[go: up one dir, main page]

ZA200204378B - Novel tiotropium-containing inhalation powder. - Google Patents

Novel tiotropium-containing inhalation powder.

Info

Publication number
ZA200204378B
ZA200204378B ZA200204378A ZA200204378A ZA200204378B ZA 200204378 B ZA200204378 B ZA 200204378B ZA 200204378 A ZA200204378 A ZA 200204378A ZA 200204378 A ZA200204378 A ZA 200204378A ZA 200204378 B ZA200204378 B ZA 200204378B
Authority
ZA
South Africa
Prior art keywords
inhalation powder
containing inhalation
novel tiotropium
tiotropium
novel
Prior art date
Application number
ZA200204378A
Other languages
English (en)
Inventor
Karoline Bechtold-Peters
Michael Walz
George Boeck
Rolf Doerr
Original Assignee
Boehringer Ingelheim Pharma
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=7659578&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ZA200204378(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Boehringer Ingelheim Pharma filed Critical Boehringer Ingelheim Pharma
Publication of ZA200204378B publication Critical patent/ZA200204378B/xx

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/007Pulmonary tract; Aromatherapy
    • A61K9/0073Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy
    • A61K9/0075Sprays or powders for inhalation; Aerolised or nebulised preparations generated by other means than thermal energy for inhalation via a dry powder inhaler [DPI], e.g. comprising micronized drug mixed with lactose carrier particles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/439Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom the ring forming part of a bridged ring system, e.g. quinuclidine
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/14Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/06Antiasthmatics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/08Bronchodilators
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pulmonology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Otolaryngology (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
ZA200204378A 2000-10-12 2002-05-21 Novel tiotropium-containing inhalation powder. ZA200204378B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
DE10050635 2000-10-12

Publications (1)

Publication Number Publication Date
ZA200204378B true ZA200204378B (en) 2003-05-19

Family

ID=7659578

Family Applications (1)

Application Number Title Priority Date Filing Date
ZA200204378A ZA200204378B (en) 2000-10-12 2002-05-21 Novel tiotropium-containing inhalation powder.

Country Status (49)

Country Link
US (4) US7070800B2 (pt)
EP (2) EP1430887A1 (pt)
JP (1) JP3870159B2 (pt)
KR (1) KR100488644B1 (pt)
CN (1) CN1210017C (pt)
AP (1) AP1712A (pt)
AR (1) AR031819A1 (pt)
AT (1) ATE275391T1 (pt)
AU (1) AU757008B2 (pt)
BG (1) BG65753B1 (pt)
BR (1) BR0107304A (pt)
CA (1) CA2395653C (pt)
CR (1) CR6937A (pt)
CU (1) CU23284B7 (pt)
CZ (1) CZ301465B6 (pt)
DE (1) DE50103551C5 (pt)
DK (1) DK1292281T3 (pt)
DZ (1) DZ3477A1 (pt)
EA (1) EA004034B1 (pt)
EC (2) ECSP024268A (pt)
EE (1) EE04414B1 (pt)
EG (1) EG24139A (pt)
ES (1) ES2227268T3 (pt)
GE (1) GEP20063865B (pt)
HK (1) HK1051812A1 (pt)
HR (1) HRP20020437B1 (pt)
HU (1) HU226982B1 (pt)
IL (2) IL149984A0 (pt)
IS (1) IS2360B (pt)
MA (1) MA25843A1 (pt)
ME (2) ME00245B (pt)
MX (1) MXPA02005666A (pt)
MY (1) MY123544A (pt)
NO (1) NO331956B1 (pt)
NZ (1) NZ519406A (pt)
OA (1) OA12522A (pt)
PE (1) PE20020577A1 (pt)
PL (1) PL200063B1 (pt)
PT (1) PT1292281E (pt)
RS (1) RS50197B (pt)
SA (1) SA01220460B1 (pt)
SI (1) SI1292281T1 (pt)
SK (1) SK285389B6 (pt)
TR (1) TR200402367T4 (pt)
TW (1) TWI285553B (pt)
UA (1) UA72014C2 (pt)
UY (1) UY26959A1 (pt)
WO (1) WO2002030389A1 (pt)
ZA (1) ZA200204378B (pt)

