UA35636C2 - Поліпептид, який має активність легеневої поверхнево-активної речовини, та фармацевтична композиція для лікування респіраторного дистрес-синдрому у ссавців - Google Patents
Поліпептид, який має активність легеневої поверхнево-активної речовини, та фармацевтична композиція для лікування респіраторного дистрес-синдрому у ссавцівInfo
- Publication number
- UA35636C2 UA35636C2 UA96114479A UA96114479A UA35636C2 UA 35636 C2 UA35636 C2 UA 35636C2 UA 96114479 A UA96114479 A UA 96114479A UA 96114479 A UA96114479 A UA 96114479A UA 35636 C2 UA35636 C2 UA 35636C2
- Authority
- UA
- Ukraine
- Prior art keywords
- leu
- mammals
- val
- pharmaceutical composition
- ile
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/785—Alveolar surfactant peptides; Pulmonary surfactant peptides
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/08—Bronchodilators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/16—Central respiratory analeptics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pulmonology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmacology & Pharmacy (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Toxicology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Epidemiology (AREA)
- Immunology (AREA)
- Peptides Or Proteins (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Emulsifying, Dispersing, Foam-Producing Or Wetting Agents (AREA)
- Medicinal Preparation (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
Винахід належить до легеневих поверхнево-активних поліпептидів, способу їх отримання і до композицій, що містять їх. Поліпептид з активністю легеневої поверхнево-активної речовини, загальної формули I: 0 1 2 3 4 5 6 7 8 9 10 (A) Gly Ile Pro B B Pro Val His Leu Lys 11 12 13 14 15 16 17 18 19 20 Arg Leu Leu Ile Val Val Val Val Val Val 21 22 23 24 25 26 27 28 29 30 Leu Ile Val Val Val Ile Val Gly Ala Leu 31 32 33 34 Leu C Gly Leu (1) де А означає Н або Phe, В означає Phe або Тгр і С означає Ile, Leu або Ser.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
DE4418936A DE4418936A1 (de) | 1994-05-31 | 1994-05-31 | Polypeptid |
PCT/EP1995/002028 WO1995032992A1 (de) | 1994-05-31 | 1995-05-27 | Synthetische peptidanaloge des lungenoberflächenproteins sp-c |
Publications (1)
Publication Number | Publication Date |
---|---|
UA35636C2 true UA35636C2 (uk) | 2001-04-16 |
Family
ID=6519392
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
UA96114479A UA35636C2 (uk) | 1994-05-31 | 1995-05-27 | Поліпептид, який має активність легеневої поверхнево-активної речовини, та фармацевтична композиція для лікування респіраторного дистрес-синдрому у ссавців |
Country Status (29)
Country | Link |
---|---|
US (1) | US5874406A (uk) |
EP (1) | EP0764172B1 (uk) |
JP (1) | JP3359638B2 (uk) |
KR (1) | KR100355626B1 (uk) |
CN (1) | CN1130374C (uk) |
AT (1) | ATE275154T1 (uk) |
AU (1) | AU690280B2 (uk) |
BG (1) | BG63210B1 (uk) |
BR (1) | BR9507811B1 (uk) |
CA (1) | CA2191344C (uk) |
CY (1) | CY2552B1 (uk) |
CZ (1) | CZ286976B6 (uk) |
DE (2) | DE4418936A1 (uk) |
DK (1) | DK0764172T3 (uk) |
EE (1) | EE03775B1 (uk) |
ES (1) | ES2227548T3 (uk) |
FI (1) | FI118126B (uk) |
HK (1) | HK1000891A1 (uk) |
HU (1) | HU220191B (uk) |
NO (1) | NO317149B1 (uk) |
NZ (1) | NZ287447A (uk) |
PL (1) | PL181234B1 (uk) |
PT (1) | PT764172E (uk) |
RO (1) | RO118752B1 (uk) |
RU (1) | RU2145611C1 (uk) |
SI (1) | SI0764172T1 (uk) |
SK (1) | SK282441B6 (uk) |
