YU46713B - PROCEDURE FOR OBTAINING NEW MICROLIDE COMPOUNDS - Google Patents
PROCEDURE FOR OBTAINING NEW MICROLIDE COMPOUNDSInfo
- Publication number
- YU46713B YU46713B YU148888A YU148888A YU46713B YU 46713 B YU46713 B YU 46713B YU 148888 A YU148888 A YU 148888A YU 148888 A YU148888 A YU 148888A YU 46713 B YU46713 B YU 46713B
- Authority
- YU
- Yugoslavia
- Prior art keywords
- group
- microlide
- compounds
- hydrogen atom
- formula
- Prior art date
Links
Landscapes
- Saccharide Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Pyrane Compounds (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
POSTUPAK ZA DOBIJANJE NOVIH MIKROLIDNIH JEDINJENJA opšte formule (I): i njihovih soli, u kojoj: R1 pretstavlja metil, etil ili izopropil grupu; R2 pretstavlja vodonikov atom, C1-4alkil grupu ili alil grupu i grupa =NOR2 je u E-konfiguraciji; OR3 je hidroksilna grupa ili grupe -OCOOR4 ili -OCOR4, gde je R4 C1-6 alkil, ili grupa -OCONR8R9 gde su R8 i R9 nezavisno vodonikov atom ili C1-4alkil, naznačen time, što obuhvata reakciju jedinjenja formule (I) u kojoj je OR3 hidroksilna grupa sa sredstvom za acilovanje u inertnom organskom rastvaraču, poželjno dihlorometanu, na temperaturi od -20 В°C do 100 В°C, poželjno na 0-3 В°C i u prisustvu sredstva za hvatanje kiseline kao što je piridin, i/ili ukoliko je R2 vodonik, reakciju sa sredstvom za eterifikaciju formule R2Y u kojoj je R2 kao što je definisano ranije, osim što nije vodonikov atom, a Y je odlazeća grupa, posle ćega se, prema potrebi vrši uklanjanje zaštite sa OR3 zaštićene hidroksilne grupe.A process for the preparation of novel MICROLIDE COMPOUNDS of the general formula (I): and their salts, in which: R 1 represents a methyl, ethyl or isopropyl group; R2 represents a hydrogen atom, a C1-4alkyl group or an allyl group and the group = NOR2 is in the E-configuration; OR3 is a hydroxyl group or groups -OCOOR4 or -OCOR4, wherein R4 is C1-6 alkyl, or a group -OCONR8R9 wherein R8 and R9 are independently a hydrogen atom or C1-4alkyl, comprising the reaction of a compound of formula (I) wherein OR3 is a hydroxyl group with an acylating agent in an inert organic solvent, preferably dichloromethane, at a temperature of -20 V ° C to 100 V ° C, preferably at 0-3 V ° C and in the presence of an acid scavenger such as pyridine, and / or if R2 is hydrogen, reaction with an esterifying agent of formula R2Y in which R2 is as previously defined, except that it is not a hydrogen atom and Y is a leaving group, after which, if necessary, deprotection of the OR3 protected hydroxyl group is performed .
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB878708423A GB8708423D0 (en) | 1987-04-08 | 1987-04-08 | Chemical compounds |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| YU148888A YU148888A (en) | 1988-12-31 |
| YU46713B true YU46713B (en) | 1994-04-05 |
Family
ID=10615471
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| YU218687A YU46777B (en) | 1987-04-08 | 1987-12-04 | PROCEDURE FOR OBTAINING NEW MACROLIDE COMPOUNDS |
| YU148988A YU46714B (en) | 1987-04-08 | 1988-08-02 | PROCEDURE FOR PREPARATION OF MICROLIDE COMPOUNDS |
| YU148888A YU46713B (en) | 1987-04-08 | 1988-08-02 | PROCEDURE FOR OBTAINING NEW MICROLIDE COMPOUNDS |
| YU148788A YU46712B (en) | 1987-04-08 | 1988-08-02 | PROCEDURE FOR OBTAINING NEW MICROLIDE COMPOUNDS |
| YU106689A YU47126B (en) | 1987-04-08 | 1989-05-24 | PREPARATION FOR PEST CONTROL AND ITS USE IN AGRICULTURE |
Family Applications Before (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| YU218687A YU46777B (en) | 1987-04-08 | 1987-12-04 | PROCEDURE FOR OBTAINING NEW MACROLIDE COMPOUNDS |
| YU148988A YU46714B (en) | 1987-04-08 | 1988-08-02 | PROCEDURE FOR PREPARATION OF MICROLIDE COMPOUNDS |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| YU148788A YU46712B (en) | 1987-04-08 | 1988-08-02 | PROCEDURE FOR OBTAINING NEW MICROLIDE COMPOUNDS |
| YU106689A YU47126B (en) | 1987-04-08 | 1989-05-24 | PREPARATION FOR PEST CONTROL AND ITS USE IN AGRICULTURE |
Country Status (4)
| Country | Link |
|---|---|
| GB (1) | GB8708423D0 (en) |
| HR (1) | HRP920589B1 (en) |
| SI (1) | SI8712186A (en) |
| YU (5) | YU46777B (en) |
-
1987
- 1987-04-08 GB GB878708423A patent/GB8708423D0/en active Pending
- 1987-12-04 YU YU218687A patent/YU46777B/en unknown
- 1987-12-04 SI SI8712186A patent/SI8712186A/en unknown
-
1988
- 1988-08-02 YU YU148988A patent/YU46714B/en unknown
- 1988-08-02 YU YU148888A patent/YU46713B/en unknown
- 1988-08-02 YU YU148788A patent/YU46712B/en unknown
-
1989
- 1989-05-24 YU YU106689A patent/YU47126B/en unknown
-
1992
- 1992-09-29 HR HR920589A patent/HRP920589B1/en not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| YU148788A (en) | 1988-12-31 |
| HRP920589B1 (en) | 2000-12-31 |
| YU46714B (en) | 1994-04-05 |
| YU106689A (en) | 1991-02-28 |
| YU46712B (en) | 1994-04-05 |
| YU46777B (en) | 1994-05-10 |
| YU47126B (en) | 1994-12-28 |
| GB8708423D0 (en) | 1987-05-13 |
| SI8712186A (en) | 1997-02-28 |
| YU148988A (en) | 1988-12-31 |
| YU148888A (en) | 1988-12-31 |
| YU218687A (en) | 1988-12-31 |
| HRP920589A2 (en) | 1995-06-30 |
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