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WO2009072604A1 - 抗nr10抗体、およびその利用 - Google Patents

抗nr10抗体、およびその利用 Download PDF

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Publication number
WO2009072604A1
WO2009072604A1 PCT/JP2008/072152 JP2008072152W WO2009072604A1 WO 2009072604 A1 WO2009072604 A1 WO 2009072604A1 JP 2008072152 W JP2008072152 W JP 2008072152W WO 2009072604 A1 WO2009072604 A1 WO 2009072604A1
Authority
WO
WIPO (PCT)
Prior art keywords
antibody
prevention
useful
treatment
inflammatory diseases
Prior art date
Application number
PCT/JP2008/072152
Other languages
English (en)
French (fr)
Inventor
Taichi Kuramochi
Keiko Kasutani
Souhei Ohyama
Hiroyuki Tsunoda
Tomoyuki Igawa
Tatsuhiko Tachibana
Hirotaka Shiraiwa
Original Assignee
Chugai Seiyaku Kabushiki Kaisha
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority to ES08857126.0T priority Critical patent/ES2585480T3/es
Priority to AU2008332271A priority patent/AU2008332271C1/en
Priority to US12/745,781 priority patent/US20110129459A1/en
Priority to KR1020167013226A priority patent/KR20160062207A/ko
Priority to KR1020167016319A priority patent/KR20160074019A/ko
Priority to BRPI0821110A priority patent/BRPI0821110B8/pt
Priority to RU2010127292/10A priority patent/RU2531521C2/ru
Priority to JP2009544736A priority patent/JP5682995B2/ja
Priority to CA2708532A priority patent/CA2708532C/en
Application filed by Chugai Seiyaku Kabushiki Kaisha filed Critical Chugai Seiyaku Kabushiki Kaisha
Priority to CN200880126539.4A priority patent/CN101939424B/zh
Priority to MX2010006096A priority patent/MX337081B/es
Priority to EP08857126.0A priority patent/EP2236604B1/en
Priority to KR1020177031058A priority patent/KR101840994B1/ko
Priority to DK08857126.0T priority patent/DK2236604T3/en
Priority to EP16172648.4A priority patent/EP3095862B9/en
Priority to PCT/JP2009/054941 priority patent/WO2010064456A1/ja
Publication of WO2009072604A1 publication Critical patent/WO2009072604A1/ja
Priority to TW098141125A priority patent/TWI432209B/zh
Priority to EP15172595.9A priority patent/EP2949672A1/en
Priority to ES09830463.7T priority patent/ES2552690T3/es
Priority to SI200931302T priority patent/SI2354161T1/sl
Priority to US12/809,138 priority patent/US8575317B2/en
Priority to DK09830463.7T priority patent/DK2354161T3/en
Priority to JP2010507563A priority patent/JP5139517B2/ja
Priority to AU2009323249A priority patent/AU2009323249B2/en
Priority to KR1020107014700A priority patent/KR101271323B1/ko
Priority to PCT/JP2009/070376 priority patent/WO2010064697A1/ja
Priority to HUE09830463A priority patent/HUE025958T2/en
Priority to CA2710264A priority patent/CA2710264C/en
Priority to PT98304637T priority patent/PT2354161E/pt
Priority to CN200980106176.2A priority patent/CN101952318B/zh
Priority to RU2010126078/10A priority patent/RU2487136C2/ru
Priority to MYPI2010002989A priority patent/MY154715A/en
Priority to EP09830463.7A priority patent/EP2354161B1/en
Priority to MX2010007936A priority patent/MX2010007936A/es
Priority to BRPI0906478A priority patent/BRPI0906478B8/pt
Priority to PL09830463T priority patent/PL2354161T3/pl
Priority to HK11105170.8A priority patent/HK1151048A1/xx
Priority to US14/047,316 priority patent/US9399680B2/en
Priority to US14/340,883 priority patent/US20150175704A1/en
Priority to HRP20151215TT priority patent/HRP20151215T1/hr
Priority to US16/560,143 priority patent/US20200002429A1/en
Priority to US17/975,865 priority patent/US20230183363A1/en
Priority to US18/661,829 priority patent/US20240294653A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6863—Cytokines, i.e. immune system proteins modifying a biological response such as cell growth proliferation or differentiation, e.g. TNF, CNF, GM-CSF, lymphotoxin, MIF or their receptors
    • G01N33/6869—Interleukin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/24—Immunoglobulins specific features characterized by taxonomic origin containing regions, domains or residues from different species, e.g. chimeric, humanized or veneered
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/567—Framework region [FR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/70—Immunoglobulins specific features characterized by effect upon binding to a cell or to an antigen
    • C07K2317/76—Antagonist effect on antigen, e.g. neutralization or inhibition of binding
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/92—Affinity (KD), association rate (Ka), dissociation rate (Kd) or EC50 value
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705—Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/715—Assays involving receptors, cell surface antigens or cell surface determinants for cytokines; for lymphokines; for interferons
    • G01N2333/7155—Assays involving receptors, cell surface antigens or cell surface determinants for cytokines; for lymphokines; for interferons for interleukins [IL]

