HK1135389A1 - Process for preparing n-alkyl naltrexone halides - Google Patents

Process for preparing n-alkyl naltrexone halides

Info

Publication number: HK1135389A1
Authority: HK; Hong Kong
Prior art keywords: halides; preparing; naltrexone; alkyl; alkyl naltrexone
Prior art date: 2006-09-21

Application number

HK10101845.3A

Other languages

English (en)

Inventor

Dlubala Alain

Original Assignee

Sanofi Aventis

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2006-09-21

Filing date

2010-02-22

Publication date

2010-06-04

2010-02-22 Application filed by Sanofi Aventis filed Critical Sanofi Aventis

2010-06-04 Publication of HK1135389A1 publication Critical patent/HK1135389A1/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D498/00—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D498/02—Heterocyclic compounds containing in the condensed system at least one hetero ring having nitrogen and oxygen atoms as the only ring hetero atoms in which the condensed system contains two hetero rings
- C07D498/08—Bridged systems
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D489/00—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula:
- C07D489/06—Heterocyclic compounds containing 4aH-8, 9 c- Iminoethano-phenanthro [4, 5-b, c, d] furan ring systems, e.g. derivatives of [4, 5-epoxy]-morphinan of the formula: with a hetero atom directly attached in position 14
- C07D489/08—Oxygen atom
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Chemical Kinetics & Catalysis (AREA)
Life Sciences & Earth Sciences (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Bioinformatics & Cheminformatics (AREA)
Pharmacology & Pharmacy (AREA)
Engineering & Computer Science (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

HK10101845.3A 2006-09-21 2010-02-22 Process for preparing n-alkyl naltrexone halides HK1135389A1 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR0608286A FR2906252B1 (fr)	2006-09-21	2006-09-21	Procede de preparation d'halogenures de n-aklyl naltrexone
PCT/FR2007/001516 WO2008034973A1 (fr)	2006-09-21	2007-09-19	Procede de preparation d'halogenures de n-alkyl naltrexone

Publications (1)

Publication Number	Publication Date
HK1135389A1 true HK1135389A1 (en)	2010-06-04

Family

ID=38016779

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
HK10101845.3A HK1135389A1 (en)	2006-09-21	2010-02-22	Process for preparing n-alkyl naltrexone halides

Country Status (36)

