BR9709569B1 - processo para ativação de proteìna desnaturada. - Google Patents
processo para ativação de proteìna desnaturada.Info
- Publication number
- BR9709569B1 BR9709569B1 BRPI9709569-9A BR9709569A BR9709569B1 BR 9709569 B1 BR9709569 B1 BR 9709569B1 BR 9709569 A BR9709569 A BR 9709569A BR 9709569 B1 BR9709569 B1 BR 9709569B1
- Authority
- BR
- Brazil
- Prior art keywords
- activating
- denatured protein
- denaturing agent
- mixed disulfide
- disulphide
- Prior art date
Links
- 230000003213 activating effect Effects 0.000 title 1
- 102000004169 proteins and genes Human genes 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K1/00—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length
- C07K1/107—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides
- C07K1/113—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure
- C07K1/1133—General methods for the preparation of peptides, i.e. processes for the organic chemical preparation of peptides or proteins of any length by chemical modification of precursor peptides without change of the primary structure by redox-reactions involving cystein/cystin side chains
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/48—Nerve growth factor [NGF]
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/745—Blood coagulation or fibrinolysis factors
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
- C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
- C12N9/52—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from bacteria or Archaea
Landscapes
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Engineering & Computer Science (AREA)
- Biophysics (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Toxicology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biomedical Technology (AREA)
- Hematology (AREA)
- General Chemical & Material Sciences (AREA)
- Analytical Chemistry (AREA)
- Peptides Or Proteins (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Enzymes And Modification Thereof (AREA)
- Immobilizing And Processing Of Enzymes And Microorganisms (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP96109288 | 1996-06-11 | ||
| EP96110109 | 1996-06-22 | ||
| PCT/EP1997/003026 WO1997047735A1 (de) | 1996-06-11 | 1997-06-11 | Verfahren zur aktivierung von denaturiertem protein |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| BR9709569A BR9709569A (pt) | 1999-08-10 |
| BR9709569B1 true BR9709569B1 (pt) | 2010-05-18 |
Family
ID=26141986
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI9709569-9A BR9709569B1 (pt) | 1996-06-11 | 1997-06-11 | processo para ativação de proteìna desnaturada. |
Country Status (12)
| Country | Link |
|---|---|
| US (1) | US6342585B1 (pt) |
| EP (1) | EP0904355B1 (pt) |
| JP (1) | JP3288720B2 (pt) |
| KR (1) | KR100305341B1 (pt) |
| AT (1) | ATE260972T1 (pt) |
| AU (1) | AU714318B2 (pt) |
| BR (1) | BR9709569B1 (pt) |
| CA (1) | CA2257122C (pt) |
| DE (1) | DE59711375D1 (pt) |
| ES (1) | ES2214624T3 (pt) |
| TR (1) | TR199802584T2 (pt) |
| WO (1) | WO1997047735A1 (pt) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ES2213861T3 (es) | 1998-10-09 | 2004-09-01 | Scil Proteins Gmbh | Procedimiento de obtencion de ngf-beta activa. |
| DE19957904A1 (de) * | 1999-12-01 | 2001-06-07 | Merck Patent Gmbh | Insektengift-Allergene mit verminderter IgE-Reaktivität und Verfahren zu ihrer Herstellung |
| US20040223967A1 (en) * | 2000-05-24 | 2004-11-11 | Riken | Blood coagulation factor-activating protein and antibody thereto |
| AU2001273348A1 (en) * | 2000-07-10 | 2002-01-21 | Diosynth Rtp, Inc. | Purification of human troponin i |
| US7112570B2 (en) * | 2000-08-24 | 2006-09-26 | Neuren Pharmaceuticals, Ltd. | GPE analogs |
| DE10105912A1 (de) * | 2001-02-09 | 2002-08-14 | Roche Diagnostics Gmbh | Rekombinante Proteinase K |
| US20070004641A1 (en) * | 2001-05-24 | 2007-01-04 | Neuren Pharmaceuticals Limited | Cognitive enhancement and cognitive therapy using glycyl-L-2-methylprolyl-L-glutamate |
| US7605177B2 (en) | 2001-05-24 | 2009-10-20 | Neuren Pharmaceuticals Limited | Effects of glycyl-2 methyl prolyl glutamate on neurodegeneration |
| US7714020B2 (en) * | 2001-05-24 | 2010-05-11 | Neuren Pharmaceuticals Limited | Treatment of non-convulsive seizures in brain injury using G-2-methyl-prolyl glutamate |