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Urology & Nephrology (AREA)
  • Cell Biology (AREA)
  • Hematology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Physics & Mathematics (AREA)
  • Biotechnology (AREA)
  • Pathology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Mycology (AREA)
  • Epidemiology (AREA)
  • Rheumatology (AREA)
  • Pain & Pain Management (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

　本発明者らは、ＮＲ１０に対して有効な中和活性を有する抗ＮＲ１０抗体を取得することに成功した。本発明によって提供される抗ＮＲ１０抗体は、例えば、炎症性疾患の治療もしくは予防のための医薬品として有用である。
PCT/JP2008/072152 2007-12-05 2008-12-05 抗nr10抗体、およびその利用 WO2009072604A1 (ja)

Priority Applications (43)

Application Number Priority Date Filing Date Title
CA2708532A CA2708532C (en) 2007-12-05 2008-12-05 Anti-il31ra antibody and use thereof
US12/745,781 US20110129459A1 (en) 2007-12-05 2008-12-05 Anti-nr10 antibody and use thereof
CN200880126539.4A CN101939424B (zh) 2007-12-05 2008-12-05 抗nr10抗体及其应用
KR1020167016319A KR20160074019A (ko) 2007-12-05 2008-12-05 항ｎｒ１０ 항체 및 그의 이용
BRPI0821110A BRPI0821110B8 (pt) 2007-12-05 2008-12-05 anticorpo de neutralização de anti-nr10/il31ra, composição farmacêutica compreendendo o referido anticorpo e uso do mesmo
RU2010127292/10A RU2531521C2 (ru) 2007-12-05 2008-12-05 Антитело против nr10 и его применение
JP2009544736A JP5682995B2 (ja) 2007-12-05 2008-12-05 抗ｎｒ１０抗体、およびその利用
ES08857126.0T ES2585480T3 (es) 2007-12-05 2008-12-05 Anticuerpo anti-NR10 y uso del mismo
KR1020167013226A KR20160062207A (ko) 2008-12-05 2008-12-05 항ｎｒ１０ 항체 및 그의 이용
AU2008332271A AU2008332271C1 (en) 2007-12-05 2008-12-05 Anti-NR10 antibody and use thereof
MX2010006096A MX337081B (es) 2007-12-05 2008-12-05 Anticuerpo anti-nr10 y su uso.
EP08857126.0A EP2236604B1 (en) 2007-12-05 2008-12-05 Anti-nr10 antibody and use thereof
KR1020177031058A KR101840994B1 (ko) 2007-12-05 2008-12-05 항ｎｒ１０ 항체 및 그의 이용
DK08857126.0T DK2236604T3 (en) 2007-12-05 2008-12-05 The anti-NR10 antibody and use thereof
EP16172648.4A EP3095862B9 (en) 2007-12-05 2008-12-05 Anti-nr10 antibody and use thereof
PCT/JP2009/054941 WO2010064456A1 (ja) 2008-12-05 2009-03-13 抗nr10抗体、およびその利用
TW098141125A TWI432209B (zh) 2008-12-05 2009-12-02 Anti-NR10 antibody and its use
PL09830463T PL2354161T3 (pl) 2008-12-05 2009-12-04 Przeciwciało anty -NR10 i jego zastosowanie
