UA85531C2 - Применение ингибитора il-18 для лечения или предупреждения связанной с сепсисом дисфункции сердца - Google Patents
Применение ингибитора il-18 для лечения или предупреждения связанной с сепсисом дисфункции сердца Download PDFInfo
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- UA85531C2 UA85531C2 UA20031211613A UA20031211613A UA85531C2 UA 85531 C2 UA85531 C2 UA 85531C2 UA 20031211613 A UA20031211613 A UA 20031211613A UA 20031211613 A UA20031211613 A UA 20031211613A UA 85531 C2 UA85531 C2 UA 85531C2
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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Abstract
Данное изобретение относится к применению ингибитора IL-18 для получения лекарственного средства для лечения и/или предупреждения связанной с сепсисом дисфункции сердца.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US29146301P | 2001-05-16 | 2001-05-16 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| UA85531C2 true UA85531C2 (ru) | 2009-02-10 |
Family
ID=23120395
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| UA20031211613A UA85531C2 (ru) | 2001-05-16 | 2002-05-16 | Применение ингибитора il-18 для лечения или предупреждения связанной с сепсисом дисфункции сердца |
Country Status (20)
| Country | Link |
|---|---|
| US (1) | US20030008822A1 (ru) |
| EP (1) | EP1425028B1 (ru) |
| JP (1) | JP4502580B2 (ru) |
| KR (1) | KR100877033B1 (ru) |
| CN (1) | CN100556450C (ru) |
| AT (1) | ATE451930T1 (ru) |
| BR (1) | BR0210904A (ru) |
| CA (1) | CA2446942C (ru) |
| CY (1) | CY1109713T1 (ru) |
| DE (1) | DE60234778D1 (ru) |
| DK (1) | DK1425028T3 (ru) |
| EA (1) | EA009125B1 (ru) |
| ES (1) | ES2334773T3 (ru) |
| HK (1) | HK1066723A1 (ru) |
| IL (2) | IL158866A0 (ru) |
| MX (1) | MXPA03010575A (ru) |
| PT (1) | PT1425028E (ru) |
| SI (1) | SI1425028T1 (ru) |
| UA (1) | UA85531C2 (ru) |
| WO (1) | WO2002092008A2 (ru) |
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| US7718368B2 (en) | 2000-12-04 | 2010-05-18 | Viron Therapeutics Inc. | Immunomodulatory protein and useful embodiments thereof |
| PL1622939T3 (pl) | 2003-05-13 | 2012-08-31 | Merck Serono Sa | Aktywne warianty białka wiążącego IL-18 i ich medyczne zastosowania |
| AU2004241069B2 (en) | 2003-05-15 | 2010-09-09 | Genentech, Inc. | Methods and compositions for the prevention and treatment of sepsis |
| US7482376B2 (en) * | 2003-07-03 | 2009-01-27 | 3-Dimensional Pharmaceuticals, Inc. | Conjugated complement cascade inhibitors |
| US7968684B2 (en) | 2003-11-12 | 2011-06-28 | Abbott Laboratories | IL-18 binding proteins |
| EP1752159A4 (en) * | 2004-05-17 | 2009-07-01 | Univ Keio | MEDICAL COMPOSITION AND THERAPEUTIC PROCEDURE |
| FI116804B (fi) * | 2004-05-18 | 2006-02-28 | Ekspansio Engineering Ltd Oy | Materiaalikappaleiden eri suuntiin osoittavien pintojen optinen tarkastus |
| JP5199073B2 (ja) | 2005-06-03 | 2013-05-15 | アレス トレーディング ソシエテ アノニム | 組換えｉｌ−１８結合タンパク質の生産 |
| CA2610804C (en) | 2005-06-10 | 2013-11-19 | Ares Trading S.A. | Process for the purification of il-18 binding protein |
| CA2681828A1 (en) * | 2007-03-28 | 2008-10-09 | Universidad De Barcelona | Cd6 products for the treatment of sepsis |
| CL2008002153A1 (es) | 2007-07-24 | 2009-06-05 | Amgen Inc | Anticuerpo aislado o fragmanto de unión de antigeno del mismo que se une al receptor de il-18 (il-18r); molecula de ácido nucleico codificante; celula huesped que la comprende; composición farmaceutica; uso médico para tratar o prevenir una condición asociada con il-18r; método in vitro para inhibir la unión de il-18 al il-18r. |
| MX2013002255A (es) | 2010-08-27 | 2013-07-03 | Stem Centrx Inc | Moduladores de proteina de notum y metodos de uso. |
