[go: up one dir, main page]

ZA200406856B - Selective dipeptide inhibitors of kallikrein. - Google Patents

Selective dipeptide inhibitors of kallikrein. Download PDF

Info

Publication number
ZA200406856B
ZA200406856B ZA200406856A ZA200406856A ZA200406856B ZA 200406856 B ZA200406856 B ZA 200406856B ZA 200406856 A ZA200406856 A ZA 200406856A ZA 200406856 A ZA200406856 A ZA 200406856A ZA 200406856 B ZA200406856 B ZA 200406856B
Authority
ZA
South Africa
Prior art keywords
lower alkyl
piperidine
carboxamidine
phenylpropanoylamino
amino
Prior art date
Application number
ZA200406856A
Other languages
English (en)
Inventor
David Michael Evans
Original Assignee
Ferring Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ferring Bv filed Critical Ferring Bv
Publication of ZA200406856B publication Critical patent/ZA200406856B/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/0606—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing heteroatoms not provided for by C07K5/06086 - C07K5/06139, e.g. Ser, Met, Cys, Thr
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/02—Drugs for skeletal disorders for joint disorders, e.g. arthritis, arthrosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
    • C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06008—Dipeptides with the first amino acid being neutral
    • C07K5/06078—Dipeptides with the first amino acid being neutral and aromatic or cycloaliphatic
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Immunology (AREA)
  • Rheumatology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Cardiology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Pulmonology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pyridine Compounds (AREA)
ZA200406856A 2002-03-08 2004-08-27 Selective dipeptide inhibitors of kallikrein. ZA200406856B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
GBGB0205527.5A GB0205527D0 (en) 2002-03-08 2002-03-08 Inhibitors

Publications (1)

Publication Number Publication Date
ZA200406856B true ZA200406856B (en) 2005-11-30

Family

ID=9932619

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200406856A ZA200406856B (en) 2002-03-08 2004-08-27 Selective dipeptide inhibitors of kallikrein.

Country Status (27)

Country Link
US (1) US7649000B2 (zh)
EP (1) EP1483284B1 (zh)
JP (1) JP4330450B2 (zh)
KR (1) KR100974633B1 (zh)
CN (1) CN1274713C (zh)
AR (1) AR039868A1 (zh)
AT (1) ATE333463T1 (zh)
AU (1) AU2003208471B2 (zh)
CA (1) CA2478099C (zh)
DE (1) DE60306904T2 (zh)
DK (1) DK1483284T3 (zh)
EG (1) EG25482A (zh)
ES (1) ES2264523T3 (zh)
GB (1) GB0205527D0 (zh)
HK (1) HK1072265A1 (zh)
IL (2) IL163710A0 (zh)
MX (1) MXPA04008523A (zh)
MY (1) MY130830A (zh)
NO (1) NO332678B1 (zh)
NZ (1) NZ534891A (zh)
PL (1) PL209670B1 (zh)
PT (1) PT1483284E (zh)
RU (1) RU2301225C2 (zh)
TW (1) TWI283685B (zh)
UY (1) UY27699A1 (zh)
WO (1) WO2003076458A2 (zh)
ZA (1) ZA200406856B (zh)