Families Citing this family (79)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL200063B1 (pl) * 2000-10-12 2008-12-31 Boehringer Ingelheim Pharma Nowe proszki do inhalacji zawierające tiotropium
DK2283817T3 (en) 2000-11-30 2016-09-05 Vectura Ltd Process for preparing particles for use in a pharmaceutical composition
ES2334642T5 (es) 2000-11-30 2016-03-07 Vectura Limited Partículas para usar en una composición farmacéutica
US20030055026A1 (en) 2001-04-17 2003-03-20 Dey L.P. Formoterol/steroid bronchodilating compositions and methods of use thereof
US20030070679A1 (en) * 2001-06-01 2003-04-17 Boehringer Ingelheim Pharma Kg Capsules containing inhalable tiotropium
DE10128779A1 (de) * 2001-06-13 2003-01-02 Boehringer Ingelheim Pharma Verfahren zur Reinigung von Hartgelatinekapseln
US20030008001A1 (en) * 2001-06-13 2003-01-09 Boehringer Ingelheim Pharma Kg Process for cleaning hard gelatine capsules
DE10141376A1 (de) * 2001-08-23 2003-03-13 Boehringer Ingelheim Pharma Verfahren zur Herstellung von Inhalationspulvern
DE10141377A1 (de) * 2001-08-23 2003-03-13 Boehringer Ingelheim Pharma Aufstreuverfahren zur Herstellung von Pulverformulierungen
DE10212264A1 (de) 2002-03-20 2003-10-02 Boehringer Ingelheim Pharma Kristallines Mikronisat, Verfahren zu dessen Herstellung und dessen Verwendung zur Herstellung eines Arzneimittels
US7309707B2 (en) * 2002-03-20 2007-12-18 Boehringer Ingelheim Pharma Gmbh & Co. Kg Crystalline micronisate, process for the manufacture thereof and use thereof for the preparation of a medicament
US7244415B2 (en) * 2002-03-28 2007-07-17 Boehringer Ingelheim Pharma Gmbh & Co. Kg HFA suspension formulations of an anhydrate
DK1494648T3 (da) * 2002-04-04 2006-12-27 Boehringer Ingelheim Pharma Pulverpræparat til inhalation
US20030235538A1 (en) * 2002-04-09 2003-12-25 Boehringer Ingelheim Pharma Gmbh & Co. Kg Method for the administration of an anticholinergic by inhalation
AU2003276837B2 (en) * 2002-06-12 2006-07-20 Epigenesis Pharmaceuticals, Llc. Combination of anti-muscarinic agents and non-glucocorticoid steroids
GB0219513D0 (en) 2002-08-21 2002-10-02 Norton Healthcare Ltd Inhalation compositions including coarse carrier
JP2006516531A (ja) * 2002-08-21 2006-07-06 ノートン ヘルスケアー リミテッド 吸入組成物
GB0219511D0 (en) * 2002-08-21 2002-10-02 Norton Healthcare Ltd Method of preparing dry powder inhalation compositions
NZ538965A (en) * 2002-08-21 2006-11-30 Norton Healthcare Ltd Dry powder inhalation compositions
DE10255387A1 (de) * 2002-11-28 2004-06-09 Boehringer Ingelheim Pharma Gmbh & Co. Kg Neue Tiotropium-haltige Pulverformulierung für die Inhalation
US7763280B2 (en) 2002-11-28 2010-07-27 Boehringer Ingelheim Pharma Gmbh & Co. Kg Tiotropium containing powder formulation for inhalation
US20050058606A1 (en) * 2002-12-16 2005-03-17 Boehringer Ingelheim Pharma Gmbh & Co. Kg Tiotropium containing HFC solution formulations
US20040152720A1 (en) * 2002-12-20 2004-08-05 Boehringer Ingelheim Pharma Gmbh & Co. Kg Powdered medicaments containing a tiotropium salt and salmeterol xinafoate
DE10317461A1 (de) 2003-04-16 2004-10-28 Boehringer Ingelheim Pharma Gmbh & Co. Kg Radioaktiv markierte Mikropartikel, Verfahren zu deren Herstellung und deren Verwendung
US20040226556A1 (en) 2003-05-13 2004-11-18 Deem Mark E. Apparatus for treating asthma using neurotoxin
