UA72460C2 - A process for the preparation of polymer- bound cyclic peptides - Google Patents

A process for the preparation of polymer- bound cyclic peptides Download PDF

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Publication number: UA72460C2
Authority: UA; Ukraine
Prior art keywords: peptide; amino acid; avr; polymer; azr
Prior art date: 1998-04-15

Application number

UA2000116453A

Other languages

English (en)

Ukrainian (uk)

Original Assignee

Aventic Pharmaceuticals Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1998-04-15

Filing date

1999-04-15

Publication date

2005-03-15

1999-04-15 Application filed by Aventic Pharmaceuticals Inc filed Critical Aventic Pharmaceuticals Inc

2005-03-15 Publication of UA72460C2 publication Critical patent/UA72460C2/uk

Links

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125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 description 1
230000004962 physiological condition Effects 0.000 description 1
OXNIZHLAWKMVMX-UHFFFAOYSA-N picric acid Chemical compound OC1=C([N+]([O-])=O)C=C([N+]([O-])=O)C=C1[N+]([O-])=O OXNIZHLAWKMVMX-UHFFFAOYSA-N 0.000 description 1
102000005162 pleiotrophin Human genes 0.000 description 1
229920000573 polyethylene Polymers 0.000 description 1
239000000843 powder Substances 0.000 description 1
230000001376 precipitating effect Effects 0.000 description 1
125000002924 primary amino group Chemical group [H]N([H])* 0.000 description 1
201000009395 primary hyperaldosteronism Diseases 0.000 description 1
229940002612 prodrug Drugs 0.000 description 1
239000000651 prodrug Substances 0.000 description 1
IVRIRQXJSNCSPQ-UHFFFAOYSA-N propan-2-yl carbonochloridate Chemical compound CC(C)OC(Cl)=O IVRIRQXJSNCSPQ-UHFFFAOYSA-N 0.000 description 1
125000004368 propenyl group Chemical group C(=CC)* 0.000 description 1
125000002568 propynyl group Chemical group [*]C#CC([H])([H])[H] 0.000 description 1
230000001681 protective effect Effects 0.000 description 1
239000012264 purified product Substances 0.000 description 1
238000011002 quantification Methods 0.000 description 1
230000006340 racemization Effects 0.000 description 1
230000035484 reaction time Effects 0.000 description 1
239000002464 receptor antagonist Substances 0.000 description 1
229940044551 receptor antagonist Drugs 0.000 description 1
238000001953 recrystallisation Methods 0.000 description 1
206010038464 renal hypertension Diseases 0.000 description 1
108010004093 retinal S antigen peptide M Proteins 0.000 description 1
229940043230 sarcosine Drugs 0.000 description 1
229930195734 saturated hydrocarbon Natural products 0.000 description 1
125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 description 1
238000007086 side reaction Methods 0.000 description 1
239000000377 silicon dioxide Substances 0.000 description 1
IZTQOLKUZKXIRV-YRVFCXMDSA-N sincalide Chemical class C([C@@H](C(=O)N[C@@H](CCSC)C(=O)NCC(=O)N[C@@H](CC=1C2=CC=CC=C2NC=1)C(=O)N[C@@H](CCSC)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@@H](CC=1C=CC=CC=1)C(N)=O)NC(=O)[C@@H](N)CC(O)=O)C1=CC=C(OS(O)(=O)=O)C=C1 IZTQOLKUZKXIRV-YRVFCXMDSA-N 0.000 description 1
239000011780 sodium chloride Substances 0.000 description 1
HPALAKNZSZLMCH-UHFFFAOYSA-M sodium;chloride;hydrate Chemical compound O.[Na+].[Cl-] HPALAKNZSZLMCH-UHFFFAOYSA-M 0.000 description 1
230000002194 synthesizing effect Effects 0.000 description 1
238000010189 synthetic method Methods 0.000 description 1
UGNWTBMOAKPKBL-UHFFFAOYSA-N tetrachloro-1,4-benzoquinone Chemical compound ClC1=C(Cl)C(=O)C(Cl)=C(Cl)C1=O UGNWTBMOAKPKBL-UHFFFAOYSA-N 0.000 description 1
125000001412 tetrahydropyranyl group Chemical group 0.000 description 1
230000001225 therapeutic effect Effects 0.000 description 1
238000004809 thin layer chromatography Methods 0.000 description 1
125000003396 thiol group Chemical group [H]S* 0.000 description 1
FGMPLJWBKKVCDB-UHFFFAOYSA-N trans-L-hydroxy-proline Natural products ON1CCCC1C(O)=O FGMPLJWBKKVCDB-UHFFFAOYSA-N 0.000 description 1
125000004044 trifluoroacetyl group Chemical group FC(C(=O)*)(F)F 0.000 description 1
LZTRCELOJRDYMQ-UHFFFAOYSA-N triphenylmethanol Chemical compound C=1C=CC=CC=1C(C=1C=CC=CC=1)(O)C1=CC=CC=C1 LZTRCELOJRDYMQ-UHFFFAOYSA-N 0.000 description 1
JBWKIWSBJXDJDT-UHFFFAOYSA-N triphenylmethyl chloride Chemical compound C=1C=CC=CC=1C(C=1C=CC=CC=1)(Cl)C1=CC=CC=C1 JBWKIWSBJXDJDT-UHFFFAOYSA-N 0.000 description 1
125000002221 trityl group Chemical group [H]C1=C([H])C([H])=C([H])C([H])=C1C([*])(C1=C(C(=C(C(=C1[H])[H])[H])[H])[H])C1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 description 1
102000003390 tumor necrosis factor Human genes 0.000 description 1
238000000825 ultraviolet detection Methods 0.000 description 1
229940005605 valeric acid Drugs 0.000 description 1
230000002227 vasoactive effect Effects 0.000 description 1
125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 description 1