US12/809,138 US8575317B2 (en) 2007-12-05 2009-12-04 Anti-NR10 antibody and use thereof
RU2010126078/10A RU2487136C2 (ru) 2008-12-05 2009-12-04 Антитело против nr10 и его применение
SI200931302T SI2354161T1 (sl) 2008-12-05 2009-12-04 Anti-NR10 protitelo in njegova uporaba
EP15172595.9A EP2949672A1 (en) 2008-12-05 2009-12-04 Anti-nr10 antibody, and use thereof
DK09830463.7T DK2354161T3 (en) 2008-12-05 2009-12-04 ANTI-NR10 ANTIBODY AND USE THEREOF.
JP2010507563A JP5139517B2 (ja) 2008-12-05 2009-12-04 抗ｎｒ１０抗体、およびその利用
AU2009323249A AU2009323249B2 (en) 2007-12-05 2009-12-04 Anti-NR10 antibody, and use thereof
KR1020107014700A KR101271323B1 (ko) 2008-12-05 2009-12-04 항ｎｒ１０ 항체 및 그의 이용
PCT/JP2009/070376 WO2010064697A1 (ja) 2008-12-05 2009-12-04 抗nr10抗体、およびその利用
HUE09830463A HUE025958T2 (en) 2007-12-05 2009-12-04 Anti-NR10 antibody and application
CA2710264A CA2710264C (en) 2007-12-05 2009-12-04 Anti-nr10 antibody and use thereof
PT98304637T PT2354161E (pt) 2008-12-05 2009-12-04 Anticorpo anti-nr10, e a sua utilização
CN200980106176.2A CN101952318B (zh) 2007-12-05 2009-12-04 抗nr10抗体及其应用
ES09830463.7T ES2552690T3 (es) 2008-12-05 2009-12-04 Anticuerpo anti-NR10 y uso del mismo
MYPI2010002989A MY154715A (en) 2008-12-05 2009-12-04 Anti-nr10 antibody and use thereof
EP09830463.7A EP2354161B1 (en) 2008-12-05 2009-12-04 Anti-nr10 antibody, and use thereof
MX2010007936A MX2010007936A (es) 2007-12-05 2009-12-04 Anticuerpo anti-nr-10 y su uso.
BRPI0906478A BRPI0906478B8 (pt) 2008-12-05 2009-12-04 anticorpo anti-nr10, seu uso e composição farmacêutica que o compreende
HK11105170.8A HK1151048A1 (en) 2008-12-05 2011-05-24 Anti-nr 10 antibody, and use thereof nr10
US14/047,316 US9399680B2 (en) 2007-12-05 2013-10-07 Nucleic acids encoding anti-NR10 antibodies
US14/340,883 US20150175704A1 (en) 2007-12-05 2014-07-25 Anti-nr10 antibody and use thereof
HRP20151215TT HRP20151215T1 (hr) 2007-12-05 2015-11-12 Anti-nr10 protutijela i njihova uporaba
US16/560,143 US20200002429A1 (en) 2007-12-05 2019-09-04 Anti-nr10 antibody and use thereof
US17/975,865 US20230183363A1 (en) 2007-12-05 2022-10-28 Anti-nr10 antibody and use thereof
US18/661,829 US20240294653A1 (en) 2007-12-05 2024-05-13 Anti-nr10 antibody and use thereof

