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BR9909634A - Processo para preparar análogos de peptìdeo cìclico, e, peptìdeo adequado como um intermediário para realização do processo - Google Patents

Processo para preparar análogos de peptìdeo cìclico, e, peptìdeo adequado como um intermediário para realização do processo

Info

Publication number
BR9909634A
BR9909634A BR9909634-0A BR9909634A BR9909634A BR 9909634 A BR9909634 A BR 9909634A BR 9909634 A BR9909634 A BR 9909634A BR 9909634 A BR9909634 A BR 9909634A
Authority
BR
Brazil
Prior art keywords
analogs
peptide
carrying
cyclic peptide
preparing cyclic
Prior art date
Application number
BR9909634-0A
Other languages
English (en)
Inventor
Adam W Sledeski
James J Mencel
Original Assignee
Aventis Pharm Prod Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Aventis Pharm Prod Inc filed Critical Aventis Pharm Prod Inc
Publication of BR9909634A publication Critical patent/BR9909634A/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K17/00—Carrier-bound or immobilised peptides; Preparation thereof
    • C07K17/02—Peptides being immobilised on, or in, an organic carrier
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K5/00—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof
    • C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
    • C07K5/06—Dipeptides
    • C07K5/06139—Dipeptides with the first amino acid being heterocyclic
    • C07K5/06182—Dipeptides with the first amino acid being heterocyclic and Pristinamycin II; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
    • C07K1/04—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length on carriers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/575—Hormones
    • C07K14/635—Parathyroid hormone, i.e. parathormone; Parathyroid hormone-related peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Biophysics (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Endocrinology (AREA)
  • Analytical Chemistry (AREA)
  • Toxicology (AREA)
  • Zoology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

"PROCESSO PARA PREPARAR ANáLOGOS DE PEPTìDEO CìCLICO, E, PEPTìDEO ADEQUADO COMO UM INTERMEDIáRIO PARA REALIZAçãO DO PROCESSO". Esta invenção refere-se a um processo para a sintese, baseada em fragmentos, em fase sólida, de análogos de peptídeo cíclico ligado a resina de hormónios de paratireóide e de análogos de proteínas relacionadas a hormónio de paratireóide, cujos análogos contêm pelo menos uma ponte entre as cadeias laterais de dois resíduos de aminoácido não adjacentes, e aos fragmentos de peptídeo usados úteis a mesma.
BR9909634-0A 1998-04-15 1999-04-15 Processo para preparar análogos de peptìdeo cìclico, e, peptìdeo adequado como um intermediário para realização do processo BR9909634A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US8189798P 1998-04-15 1998-04-15
PCT/US1999/008435 WO1999052933A1 (en) 1998-04-15 1999-04-15 Process for the preparation of resin-bound cyclic peptides

Publications (1)

Publication Number Publication Date
BR9909634A true BR9909634A (pt) 2001-10-16

Family

ID=22167111

Family Applications (1)

Application Number Title Priority Date Filing Date
BR9909634-0A BR9909634A (pt) 1998-04-15 1999-04-15 Processo para preparar análogos de peptìdeo cìclico, e, peptìdeo adequado como um intermediário para realização do processo

Country Status (20)

Country Link
US (1) US6569993B1 (pt)
EP (1) EP1093458A4 (pt)
JP (1) JP2002511483A (pt)
KR (1) KR20010085236A (pt)
CN (2) CN1163504C (pt)
AP (1) AP1117A (pt)
AU (1) AU744812B2 (pt)
BG (1) BG104903A (pt)
BR (1) BR9909634A (pt)
CA (1) CA2325572A1 (pt)
CZ (1) CZ20003798A3 (pt)
EA (1) EA200001071A1 (pt)
HU (1) HUP0101629A2 (pt)
IL (1) IL138338A0 (pt)
NO (1) NO20005165L (pt)
OA (1) OA11501A (pt)
PL (1) PL347103A1 (pt)
SK (1) SK15352000A3 (pt)
UA (1) UA72460C2 (pt)
WO (1) WO1999052933A1 (pt)

