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ES2176613T3 - Acido adipoil-7-amino-desacetil-cefalosporanico. - Google Patents

Acido adipoil-7-amino-desacetil-cefalosporanico.

Info

Publication number
ES2176613T3
ES2176613T3 ES97204046T ES97204046T ES2176613T3 ES 2176613 T3 ES2176613 T3 ES 2176613T3 ES 97204046 T ES97204046 T ES 97204046T ES 97204046 T ES97204046 T ES 97204046T ES 2176613 T3 ES2176613 T3 ES 2176613T3
Authority
ES
Spain
Prior art keywords
adipoil
acid
aca
gene
side chain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES97204046T
Other languages
English (en)
Inventor
Michael J Conder
Anthony Michael Stepan
Lorilee Crawford
John A Rambosek
Phyllis C Mcada
Christopher D Reeves
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Koninklijke DSM NV
Original Assignee
DSM NV
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by DSM NV filed Critical DSM NV
Application granted granted Critical
Publication of ES2176613T3 publication Critical patent/ES2176613T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P37/00—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin
    • C12P37/04—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin by acylation of the substituent in the 6 position
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/911—Microorganisms using fungi
    • Y10S435/933—Penicillium
    • Y10S435/935—Penicillium chrysogenum

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Cephalosporin Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)

Abstract

SE PREPARA EL ACIDO 7 - AMINOCEFALOSPORANICO (7 - ACA) Y EL ACIDO 7 - AMINODESACETILCEFALOSPORANICO (7 - ADAC), IMPORTANTES INTERMEDIOS PARA PREPARAR ANTIBIOTICOS DE CEFALOSPORINA, MEDIANTE UN NUEVO BIOPROCEDIMIENTO EN EL CUAL UNA CEPA TRANSFORMADA DE PENICILLIUM CHRYSOGENUM SE CULTIVA EN PRESENCIA DE UN CULTIVO DE DESARROLLO DE ADIPATO PARA PRODUCIR ADIPOIL - 6 - APA (ACIDO 6 AMINOPENICILANICO); SEGUIDO DE LA EXPRESION IN SITU DE LOS SIGUIENTES GENES CON LOS CUALES HA SIDO TRANSFORMADO EL P. CHRYSOGENUM: 1) UN GEN DE EXPANDASA, POR EJEMPLO PROCEDENTE DE CEPHALOSPORIUM ACREMONIUM, CUYO PRODUCTO DE EXPRESION CONVIERTE EL ADIPOIL - 6 APA MEDIANTE LA EXPANSION DEL ANILLO EN ADIPOIL - 7 - ADCA; 2) UN GEN DE HIDROXILASA CUYO PRODUCTO DE EXPRESION CONVIERTE LA CADENA LATERAL 3 - METILO DEL ADIPOIL 7 - ADCA EN 3 HIDROXIMETILO, PARA PRODUCIR EL PRIMER PRODUCTO, ACIDO ADIPOIL 7 - AMINODESACETILCEFALOSPORANICO (7 - ADAC); Y 3) UN GEN DE ACETILTRANSFERASA CUYO PRODUCTO DE EXPRESION CONVIERTE LA CADENALATERAL 3 - HIDROXIMETILO EN LA CADENA LATERAL 3 - ACETILOXIMETILO DEL ADIPOIL - 7 - ACA. EL PRODUCTO FINAL, 7 - ACA, SE PREPARA ENTONCES MEDIANTE ESCISION DE LA CADENA LATERAL ADIPOILO UTILIZANDO UNA ADIPOILO ACILASA. POR CONSIGUIENTE, LA SINTESIS COMPLETA SE LLEVA A CABO UTILIZANDO BIOPROCEDIMIENTOS, Y RESULTA EFICAZ Y ECONOMICA.
ES97204046T 1991-10-15 1992-10-14 Acido adipoil-7-amino-desacetil-cefalosporanico. Expired - Lifetime ES2176613T3 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US77783391A 1991-10-15 1991-10-15
US95349292A 1992-10-06 1992-10-06