Country	Link
US (2)	US7645880B2 (ru)
EP (1)	EP2069362B1 (ru)
JP (1)	JP5214615B2 (ru)
KR (1)	KR101434693B1 (ru)
CN (2)	CN102225939A (ru)
AR (1)	AR062918A1 (ru)
AU (1)	AU2007298855B2 (ru)
BR (1)	BRPI0718440A2 (ru)
CA (1)	CA2663509C (ru)
CL (1)	CL2007002711A1 (ru)
CO (1)	CO6170362A2 (ru)
CR (1)	CR10660A (ru)
DO (1)	DOP2011000307A (ru)
EA (1)	EA015426B1 (ru)
ES (1)	ES2531093T3 (ru)
FR (1)	FR2906252B1 (ru)
GT (1)	GT200900060A (ru)
HK (1)	HK1135389A1 (ru)
HN (1)	HN2009000503A (ru)
IL (1)	IL197402A (ru)
JO (1)	JO3023B1 (ru)
MA (1)	MA30793B1 (ru)
ME (1)	ME00613B (ru)
MX (1)	MX2009003084A (ru)
MY (1)	MY148094A (ru)
NI (1)	NI200900035A (ru)
NO (1)	NO20091561L (ru)
NZ (1)	NZ575417A (ru)
PE (1)	PE20080867A1 (ru)
SV (1)	SV2009003192A (ru)
TN (1)	TN2009000080A1 (ru)
TW (1)	TWI465451B (ru)
UA (1)	UA96957C2 (ru)
UY (1)	UY30599A1 (ru)
WO (1)	WO2008034973A1 (ru)
ZA (1)	ZA200901846B (ru)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
BRPI0809579B8 (pt)	2007-03-29	2021-05-25	Progenics Pharm Inc	formas cristalinas e seus usos
WO2008138383A1 (de)	2007-05-16	2008-11-20	Cilag Ag	Verfahren zur herstellung von n-methylnaltrexonbromid
WO2009009292A2 (en) *	2007-07-11	2009-01-15	Mallinckrodt Inc.	Crystalline forms of naltrexone methobromide
EP2019105A1 (en) *	2007-07-19	2009-01-28	Siegfried Ltd.	Process for the preparation of quaternary n-alkyl morphine or morphinane alkaloid derivatives
US8080661B2 (en) *	2008-09-30	2011-12-20	Mallinckrodt Llc	Processes for the synthesis of tertiary amines
WO2010096788A1 (en) *	2009-02-23	2010-08-26	Mallinckrodt Inc.	(+)-morphinanium quaternary salts and processes for their production
US8563724B2 (en) *	2009-02-23	2013-10-22	Mallinckrodt Llc	(+)-6-hydroxy-morphinan or (+)-6-amino-morphinan derivatives
US8563727B2 (en) *	2009-02-23	2013-10-22	Mallinckrodt Llc	(+)-morphinanium N-oxides and processes for their production
US8946419B2 (en)	2009-02-23	2015-02-03	Mallinckrodt Llc	(+)-6-hydroxy-morphinan or (+)-6-amino-morphinan derivatives
JP5824448B2 (ja)	2009-04-24	2015-11-25	ブロックユニバーシティ	モルフィナンおよびモルフィノン化合物の調製法
WO2011009020A2 (en)	2009-07-16	2011-01-20	Mallinckrodt Inc.	Compounds and compositions for use in phototherapy and in treatment of ocular neovascular disease and cancers
CN101845047B (zh) *	2009-12-31	2011-12-07	南京臣功制药有限公司	一种溴甲基纳曲酮的制备方法
AP3415A (en)	2010-11-05	2015-09-30	Lundbeck & Co As H	Method for manufacturing of naltrexone
US8580963B2 (en)	2010-11-05	2013-11-12	H. Lundbeck A/S	Method for the manufacturing of naltrexone
JO3209B1 (ar) *	2010-11-05	2018-03-08	H Lundbeck As	طريقة لتصنيع نالتريكسون
WO2012138888A1 (en)	2011-04-05	2012-10-11	Alkermes, Inc.	Process for the synthesis of quaternary amine compounds
ES2566620T3 (es)	2011-09-08	2016-04-14	Mallinckrodt Llc	Procesamiento de alcaloides sin el aislamiento de intermedios
CN103172640A (zh) *	2011-12-22	2013-06-26	天津康鸿医药科技发展有限公司	一种(r)-n-溴甲基纳曲酮的制备方法以及纳曲酮衍生物
AR090916A1 (es)	2012-05-03	2014-12-17	Lundbeck & Co As H	Metodo para la fabricacion de naltrexona
CN105985348B (zh) *	2015-02-12	2019-02-01	正大天晴药业集团股份有限公司	一种溴甲基纳曲酮的制备方法
CN106317064B (zh) *	2015-06-30	2018-06-19	北大方正集团有限公司	溴甲纳曲酮的制备方法
KR102201609B1 (ko) *	2019-04-19	2021-01-12	연성정밀화학(주)	날데메딘의 제조방법
CN111777617A (zh) *	2020-07-10	2020-10-16	华润三九医药股份有限公司	一种溴甲纳曲酮的精制方法
CA3194746A1 (en)	2020-10-06	2022-04-14	Tien-Li Lee	Oral delayed burst formulation of low-dose naltrexone or naloxone used for\|treating fibromyalgia and long covid

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US4176186A (en) *	1978-07-28	1979-11-27	Boehringer Ingelheim Gmbh	Quaternary derivatives of noroxymorphone which relieve intestinal immobility
JP2006509745A (ja) *	2002-11-08	2006-03-23	マリンクロッド・インコーポレイテッド	第四級ｎ−アルキルモルフィナンアルカロイド塩の製造方法
AR057325A1 (es) *	2005-05-25	2007-11-28	Progenics Pharm Inc	Sintesis de (s)-n-metilnaltrexona, composiciones farmaceuticas y usos