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
- C07K17/02—Peptides being immobilised on, or in, an organic carrier
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06139—Dipeptides with the first amino acid being heterocyclic
- C07K5/06182—Dipeptides with the first amino acid being heterocyclic and Pristinamycin II; Derivatives thereof
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/575—Hormones
- C07K14/635—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
- C07K7/50—Cyclic peptides containing at least one abnormal peptide link
- C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Molecular Biology (AREA)
Genetics & Genomics (AREA)
Medicinal Chemistry (AREA)
Biophysics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Biochemistry (AREA)
General Health & Medical Sciences (AREA)
Endocrinology (AREA)
Analytical Chemistry (AREA)
Toxicology (AREA)
Zoology (AREA)
Gastroenterology & Hepatology (AREA)
Peptides Or Proteins (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Preparation Of Compounds By Using Micro-Organisms (AREA)

UA2000116453A 1998-04-15 1999-04-15 A process for the preparation of polymer- bound cyclic peptides UA72460C2 (en)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
US8189798P	1998-04-15	1998-04-15
PCT/US1999/008435 WO1999052933A1 (en)	1998-04-15	1999-04-15	Process for the preparation of resin-bound cyclic peptides

Publications (1)

Publication Number	Publication Date
UA72460C2 true UA72460C2 (en)	2005-03-15

Family

ID=22167111

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
UA2000116453A UA72460C2 (en)	1998-04-15	1999-04-15	A process for the preparation of polymer- bound cyclic peptides

Country Status (20)

Country	Link
US (1)	US6569993B1 (zh)
EP (1)	EP1093458A4 (zh)
JP (1)	JP2002511483A (zh)
KR (1)	KR20010085236A (zh)
CN (2)	CN1163504C (zh)
AP (1)	AP1117A (zh)
AU (1)	AU744812B2 (zh)
BG (1)	BG104903A (zh)
BR (1)	BR9909634A (zh)
CA (1)	CA2325572A1 (zh)
CZ (1)	CZ20003798A3 (zh)
EA (1)	EA200001071A1 (zh)
HU (1)	HUP0101629A2 (zh)
IL (1)	IL138338A0 (zh)
NO (1)	NO20005165L (zh)
OA (1)	OA11501A (zh)
PL (1)	PL347103A1 (zh)
SK (1)	SK15352000A3 (zh)
UA (1)	UA72460C2 (zh)
WO (1)	WO1999052933A1 (zh)