JP2007517537A (ja) 2003-06-13 2007-07-05 アドバンスト インハレーション リサーチ,インコーポレイテッド 吸入用低投薬量医薬粉末
TWI359675B (en) * 2003-07-10 2012-03-11 Dey L P Bronchodilating β-agonist compositions
US20050038004A1 (en) * 2003-07-31 2005-02-17 Robinson Cynthia B. Combination of dehydroepiandrosterone or dehydroepiandrosterone-sulfate with an anticholinergic bronchodilator for treatment of asthma or chronic obstructive pulmonary disease
DK1682543T3 (da) 2003-11-03 2010-12-13 Boehringer Ingelheim Int Fremgangsmåde til fremstilling af nye tiotropiumsalte
PL2067779T3 (pl) 2003-11-03 2013-09-30 Boehringer Ingelheim Int Sole tiotropium, sposoby ich wytwarzania oraz zawierające je kompozycje farmaceutyczne
AU2004294889B2 (en) * 2003-12-03 2010-08-26 Boehringer Ingelheim International Gmbh Medical product containing tiotropium
SE0303270L (sv) * 2003-12-03 2005-06-04 Microdrug Ag Metod för administration av tiotropium
SE0303269L (sv) * 2003-12-03 2005-06-04 Microdrug Ag Medicinsk produkt
SE0303570L (sv) * 2003-12-03 2005-06-04 Microdrug Ag Fukt-känslig medicinsk produkt
WO2005053648A1 (en) * 2003-12-03 2005-06-16 Microdrug Ag Pre-metered dry powder inhaler for moisture-sensitive medicaments
DE102004048389A1 (de) 2004-10-01 2006-04-06 Boehringer Ingelheim Pharma Gmbh & Co. Kg Modifizierung von Oberflächen von Laktose als Hilfsstoff zur Verwendung für Pulverinhalativa
NZ556709A (en) 2005-02-10 2009-09-25 Glaxo Group Ltd Process for making lactose utilizing pre-classification techniques and pharmaceutical formulations formed therefrom
RU2417224C2 (ru) * 2005-05-02 2011-04-27 Бёрингер Ингельхайм Интернациональ Гмбх Новые кристаллические формы тиотропийбромида
CN101227905A (zh) * 2005-06-15 2008-07-23 贝林格尔·英格海姆国际有限公司 制备噻托铵盐的方法、噻托铵盐及其药物组合物
TWI274641B (en) * 2005-08-30 2007-03-01 Rexon Ind Corp Ltd Cutting machine
PL2123650T3 (pl) * 2005-12-19 2012-09-28 Sicor Inc Nowa postać bromku tiotropium i sposób jej wytwarzania
US9108962B2 (en) 2005-12-19 2015-08-18 Sicor, Inc. Forms of tiotropium bromide and processes for preparation thereof
KR20080079586A (ko) * 2005-12-19 2008-09-01 시코르, 인크. 순수하고 안정한 티오트로퓸 브로마이드
RU2453547C2 (ru) * 2005-12-19 2012-06-20 Сикор Инк. Новые формы тиотропия бромида и способы их получения
US20070167480A1 (en) * 2005-12-19 2007-07-19 Sicor Inc. Pure and stable tiotropium bromide
US20080051582A1 (en) * 2006-07-10 2008-02-28 Sicor Inc. Process for the preparation of tiotropium bromide
GB0716026D0 (en) * 2007-08-16 2007-09-26 Norton Healthcare Ltd An inhalable medicament
RU2479587C2 (ru) * 2007-07-27 2013-04-20 Карджилл, Инкорпорейтед Микронизация полиолов
US8483831B1 (en) 2008-02-15 2013-07-09 Holaira, Inc. System and method for bronchial dilation
JP2011519699A (ja) 2008-05-09 2011-07-14 インノブアトイブエ プルモナルイ ソルウトイオンス,インコーポレイティッド 気管支樹の治療のためのシステム、アセンブリ、及び方法
EP2172190A1 (en) 2008-10-02 2010-04-07 Laboratorios Liconsa, S.A. Inhalable particles comprising tiotropium
CN102439007A (zh) 2009-03-17 2012-05-02 第一三共株式会社 酰胺衍生物
CA2779135C (en) 2009-10-27 2018-09-04 Innovative Pulmonary Solutions, Inc. Delivery devices with coolable energy emitting assemblies
EP4111995A1 (en) 2009-11-11 2023-01-04 Nuvaira, Inc. Device for treating tissue and controlling stenosis
US8911439B2 (en) 2009-11-11 2014-12-16 Holaira, Inc. Non-invasive and minimally invasive denervation methods and systems for performing the same
US8834931B2 (en) 2009-12-25 2014-09-16 Mahmut Bilgic Dry powder formulation containing tiotropium for inhalation