| KR101451357B1 (ko) * | 2011-02-18 | 2014-10-15 | 주식회사 스템디알 | Ｓｉｒｔ１ 발현 유도 물질을 포함하는 패혈증 또는 패혈증 쇼크의 예방 또는 치료용 조성물 |
| ES2691070T3 (es) | 2012-05-11 | 2018-11-23 | Kael-Gemvax Co.,Ltd | Péptidos antiinflamatorios y composición que comprende los mismos |
| CN104487081B (zh) | 2012-05-11 | 2017-12-12 | 珍白斯凯尔有限公司 | 用于预防或治疗恶病质的组合物 |
| EP2873678B8 (en) | 2012-07-11 | 2024-07-17 | Gemvax & Kael Co., Ltd. | Conjugate comprising a cell-penetrating peptide and compositions comprising same |
| JP6474786B2 (ja) | 2013-04-19 | 2019-02-27 | ジェムバックス アンド カエル カンパニー，リミティド | 虚血性損傷の治療及び予防用の組成物 |
| EP3004883B1 (en) | 2013-06-07 | 2022-09-14 | Gemvax & Kael Co., Ltd. | Gv1001, gemcitabine and capecitabine for use in the treatment of pancreatic cancer in high eotaxin baseline level patients |
| US10561703B2 (en) | 2013-06-21 | 2020-02-18 | Gemvax & Kael Co., Ltd. | Method of modulating sex hormone levels using a sex hormone secretion modulator |
| SG11201601717VA (en) * | 2013-09-05 | 2016-04-28 | Ab2 Bio Sa | Il-18 binding protein (il-18bp) in inflammatory diseases |
| ES2773296T3 (es) | 2013-10-23 | 2020-07-10 | Gemvax & Kael Co Ltd | Composición para tratar y prevenir la hiperplasia prostática benigna |
| ES2818921T3 (es) | 2013-11-22 | 2021-04-14 | Gemvax & Kael Co Ltd | Péptido que tiene actividad inhibidora de la angiogénesis y composición que contiene el mismo |
| ES2809251T3 (es) | 2013-12-17 | 2021-03-03 | Gemvax & Kael Co Ltd | Composición para tratar cáncer de próstata |
| GB201400997D0 (en) * | 2014-01-21 | 2014-03-05 | Vib Vzw | Targeting of interleukin-1 and -18 in treatment of septic shock |
| KR102373603B1 (ko) | 2014-04-11 | 2022-03-14 | 주식회사 젬백스앤카엘 | 섬유증 억제 활성을 가지는 펩티드 및 이를 포함하는 조성물 |
| WO2015167067A1 (ko) | 2014-04-30 | 2015-11-05 | 주식회사 카엘젬백스 | 장기, 조직 또는 세포 이식용 조성물, 키트 및 이식 방법 |
| KR102413243B1 (ko) | 2014-12-23 | 2022-06-27 | 주식회사 젬백스앤카엘 | 안질환 치료 펩티드 및 이를 포함하는 안질환 치료용 조성물 |
| JP6751097B2 (ja) | 2015-02-27 | 2020-09-02 | ジェムバックス アンド カエル カンパニー，リミティド | 聴力損傷予防用ペプチド及びそれを含む組成物 |
| US10882905B2 (en) | 2015-03-05 | 2021-01-05 | Ab2 Bio Sa | IL-18 binding protein (IL-18BP) and antibodies in inflammatory diseases |
| KR102638286B1 (ko) | 2015-07-02 | 2024-02-20 | 주식회사 젬백스앤카엘 | 항바이러스 활성 효능을 가지는 펩티드 및 이를 포함하는 조성물 |
| CN109328068A (zh) | 2016-04-07 | 2019-02-12 | 珍白斯凯尔有限公司 | 具有增加端粒酶活性和延长端粒的效果的肽以及包含该肽的组合物 |
| AU2017360043A1 (en) | 2016-11-18 | 2019-06-20 | Hospital Clinic De Barcelona | Combined CD6 and imipenem therapy for treatment of infectious diseases and related inflammatory processes |
| CN107715105B (zh) * | 2017-10-26 | 2020-11-24 | 重庆医科大学 | Il-34在制备治疗或预防脓毒症药物中的应用 |
| CN109954131B (zh) * | 2017-12-14 | 2023-05-02 | 深圳市中科艾深医药有限公司 | 一种肿瘤坏死因子相关凋亡诱导配体拮抗剂作为脓毒血症治疗药物的应用 |
| CN111012899A (zh) * | 2020-01-08 | 2020-04-17 | 重庆医科大学 | Il-38的新用途 |
| CN115154581A (zh) * | 2022-05-31 | 2022-10-11 | 八加一药业股份有限公司 | 选择性TNFR1拮抗肽Hydrostatin-SN10在治疗脓毒症中的应用 |
| CN115754304A (zh) * | 2022-11-24 | 2023-03-07 | 重庆医科大学 | 骨形态蛋白-7作为生物标志物在脓毒血症诊断、预后或治疗监测中的用途 |
| WO2024148232A2 (en) | 2023-01-06 | 2024-07-11 | Alector Llc | Anti-il18 binding protein antibodies and methods of use thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| US4847325A (en) * | 1988-01-20 | 1989-07-11 | Cetus Corporation | Conjugation of polymer to colony stimulating factor-1 |
| EP0504257A4 (en) * | 1989-11-29 | 1993-03-03 | Brigham And Women's Hospital | (ala il-8) 77 as a leukocyte adhesion inhibitor |
| US5536637A (en) * | 1993-04-07 | 1996-07-16 | Genetics Institute, Inc. | Method of screening for cDNA encoding novel secreted mammalian proteins in yeast |
