[go: up one dir, main page]

WO2014007549A3 - 에스-알릴-엘-시스테인을 유효성분으로 포함하는 대장염 예방 또는 치료용 조성물 및 이를 포함하는 의약제제 - Google Patents

에스-알릴-엘-시스테인을 유효성분으로 포함하는 대장염 예방 또는 치료용 조성물 및 이를 포함하는 의약제제 Download PDF

Info

Publication number
WO2014007549A3
WO2014007549A3 PCT/KR2013/005922 KR2013005922W WO2014007549A3 WO 2014007549 A3 WO2014007549 A3 WO 2014007549A3 KR 2013005922 W KR2013005922 W KR 2013005922W WO 2014007549 A3 WO2014007549 A3 WO 2014007549A3
Authority
WO
WIPO (PCT)
Prior art keywords
preventing
cysteine
allyl
composition
colitis
Prior art date
Application number
PCT/KR2013/005922
Other languages
English (en)
French (fr)
Other versions
WO2014007549A2 (ko
Inventor
김순배
김광순
김완배
곽의종
전선덕
윤형영
함기백
김은희
Original Assignee
주식회사파마킹
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by 주식회사파마킹 filed Critical 주식회사파마킹
Priority to US14/412,674 priority Critical patent/US20150147411A1/en
Priority to BR112014033088A priority patent/BR112014033088A2/pt
Priority to CN201380035480.9A priority patent/CN104487065A/zh
Priority to RU2015100897A priority patent/RU2015100897A/ru
Priority to EP13813180.0A priority patent/EP2870964A4/en
Priority to JP2015520061A priority patent/JP2015521657A/ja
Publication of WO2014007549A2 publication Critical patent/WO2014007549A2/ko
Publication of WO2014007549A3 publication Critical patent/WO2014007549A3/ko

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/195—Carboxylic acids, e.g. valproic acid having an amino group
    • A61K31/197—Carboxylic acids, e.g. valproic acid having an amino group the amino and the carboxyl groups being attached to the same acyclic carbon chain, e.g. gamma-aminobutyric acid [GABA], beta-alanine, epsilon-aminocaproic acid or pantothenic acid
    • A61K31/198—Alpha-amino acids, e.g. alanine or edetic acid [EDTA]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18—Magnoliophyta (angiosperms)
    • A61K36/88—Liliopsida (monocotyledons)
    • A61K36/896—Liliaceae (Lily family), e.g. daylily, plantain lily, Hyacinth or narcissus
    • A61K36/8962—Allium, e.g. garden onion, leek, garlic or chives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A61K45/06—Mixtures of active ingredients without chemical characterisation, e.g. antiphlogistics and cardiaca
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
    • A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
    • A61K47/38—Cellulose; Derivatives thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/08—Solutions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/141—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers
    • A61K9/146—Intimate drug-carrier mixtures characterised by the carrier, e.g. ordered mixtures, adsorbates, solid solutions, eutectica, co-dried, co-solubilised, co-kneaded, co-milled, co-ground products, co-precipitates, co-evaporates, co-extrudates, co-melts; Drug nanoparticles with adsorbed surface modifiers with organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2059—Starch, including chemically or physically modified derivatives; Amylose; Amylopectin; Dextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/4841—Filling excipients; Inactive ingredients
    • A61K9/4866—Organic macromolecular compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61M—DEVICES FOR INTRODUCING MEDIA INTO, OR ONTO, THE BODY; DEVICES FOR TRANSDUCING BODY MEDIA OR FOR TAKING MEDIA FROM THE BODY; DEVICES FOR PRODUCING OR ENDING SLEEP OR STUPOR
    • A61M15/00—Inhalators
    • A61M15/009—Inhalators using medicine packages with incorporated spraying means, e.g. aerosol cans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/06—Free radical scavengers or antioxidants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
    • A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
    • A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Natural Medicines & Medicinal Plants (AREA)
  • Hematology (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Biomedical Technology (AREA)
  • Pulmonology (AREA)
  • Anesthesiology (AREA)
  • Dermatology (AREA)
  • Inorganic Chemistry (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Toxicology (AREA)
  • Dispersion Chemistry (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Nutrition Science (AREA)
  • Physiology (AREA)
  • Biochemistry (AREA)
  • Alternative & Traditional Medicine (AREA)
  • Biotechnology (AREA)
  • Botany (AREA)
  • Medical Informatics (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