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US6756480B2 (en) 2000-04-27 2004-06-29 Amgen Inc. Modulators of receptors for parathyroid hormone and parathyroid hormone-related protein
US20040082783A1 (en) * 2002-08-06 2004-04-29 Schafmeister Christian E. Bis (amino acid) molecular scaffolds
EP2332968B1 (en) 2003-11-05 2016-05-04 Dana-Farber Cancer Institute, Inc. Alpha-helical peptides suitable for activating or inhibiting cell death
GB0408958D0 (en) * 2004-04-22 2004-05-26 Pharma Mar Sa Convergent synthesis for kahalalide compounds
TW200626611A (en) * 2004-09-20 2006-08-01 Lonza Ag Peptide cyclisation
GB0505199D0 (en) * 2005-03-14 2005-04-20 Southampton Polypeptides Process
EA014696B1 (ru) 2006-10-13 2010-12-30 Эли Лилли Энд Компани Пэгилированный паратиреоидный гормон в качестве модулятора рецептора паратиреоидного гормона и его применение
CN101235080B (zh) * 2007-01-31 2010-09-08 中国科学院上海有机化学研究所 一种达托霉素的合成方法
EP2952522B1 (en) 2007-01-31 2019-10-30 Dana-Farber Cancer Institute, Inc. Stabilized p53 peptides and uses thereof
ES2610531T3 (es) 2007-03-28 2017-04-28 President And Fellows Of Harvard College Polipéptidos cosidos
CN101980718A (zh) 2008-02-08 2011-02-23 爱勒让治疗公司 治疗性的拟肽大环化合物
US20110144303A1 (en) * 2008-04-08 2011-06-16 Aileron Therapeutics, Inc. Biologically Active Peptidomimetic Macrocycles
CA2737921C (en) * 2008-09-22 2019-01-15 Aileron Therapeutics, Inc. Methods for preparing purified alpha-helical peptidomimetic macrocycle compositions with low metal ppm levels
AU2010204648B2 (en) 2009-01-14 2016-09-01 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
AU2010298338A1 (en) 2009-09-22 2012-04-12 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
RU2582678C2 (ru) 2010-08-13 2016-04-27 Эйлерон Терапьютикс, Инк. Пептидомиметические макроциклы
AR088392A1 (es) 2011-10-18 2014-05-28 Aileron Therapeutics Inc Macrociclos peptidomimeticos
US8987414B2 (en) 2012-02-15 2015-03-24 Aileron Therapeutics, Inc. Triazole-crosslinked and thioether-crosslinked peptidomimetic macrocycles
MX362492B (es) 2012-02-15 2019-01-21 Aileron Therapeutics Inc Macrociclos peptidomiméticos.
AU2013337388B2 (en) 2012-11-01 2018-08-02 Aileron Therapeutics, Inc. Disubstituted amino acids and methods of preparation and use thereof
BR112017005598A2 (pt) 2014-09-24 2017-12-12 Aileron Therapeutics Inc macrociclos peptidomiméticos e usos dos mesmos
AU2015320545C1 (en) 2014-09-24 2020-05-14 Aileron Therapeutics, Inc. Peptidomimetic macrocycles and formulations thereof
KR20170129879A (ko) 2015-03-20 2017-11-27 에일러론 테라퓨틱스 인코포레이티드 펩티드모방 거대고리 및 이의 용도
CN106146648B (zh) * 2015-03-26 2020-06-12 深圳翰宇药业股份有限公司 一种甲状旁腺激素类似物的合成方法
US10059741B2 (en) 2015-07-01 2018-08-28 Aileron Therapeutics, Inc. Peptidomimetic macrocycles
JP2018528217A (ja) 2015-09-10 2018-09-27 エルロン・セラピューティクス・インコーポレイテッドＡｉｌｅｒｏｎ Ｔｈｅｒａｐｅｕｔｉｃｓ，Ｉｎｃ． Ｍｃｌ−１のモジュレーターとしてのペプチド模倣大環状分子
CN110551178B (zh) * 2018-06-01 2020-07-21 深圳翰宇药业股份有限公司 一种含脯氨酸的首尾环肽合成方法
CN112538103B (zh) * 2020-12-28 2022-10-25 合肥科生景肽生物科技有限公司 制备生长激素释放抑制素的方法

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Also Published As

Publication number Publication date
JP2002511483A (ja) 2002-04-16
AP1117A (en) 2002-11-02
CN1323313A (zh) 2001-11-21
CN1552737A (zh) 2004-12-08
PL347103A1 (en) 2002-03-25
NO20005165D0 (no) 2000-10-13
CA2325572A1 (en) 1999-10-21
CZ20003798A3 (cs) 2001-08-15
CN1163504C (zh) 2004-08-25
BG104903A (bg) 2001-07-31
EA200001071A1 (ru) 2001-08-27
US6569993B1 (en) 2003-05-27
EP1093458A4 (en) 2001-07-18
KR20010085236A (ko) 2001-09-07
UA72460C2 (en) 2005-03-15
NO20005165L (no) 2000-12-15
AP2000001972A0 (en) 2000-12-31
OA11501A (en) 2004-05-14
AU3567999A (en) 1999-11-01
SK15352000A3 (sk) 2001-04-09
EP1093458A1 (en) 2001-04-25
IL138338A0 (en) 2001-10-31
WO1999052933A1 (en) 1999-10-21
AU744812B2 (en) 2002-03-07
HUP0101629A2 (en) 2003-03-28

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Legal Events

Date Code Title Description
B25G Requested change of headquarter approved
B25D Requested change of name of applicant approved
B08F Application dismissed because of non-payment of annual fees [chapter 8.6 patent gazette]

Free format text: REFERENTE A 8A,9A E 10A ANUIDADES.

B08K Patent lapsed as no evidence of payment of the annual fee has been furnished to inpi [chapter 8.11 patent gazette]

Free format text: REFERENTE AO DESPACHO PUBLICADO NA RPI 1990 DE 25/02/2009.