WO2011152804A2 (en) * 2010-06-03 2011-12-08 Mahmut Bilgic Process for dry powder formulations
TR201007251A2 (tr) * 2010-09-01 2012-03-21 Bi̇lgi̇ç Mahmut Kalsiyum kanal blokörü formülasyonu.
GB201200525D0 (en) 2011-12-19 2012-02-29 Teva Branded Pharmaceutical Prod R & D Inc An inhalable medicament
US20150165038A1 (en) * 2012-02-10 2015-06-18 Arven llac Sanayi Ve Ticaret A.S. Compositions comprising muscarinic receptor antagonist and sorbitol
WO2013127738A1 (de) 2012-02-28 2013-09-06 Boehringer Ingelheim International Gmbh Neue treibgashaltige tiotropium-formulierung
RU2522213C2 (ru) * 2012-06-07 2014-07-10 Шолекс Девелопмент Гмбх, Фармацевтический ингаляционный препарат для лечения бронхиальной астмы и хронической обструктивной болезни легких, содержащих в качестве активного вещества микронизированный тиотропия бромид, и способ его получения
WO2014007781A2 (en) * 2012-07-05 2014-01-09 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi Inhalation compositions
US20150150802A1 (en) 2012-07-05 2015-06-04 Arven Ilac Sanayi Ve Ticaret Anonim Sirketi Dry powder inhaler compositions comprising long acting muscarinic antagonists
WO2014007772A2 (en) * 2012-07-05 2014-01-09 Sanovel Ilac Sanayi Ve Ticaret Anonim Sirketi Inhalation compositions comprising glucose anhydrous
US10105316B2 (en) 2012-07-05 2018-10-23 Arven llac Sanayi Ve Ticaret A.S. Inhalation compositions comprising muscarinic receptor antagonist
US20150165037A1 (en) * 2012-07-05 2015-06-18 Arven llac Sanayi Ve Ticaret A.S. Inhalation compositions comprising corticosteroid and sorbitol
US20150174064A1 (en) * 2012-07-05 2015-06-25 Arven IIac Sanayi Ve Ticaret A.S. Compositions comprising muscarinic receptor antagonist and glucose anhydrous
EP2705838A1 (en) 2012-09-06 2014-03-12 Xspray Microparticles Ab Tiotropium preparations
US9398933B2 (en) 2012-12-27 2016-07-26 Holaira, Inc. Methods for improving drug efficacy including a combination of drug administration and nerve modulation
WO2015065222A1 (ru) * 2013-10-28 2015-05-07 Шолекс Девелопмент Гмбх Фармацевтический ингаляционный препарат для лечения бронхиальной астмы и хронической обструктивной болезни легких, содержащий в качестве активного вещества микронизированный тиотропия бромид, и способ его получения
EP2913332A1 (en) 2014-02-27 2015-09-02 Euticals S.P.A. Crystalline form of tiotropium bromide with lactose
US10034866B2 (en) 2014-06-19 2018-07-31 Teva Branded Pharmaceutical Products R&D, Inc. Inhalable medicament comprising tiotropium
GEP20207142B (en) 2015-10-23 2020-08-10 Arven Ilac Sanayi Ve Ticaret As Blister for inhalable formulation of tiotropium bromide
KR101728116B1 (ko) * 2015-11-03 2017-04-18 한미약품 주식회사 티오트로피움 또는 이의 약학적으로 허용가능한 염을 함유하는 흡입용 건조분말 조성물
CN108289841A (zh) 2015-12-24 2018-07-17 菲利普莫里斯生产公司 带香味尼古丁粉末
EP3600306A4 (en) 2017-03-23 2020-12-02 Singapore Health Services Pte Ltd AGENT FOR PREVENTION OF MYOPIA, TREATMENT OF MYOPIA, AND / OR PREVENTION OF THE PROGRESSION OF MYOPIA INCLUDING TIOTROPIUM AS ACTIVE INGREDIENT
EP4108230A1 (en) 2021-06-24 2022-12-28 Laboratoires SMB New dry powder composition of tiotropium for inhalation
GR1010358B (el) * 2021-09-14 2022-12-16 Elpen Ανωνυμος Εταιρεια Φαρμακευτικη Βιομηχανια, Σταθερο φαρμακευτικο σκευασμα που περιεχει βρωμιουχο τιοτροπιο, για χορηγηση απο το αναπνευστικο