UA (1) | UA35636C2 (uk) |
WO (1) | WO1995032992A1 (uk) |
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AU2322097A (en) * | 1996-03-27 | 1997-10-17 | Ortho Pharmaceutical Corporation | Lyophilized pulmonary surfactant peptide compositions |
DE19851119C2 (de) | 1998-11-06 | 2001-05-31 | Byk Gulden Lomberg Chem Fab | Behälter und Vorrichtung zur Blindung der Verabreichung von nicht festen pharmazeutischen Darreichungsformen bei der klinischen Prüfung |
IT1308180B1 (it) * | 1999-02-12 | 2001-12-07 | Chiesi Farma Spa | Peptidi sintetici aventi la capacita' di diminuire la tensionesuperficiale e loro impiego nella preparazione di un surfattante |
AU5400000A (en) * | 1999-06-11 | 2001-01-02 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Pharmaceutical preparation containing modifications of surfactant protein b (sp-b) and surfactant protein c (sp-c) |
ATE350399T1 (de) | 1999-06-17 | 2007-01-15 | Altana Pharma Ag | Surfactant protein c ester |
WO2001019392A1 (en) | 1999-09-16 | 2001-03-22 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Combination of c1-inh and lung surfactant for the treatment of respiratory disorders |
AU2003201A (en) * | 1999-12-01 | 2001-06-12 | Byk Gulden Lomberg Chemische Fabrik Gmbh | Novel use of lung surfactant |
US20030091509A1 (en) * | 2000-02-11 | 2003-05-15 | Haefner Dietrich | Novel use of pulmonary surfactant for the prophylaxis and treatment of chronic pulmonary diseases |
US6660833B1 (en) | 2000-02-29 | 2003-12-09 | Harbor-Ucla Research And Education Institute | Respiratory distress syndrome therapy with peptide analogs of human SP-B |
DE10018022A1 (de) * | 2000-04-12 | 2001-10-31 | Byk Gulden Lomberg Chem Fab | Neue Verwendung von Lungensurfactant zur Prophylaxe oder Frühbehandlung von akuten Lungenerkrankungen |
US20040254112A1 (en) * | 2000-04-12 | 2004-12-16 | Dietrich Hafner | Use of pulmonary surfactant for the early treatment of acute pulmonary diseases |
ES2262656T3 (es) * | 2000-04-12 | 2006-12-01 | Altana Pharma Ag | Uso de un agente tensioactivo pulmonar recombinante para el tratamiento precoz de enfermedades pulmonares agudas. |
JP4559731B2 (ja) | 2001-10-11 | 2010-10-13 | ニコメッド ゲゼルシャフト ミット ベシュレンクテル ハフツング | 肺サーファクタントの新規使用 |
AU2002357168A1 (en) | 2001-12-12 | 2003-07-09 | Penn State Research Foundation | Surfactant prevention of lung complications from cancer chemotherapy |
AU2005268755B2 (en) * | 2004-08-06 | 2011-04-07 | Takeda Gmbh | Composition comprising a pulmonary surfactant and a TNF-derived peptide |
US7582312B2 (en) * | 2004-11-15 | 2009-09-01 | Discovery Laboratories, Inc. | Methods to produce lung surfactant formulations via lyophilization and formulations and uses thereof |
US7464012B2 (en) * | 2004-12-10 | 2008-12-09 | L'air Liquide, Societe Anonyme A Directoire Et Conseil De Surveillance Pour L'etude Et L'exploitation Des Procedes Georges Claude | Simplified process simulator |
US8337815B2 (en) | 2004-12-23 | 2012-12-25 | Discovery Laboratories, Inc. | Pulmonary surfactant formulations |
JP2008526868A (ja) | 2005-01-06 | 2008-07-24 | ディスカバリー ラボラトリーズ,インコーポレイテッド | 表面活性剤処置療法 |
DE102005014650B3 (de) | 2005-03-31 | 2006-08-17 | Altana Pharma Ag | Anordnung aus Katheter und Anschlussstück sowie Ventil zum Durchführen eines Katheters |
DE102005016229B3 (de) | 2005-04-08 | 2006-06-14 | Altana Pharma Ag | Trockenvernebler |
