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UA96957C2 - Способ получения галогенидов n-алкилнальтрексона - Google Patents

Способ получения галогенидов n-алкилнальтрексона

Info

Publication number
UA96957C2
UA96957C2 UAA200903924A UAA200903924A UA96957C2 UA 96957 C2 UA96957 C2 UA 96957C2 UA A200903924 A UAA200903924 A UA A200903924A UA A200903924 A UAA200903924 A UA A200903924A UA 96957 C2 UA96957 C2 UA 96957C2
Authority
UA
Ukraine
Prior art keywords
carbonate
methylnaltrexone
preparing
reacting
halogenides
Prior art date
Application number
UAA200903924A
Other languages
English (en)
Ukrainian (uk)
Inventor
Ален Длюбала
Original Assignee
Санофи-Авентис
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Санофи-Авентис filed Critical Санофи-Авентис
Publication of UA96957C2 publication Critical patent/UA96957C2/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
    • C07D498/08—Bridged systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
    • C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
    • C07D489/08—Oxygen atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Engineering & Computer Science (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Abstract

Изобретение касается нового способа получения бромида N-метилнальтрексона, который включает по меньшей мере стадии, которые состоят в:(i) осуществлении взаимодействия метилсульфата N-метилнальтрексона в водном растворе с щелочным агентом, выбранным из группы, которая включает карбонат натрия, карбонат калия, карбонат кальция, карбонат магния, карбонат цезия, карбонат стронция и их смеси, так чтобы величина рН водной реакционной среды находилась в диапазоне от 7 до 10, потом в(ii) осуществлении взаимодействия продукта, полученного таким образом, с бромистоводородной кислотой, которую добавляют так, чтобы величина рН водной реакционной среды находилась в диапазоне от 0,5 до 5, с получением, таким образом, бромида N-метилнальтрексона.
UAA200903924A 2006-09-21 2007-09-19 Способ получения галогенидов n-алкилнальтрексона UA96957C2 (ru)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR0608286A FR2906252B1 (fr) 2006-09-21 2006-09-21 Procede de preparation d'halogenures de n-aklyl naltrexone

Publications (1)

Publication Number Publication Date
UA96957C2 true UA96957C2 (ru) 2011-12-26

Family

ID=38016779

Family Applications (1)

Application Number Title Priority Date Filing Date
UAA200903924A UA96957C2 (ru) 2006-09-21 2007-09-19 Способ получения галогенидов n-алкилнальтрексона

Country Status (36)

Country Link
US (2) US7645880B2 (ru)
EP (1) EP2069362B1 (ru)
JP (1) JP5214615B2 (ru)
KR (1) KR101434693B1 (ru)
CN (2) CN101516892B (ru)
AR (1) AR062918A1 (ru)
AU (1) AU2007298855B2 (ru)
BR (1) BRPI0718440A2 (ru)
CA (1) CA2663509C (ru)
CL (1) CL2007002711A1 (ru)
CO (1) CO6170362A2 (ru)
CR (1) CR10660A (ru)
DO (1) DOP2011000307A (ru)
EA (1) EA015426B1 (ru)
ES (1) ES2531093T3 (ru)
FR (1) FR2906252B1 (ru)
GT (1) GT200900060A (ru)
HK (1) HK1135389A1 (ru)
HN (1) HN2009000503A (ru)
IL (1) IL197402A (ru)
JO (1) JO3023B1 (ru)
MA (1) MA30793B1 (ru)
ME (1) MEP10509A (ru)
MX (1) MX2009003084A (ru)
MY (1) MY148094A (ru)
NI (1) NI200900035A (ru)
NO (1) NO20091561L (ru)
NZ (1) NZ575417A (ru)
PE (1) PE20080867A1 (ru)
SV (1) SV2009003192A (ru)
TN (1) TN2009000080A1 (ru)
TW (1) TWI465451B (ru)
UA (1) UA96957C2 (ru)
UY (1) UY30599A1 (ru)
WO (1) WO2008034973A1 (ru)
ZA (1) ZA200901846B (ru)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP2134718A2 (en) 2007-03-29 2009-12-23 Progenics Pharmaceuticals, Inc. Crystal forms of (r)-n-methylnaltrexone bromide and uses thereof
WO2008138383A1 (de) 2007-05-16 2008-11-20 Cilag Ag Verfahren zur herstellung von n-methylnaltrexonbromid
US8383649B2 (en) * 2007-07-11 2013-02-26 Mallinckrodt Llc Crystalline forms of naltrexone methobromide
EP2019105A1 (en) * 2007-07-19 2009-01-28 Siegfried Ltd. Process for the preparation of quaternary n-alkyl morphine or morphinane alkaloid derivatives
CN102227433B (zh) * 2008-09-30 2015-01-07 马林克罗特有限公司 烷基化吗啡喃衍生物的仲胺基团的方法
US8563727B2 (en) * 2009-02-23 2013-10-22 Mallinckrodt Llc (+)-morphinanium N-oxides and processes for their production
US8946419B2 (en) 2009-02-23 2015-02-03 Mallinckrodt Llc (+)-6-hydroxy-morphinan or (+)-6-amino-morphinan derivatives
US8436174B2 (en) * 2009-02-23 2013-05-07 Mallinckrodt Llc (+)-morphinanium quaternary salts and processes for their production
US8563724B2 (en) * 2009-02-23 2013-10-22 Mallinckrodt Llc (+)-6-hydroxy-morphinan or (+)-6-amino-morphinan derivatives
WO2010121369A1 (en) 2009-04-24 2010-10-28 Brock University Processes for the preparation of morphinane and morphinone compounds
US8829020B2 (en) 2009-07-16 2014-09-09 Mallinckrodt Llc Compounds and compositions for use in phototherapy and in treatment of ocular neovascular disease and cancers
CN101845047B (zh) * 2009-12-31 2011-12-07 南京臣功制药有限公司 一种溴甲基纳曲酮的制备方法
JO3209B1 (ar) * 2010-11-05 2018-03-08 H Lundbeck As طريقة لتصنيع نالتريكسون
AP3415A (en) * 2010-11-05 2015-09-30 Lundbeck & Co As H Method for manufacturing of naltrexone
US8580963B2 (en) 2010-11-05 2013-11-12 H. Lundbeck A/S Method for the manufacturing of naltrexone
WO2012138888A1 (en) 2011-04-05 2012-10-11 Alkermes, Inc. Process for the synthesis of quaternary amine compounds
EP2753622B1 (en) 2011-09-08 2016-01-20 Mallinckrodt LLC Production of alkaloids without the isolation of intermediates
CN103172640A (zh) * 2011-12-22 2013-06-26 天津康鸿医药科技发展有限公司 一种(r)-n-溴甲基纳曲酮的制备方法以及纳曲酮衍生物
WO2013164383A1 (en) 2012-05-03 2013-11-07 H. Lundbeck A/S Method for the manufacturing of naltrexone
CN105985348B (zh) * 2015-02-12 2019-02-01 正大天晴药业集团股份有限公司 一种溴甲基纳曲酮的制备方法
CN106317064B (zh) * 2015-06-30 2018-06-19 北大方正集团有限公司 溴甲纳曲酮的制备方法
KR102201609B1 (ko) * 2019-04-19 2021-01-12 연성정밀화학(주) 날데메딘의 제조방법
CN111777617A (zh) * 2020-07-10 2020-10-16 华润三九医药股份有限公司 一种溴甲纳曲酮的精制方法
CA3194746A1 (en) 2020-10-06 2022-04-14 Tien-Li Lee Oral delayed burst formulation of low-dose naltrexone or naloxone used for|treating fibromyalgia and long covid