| DE60232880D1 (de) | 2001-05-24 | 2009-08-20 | Neuren Pharmaceuticals Ltd | Gpe-analoga und peptidomimetika |
| CA2468971A1 (en) * | 2001-12-04 | 2003-06-12 | Mitsubishi Pharma Corporation | Method of activating protein |
| DE10224111A1 (de) * | 2002-05-29 | 2003-12-18 | November Ag Molekulare Medizin | Verfahren zum Assemblieren von Untereinheiten zu Kapsoiden |
| US20040096089A1 (en) * | 2002-08-16 | 2004-05-20 | David Borsook | Non-invasive functional imaging of peripheral nervous system activation in humans and animals |
| CA2511228A1 (en) * | 2002-12-20 | 2004-07-08 | Mitsubishi Pharma Corporation | Method of protecting thiol group of protein |
| US20080131500A1 (en) * | 2006-12-04 | 2008-06-05 | The Board Of Regents Of The University Of Texas System | Methods and compositions for rapid inactivation of proteins |
| CA2862820A1 (en) * | 2012-02-29 | 2013-09-06 | F. Hoffmann-La Roche Ag | On-column enzymatic cleavage |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU712412B (en) | 1912-03-22 | 1913-03-23 | Bobert Smith Noakes | Support and adjuster for soft collars |
| GR79124B (pt) * | 1982-12-22 | 1984-10-02 | Genentech Inc | |
| US4923767A (en) * | 1985-06-18 | 1990-05-08 | International Fuel Cells | Fuel cell power plants employing an aqueous solution |
| DE3537708A1 (de) * | 1985-10-23 | 1987-04-23 | Boehringer Mannheim Gmbh | Verfahren zur aktivierung von t-pa nach expression in prokaryonten |
| US4766205A (en) * | 1985-11-13 | 1988-08-23 | Beatrice Companies, Inc. | Method for isolation of recombinant polypeptides in biologically active forms |
| EP0301835A1 (en) | 1987-07-29 | 1989-02-01 | Schering Biotech Corporation | Purification of human interleukin-4 expressed in Escherichia Coli |
| DE3832898A1 (de) * | 1988-09-28 | 1990-04-12 | Boehringer Mannheim Gmbh | Praeparat von in prokaryonten exprimiertem plasminogenaktivator |
| US5235043A (en) * | 1990-04-06 | 1993-08-10 | Synergen, Inc. | Production of biologically active, recombinant members of the ngf/bdnf family of neurotrophic proteins |
-
1997
- 1997-06-11 WO PCT/EP1997/003026 patent/WO1997047735A1/de active IP Right Grant
- 1997-06-11 ES ES97928173T patent/ES2214624T3/es not_active Expired - Lifetime
- 1997-06-11 JP JP50095798A patent/JP3288720B2/ja not_active Expired - Lifetime
- 1997-06-11 EP EP97928173A patent/EP0904355B1/de not_active Expired - Lifetime
- 1997-06-11 DE DE59711375T patent/DE59711375D1/de not_active Expired - Lifetime
- 1997-06-11 TR TR1998/02584T patent/TR199802584T2/xx unknown
- 1997-06-11 US US09/202,206 patent/US6342585B1/en not_active Expired - Lifetime
- 1997-06-11 AT AT97928173T patent/ATE260972T1/de active
- 1997-06-11 AU AU32571/97A patent/AU714318B2/en not_active Expired
- 1997-06-11 BR BRPI9709569-9A patent/BR9709569B1/pt not_active IP Right Cessation
- 1997-06-11 CA CA002257122A patent/CA2257122C/en not_active Expired - Lifetime
- 1997-06-11 KR KR1019980710184A patent/KR100305341B1/ko not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| US6342585B1 (en) | 2002-01-29 |
| CA2257122A1 (en) | 1997-12-18 |
| EP0904355B1 (de) | 2004-03-03 |
| CA2257122C (en) | 2004-04-06 |
| AU3257197A (en) | 1998-01-07 |
| WO1997047735A1 (de) | 1997-12-18 |
| ES2214624T3 (es) | 2004-09-16 |
| TR199802584T2 (xx) | 1999-03-22 |
| EP0904355A1 (de) | 1999-03-31 |
| KR100305341B1 (ko) | 2002-03-02 |
| KR20000016588A (ko) | 2000-03-25 |
| JP3288720B2 (ja) | 2002-06-04 |
| JPH11511759A (ja) | 1999-10-12 |
| DE59711375D1 (de) | 2004-04-08 |
| ATE260972T1 (de) | 2004-03-15 |
| AU714318B2 (en) | 2000-01-06 |
| BR9709569A (pt) | 1999-08-10 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| TC | Change of name | ||
| B07A | Application suspended after technical examination (opinion) [chapter 7.1 patent gazette] | ||
| B06A | Patent application procedure suspended [chapter 6.1 patent gazette] | ||
| B09A | Decision: intention to grant [chapter 9.1 patent gazette] | ||
| B16A | Patent or certificate of addition of invention granted [chapter 16.1 patent gazette] |
Free format text: PRAZO DE VALIDADE: 10 (DEZ) ANOS CONTADOS A PARTIR DE 18/05/2010, OBSERVADAS AS CONDICOES LEGAIS. |
|
| B21A | Patent or certificate of addition expired [chapter 21.1 patent gazette] |
Free format text: PATENTE EXTINTA EM 18.05.2020 |