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BR112017005598A2 (pt)	2014-09-24	2017-12-12	Aileron Therapeutics Inc	macrociclos peptidomiméticos e usos dos mesmos
AU2015320545C1 (en)	2014-09-24	2020-05-14	Aileron Therapeutics, Inc.	Peptidomimetic macrocycles and formulations thereof
KR20170129879A (ko)	2015-03-20	2017-11-27	에일러론 테라퓨틱스 인코포레이티드	펩티드모방 거대고리 및 이의 용도
CN106146648B (zh) *	2015-03-26	2020-06-12	深圳翰宇药业股份有限公司	一种甲状旁腺激素类似物的合成方法
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1999
- 1999-04-15 UA UA2000116453A patent/UA72460C2/uk unknown
- 1999-04-15 AP APAP/P/2000/001972A patent/AP1117A/en active
- 1999-04-15 JP JP2000543489A patent/JP2002511483A/ja active Pending
- 1999-04-15 EP EP99917595A patent/EP1093458A4/en not_active Withdrawn
- 1999-04-15 AU AU35679/99A patent/AU744812B2/en not_active Ceased
- 1999-04-15 CA CA002325572A patent/CA2325572A1/en not_active Abandoned
- 1999-04-15 EA EA200001071A patent/EA200001071A1/ru unknown
- 1999-04-15 WO PCT/US1999/008435 patent/WO1999052933A1/en not_active Application Discontinuation
- 1999-04-15 KR KR1020007011446A patent/KR20010085236A/ko not_active Application Discontinuation
- 1999-04-15 HU HU0101629A patent/HUP0101629A2/hu unknown
- 1999-04-15 CZ CZ20003798A patent/CZ20003798A3/cs unknown
- 1999-04-15 CN CNB998119709A patent/CN1163504C/zh not_active Expired - Fee Related
- 1999-04-15 IL IL13833899A patent/IL138338A0/xx unknown
- 1999-04-15 BR BR9909634-0A patent/BR9909634A/pt not_active IP Right Cessation
- 1999-04-15 CN CNA2004100386677A patent/CN1552737A/zh active Pending
- 1999-04-15 SK SK1535-2000A patent/SK15352000A3/sk unknown
- 1999-04-15 PL PL99347103A patent/PL347103A1/xx not_active Application Discontinuation
- 1999-11-18 US US09/442,989 patent/US6569993B1/en not_active Expired - Fee Related
2000
- 2000-10-13 OA OA1200000283A patent/OA11501A/en unknown
- 2000-10-13 NO NO20005165A patent/NO20005165L/no not_active Application Discontinuation
- 2000-11-02 BG BG104903A patent/BG104903A/bg unknown

Also Published As

Publication number	Publication date
JP2002511483A (ja)	2002-04-16
AP1117A (en)	2002-11-02
CN1323313A (zh)	2001-11-21
CN1552737A (zh)	2004-12-08
PL347103A1 (en)	2002-03-25
NO20005165D0 (no)	2000-10-13
CA2325572A1 (en)	1999-10-21
CZ20003798A3 (cs)	2001-08-15
CN1163504C (zh)	2004-08-25
BG104903A (bg)	2001-07-31
EA200001071A1 (ru)	2001-08-27
US6569993B1 (en)	2003-05-27
EP1093458A4 (en)	2001-07-18
KR20010085236A (ko)	2001-09-07
NO20005165L (no)	2000-12-15
AP2000001972A0 (en)	2000-12-31
OA11501A (en)	2004-05-14
AU3567999A (en)	1999-11-01
SK15352000A3 (sk)	2001-04-09
EP1093458A1 (en)	2001-04-25
IL138338A0 (en)	2001-10-31
WO1999052933A1 (en)	1999-10-21
AU744812B2 (en)	2002-03-07
HUP0101629A2 (en)	2003-03-28
BR9909634A (pt)	2001-10-16

Publication	Publication Date	Title
UA72460C2 (en)	2005-03-15	A process for the preparation of polymer- bound cyclic peptides
US5767239A (en)	1998-06-16	Process for preparing cardiodilatin fragments; highly purified cardiodilatin fragments and intermediate products for the preparation of same
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US4420424A (en)	1983-12-13	New peptides and a process for their preparation
AU664855B2 (en)	1995-12-07	Lanthionine bridged peptides
NO166532B (no)	1991-04-29	Fremgangsmaate for fremstilling av peptidet h-arg-x-z-y-tyr-r.
CH637111A5 (fr)	1983-07-15	Composes polypeptidiques a activite thymique ou antagoniste et leurs procedes de synthese.
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US4474765A (en)	1984-10-02	Biologically active peptides
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NO177100B (no)	1995-04-10	Peptider