Family Cites Families (42)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3957965A (en) 1967-08-08 1976-05-18 Fisons Limited Sodium chromoglycate inhalation medicament
GB1242211A (en) * 1967-08-08 1971-08-11 Fisons Pharmaceuticals Ltd Pharmaceutical composition
US3860618A (en) 1967-08-08 1975-01-14 Philip Saxton Hartley Chromone
DE2540633A1 (de) 1975-09-12 1977-04-28 Boehringer Sohn Ingelheim Neue quartaere n-beta-substituierte benzilsaeure-n-alkyl-nortropinester und verfahren zu deren herstellung
DE3211185A1 (de) 1982-03-26 1983-09-29 Boehringer Ingelheim KG, 6507 Ingelheim Neue quartaere 6,11-dihydro-dibenzo-(b,e)-thiepin-11-n-alkyl- norscopinether und verfahren zu deren herstellung
DE3215493A1 (de) 1982-04-26 1983-11-03 Boehringer Ingelheim KG, 6507 Ingelheim Neue zwischenprodukte, verfahren zu ihrer herstellung und ihre verwendung
JPS60172442A (ja) 1984-02-20 1985-09-05 Fanuc Ltd ならい加工およびνc加工による機械加工装置
DE3931041C2 (de) 1989-09-16 2000-04-06 Boehringer Ingelheim Kg Ester von Thienylcarbonsäuren mit Aminoalkoholen, ihre Quaternierungsprodukte, Verfahren zu ihrer Herstellung und diese enthaltende Arzneimittel
US5610163A (en) 1989-09-16 1997-03-11 Boehringer Ingelheim Gmbh Esters of thienyl carboxylic acids and amino alcohols and their quaternization products
DE4108393A1 (de) 1991-03-15 1992-09-17 Boehringer Ingelheim Kg Neue ester bi- und tricyclischer aminoalkohole, ihre herstellung und ihre verwendung in arzneimitteln
AU1560692A (en) 1991-04-08 1992-11-02 Nippon Shinyaku Co. Ltd. Capsule
DE4140689B4 (de) * 1991-12-10 2007-11-22 Boehringer Ingelheim Kg Inhalationspulver und Verfahren zu ihrer Herstellung
US5770738A (en) 1992-03-05 1998-06-23 Boehringer Ingelheim Kg Esters of bi- and tricyclic amino alcohols, their preparation and their use in pharmaceutical compositions
DE4318455A1 (de) 1993-06-03 1994-12-08 Boehringer Ingelheim Kg Kapselhalterung
US5819730A (en) 1993-06-09 1998-10-13 Glaxo Wellcome Australia Ltd. Device for administering pharmaceutical substances
ATE398448T1 (de) 1993-09-28 2008-07-15 Scherer Gmbh R P Herstellung von weichgelatinekapseln
GB9322014D0 (en) 1993-10-26 1993-12-15 Co Ordinated Drug Dev Improvements in and relating to carrier particles for use in dry powder inhalers
GB9404945D0 (en) 1994-03-15 1994-04-27 Glaxo Group Ltd Pharmaceutical composition
DE4425255A1 (de) 1994-07-16 1996-01-18 Asta Medica Ag Formulierung zur inhalativen Applikation
DE19515625C2 (de) 1995-04-28 1998-02-19 Boehringer Ingelheim Kg Verfahren zur Herstellung von enantiomerenreinen Tropasäureestern
FR2757173A1 (fr) 1996-12-17 1998-06-19 Warner Lambert Co Compositions polymeres d'origine non-animale pour la formation de films