Families Citing this family (40)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2005095327A1 (ja) 2004-03-31 2005-10-13 Ajinomoto Co., Inc. アニリン誘導体
WO2009026334A2 (en) * 2007-08-21 2009-02-26 Genzyme Corporation Treatment with kallikrein inhibitors
GB0918924D0 (en) * 2009-10-28 2009-12-16 Vantia Ltd Azaindole derivatives
US9290485B2 (en) 2010-08-04 2016-03-22 Novartis Ag N-((6-amino-pyridin-3-yl)methyl)-heteroaryl-carboxamides
GB2494851A (en) 2011-07-07 2013-03-27 Kalvista Pharmaceuticals Ltd Plasma kallikrein inhibitors
US20140378474A1 (en) 2012-01-27 2014-12-25 Novartis Ag 5-membered heteroarylcarboxamide derivatives as plasma kallikrein inhibitors
WO2013111107A1 (en) 2012-01-27 2013-08-01 Novartis Ag Aminopyridine derivatives as plasma kallikrein inhibitors
GB201212081D0 (en) 2012-07-06 2012-08-22 Kalvista Pharmaceuticals Ltd New polymorph
GB201300304D0 (en) 2013-01-08 2013-02-20 Kalvista Pharmaceuticals Ltd Benzylamine derivatives
IL239682B (en) 2013-01-08 2018-10-31 Kalvista Pharmaceuticals Ltd History of benzylamine and 2-(aminomethyl)pyridine
GB2510407A (en) 2013-02-04 2014-08-06 Kalvista Pharmaceuticals Ltd Aqueous suspensions of kallikrein inhibitors for parenteral administration
ES2626968T3 (es) 2013-05-23 2017-07-26 Kalvista Pharmaceuticals Limited Derivados heterocíclicos
TWI636047B (zh) 2013-08-14 2018-09-21 英商卡爾維斯塔製藥有限公司 雜環衍生物
GB2517908A (en) 2013-08-14 2015-03-11 Kalvista Pharmaceuticals Ltd Bicyclic inhibitors
CA2920815C (en) 2013-08-14 2021-09-21 Kalvista Pharmaceuticals Limited Inhibitors of plasma kallikrein
JP2017502921A (ja) * 2013-10-28 2017-01-26 バイサイクル・セラピューティクス・リミテッド 新規なポリペプチド
BR112016018062B1 (pt) 2014-02-07 2022-11-16 Exithera Pharmaceuticals Inc Compostos terapêuticos, composição farmacêutica e usos
GB201421085D0 (en) 2014-11-27 2015-01-14 Kalvista Pharmaceuticals Ltd New enzyme inhibitors
GB201421083D0 (en) 2014-11-27 2015-01-14 Kalvista Pharmaceuticals Ltd Enzyme inhibitors
GB201421088D0 (en) 2014-11-27 2015-01-14 Kalvista Pharmaceuticals Ltd New enzyme inhibitors
SG11201809922YA (en) 2016-05-31 2018-12-28 Kalvista Pharmaceuticals Ltd Pyrazole derivatives as plasma kallikrein inhibitors
GB201609607D0 (en) 2016-06-01 2016-07-13 Kalvista Pharmaceuticals Ltd Polymorphs of N-(3-Fluoro-4-methoxypyridin-2-yl)methyl)-3-(methoxymethyl)-1-({4-((2-oxopy ridin-1-yl)methyl)phenyl}methyl)pyrazole-4-carboxamide and salts
GB201609603D0 (en) 2016-06-01 2016-07-13 Kalvista Pharmaceuticals Ltd Polymorphs of N-[(6-cyano-2-fluoro-3-methoxyphenyl)Methyl]-3-(methoxymethyl)-1-({4-[(2-ox opyridin-1-YL)Methyl]phenyl}methyl)pyrazole-4-carboxamide
GB201719881D0 (en) 2017-11-29 2018-01-10 Kalvista Pharmaceuticals Ltd Solid forms of plasma kallikrein inhibitor and salts thereof
IL312036A (en) 2017-11-29 2024-06-01 Kalvista Pharmaceuticals Ltd Dosage forms comprising a plasma kallikrein inhibitor
CN113056263A (zh) 2018-10-30 2021-06-29 艾克赛特赫拉制药有限责任公司 治疗化合物和组合物
GB201910116D0 (en) 2019-07-15 2019-08-28 Kalvista Pharmaceuticals Ltd Treatments of hereditary angioedema
GB201910125D0 (en) 2019-07-15 2019-08-28 Kalvista Pharmaceuticals Ltd Treatments of angioedema
EP4010333A1 (en) 2019-08-09 2022-06-15 Kalvista Pharmaceuticals Limited Plasma kallikrein inhibitors
GB2591730A (en) 2019-12-09 2021-08-11 Kalvista Pharmaceuticals Ltd New polymorphs
GB201918994D0 (en) 2019-12-20 2020-02-05 Kalvista Pharmaceuticals Ltd Treatments of diabetic macular edema and impaired visual acuity
WO2021198534A1 (en) 2020-04-04 2021-10-07 Oxurion NV Plasma kallikrein inhibitors for use in the treatment of coronaviral disease
WO2022079446A1 (en) 2020-10-15 2022-04-21 Kalvista Pharmaceuticals Limited Treatments of angioedema
EP4232031A1 (en) 2020-10-23 2023-08-30 Kalvista Pharmaceuticals Limited Treatments of angioedema
US20240122909A1 (en) 2021-02-09 2024-04-18 Kalvista Pharmaceuticals Limited Treatments of hereditary angioedema
WO2023002219A1 (en) 2021-07-23 2023-01-26 Kalvista Pharmaceuticals Limited Treatments of hereditary angioedema
WO2023144030A1 (en) 2022-01-31 2023-08-03 Oxurion NV Plasma kallikrein inhibitor therapy for anti-vegf sensitization
WO2023148016A1 (en) 2022-02-04 2023-08-10 Oxurion NV Biomarker for plasma kallikrein inhibitor therapy response
KR20250002615A (ko) 2022-04-27 2025-01-07 칼비스타 파마슈티컬즈 리미티드 혈장 칼리크레인 저해제의 제형
WO2024180100A1 (en) 2023-02-27 2024-09-06 Kalvista Pharmaceuticals Limited New solid form of a plasma kallikrein inhibitor

