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YU92592A - Biopostupci za dobijanje 7-ack i 7-adkc - Google Patents

Biopostupci za dobijanje 7-ack i 7-adkc

Info

Publication number
YU92592A
YU92592A YU92592A YU92592A YU92592A YU 92592 A YU92592 A YU 92592A YU 92592 A YU92592 A YU 92592A YU 92592 A YU92592 A YU 92592A YU 92592 A YU92592 A YU 92592A
Authority
YU
Yugoslavia
Prior art keywords
ack
adkc
side chain
acid
adipoil
Prior art date
Application number
YU92592A
Other languages
English (en)
Other versions
YU48930B (sh
Inventor
M.J. Conder
A.M. Stepan
L. Crawford
J.A. Rambosek
P.C. Mcada
C.D. Reeves
Original Assignee
Gist Brocades B.V.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gist Brocades B.V. filed Critical Gist Brocades B.V.
Publication of YU92592A publication Critical patent/YU92592A/sh
Publication of YU48930B publication Critical patent/YU48930B/sh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P37/00—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin
    • C12P37/04—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin by acylation of the substituent in the 6 position
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/911—Microorganisms using fungi
    • Y10S435/933—Penicillium
    • Y10S435/935—Penicillium chrysogenum

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Cephalosporin Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)

Abstract

BIOPOSTUPCI ZA DOBIJANJE 7-ACK I 7-ADKC, važni intermedijeri za dobijanje cefalosporinskih antibiotika, 7-amino-cefalosporanska kiselina (7-ACK) i 7-aminodeacetilcefalosporanska kiselina (7-ADKC), dobijaju se novim biopostupkom u kome se transformisani Penicillium chrysogenum soj gaji u prisustvu adipatne sirovine za napajanje da bi se dobila adipoil-6-APK (6-amino penicilanska kiselina), a zatim in situ ekspresijom sledećih gena sa kojima je P. chrysogenum bio transformisan: 1) ekspandaza gena na pr., iz Cephalosporium acremonium, čiji ekspresioni proizvod konvertuje adipoil-6-APK ekspanzijom prstena u adipoil-7-ADCK; 2) hidroksilaza gena čiji ekspresioni proizvod konvertuje 3-metil bočni lanac adipoil-7-ADCK u 3-hidroksimetil, pri čemu daje prvi proizvod, 7-amino-deacetilcefalosporansku kiselinu (7-ADKC); i 3) acetiltransferaza gena čiji ekspresioni proizvod konvertuje 3-hidroksimetil bočni lanac u 3-acetiloksimetil bočni lanac 7-ACK. Finalni proizvod, 7-ACK, se tada dobija cepanjem adipoil bočnog lanca koristeći adipoil acilazu. Prema tome celokupna sinteza se izvodi koristeći biopostupke, i efikasna je i ekonomična.
YU92592A 1991-10-15 1992-10-15 Novi biopostupci za dobijanje 7-ack i 7-adkc YU48930B (sh)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US77783391A 1991-10-15 1991-10-15
US95349292A 1992-10-06 1992-10-06

Publications (2)

Publication Number Publication Date
YU92592A true YU92592A (sh) 1995-10-03
YU48930B YU48930B (sh) 2002-12-10

Family

ID=27119363

Family Applications (1)

Application Number Title Priority Date Filing Date
YU92592A YU48930B (sh) 1991-10-15 1992-10-15 Novi biopostupci za dobijanje 7-ack i 7-adkc

Country Status (27)

Country Link
US (4) US5559005A (sh)
EP (2) EP0540210B1 (sh)
JP (1) JP2655790B2 (sh)
KR (1) KR100227711B1 (sh)
CN (1) CN1074484A (sh)
AT (2) ATE216700T1 (sh)
AU (1) AU657800B2 (sh)
BG (1) BG62261B1 (sh)
CA (1) CA2080573C (sh)
CZ (1) CZ288721B6 (sh)
DE (2) DE69227750T2 (sh)
DK (2) DK0540210T3 (sh)
ES (2) ES2127205T3 (sh)
FI (1) FI106965B (sh)
GR (1) GR3029343T3 (sh)
HU (1) HU219370B (sh)
IL (3) IL103419A (sh)
MX (1) MX9205902A (sh)
NO (1) NO315802B1 (sh)
NZ (1) NZ244714A (sh)
RO (1) RO116648B1 (sh)
RU (1) RU2002130702A (sh)
SK (1) SK280569B6 (sh)
TW (1) TW272233B (sh)
UA (1) UA47385C2 (sh)
WO (1) WO1993008287A1 (sh)
YU (1) YU48930B (sh)