US6228394B1 (en) * 1997-10-14 2001-05-08 Boehringer Ingelheim Pharmaceuticals, Inc. Supercritical fluid extraction of mould lubricant from hard shell capsules
US6235725B1 (en) * 1998-10-30 2001-05-22 Baker Norton Pharmaceuticals, Inc. Methods and compositions for the prevention of tolerance to medications
EP1283036B2 (de) * 1998-11-13 2020-01-01 Jagotec AG Multidosis-Trockenpulverinhalator mit Pulverreservoir
GB9902689D0 (en) * 1999-02-08 1999-03-31 Novartis Ag Organic compounds
US20040002548A1 (en) 1999-05-12 2004-01-01 Boehringer Ingelheim Pharma Kg Medicament compositions containing anticholinergically-effective compounds and betamimetics
JP3931486B2 (ja) 1999-06-24 2007-06-13 住友化学株式会社 ポジ型レジスト組成物
PL200063B1 (pl) 2000-10-12 2008-12-31 Boehringer Ingelheim Pharma Nowe proszki do inhalacji zawierające tiotropium
UA75375C2 (en) 2000-10-12 2006-04-17 Boehringer Ingelheim Pharma Method for producing powdery preparations for inhaling
US6908928B2 (en) * 2000-10-12 2005-06-21 Bi Pharma Kg. Crystalline tiotropium bromide monohydrate, processes for the preparation thereof, and pharmaceutical compositions
DE10064816A1 (de) 2000-12-22 2002-06-27 Boehringer Ingelheim Pharma Verfahren zur Herstellung eines Anticholinergikums
US6506900B1 (en) 2001-01-31 2003-01-14 Boehringer Ingelheim Pharma Ag Process for preparing a scopine ester intermediate
US20030070679A1 (en) 2001-06-01 2003-04-17 Boehringer Ingelheim Pharma Kg Capsules containing inhalable tiotropium
DE10126924A1 (de) 2001-06-01 2002-12-05 Boehringer Ingelheim Pharma Inhalationskapseln
US6482429B1 (en) 2001-06-20 2002-11-19 Boehringer Ingelheim Pharmaceuticals, Inc. Stable powder inhalation dosage formulation
DE10141377A1 (de) 2001-08-23 2003-03-13 Boehringer Ingelheim Pharma Aufstreuverfahren zur Herstellung von Pulverformulierungen
DE10141376A1 (de) * 2001-08-23 2003-03-13 Boehringer Ingelheim Pharma Verfahren zur Herstellung von Inhalationspulvern
US7309707B2 (en) * 2002-03-20 2007-12-18 Boehringer Ingelheim Pharma Gmbh & Co. Kg Crystalline micronisate, process for the manufacture thereof and use thereof for the preparation of a medicament
DK1494648T3 (da) 2002-04-04 2006-12-27 Boehringer Ingelheim Pharma Pulverpræparat til inhalation
UA80123C2 (en) 2002-04-09 2007-08-27 Boehringer Ingelheim Pharma Inhalation kit comprising inhalable powder of tiotropium
US20030235538A1 (en) 2002-04-09 2003-12-25 Boehringer Ingelheim Pharma Gmbh & Co. Kg Method for the administration of an anticholinergic by inhalation
US7763280B2 (en) 2002-11-28 2010-07-27 Boehringer Ingelheim Pharma Gmbh & Co. Kg Tiotropium containing powder formulation for inhalation