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
JP2007-315143 2007-12-05
JP2007315143 2007-12-05
JP2008247425 2008-09-26
JP2008-247425 2008-09-26

Related Child Applications (2)

Application Number Title Priority Date Filing Date
US12/745,781 A-371-Of-International US20110129459A1 (en) 2007-12-05 2008-12-05 Anti-nr10 antibody and use thereof
US14/340,883 Continuation US20150175704A1 (en) 2007-12-05 2014-07-25 Anti-nr10 antibody and use thereof

Publications (1)

Publication Number Publication Date
WO2009072604A1 true WO2009072604A1 (ja) 2009-06-11

Family

ID=40717782

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/JP2008/072152 WO2009072604A1 (ja) 2007-12-05 2008-12-05 抗nr10抗体、およびその利用

Country Status (17)

Country Link
US (7) US20110129459A1 (ja)
EP (2) EP2236604B1 (ja)
JP (1) JP5682995B2 (ja)
KR (3) KR20160074019A (ja)
CN (2) CN101939424B (ja)
AU (2) AU2008332271C1 (ja)
BR (1) BRPI0821110B8 (ja)
CA (2) CA2708532C (ja)
DK (1) DK2236604T3 (ja)
ES (2) ES2834741T3 (ja)
HR (1) HRP20151215T1 (ja)
HU (1) HUE025958T2 (ja)
MX (2) MX337081B (ja)
MY (1) MY177564A (ja)
RU (1) RU2531521C2 (ja)
TW (2) TW201634479A (ja)
WO (1) WO2009072604A1 (ja)