| WO1998016504A2 (en) * | 1996-10-11 | 1998-04-23 | Warner-Lambert Company | SULFONAMIDE SUBSTITUTED ASPARTIC ACID INTERLEUKIN-1β CONVERTING ENZYME INHIBITORS |
| US6054487A (en) * | 1997-03-18 | 2000-04-25 | Basf Aktiengesellschaft | Methods and compositions for modulating responsiveness to corticosteroids |
| SK122199A3 (en) * | 1997-03-18 | 2000-12-11 | Basf Ag | Methods and compositions for modulating responsiveness to corticosteroids |
| IL121860A0 (en) * | 1997-08-14 | 1998-02-22 | Yeda Res & Dev | Interleukin-18 binding proteins their preparation and use |
| CA2276216A1 (en) * | 1998-06-24 | 1999-12-24 | Kabushiki Kaisha Hayashibara Seibutsu Kagaku Kenkyujo | An artificial peptide capable of neutralizing the biological activity of interleukin-18 |
| CN1461310B (zh) * | 2000-02-10 | 2013-06-12 | 雅培制药有限公司 | 结合人白介素-18的抗体及制备和使用方法 |
| CZ304485B6 (cs) * | 2000-02-21 | 2014-05-28 | Merck Serono S.A. | Farmaceutický prostředek pro léčení nebo prevenci alkoholické hepatitidy |
| WO2002032374A2 (en) * | 2000-10-18 | 2002-04-25 | Immunex Corporation | Methods for treating il-18 mediated disorders |
-
2002
- 2002-05-16 CA CA2446942A patent/CA2446942C/en not_active Expired - Lifetime
- 2002-05-16 SI SI200230874T patent/SI1425028T1/sl unknown
- 2002-05-16 EA EA200301248A patent/EA009125B1/ru not_active IP Right Cessation
- 2002-05-16 PT PT02736912T patent/PT1425028E/pt unknown
- 2002-05-16 AT AT02736912T patent/ATE451930T1/de active
- 2002-05-16 DE DE60234778T patent/DE60234778D1/de not_active Expired - Lifetime
- 2002-05-16 BR BR0210904-2A patent/BR0210904A/pt active Pending
- 2002-05-16 UA UA20031211613A patent/UA85531C2/ru unknown
- 2002-05-16 EP EP02736912A patent/EP1425028B1/en not_active Expired - Lifetime
- 2002-05-16 MX MXPA03010575A patent/MXPA03010575A/es active IP Right Grant
- 2002-05-16 US US10/147,341 patent/US20030008822A1/en not_active Abandoned
- 2002-05-16 WO PCT/US2002/015556 patent/WO2002092008A2/en active Search and Examination
- 2002-05-16 JP JP2002588927A patent/JP4502580B2/ja not_active Expired - Lifetime
- 2002-05-16 IL IL15886602A patent/IL158866A0/xx active IP Right Grant
- 2002-05-16 DK DK02736912.3T patent/DK1425028T3/da active
- 2002-05-16 KR KR1020037014798A patent/KR100877033B1/ko active IP Right Grant
- 2002-05-16 CN CNB028140605A patent/CN100556450C/zh not_active Expired - Lifetime
- 2002-05-16 ES ES02736912T patent/ES2334773T3/es not_active Expired - Lifetime
-
2003
- 2003-11-13 IL IL158866A patent/IL158866A/en unknown
-
2004
- 2004-12-07 HK HK04109655.3A patent/HK1066723A1/xx not_active IP Right Cessation
-
2010
- 2010-01-11 CY CY20101100029T patent/CY1109713T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| CA2446942A1 (en) | 2002-11-21 |
| WO2002092008A3 (en) | 2004-04-08 |
| BR0210904A (pt) | 2005-08-16 |
| DK1425028T3 (da) | 2010-03-01 |
| ATE451930T1 (de) | 2010-01-15 |
| KR100877033B1 (ko) | 2009-01-07 |
| CA2446942C (en) | 2010-07-20 |
| EP1425028A2 (en) | 2004-06-09 |
| EP1425028A4 (en) | 2006-03-01 |
| IL158866A0 (en) | 2004-05-12 |
| MXPA03010575A (es) | 2005-03-07 |
| EP1425028B1 (en) | 2009-12-16 |
| HK1066723A1 (en) | 2005-04-01 |
| EA009125B1 (ru) | 2007-10-26 |
| JP4502580B2 (ja) | 2010-07-14 |
| PT1425028E (pt) | 2010-01-06 |
| ES2334773T3 (es) | 2010-03-16 |
| JP2004531546A (ja) | 2004-10-14 |
| EA200301248A1 (ru) | 2005-06-30 |
| SI1425028T1 (sl) | 2010-02-26 |
| CY1109713T1 (el) | 2014-08-13 |
| CN1529611A (zh) | 2004-09-15 |
| DE60234778D1 (de) | 2010-01-28 |
| IL158866A (en) | 2011-01-31 |
| WO2002092008A2 (en) | 2002-11-21 |
| US20030008822A1 (en) | 2003-01-09 |
| CN100556450C (zh) | 2009-11-04 |
| KR20040045400A (ko) | 2004-06-01 |
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