2006
- 2006-09-21 FR FR0608286A patent/FR2906252B1/fr not_active Expired - Fee Related
2007
- 2007-09-19 CN CN2011101080743A patent/CN102225939A/zh active Pending
- 2007-09-19 EP EP07848250.2A patent/EP2069362B1/fr active Active
- 2007-09-19 CA CA2663509A patent/CA2663509C/fr not_active Expired - Fee Related
- 2007-09-19 AU AU2007298855A patent/AU2007298855B2/en not_active Ceased
- 2007-09-19 TW TW096134967A patent/TWI465451B/zh not_active IP Right Cessation
- 2007-09-19 WO PCT/FR2007/001516 patent/WO2008034973A1/fr active Application Filing
- 2007-09-19 CN CN2007800350747A patent/CN101516892B/zh not_active Expired - Fee Related
- 2007-09-19 EA EA200970307A patent/EA015426B1/ru not_active IP Right Cessation
- 2007-09-19 ME MEP-2009-105A patent/ME00613B/me unknown
- 2007-09-19 NZ NZ575417A patent/NZ575417A/en not_active IP Right Cessation
- 2007-09-19 ZA ZA200901846A patent/ZA200901846B/xx unknown
- 2007-09-19 ES ES07848250T patent/ES2531093T3/es active Active
- 2007-09-19 KR KR1020097005731A patent/KR101434693B1/ko not_active Expired - Fee Related
- 2007-09-19 MX MX2009003084A patent/MX2009003084A/es active IP Right Grant
- 2007-09-19 JP JP2009528751A patent/JP5214615B2/ja not_active Expired - Fee Related
- 2007-09-19 UA UAA200903924A patent/UA96957C2/ru unknown
- 2007-09-19 BR BRPI0718440-9A2A patent/BRPI0718440A2/pt not_active IP Right Cessation
- 2007-09-19 MY MYPI20091158A patent/MY148094A/en unknown
- 2007-09-20 CL CL200702711A patent/CL2007002711A1/es unknown
- 2007-09-20 JO JOP/2007/0399A patent/JO3023B1/ar active
- 2007-09-20 AR ARP070104157A patent/AR062918A1/es unknown
- 2007-09-20 PE PE2007001269A patent/PE20080867A1/es not_active Application Discontinuation
- 2007-09-20 UY UY30599A patent/UY30599A1/es not_active Application Discontinuation
2008
- 2008-03-17 US US12/049,607 patent/US7645880B2/en not_active Expired - Fee Related
2009
- 2009-03-04 IL IL197402A patent/IL197402A/en not_active IP Right Cessation
- 2009-03-10 TN TN2009000080A patent/TN2009000080A1/fr unknown
- 2009-03-11 CR CR10660A patent/CR10660A/es unknown
- 2009-03-12 GT GT200900060A patent/GT200900060A/es unknown
- 2009-03-18 HN HN2009000503A patent/HN2009000503A/es unknown
- 2009-03-19 CO CO09028774A patent/CO6170362A2/es active IP Right Grant
- 2009-03-19 NI NI200900035A patent/NI200900035A/es unknown
- 2009-03-19 SV SV2009003192A patent/SV2009003192A/es active IP Right Grant
- 2009-04-16 MA MA31789A patent/MA30793B1/fr unknown
- 2009-04-20 NO NO20091561A patent/NO20091561L/no not_active Application Discontinuation
- 2009-11-25 US US12/625,649 patent/US8288547B2/en not_active Expired - Fee Related
2010
- 2010-02-22 HK HK10101845.3A patent/HK1135389A1/xx not_active IP Right Cessation
2011
- 2011-10-07 DO DO2011000307A patent/DOP2011000307A/es unknown

Also Published As

Publication number	Publication date
CN102225939A (zh)	2011-10-26
ES2531093T3 (es)	2015-03-10
MA30793B1 (fr)	2009-10-01
NI200900035A (es)	2010-01-26
BRPI0718440A2 (pt)	2013-11-19
EA200970307A1 (ru)	2009-12-30
MEP10509A (en)	2011-12-20
FR2906252A1 (fr)	2008-03-28
DOP2011000307A (es)	2011-10-31
IL197402A (en)	2012-12-31
KR20090057031A (ko)	2009-06-03
HN2009000503A (es)	2011-03-02
EP2069362A1 (fr)	2009-06-17
CA2663509C (fr)	2014-03-18
US7645880B2 (en)	2010-01-12
CN101516892B (zh)	2012-06-20
IL197402A0 (en)	2009-12-24
TN2009000080A1 (en)	2010-08-19
KR101434693B1 (ko)	2014-08-27
US20100145051A1 (en)	2010-06-10
TW200821314A (en)	2008-05-16
TWI465451B (zh)	2014-12-21
JO3023B1 (ar)	2016-09-05
AU2007298855B2 (en)	2012-09-13
JP2010504308A (ja)	2010-02-12
NO20091561L (no)	2009-06-16
PE20080867A1 (es)	2008-08-22
JP5214615B2 (ja)	2013-06-19
EP2069362B1 (fr)	2014-07-09
UA96957C2 (ru)	2011-12-26
CL2007002711A1 (es)	2008-04-18
WO2008034973A1 (fr)	2008-03-27
CA2663509A1 (fr)	2008-03-27
ZA200901846B (en)	2010-07-28
FR2906252B1 (fr)	2008-11-28
MX2009003084A (es)	2009-04-02
US20080214817A1 (en)	2008-09-04
UY30599A1 (es)	2008-05-02
US8288547B2 (en)	2012-10-16
CO6170362A2 (es)	2010-06-18
AR062918A1 (es)	2008-12-17
CR10660A (es)	2009-06-24
NZ575417A (en)	2011-09-30
CN101516892A (zh)	2009-08-26
GT200900060A (es)	2011-01-04
EA015426B1 (ru)	2011-08-30
SV2009003192A (es)	2009-10-27
AU2007298855A1 (en)	2008-03-27
MY148094A (en)	2013-02-28
ME00613B (me)	2011-12-20

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Legal Events

Date	Code	Title	Description
2018-04-13	PC	Patent ceased (i.e. patent has lapsed due to the failure to pay the renewal fee)	Effective date: 20170919