AU2007297691B2 (en) * | 2006-09-19 | 2013-12-19 | Discovery Laboratories, Inc. | Pulmonary surfactant formulations and methods for promoting mucus clearance |
US7951781B2 (en) | 2006-11-02 | 2011-05-31 | University Of Iowa Research Foundation | Methods and compositions related to PLUNC surfactant polypeptides |
EP2009023A1 (en) * | 2007-06-04 | 2008-12-31 | Rentschler Beteiligungs GmbH | Novel peptides and their use for the treatment of edema |
US8048043B2 (en) | 2007-06-08 | 2011-11-01 | Chiesi Farmaceutici S. P. A. | Method of administration of a pulmonary surfactant |
WO2010068754A2 (en) | 2008-12-10 | 2010-06-17 | Paka Pulmonary Pharmaceuticals, Inc. | Methods and compositions for delivery of medicaments to the lungs |
KR101767693B1 (ko) | 2009-09-08 | 2017-08-23 | 키에시 파르마슈티시 엣스. 피. 에이. | 폐 계면 활성제와 항산화 효소를 포함하는 치료용 혼합물 |
WO2012025496A1 (en) | 2010-08-23 | 2012-03-01 | Nycomed Gmbh | Humidified particles comprising a therapeutically active substance |
US9815869B2 (en) * | 2012-02-09 | 2017-11-14 | University Of Rochester | SP-B and SP-C peptides, synthetic lung surfactants, and use thereof |
US20130303726A1 (en) * | 2012-04-17 | 2013-11-14 | Chiesi Farmaceutici S.P.A. | Method for the preparation of surfactant peptides |
WO2013188016A2 (en) | 2012-05-04 | 2013-12-19 | Discovery Laboratories, Inc. | Surfactant therapy for exposure to ionizing radiation |
US11123513B2 (en) | 2014-03-05 | 2021-09-21 | Fraunhofer-Gesellschaft zur Förderung der angewandten Forschung e.V. | Humidifier for humidifying an aerosol |
ES2827948T3 (es) | 2015-04-22 | 2021-05-25 | Chiesi Farm Spa | Sistema eficaz para la administración de medicamento sincronizada con la respiración a los pulmones |
EP3106090A1 (en) | 2015-06-15 | 2016-12-21 | CHIESI FARMACEUTICI S.p.A. | System for effective breath-synchronized delivery of medicament to the lungs |
US11311691B2 (en) | 2015-04-28 | 2022-04-26 | Chiesi Farmaceutici S.P.A | Device for facilitating the administration of a medicament to the lung by a catheter |
CN107979996A (zh) | 2015-04-30 | 2018-05-01 | 不莱梅大学 | 新的皮肤医疗和美容护理产品 |
CN109496159A (zh) | 2016-07-28 | 2019-03-19 | 奇斯药制品公司 | 用于递送雾化药剂的方法和系统 |
WO2018077623A1 (en) | 2016-10-26 | 2018-05-03 | Chiesi Farmaceutici S.P.A. | Device for facilitating the administration of a medicament to the lung by a catheter |
EP3558376B1 (en) | 2016-12-22 | 2021-10-20 | Chiesi Farmaceutici S.p.A. | A therapeutic combination comprising a pulmonary surfactant and a steroid for the treatment of evolving bpd |
CN107163148A (zh) * | 2017-05-15 | 2017-09-15 | 重庆理工大学 | 肺表面活性蛋白b前肽的重组蛋白及其制备方法和应用 |
WO2019115771A1 (en) | 2017-12-15 | 2019-06-20 | Pari Pharma Gmbh | Nebuliser system, holding system, combination comprising nebuliser system and holding system, and aerosol administration method |
TW201927286A (zh) | 2017-12-15 | 2019-07-16 | 義大利商凱西製藥公司 | 用於噴霧投藥之包含肺表面張力素的藥學調配物 |
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WO2021151853A1 (en) | 2020-01-28 | 2021-08-05 | Chiesi Farmaceutici S.P.A. | Polypeptides having improved properties |
EP4411745A1 (en) | 2023-02-01 | 2024-08-07 | Pari Medical Holding GmbH | Medical evaluation method, aerosol nebulizer and medical evaluation system |
EP4464354A1 (en) | 2023-05-15 | 2024-11-20 | Pari Medical Holding GmbH | Method of operating an inhalation device, inhalation device and inhalation device system for providing inhalation process/breath guiding |