Publications (1)

Publication Number Publication Date
ES2176613T3 true ES2176613T3 (es) 2002-12-01

Family

ID=27119363

Family Applications (2)

Application Number Title Priority Date Filing Date
ES92309351T Expired - Lifetime ES2127205T3 (es) 1991-10-15 1992-10-14 Nuevo bioproceso para preparar 7-aca y 7-adac.
ES97204046T Expired - Lifetime ES2176613T3 (es) 1991-10-15 1992-10-14 Acido adipoil-7-amino-desacetil-cefalosporanico.

Family Applications Before (1)

Application Number Title Priority Date Filing Date
ES92309351T Expired - Lifetime ES2127205T3 (es) 1991-10-15 1992-10-14 Nuevo bioproceso para preparar 7-aca y 7-adac.

Country Status (27)

Country Link
US (4) US5559005A (es)
EP (2) EP0856516B1 (es)
JP (1) JP2655790B2 (es)
KR (1) KR100227711B1 (es)
CN (1) CN1074484A (es)
AT (2) ATE174057T1 (es)
AU (1) AU657800B2 (es)
BG (1) BG62261B1 (es)
CA (1) CA2080573C (es)
CZ (1) CZ288721B6 (es)
DE (2) DE69227750T2 (es)
DK (2) DK0540210T3 (es)
ES (2) ES2127205T3 (es)
FI (1) FI106965B (es)
GR (1) GR3029343T3 (es)
HU (1) HU219370B (es)
IL (3) IL103419A (es)
MX (1) MX9205902A (es)
NO (1) NO315802B1 (es)
NZ (1) NZ244714A (es)
RO (1) RO116648B1 (es)
RU (1) RU2002130702A (es)
SK (1) SK280569B6 (es)
TW (1) TW272233B (es)
UA (1) UA47385C2 (es)
WO (1) WO1993008287A1 (es)
YU (1) YU48930B (es)

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US6709859B1 (en) 1986-01-31 2004-03-23 Beecham Group P.L.C. Chromosomal DNA Fragments Encoding Enzymes for Encoding B-Lactam Biosynthesis Enzymes, and Vector and Transformants for Their Expression
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US5318896A (en) * 1991-09-11 1994-06-07 Merck & Co., Inc. Recombinant expandase bioprocess for preparing 7-aminodesacetoxy cephalosporanic acid (7-ADCA)
KR100336174B1 (ko) * 1993-07-30 2002-11-01 디에스엠 기스트 베.파우. 2-(카르복시에틸티오)아세틸-7-adca및3-(카르복시메틸티오)프로피오닐-7-adca를경유하여7-adca를제조하는효율적인방법
US5795733A (en) * 1993-07-30 1998-08-18 Gist-Brocades, B.V. Process for the efficient production of 7-ADCA via 3-(carboxyethylthio) propionyl-7-ADCA
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US6383773B2 (en) 1998-04-23 2002-05-07 Massachusetts Institute Of Technology Penicillin conversion
AU3042600A (en) * 1998-12-22 2000-07-12 Dsm N.V. Improved (in vivo) production of cephalosporins
ES2165276B1 (es) * 1999-06-18 2003-03-01 Antibioticos Sau Procedimiento biotecnologico para la produccion de acido 7-aminocefal osporanico (7-adca) y compuestos de sintesis intermedios particularmente penicilina n y desacetoxicefalosporina c (daoc)
WO2001087891A1 (en) 2000-05-13 2001-11-22 Smithkline Beecham P.L.C. Process for the purification of a salt of clavulanic acid
US6699699B2 (en) * 2002-03-26 2004-03-02 Synmax Biochemical Co., Ltd. Mutated penicillin expandases
EP1658296B1 (en) 2003-05-28 2012-12-19 DSM Sinochem Pharmaceuticals Netherlands B.V. Cephem compound
BRPI0708232A2 (pt) * 2006-02-23 2011-05-17 Dsm Ip Assets Bv microorganismo que produz cefalosporina, método para a construção de um microorganismo e processo para a produção de uma cefalosporina
KR101569832B1 (ko) * 2008-11-19 2015-11-18 삼성전자주식회사 시료 중의 게놈 ｄｎａ 및 플라스미드 ｄｎａ를 서로 분리하는 방법 및 그를 위한 키트
CN101429538B (zh) * 2008-12-12 2011-05-25 河北九派制药有限公司 7-α-甲氧基-3-去乙酰基头孢噻吩苄星盐的制备方法
CN102369290A (zh) 2009-04-03 2012-03-07 帝斯曼知识产权资产管理有限公司 发酵工艺
US8863444B2 (en) 2010-05-31 2014-10-21 Feature Walters Assembly system for modular building units
HUE035540T2 (en) 2010-06-22 2018-05-02 Dsm Sinochem Pharm Nl Bv Air bubble fermentation process
SMT201800111T1 (it) 2010-09-07 2018-05-02 Dsm Sinochem Pharm Nl Bv Processo per la produzione di cefalosporine
CN102702229A (zh) * 2011-08-04 2012-10-03 重庆天地药业有限责任公司 一种头孢唑肟钠关键中间体的制备及高含量头孢唑肟钠的制备
WO2015091455A1 (en) 2013-12-17 2015-06-25 Dpx Holdings B.V. Bioreactor
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Also Published As

