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UY25574A1 - Procedimiento para preparar nuevos macrolidos - Google Patents

Procedimiento para preparar nuevos macrolidos

Info

Publication number
UY25574A1
UY25574A1 UY25574A UY25574A UY25574A1 UY 25574 A1 UY25574 A1 UY 25574A1 UY 25574 A UY25574 A UY 25574A UY 25574 A UY25574 A UY 25574A UY 25574 A1 UY25574 A1 UY 25574A1
Authority
UY
Uruguay
Prior art keywords
infections
compounds
alkyl
preparing new
procedure
Prior art date
Application number
UY25574A
Other languages
English (en)
Inventor
Philip Dirlam John
Alastair Irvine Mcarthur Hamish
Original Assignee
Pfizer Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Pfizer Prod Inc filed Critical Pfizer Prod Inc
Publication of UY25574A1 publication Critical patent/UY25574A1/es

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals
    • C07H17/04—Heterocyclic radicals containing only oxygen as ring hetero atoms
    • C07H17/08—Hetero rings containing eight or more ring members, e.g. erythromycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7048—Compounds having saccharide radicals and heterocyclic rings having oxygen as a ring hetero atom, e.g. leucoglucosan, hesperidin, erythromycin, nystatin, digitoxin or digoxin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H1/00—Processes for the preparation of sugar derivatives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H17/00—Compounds containing heterocyclic radicals directly attached to hetero atoms of saccharide radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Epidemiology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)

Abstract

La invención se refiere a procedimientos para preparar nuevos análogos de eritromicina y azalidas,en particular, con nuevos sustituyentes en la posición C-13, y a sus sales farmacéuticamente aceptables. Los compuestos de esta invención son agentes antibacterianos que se pueden usar para tratar diversas infecciones bacterianas y provocadas por protozoos. Compuestos de fórmula (I) en la que R1 es un grupo alquilo, alquenilo, alquinilo, fenilo, CH2R24, con R24 es H, alquilo, etc; R2 es H u OH. Son compuestos útiles contra el cáncer, aterosclerosis, reducción de motilidad gástrica. Las infecciones relacionadas incluyen, neumonía, otitis media, sinusutis, bronquitis, tonsilitis y mastoiditis,infecciones del tracto urinario, de trasmición sexual
UY25574A 1998-01-02 1999-06-18 Procedimiento para preparar nuevos macrolidos UY25574A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US7034398P 1998-01-02 1998-01-02
UY25330A UY25330A1 (es) 1998-01-02 1998-12-30 Nuevos macrólidos

Publications (1)

Publication Number Publication Date
UY25574A1 true UY25574A1 (es) 1999-09-27

Family

ID=22094723

Family Applications (2)

Application Number Title Priority Date Filing Date
UY25330A UY25330A1 (es) 1998-01-02 1998-12-30 Nuevos macrólidos
UY25574A UY25574A1 (es) 1998-01-02 1999-06-18 Procedimiento para preparar nuevos macrolidos

Family Applications Before (1)

Application Number Title Priority Date Filing Date
UY25330A UY25330A1 (es) 1998-01-02 1998-12-30 Nuevos macrólidos

Country Status (34)

Country Link
US (2) US6472371B1 (es)
EP (1) EP1044207A1 (es)
JP (1) JP2002500230A (es)
KR (1) KR100352809B1 (es)
CN (1) CN1284081A (es)
AP (1) AP9801420A0 (es)
AR (4) AR014948A1 (es)
AU (1) AU756409B2 (es)
BG (1) BG104644A (es)
BR (1) BR9814601A (es)
CA (1) CA2316919C (es)
CO (1) CO4970821A1 (es)
CZ (1) CZ20002458A3 (es)
DZ (1) DZ2698A1 (es)
EA (1) EA200000594A1 (es)
GT (1) GT199800206A (es)
HR (1) HRP20000442A2 (es)
HU (1) HUP0100420A3 (es)
IL (1) IL137024A0 (es)
IS (1) IS5528A (es)
MA (1) MA24729A1 (es)
NO (1) NO20003347L (es)
NZ (1) NZ504986A (es)
OA (1) OA11438A (es)
PA (1) PA8465301A1 (es)
PE (1) PE20000049A1 (es)
PL (1) PL341642A1 (es)
SK (1) SK9782000A3 (es)
TN (1) TNSN98238A1 (es)
TW (1) TW520374B (es)
UY (2) UY25330A1 (es)
WO (1) WO1999035156A1 (es)
YU (1) YU41500A (es)
ZA (1) ZA9811939B (es)

