion animal that express an activating receptor and cells that express B7-H3 and uses thereof |
AP2015008740A0 (en) | 2013-03-14 | 2015-09-30 | Macrogenics Inc | Bispecific molecules that are immunoreactive with immune effector cells that express an activating receptor and an antigen expressed by a cell infected by a virus and uses thereof |
RU2705797C2 (ru) | 2013-04-03 | 2019-11-12 | Санофи | Лечение сахарного диабета с помощью составов инсулинов длительного действия |
US11384149B2 (en) | 2013-08-09 | 2022-07-12 | Macrogenics, Inc. | Bi-specific monovalent Fc diabodies that are capable of binding CD32B and CD79b and uses thereof |
UA116479C2 (uk) | 2013-08-09 | 2018-03-26 | Макродженікс, Інк. | БІСПЕЦИФІЧНЕ МОНОВАЛЕНТНЕ Fc-ДІАТІЛО, ЯКЕ ОДНОЧАСНО ЗВ'ЯЗУЄ CD32B I CD79b, ТА ЙОГО ЗАСТОСУВАННЯ |
CN104371019B (zh) * | 2013-08-13 | 2019-09-10 | 鸿运华宁(杭州)生物医药有限公司 | 一种能与glp-1r特异性结合的抗体及其与glp-1的融合蛋白质 |
EP2840091A1 (en) | 2013-08-23 | 2015-02-25 | MacroGenics, Inc. | Bi-specific diabodies that are capable of binding gpA33 and CD3 and uses thereof |
EP2839842A1 (en) | 2013-08-23 | 2015-02-25 | MacroGenics, Inc. | Bi-specific monovalent diabodies that are capable of binding CD123 and CD3 and uses thereof |
US12174188B2 (en) | 2013-10-17 | 2024-12-24 | The General Hospital Corporation | Methods of identifying subjects responsive to treatment for type 1 diabetes and compositions for treating the same |
BR112017006515A8 (pt) | 2014-09-29 | 2018-02-27 | Univ Duke | moléculas biespecíficas, composições, método para tratar ou prevenir infecção por hiv-1 em um indivíduo com essa necessidade, e vetor |
MX389178B (es) | 2014-12-12 | 2025-03-20 | Sanofi Aventis Deutschland | Formulacion de proporcion fija de insulina glargina/lixisenatida. |
TWI748945B (zh) | 2015-03-13 | 2021-12-11 | 德商賽諾菲阿凡提斯德意志有限公司 | 第2型糖尿病病患治療 |
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WO2021195344A2 (en) * | 2020-03-25 | 2021-09-30 | The General Hospital Corporation | Compositions and methods for diabetes treatment |
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-
2005
- 2005-03-28 KR KR1020067022887A patent/KR20070004078A/ko not_active Ceased
- 2005-03-28 SG SG200902141-1A patent/SG151315A1/en unknown
- 2005-03-28 BR BRPI0509528-0A patent/BRPI0509528A/pt not_active Application Discontinuation
- 2005-03-28 WO PCT/US2005/010456 patent/WO2005097175A2/en active Application Filing
- 2005-03-28 CA CA002563379A patent/CA2563379A1/en not_active Abandoned
- 2005-03-28 US US11/091,181 patent/US20070135338A1/en not_active Abandoned
- 2005-03-28 AU AU2005231359A patent/AU2005231359A1/en not_active Abandoned
- 2005-03-28 EA EA200601603A patent/EA011583B1/ru not_active IP Right Cessation
- 2005-03-28 EP EP05730437A patent/EP1750754A4/en not_active Withdrawn
- 2005-03-28 JP JP2007506454A patent/JP2008537873A/ja active Pending
- 2005-03-28 MX MXPA06011425A patent/MXPA06011425A/es not_active Application Discontinuation
- 2005-03-30 TW TW094109910A patent/TW200602491A/zh unknown
- 2005-03-31 AR ARP050101276A patent/AR049014A1/es unknown
- 2005-12-22 EA EA200702093A patent/EA200702093A1/ru unknown
-
2006
- 2006-10-03 IL IL178432A patent/IL178432A0/en unknown
- 2006-10-25 CR CR8706A patent/CR8706A/es not_active Application Discontinuation
- 2006-10-30 NO NO20064953A patent/NO20064953L/no not_active Application Discontinuation
-
2007
- 2007-10-26 ZA ZA200709266A patent/ZA200709266B/xx unknown
Also Published As
Publication number | Publication date |
---|---|
US20070135338A1 (en) | 2007-06-14 |
CA2563379A1 (en) | 2005-10-20 |
EP1750754A2 (en) | 2007-02-14 |
NO20064953L (no) | 2006-12-18 |
EA200702093A1 (ru) | 2009-06-30 |
TW200602491A (en) | 2006-01-16 |
MXPA06011425A (es) | 2007-03-12 |
EA011583B1 (ru) | 2009-04-28 |
EP1750754A4 (en) | 2010-09-22 |
KR20070004078A (ko) | 2007-01-05 |
JP2008537873A (ja) | 2008-10-02 |
CR8706A (es) | 2009-01-16 |
IL178432A0 (en) | 2007-02-11 |
BRPI0509528A (pt) | 2007-08-07 |
WO2005097175A2 (en) | 2005-10-20 |
AU2005231359A1 (en) | 2005-10-20 |
SG151315A1 (en) | 2009-04-30 |
AR049014A1 (es) | 2006-06-21 |
EA200601603A1 (ru) | 2007-08-31 |
WO2005097175A3 (en) | 2009-11-19 |
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