Publication number Publication date
NO941345L (no) 1994-06-15
SK43194A3 (en) 1996-11-06
YU48930B (sh) 2002-12-10
US6017726A (en) 2000-01-25
FI941730A0 (fi) 1994-04-14
EP0856516B1 (en) 2002-04-24
FI106965B (fi) 2001-05-15
DE69232581T2 (de) 2002-11-14
NZ244714A (en) 1994-03-25
RO116648B1 (ro) 2001-04-30
SK280569B6 (sk) 2000-03-13
IL133734A0 (en) 2001-04-30
JPH06113884A (ja) 1994-04-26
DE69232581D1 (de) 2002-05-29
US6071713A (en) 2000-06-06
DK0540210T3 (da) 1999-06-23
CA2080573C (en) 2004-01-06
ATE174057T1 (de) 1998-12-15
HU219370B (en) 2001-03-28
HU9401073D0 (en) 1994-07-28
MX9205902A (es) 1994-06-30
DK0856516T3 (da) 2002-07-29
FI941730L (fi) 1994-04-14
HUT69783A (en) 1995-09-28
JP2655790B2 (ja) 1997-09-24
US5559005A (en) 1996-09-24
IL103419A0 (en) 1993-03-15
YU92592A (sh) 1995-10-03
EP0540210A1 (en) 1993-05-05
TW272233B (es) 1996-03-11
KR100227711B1 (ko) 1999-12-01
AU2701692A (en) 1993-04-22
EP0856516A1 (en) 1998-08-05
CA2080573A1 (en) 1993-04-16
AU657800B2 (en) 1995-03-23
UA47385C2 (uk) 2002-07-15
ES2127205T3 (es) 1999-04-16
ATE216700T1 (de) 2002-05-15
CN1074484A (zh) 1993-07-21
NO315802B1 (no) 2003-10-27
EP0540210B1 (en) 1998-12-02
CZ288721B6 (cs) 2001-08-15
WO1993008287A1 (en) 1993-04-29
BG98714A (bg) 1995-02-28
IL103419A (en) 2003-06-24
BG62261B1 (bg) 1999-06-30
RU2002130702A (ru) 2004-05-20
IL133733A0 (en) 2001-04-30
CZ88494A3 (en) 1995-03-15
DE69227750T2 (de) 1999-04-22
NO941345D0 (no) 1994-04-14
GR3029343T3 (en) 1999-05-28
DE69227750D1 (de) 1999-01-14
US5629171A (en) 1997-05-13

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