본 발명은 대장염 예방용 또는 치료용 조성물에 관한 것으로서, 본 발명의 일 실시예에 따른 대장염 예방 또는 치료용 조성물은 에스-알릴-엘-시스테인(S-allyl-L-cysteine), 이의 약학적으로 허용가능한 염, 또는 이들의 용매화물 또는 수화물을 유효성분으로 포함하고, 대장염에 항염증(Anti-inflammation) 활성을 나타내는 것이다. 상기 대장염 예방 또는 치료용 조성물은 에스-알릴-엘-시스테인의 항염증 활성효과 및 항산화 활성효과로서 대장염에 대한 예방 및 개선효과가 우수하면서도, 에스-알릴-엘-시스테인은 부작용을 동반하지 않으므로 대장염에 대한 활용범위가 높다.
PCT/KR2013/005922 2012-07-03 2013-07-03 에스-알릴-엘-시스테인을 유효성분으로 포함하는 대장염 예방 또는 치료용 조성물 및 이를 포함하는 의약제제 WO2014007549A2 (ko)

Priority Applications (6)

Application Number Priority Date Filing Date Title
US14/412,674 US20150147411A1 (en) 2012-07-03 2013-07-03 Composition for preventing or treating colitis comprising s-allyl-l-cysteine as active ingredient, and medical preparation comprising same
BR112014033088A BR112014033088A2 (pt) 2012-07-03 2013-07-03 composição para prevenção ou tratamento de colite compreendendo s-alil-l-cisteína como ingrediente ativo, e preparação médica compreendendo a mesma
CN201380035480.9A CN104487065A (zh) 2012-07-03 2013-07-03 包含s-烯丙基-l-半胱氨酸作为活性成分的结肠炎预防或治疗用组合物及包含它的医药制剂
RU2015100897A RU2015100897A (ru) 2012-07-03 2013-07-03 Композиция для предупреждения или лечения колита, содержащая s-аллил-l-цистеин в качестве активного ингредиента, и содержащий ее медицинский препарат
EP13813180.0A EP2870964A4 (en) 2012-07-03 2013-07-03 COMPOSITION FOR THE PREVENTION OR TREATMENT OF COLITIET COMPRISING S-ALLYL-L-CYSTEINE AS ACTIVE INGREDIENT AND MEDICAL PREPARATION COMPRISING THE SAME
JP2015520061A JP2015521657A (ja) 2012-07-03 2013-07-03 Ｓ−アリル−ｌ−システインを有効成分として含む大腸炎予防または治療用組成物、およびこれを含む医薬製剤

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
KR20120072080A KR101320945B1 (ko) 2012-07-03 2012-07-03 에스-알릴-엘-시스테인을 유효성분으로 포함하는 대장염 예방 또는 치료용 조성물 및 이를 포함하는 의약제제
KR10-2012-0072080 2012-07-03

Publications (2)

Publication Number Publication Date
WO2014007549A2 WO2014007549A2 (ko) 2014-01-09
WO2014007549A3 true WO2014007549A3 (ko) 2014-02-20

Family

ID=49639041

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/KR2013/005922 WO2014007549A2 (ko) 2012-07-03 2013-07-03 에스-알릴-엘-시스테인을 유효성분으로 포함하는 대장염 예방 또는 치료용 조성물 및 이를 포함하는 의약제제

Country Status (8)