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4176186A (en) * 1978-07-28 1979-11-27 Boehringer Ingelheim Gmbh Quaternary derivatives of noroxymorphone which relieve intestinal immobility
WO2004043964A2 (en) * 2002-11-08 2004-05-27 Mallinckrodt Inc. Process for the preparation of quaternary n-alkyl morphinan alkaloid salts
AR057325A1 (es) * 2005-05-25 2007-11-28 Progenics Pharm Inc Sintesis de (s)-n-metilnaltrexona, composiciones farmaceuticas y usos

Also Published As

Publication number Publication date
US8288547B2 (en) 2012-10-16
US20100145051A1 (en) 2010-06-10
KR20090057031A (ko) 2009-06-03
US7645880B2 (en) 2010-01-12
IL197402A (en) 2012-12-31
US20080214817A1 (en) 2008-09-04
AU2007298855A1 (en) 2008-03-27
IL197402A0 (en) 2009-12-24
ZA200901846B (en) 2010-07-28
CA2663509A1 (fr) 2008-03-27
AR062918A1 (es) 2008-12-17
CA2663509C (fr) 2014-03-18
NZ575417A (en) 2011-09-30
TW200821314A (en) 2008-05-16
SV2009003192A (es) 2009-10-27
ME00613B (me) 2011-12-20
BRPI0718440A2 (pt) 2013-11-19
KR101434693B1 (ko) 2014-08-27
PE20080867A1 (es) 2008-08-22
EA015426B1 (ru) 2011-08-30
MX2009003084A (es) 2009-04-02
FR2906252B1 (fr) 2008-11-28
MY148094A (en) 2013-02-28
MEP10509A (en) 2011-12-20
NI200900035A (es) 2010-01-26
WO2008034973A1 (fr) 2008-03-27
HN2009000503A (es) 2011-03-02
CN101516892A (zh) 2009-08-26
EP2069362A1 (fr) 2009-06-17
DOP2011000307A (es) 2011-10-31
CN101516892B (zh) 2012-06-20
CN102225939A (zh) 2011-10-26
CL2007002711A1 (es) 2008-04-18
JP5214615B2 (ja) 2013-06-19
GT200900060A (es) 2011-01-04
FR2906252A1 (fr) 2008-03-28
HK1135389A1 (en) 2010-06-04
EA200970307A1 (ru) 2009-12-30
TN2009000080A1 (en) 2010-08-19
AU2007298855B2 (en) 2012-09-13
UY30599A1 (es) 2008-05-02
CR10660A (es) 2009-06-24
JO3023B1 (ar) 2016-09-05
CO6170362A2 (es) 2010-06-18
EP2069362B1 (fr) 2014-07-09
MA30793B1 (fr) 2009-10-01
ES2531093T3 (es) 2015-03-10
NO20091561L (no) 2009-06-16
TWI465451B (zh) 2014-12-21
JP2010504308A (ja) 2010-02-12

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