Also Published As

Publication number Publication date
IL149984A (en) 2007-06-03
ECSP034546A (es) 2003-06-25
KR100488644B1 (ko) 2005-05-11
CZ20021785A3 (cs) 2002-09-11
MXPA02005666A (es) 2002-11-29
MEP40108A (en) 2011-02-10
PL356840A1 (en) 2004-07-12
HK1051812A1 (en) 2003-08-22
KR20020063912A (ko) 2002-08-05
CZ301465B6 (cs) 2010-03-10
HRP20020437A2 (en) 2004-08-31
DZ3477A1 (pt) 2002-04-18
EA200200551A1 (ru) 2002-12-26
ES2227268T3 (es) 2005-04-01
US20020110529A1 (en) 2002-08-15
NO331956B1 (no) 2012-05-14
BG106730A (bg) 2003-03-31
IL149984A0 (en) 2002-12-01
EP1292281A1 (de) 2003-03-19
MA25843A1 (fr) 2003-07-01
BG65753B1 (bg) 2009-10-30
EP1430887A1 (de) 2004-06-23
CR6937A (es) 2003-11-28
EP1292281B1 (de) 2004-09-08
JP2004510805A (ja) 2004-04-08
JP3870159B2 (ja) 2007-01-17
CN1392795A (zh) 2003-01-22
NO20022414D0 (no) 2002-05-22
PT1292281E (pt) 2004-11-30
US20060039868A1 (en) 2006-02-23
OA12522A (en) 2006-05-30
SK7062002A3 (en) 2002-10-08
CA2395653A1 (en) 2002-04-18
EE04414B1 (et) 2005-02-15
US20080292563A1 (en) 2008-11-27
AP2003002774A0 (en) 2003-03-31
ECSP024268A (es) 2002-08-01
TWI285553B (en) 2007-08-21
UY26959A1 (es) 2002-06-20
HU226982B1 (en) 2010-04-28
PE20020577A1 (es) 2002-08-08
DE50103551C5 (de) 2014-08-21
HRP20020437B1 (en) 2005-10-31
HUP0203885A3 (en) 2005-01-28
DK1292281T3 (da) 2004-10-11
AU8993501A (en) 2002-04-22
GEP20063865B (en) 2006-07-10
TR200402367T4 (tr) 2004-12-21
AR031819A1 (es) 2003-10-08
UA72014C2 (en) 2005-01-17
ATE275391T1 (de) 2004-09-15
PL200063B1 (pl) 2008-12-31
SK285389B6 (sk) 2006-12-07
RS50197B (sr) 2009-05-06
NO20022414L (no) 2002-05-30
EE200200428A (et) 2003-02-17
DE50103551D1 (de) 2004-10-14
AP1712A (en) 2007-01-24
IS2360B (is) 2008-05-15
SI1292281T1 (en) 2004-12-31
AU757008B2 (en) 2003-01-30
HUP0203885A2 (hu) 2003-03-28
SA01220460B1 (ar) 2006-10-31
EG24139A (en) 2008-08-06
CU23284B7 (es) 2008-06-30
US7070800B2 (en) 2006-07-04
MY123544A (en) 2006-05-31
IS6771A (is) 2003-04-08
CN1210017C (zh) 2005-07-13
NZ519406A (en) 2003-07-25
WO2002030389A1 (de) 2002-04-18
YU36302A (sh) 2002-09-19
BR0107304A (pt) 2002-08-13
US20040228806A1 (en) 2004-11-18
EA004034B1 (ru) 2003-12-25
ME00245B (me) 2011-02-10
CA2395653C (en) 2006-05-09

Similar Documents

Publication Publication Date Title
HK1051812A1 (en) Novel tiotropium-containing inhalation powder.
EG25378A (en) Powder inhalator.
HK1068007A1 (zh) 粉末吸入器
EG23340A (en) Dry powder inhaler.
IL133031A0 (en) Powder inhaler
GB0009592D0 (en) Respiratory combinations
ZA200205479B (en) Novel biarylcarboxamides.
EP1307256A4 (en) dry powder inhaler
SI1294421T1 (sl) Suhoprašni inhalator
ZA200308340B (en) Inhalation capsules.
AU145610S (en) Inhaler
HK1051153A1 (en) Toy figure.
EG23262A (en) Delta -pyrrolines.
HK1055426A1 (en) Indoloquinazolinones.
MXPA03001591A (es) Derivados y analogos de 10-aril-11-h-benzo(b) fluorena para uso medicinal.
MXPA03001877A (es) 2-guanidin-4-arilquinazolinas.
MXPA03001991A (es) Novedosas arilalcano-sulfonamidas.
HK1061560A1 (en) Triazolo-epothilones.
GB0009617D0 (en) Respiratory combinations
AU145556S (en) Inhaler
HK1044901A1 (zh) 呼吸器
GB0007510D0 (en) D.o.t.t.s
ZA200000695B (en) Respirator.
GB0031560D0 (en) Inhaler
GB0029979D0 (en) Inhaler