EP4464236A1 (en) | 2023-05-15 | 2024-11-20 | Pari Medical Holding GmbH | Method of operating an inhalation device, inhalation device and inhalation device system for providing inhalation process feedback |
Family Cites Families (10)
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JPS59164724A (ja) * | 1983-03-10 | 1984-09-17 | Tokyo Tanabe Co Ltd | サ−フアクタント及びそれを含有する呼吸窮迫症候群治療剤 |
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US4933280A (en) * | 1984-12-11 | 1990-06-12 | California Biotechnology Inc. | Recombinant DNA sequence encoding Alveolar Surfactant Protein |
US5169761A (en) * | 1984-12-11 | 1992-12-08 | California Biotechnology Inc. | Dna encoding and expression systems for alveolar surfactant proteins |
US5013720A (en) * | 1986-05-06 | 1991-05-07 | Abbott Laboratories | SAP-6-Val proteins and methods |
JP2602968B2 (ja) * | 1987-11-04 | 1997-04-23 | カリフォルニア バイオテクノロジー インコーポレイテッド | 肺胞の界面活性タンパク類 |
SE8803713D0 (sv) * | 1988-10-18 | 1988-10-18 | Kabigen Ab | Biologically active lipoprotein and its use |
DE3921954A1 (de) * | 1989-07-04 | 1991-01-17 | Thomae Gmbh Dr K | Niedrig-viskose, hochkonzentrierte surfactant-suspension |
JPH05294996A (ja) * | 1992-04-17 | 1993-11-09 | Tokyo Tanabe Co Ltd | 合成ペプチド、それを含有する肺サーファクタント及び呼吸窮迫症候群治療剤 |
-
1994
- 1994-05-31 DE DE4418936A patent/DE4418936A1/de not_active Withdrawn
-
1995
- 1995-05-27 RU RU96124768A patent/RU2145611C1/ru active
- 1995-05-27 CA CA002191344A patent/CA2191344C/en not_active Expired - Lifetime
- 1995-05-27 JP JP50030596A patent/JP3359638B2/ja not_active Expired - Lifetime
- 1995-05-27 CN CN95194374A patent/CN1130374C/zh not_active Expired - Lifetime
- 1995-05-27 SI SI9530712T patent/SI0764172T1/xx unknown
- 1995-05-27 EE EE9600175A patent/EE03775B1/xx unknown
- 1995-05-27 SK SK1524-96A patent/SK282441B6/sk not_active IP Right Cessation
- 1995-05-27 DE DE59510941T patent/DE59510941D1/de not_active Expired - Lifetime
- 1995-05-27 AU AU26169/95A patent/AU690280B2/en not_active Expired
- 1995-05-27 PT PT95920906T patent/PT764172E/pt unknown
- 1995-05-27 BR BRPI9507811-8A patent/BR9507811B1/pt not_active IP Right Cessation
- 1995-05-27 DK DK95920906T patent/DK0764172T3/da active
- 1995-05-27 HU HU9603249A patent/HU220191B/hu unknown
- 1995-05-27 RO RO96-02248A patent/RO118752B1/ro unknown
- 1995-05-27 KR KR1019960706778A patent/KR100355626B1/ko not_active IP Right Cessation
- 1995-05-27 NZ NZ287447A patent/NZ287447A/en not_active IP Right Cessation
- 1995-05-27 AT AT95920906T patent/ATE275154T1/de active
- 1995-05-27 ES ES95920906T patent/ES2227548T3/es not_active Expired - Lifetime
- 1995-05-27 US US08/750,194 patent/US5874406A/en not_active Expired - Lifetime
- 1995-05-27 CZ CZ19963502A patent/CZ286976B6/cs not_active IP Right Cessation
- 1995-05-27 UA UA96114479A patent/UA35636C2/uk unknown
- 1995-05-27 EP EP95920906A patent/EP0764172B1/de not_active Expired - Lifetime
- 1995-05-27 PL PL95317420A patent/PL181234B1/pl unknown
- 1995-05-27 WO PCT/EP1995/002028 patent/WO1995032992A1/de active IP Right Grant
-
1996
- 1996-11-27 NO NO19965052A patent/NO317149B1/no not_active IP Right Cessation
- 1996-11-29 FI FI964766A patent/FI118126B/fi not_active IP Right Cessation
- 1996-12-04 BG BG101028A patent/BG63210B1/bg unknown
-
1997
- 1997-12-18 HK HK97102503A patent/HK1000891A1/xx not_active IP Right Cessation
-
2006
- 2006-02-20 CY CY0600006A patent/CY2552B1/xx unknown
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