Country Link
US (1) US20150147411A1 (ko)
EP (1) EP2870964A4 (ko)
JP (1) JP2015521657A (ko)
KR (1) KR101320945B1 (ko)
CN (1) CN104487065A (ko)
BR (1) BR112014033088A2 (ko)
RU (1) RU2015100897A (ko)
WO (1) WO2014007549A2 (ko)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR101811440B1 (ko) * 2014-12-16 2017-12-21 경희대학교 산학협력단 에스-알릴-엘-시스테인을 유효성분으로 함유하는 위장관 운동 촉진용 약학적 조성물
EP3587397B1 (en) * 2017-01-26 2022-03-02 Canvax Biotech, S.L. S-allyl-l-cysteine for use in the treatment of multiple sclerosis
CN117503745A (zh) * 2024-01-04 2024-02-06 潍坊现代农业山东省实验室 脱氧蒜氨酸作为肥大细胞活化抑制剂的应用

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20090068560A (ko) * 2007-12-24 2009-06-29 덕성여자대학교 산학협력단 항염증 활성을 갖는 산마늘 추출물
KR20100026597A (ko) * 2008-09-01 2010-03-10 경남도립남해대학 산학협력단 흑마늘 추출물을 유효성분으로 함유하는 염증성 질환의 예방 및 치료용 조성물

Family Cites Families (12)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH540049A (de) * 1973-03-05 1973-08-15 Lehner Ag Verfahren zur Herstellung von stabilisiertem Knoblauchpulver hohen Wirkstoffgehalts
JP2875308B2 (ja) 1989-11-22 1999-03-31 湧永製薬株式会社 Ｓ−アリルシステイン高濃度含有組成物の製造方法
DK1343492T3 (da) * 2000-11-22 2006-03-06 Rxkinetix Inc Behandling af mucositis
JP2005306831A (ja) * 2004-04-20 2005-11-04 Sakamoto Yakusoen:Kk 皮膚外用剤
WO2005105065A2 (en) * 2004-05-05 2005-11-10 Renopharm Ltd. Thiazole-based nitric oxide donors for treating inflammatory bowel diseases
KR100530386B1 (ko) * 2005-08-03 2005-11-22 (주)코스트플러스코리아 숙성 마늘의 제조방법
JP4564471B2 (ja) * 2006-07-06 2010-10-20 株式会社コーセー 外用に適する組成物
EP2118107A1 (en) 2007-03-02 2009-11-18 Talia Miron Mercaptopurine derivatives as anticancer agents
US20110166142A1 (en) * 2007-06-29 2011-07-07 Eleanor Eiffe 2-substituted isoflavonoid compounds, medicaments and uses
CN102316730A (zh) * 2008-05-09 2012-01-11 天雅瑞药业有限公司 用于减轻全身性炎症和/或血管炎症的n-乙酰半胱氨酸(nac)的控释
JP5648216B2 (ja) * 2008-06-06 2015-01-07 ファーマ ツゥ ビー リミテッド パーキンソン病治療医薬組成物
KR101188746B1 (ko) * 2009-09-23 2012-10-11 주식회사파마킹 에스-알릴-엘-시스테인을 유효성분으로 포함하는 위장질환 예방 또는 치료용 조성물

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
KR20090068560A (ko) * 2007-12-24 2009-06-29 덕성여자대학교 산학협력단 항염증 활성을 갖는 산마늘 추출물
KR20100026597A (ko) * 2008-09-01 2010-03-10 경남도립남해대학 산학협력단 흑마늘 추출물을 유효성분으로 함유하는 염증성 질환의 예방 및 치료용 조성물

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
BANG, SUNG HYE: "S-allyl-L-cysteine (SAC) on Helicobacter pyroli-infected mice.", DOCTORATE THESIS OF DEPARTMENT OF VETERINARY MEDICINE SCIENCE, February 2010 (2010-02-01), pages 1 - 56, XP008176180 *
GENG, ZHAOHUI ET AL.: "S-Ally cysteine inhibits activation of nuclear factor Kappa B in Human T Cells.", FREE RADICAL BIOLOGY & MEDICINE., vol. 23, no. 2, 1997, pages 345 - 350, XP055182108 *