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9019558D0 (en) * 1990-09-07 1990-10-24 Szelke Michael Enzyme inhibitors
AU2882792A (en) * 1991-10-23 1993-05-21 Procter & Gamble Company, The Tripeptide derivative anti-inflammatory agents
SE9301911D0 (sv) * 1993-06-03 1993-06-03 Ab Astra New peptide derivatives
GB9318637D0 (en) 1993-09-08 1993-10-27 Ferring Res Ltd Enzyme inhibitors

Also Published As

Publication number Publication date
GB0205527D0 (en) 2002-04-24
DE60306904T2 (de) 2007-02-08
NZ534891A (en) 2006-03-31
AR039868A1 (es) 2005-03-09
KR20040089705A (ko) 2004-10-21
JP4330450B2 (ja) 2009-09-16
RU2004126610A (ru) 2005-05-27
NO332678B1 (no) 2012-12-03
US7649000B2 (en) 2010-01-19
IL163710A0 (en) 2005-12-18
MY130830A (en) 2007-07-31
DE60306904D1 (de) 2006-08-31
WO2003076458A3 (en) 2003-11-06
EP1483284B1 (en) 2006-07-19
EP1483284A2 (en) 2004-12-08
ES2264523T3 (es) 2007-01-01
TW200403255A (en) 2004-03-01
DK1483284T3 (da) 2006-10-16
JP2005533750A (ja) 2005-11-10
ATE333463T1 (de) 2006-08-15
NO20043695L (no) 2004-10-07
KR100974633B1 (ko) 2010-08-06
TWI283685B (en) 2007-07-11
AU2003208471B2 (en) 2006-09-28
EG25482A (en) 2012-01-15
PL209670B1 (pl) 2011-10-31
US20060052313A1 (en) 2006-03-09
PL372977A1 (en) 2005-08-08
CA2478099C (en) 2011-10-04
RU2301225C2 (ru) 2007-06-20
WO2003076458A2 (en) 2003-09-18
CN1274713C (zh) 2006-09-13
HK1072265A1 (en) 2005-08-19
UY27699A1 (es) 2003-10-31
CA2478099A1 (en) 2003-09-18
IL163710A (en) 2010-12-30
AU2003208471A1 (en) 2003-09-22
PT1483284E (pt) 2006-11-30
CN1639186A (zh) 2005-07-13
MXPA04008523A (es) 2004-12-06

Similar Documents

Publication Publication Date Title
ZA200406856B (en) Selective dipeptide inhibitors of kallikrein.
EP0772590B1 (en) Thrombin inhibitors
NO169543B (no) Analogifremgangsmaate ved fremstilling av terapeutisk aktive peptidaseinhibitorer
CA2217682A1 (en) Thrombin inhibitors
EP0542525A2 (en) Antithrombotic agents
WO1993025574A1 (en) Inhibitors of angiotensin i chymase(s) including human heart chymase
HU204847B (en) Process for producing new peptidase inhibitors
PL188411B1 (pl) Nowe inhibitory trombiny i ich zastosowanie
EP1244621A1 (en) Nitrile derivatives as cathepsin k inhibitors
WO1992016549A1 (de) Para-substituierte phenylalanin-derivate
CA2449292A1 (en) Dipeptide derivatives
CA2170896A1 (en) Kininogen inhibitors
WO1999037668A1 (de) Thrombininhibitoren
CA2342985C (en) Hydroxamate-containing cysteine and serine protease inhibitors
US5798377A (en) Thrombin inhibitors
EP0858262B1 (en) Thrombin inhibitors
US5888971A (en) Macrocyclic peptides useful in the treatment of thrombin related disorders
EP1049673A1 (de) Heterocyclische amidine als kallikrein protease inhibitoren
CZ200392A3 (cs) Aminoisochinolinové deriváty
DE69606552T2 (de) Acylierte enolderivate von alpha-ketoestern und alpha-ketoamiden
KR840002357B1 (ko) S-(아실아미도아실)메르캅토아실 프롤린류의 제조방법
CZ20002463A3 (cs) Nové inhibitory trombinu
CA2163011A1 (en) New peptides derivatives