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TWI430995B (zh) 2007-06-26 2014-03-21 Du Pont 萘異唑啉無脊椎有害動物控制劑
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BR112012002519A2 (pt) 2009-08-05 2019-09-24 Du Pont "pesticidas mesoiônicos"
UA110924C2 (uk) 2009-08-05 2016-03-10 Е. І. Дю Пон Де Немур Енд Компані Мезоіонні пестициди
JP5933530B2 (ja) 2010-05-27 2016-06-08 イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニーＥ．Ｉ．Ｄｕ Ｐｏｎｔ Ｄｅ Ｎｅｍｏｕｒｓ Ａｎｄ Ｃｏｍｐａｎｙ ４−［５−［３−クロロ−５−（トリフルオロメチル）フェニル］−４，５−ジヒドロ−５−（トリフルオロメチル）−３−イソオキサゾリル］−ｎ−［２−オキソ−２−［（２，２，２−トリフルオロエチル）アミノ］エチル］−１−ナフタレンカルボキサミドの結晶質形態
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CN102260306B (zh) * 2011-07-22 2012-07-18 山东鲁抗舍里乐药业有限公司 一种制备泰拉霉素的方法
JP2015502936A (ja) 2011-11-28 2015-01-29 イー・アイ・デュポン・ドウ・ヌムール・アンド・カンパニーＥ．Ｉ．Ｄｕ Ｐｏｎｔ Ｄｅ Ｎｅｍｏｕｒｓ Ａｎｄ Ｃｏｍｐａｎｙ スルホンアミド駆虫薬
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CN105669798B (zh) * 2013-08-23 2019-07-26 普莱柯生物工程股份有限公司 一种大环内酯类化合物
CN103965273B (zh) * 2013-08-23 2016-05-25 普莱柯生物工程股份有限公司 一种大环内酯类化合物

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Also Published As

Publication number Publication date
TNSN98238A1 (fr) 2005-03-15
AR020551A2 (es) 2002-05-15
CO4970821A1 (es) 2000-11-07
AR019787A2 (es) 2002-03-13
CN1284081A (zh) 2001-02-14
HRP20000442A2 (en) 2001-04-30
KR100352809B1 (ko) 2002-11-01
AR020851A2 (es) 2002-05-29
WO1999035156B1 (en) 1999-10-21
SK9782000A3 (en) 2001-12-03
WO1999035156A1 (en) 1999-07-15
YU41500A (sh) 2003-02-28
HUP0100420A2 (hu) 2001-07-30
US20040092459A1 (en) 2004-05-13
CA2316919A1 (en) 1999-07-15
BR9814601A (pt) 2000-10-17
AR014948A1 (es) 2001-04-11
PA8465301A1 (es) 2000-09-29
MA24729A1 (fr) 1999-07-01
EA200000594A1 (ru) 2001-04-23
NO20003347D0 (no) 2000-06-27
KR20010024818A (ko) 2001-03-26
NO20003347L (no) 2000-08-28
US6472371B1 (en) 2002-10-29
NZ504986A (en) 2003-03-28
AP9801420A0 (en) 1998-12-31
OA11438A (en) 2004-04-30
HUP0100420A3 (en) 2003-07-28
BG104644A (en) 2001-01-31
CA2316919C (en) 2004-10-26
UY25330A1 (es) 2000-12-29
JP2002500230A (ja) 2002-01-08
CZ20002458A3 (cs) 2001-10-17
EP1044207A1 (en) 2000-10-18
US7015203B2 (en) 2006-03-21
ZA9811939B (en) 2000-06-30
DZ2698A1 (fr) 2003-03-29
GT199800206A (es) 2000-06-21
AU1444799A (en) 1999-07-26
PL341642A1 (en) 2001-04-23
TW520374B (en) 2003-02-11
IL137024A0 (en) 2001-06-14
PE20000049A1 (es) 2000-02-07
IS5528A (is) 2000-06-09
AU756409B2 (en) 2003-01-09

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Effective date: 20110808