Also Published As

Publication number Publication date
JP2015521657A (ja) 2015-07-30
EP2870964A2 (en) 2015-05-13
BR112014033088A2 (pt) 2017-06-27
CN104487065A (zh) 2015-04-01
WO2014007549A2 (ko) 2014-01-09
KR101320945B1 (ko) 2013-10-23
RU2015100897A (ru) 2016-08-20
EP2870964A4 (en) 2015-11-25
US20150147411A1 (en) 2015-05-28

Similar Documents

Publication Publication Date Title
WO2012143576A3 (en) Compounds for preventing, reducing and/or alleviating itchy skin condition(s)
PH12015501404B1 (en) Neuroactive 19-alkoxy-17-substituted steroids, prodrugs thereof, and methods of treatment using same
WO2014205389A8 (en) Nuclear transport modulators and uses thereof
CA2894891A1 (en) Boronic acid derivatives and therapeutic uses thereof
UA109868C2 (ru) Соединения n-алкилтриазола как антагонисты лизофосфатидной кислоты (lpar)
WO2013188273A8 (en) Topical ophthalmological pharmaceutical composition containing axitinib
TN2012000566A1 (en) Dry powder formulation comprising an antimuscarinic drug
WO2013112959A8 (en) Antifibrotic compounds and uses thereof
NZ720328A (en) Pyranochromenyl phenol derivative, and pharmaceutical composition for treating metabolic syndrome or inflammatory disease
HK1213779A1 (zh) 用於立即和延长释放的组合物
WO2013188268A8 (en) Topical ophthalmological pharmaceutical composition containing pazopanib
MY168212A (en) A new therapeutical composition containing apomorphine as active ingredient
WO2015056094A3 (en) Pharmaceutical composition comprising a trpa1 antagonist and an analgesic agent
WO2013022243A3 (ko) 신규한 바이페닐 유도체 또는 이의 약학적으로 허용가능한 염, 및 이를 유효성분으로 포함하는 염증성 질환 또는 자가면역질환의 예방 또는 치료용 약학적 조성물
HK1231390A1 (zh) 用於局部給藥的藥用組合物
MD4563B1 (ro) Produs de comicronizare cu conţinut de acetat de ulipristal
PH12015502406A1 (en) Orally administrable pharmaceutical composition for prevention or treatment of dry eye syndrome, comprising rebamipide or prodrug thereof
MX2016001422A (es) Composicion farmaceutica de fingolimod.
BR112015027436A2 (en) Topical composition and carrier for administration of pharmaceutically or cosmetically active ingredients
MX2017013099A (es) Metodos para el tratamiento de trastornos inflamatorios.
MX357704B (es) Composiciones farmaceuticas topicas de tipo emulsion aceite en agua que contienen un retinoide.
WO2014007549A3 (ko) 에스-알릴-엘-시스테인을 유효성분으로 포함하는 대장염 예방 또는 치료용 조성물 및 이를 포함하는 의약제제
MX2016004909A (es) Composicion que contiene eugenol como principio activo para prevenir o tratar la dermatitis atopica.
WO2014166836A8 (en) Growth hormone compound formulation
WO2015002755A3 (en) Compounds for the treatment of malaria

Legal Events

Date Code Title Description
121 Ep: the epo has been informed by wipo that ep was designated in this application

Ref document number: 13813180

Country of ref document: EP

Kind code of ref document: A2

ENP Entry into the national phase

Ref document number: 2015520061

Country of ref document: JP

Kind code of ref document: A

WWE Wipo information: entry into national phase

Ref document number: 14412674

Country of ref document: US

NENP Non-entry into the national phase

Ref country code: DE

REEP Request for entry into the european phase

Ref document number: 2013813180

Country of ref document: EP

WWE Wipo information: entry into national phase

Ref document number: 2013813180

Country of ref document: EP

ENP Entry into the national phase

Ref document number: 2015100897

Country of ref document: RU

Kind code of ref document: A

REG Reference to national code

Ref country code: BR

Ref legal event code: B01A

Ref document number: 112014033088

Country of ref document: BR

ENP Entry into the national phase

Ref document number: 112014033088

Country of ref document: BR

Kind code of ref document: A2

Effective date: 20141230