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CN1103814C (zh) * 1993-07-30 2003-03-26 吉斯特·布罗卡迪斯公司 通过2－(羧乙硫基)乙酰－7－adca和3－(羧甲硫基)丙酰－7－adca有效生产7－adca的方法
CA2168004A1 (en) * 1993-07-30 1995-02-09 Roelof Ary Lans Bovenberg Process for the efficient production of 7-adca via 3-(carboxyethylthio)propionyl-7-adca
ATE334203T1 (de) * 1994-09-28 2006-08-15 Novozymes As Verfahren zur herstellung von sekundären metaboliten
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WO1997038107A1 (en) * 1996-04-04 1997-10-16 Gist-Brocades B.V. An enzyme with high adipoyl-coenzyme a synthetase activity and uses thereof
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BRPI0708232A2 (pt) * 2006-02-23 2011-05-17 Dsm Ip Assets Bv microorganismo que produz cefalosporina, método para a construção de um microorganismo e processo para a produção de uma cefalosporina
KR101569832B1 (ko) * 2008-11-19 2015-11-18 삼성전자주식회사 시료 중의 게놈 ｄｎａ 및 플라스미드 ｄｎａ를 서로 분리하는 방법 및 그를 위한 키트
CN101429538B (zh) * 2008-12-12 2011-05-25 河北九派制药有限公司 7-α-甲氧基-3-去乙酰基头孢噻吩苄星盐的制备方法
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US8863444B2 (en) 2010-05-31 2014-10-21 Feature Walters Assembly system for modular building units
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Also Published As

Publication number Publication date
EP0540210A1 (en) 1993-05-05
HU9401073D0 (en) 1994-07-28
DK0856516T3 (da) 2002-07-29
HU219370B (en) 2001-03-28
UA47385C2 (uk) 2002-07-15
ATE216700T1 (de) 2002-05-15
AU657800B2 (en) 1995-03-23
KR100227711B1 (ko) 1999-12-01
DE69227750D1 (de) 1999-01-14
US5629171A (en) 1997-05-13
US6071713A (en) 2000-06-06
SK43194A3 (en) 1996-11-06
CZ288721B6 (cs) 2001-08-15
EP0540210B1 (en) 1998-12-02
MX9205902A (es) 1994-06-30
SK280569B6 (sk) 2000-03-13
DE69227750T2 (de) 1999-04-22
BG62261B1 (bg) 1999-06-30
ATE174057T1 (de) 1998-12-15
DE69232581D1 (de) 2002-05-29
DK0540210T3 (da) 1999-06-23
US5559005A (en) 1996-09-24
IL133734A0 (en) 2001-04-30
CZ88494A3 (en) 1995-03-15
IL103419A (en) 2003-06-24
HUT69783A (en) 1995-09-28
FI941730A0 (fi) 1994-04-14
IL103419A0 (en) 1993-03-15
NZ244714A (en) 1994-03-25
RU2002130702A (ru) 2004-05-20
JP2655790B2 (ja) 1997-09-24
YU48930B (sh) 2002-12-10
TW272233B (sh) 1996-03-11
CN1074484A (zh) 1993-07-21
RO116648B1 (ro) 2001-04-30
NO315802B1 (no) 2003-10-27
WO1993008287A1 (en) 1993-04-29
ES2176613T3 (es) 2002-12-01
DE69232581T2 (de) 2002-11-14
US6017726A (en) 2000-01-25
AU2701692A (en) 1993-04-22
GR3029343T3 (en) 1999-05-28
CA2080573C (en) 2004-01-06
IL133733A0 (en) 2001-04-30
BG98714A (bg) 1995-02-28
NO941345D0 (no) 1994-04-14
EP0856516B1 (en) 2002-04-24
FI106965B (fi) 2001-05-15
EP0856516A1 (en) 1998-08-05
FI941730L (fi) 1994-04-14
NO941345L (no) 1994-06-15
JPH06113884A (ja) 1994-04-26
CA2080573A1 (en) 1993-04-16
ES2127205T3 (es) 1999-04-16

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