Cited By (43)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101952318A (zh) * 2007-12-05 2011-01-19 中外制药株式会社 抗nr10抗体及其应用
WO2011055550A1 (ja) 2009-11-05 2011-05-12 国立大学法人大阪大学 自己免疫疾患又はアレルギー治療剤とそのスクリーニング方法
WO2011090088A1 (ja) 2010-01-20 2011-07-28 中外製薬株式会社 安定化抗体含有溶液製剤
EP2354161A1 (en) * 2008-12-05 2011-08-10 Chugai Seiyaku Kabushiki Kaisha Anti-nr10 antibody, and use thereof
WO2011143318A3 (en) * 2010-05-11 2012-01-05 Aveo Pharmaceuticals, Inc. Anti-fgfr2 antibodies
JPWO2010064697A1 (ja) * 2008-12-05 2012-05-10 中外製薬株式会社 抗ｎｒ１０抗体、およびその利用
WO2012091124A1 (ja) 2010-12-28 2012-07-05 中外製薬株式会社 動物細胞の培養方法
WO2013012022A1 (ja) 2011-07-19 2013-01-24 中外製薬株式会社 アルギニンアミドまたはその類似化合物を含む安定なタンパク質含有製剤
WO2013031237A1 (en) 2011-09-01 2013-03-07 Chugai Seiyaku Kabushiki Kaisha Method for preparing a composition comprising highly concentrated antibodies by ultrafiltration
US8431127B2 (en) 2007-12-05 2013-04-30 Chugai Seiyaku Kabushiki Kaisha Method for treating pruritus comprising administering an NR10 antagonist
JPWO2011108714A1 (ja) * 2010-03-04 2013-06-27 中外製薬株式会社 抗体定常領域改変体
US8562991B2 (en) 2008-09-26 2013-10-22 Chugai Seiyaku Kabushiki Kaisha Antibody molecules that bind to IL-6 receptor
US9028821B2 (en) 2006-06-08 2015-05-12 Chugai Seiyaku Kabushiki Kaisha Method of treating an inflammatory disease comprising administering an NR 10 antibody antagonist
WO2015099165A1 (ja) 2013-12-27 2015-07-02 中外製薬株式会社 等電点の低い抗体の精製方法
US9096651B2 (en) 2007-09-26 2015-08-04 Chugai Seiyaku Kabushiki Kaisha Method of modifying isoelectric point of antibody via amino acid substitution in CDR
US9228017B2 (en) 2009-03-19 2016-01-05 Chugai Seiyaku Kabushiki Kaisha Antibody constant region variant
US9670269B2 (en) 2006-03-31 2017-06-06 Chugai Seiyaku Kabushiki Kaisha Methods of modifying antibodies for purification of bispecific antibodies
US9688762B2 (en) 2007-09-26 2017-06-27 Chugai Sciyaku Kabushiki Kaisha Modified antibody constant region
US9868948B2 (en) 2008-04-11 2018-01-16 Chugai Seiyaku Kabushiki Kaisha Antigen-binding molecule capable of binding to two or more antigen molecules repeatedly
US10011858B2 (en) 2005-03-31 2018-07-03 Chugai Seiyaku Kabushiki Kaisha Methods for producing polypeptides by regulating polypeptide association
US10150808B2 (en) 2009-09-24 2018-12-11 Chugai Seiyaku Kabushiki Kaisha Modified antibody constant regions
JP2019504060A (ja) * 2016-01-08 2019-02-14 オンコバイオロジクス，インコーポレイティド モノクローナル抗体のアイソフォームを分離するための方法
US10253091B2 (en) 2009-03-19 2019-04-09 Chugai Seiyaku Kabushiki Kaisha Antibody constant region variant
WO2019225568A1 (ja) 2018-05-21 2019-11-28 中外製薬株式会社 ガラス容器に封入された凍結乾燥製剤
WO2019230725A1 (ja) 2018-05-28 2019-12-05 中外製薬株式会社 充填ノズル
US10544227B2 (en) 2015-04-14 2020-01-28 Chugai Seiyaku Kabushiki Kaisha Pharmaceutical composition for prevention and/or treatment of atopic dermatitis comprising IL-31 antagonist as active ingredient
US10604561B2 (en) 2016-09-16 2020-03-31 Chugai Seiyaku Kabushiki Kaisha Anti-dengue virus antibodies, polypeptides containing variant Fc regions, and methods of use
US10774148B2 (en) 2015-02-27 2020-09-15 Chugai Seiyaku Kabushiki Kaisha Composition for treating IL-6-related diseases
JP6845973B1 (ja) * 2019-11-20 2021-03-24 中外製薬株式会社 抗体含有製剤
US11046784B2 (en) 2006-03-31 2021-06-29 Chugai Seiyaku Kabushiki Kaisha Methods for controlling blood pharmacokinetics of antibodies
US11124576B2 (en) 2013-09-27 2021-09-21 Chungai Seiyaku Kabushiki Kaisha Method for producing polypeptide heteromultimer
US11142587B2 (en) 2015-04-01 2021-10-12 Chugai Seiyaku Kabushiki Kaisha Method for producing polypeptide hetero-oligomer
KR20210145295A (ko) 2015-04-14 2021-12-01 추가이 세이야쿠 가부시키가이샤 Il-31 안타고니스트를 유효 성분으로서 함유하는 아토피성 피부염의 예방용 및/또는 치료용 의약 조성물
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WO2023058723A1 (ja) 2021-10-08 2023-04-13 中外製薬株式会社 プレフィルドシリンジ製剤の調製方法
KR20240117039A (ko) 2021-12-22 2024-07-31 추가이 세이야쿠 가부시키가이샤 생물 활성이 저하된 항체 배리언트
JPWO2023120561A1 (ja) * 2021-12-22 2023-06-29
WO2023120561A1 (ja) * 2021-12-22 2023-06-29 中外製薬株式会社 生物活性が低下した抗体バリアント
WO2023210670A1 (ja) 2022-04-26 2023-11-02 中外製薬株式会社 医薬製剤含有フィルター内蔵シリンジ

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