[go: up one dir, main page]

UA29505C2 - Фармацевтична композиція для лікування і/або профілактики розрідження кістки і спосіб лікування і/або профілактики розрідження кістки у ссавців - Google Patents

Фармацевтична композиція для лікування і/або профілактики розрідження кістки і спосіб лікування і/або профілактики розрідження кістки у ссавців

Info

Publication number
UA29505C2
UA29505C2 UA96124659A UA96124659A UA29505C2 UA 29505 C2 UA29505 C2 UA 29505C2 UA 96124659 A UA96124659 A UA 96124659A UA 96124659 A UA96124659 A UA 96124659A UA 29505 C2 UA29505 C2 UA 29505C2
Authority
UA
Ukraine
Prior art keywords
prophylaxis
bone resorption
treatment
mammals
pharmaceutical composition
Prior art date
Application number
UA96124659A
Other languages
English (en)
Russian (ru)
Inventor
Джеральд С. БРЕННЕР
Ешок В. Кетдейр
Эшок В. КЕТДЕЙР
Деніз ПРЕЦЕР
Дениз ПРЕЦЕР
Донна Т. УАЙТФОРД
Original Assignee
Мерк Енд Ко., Інк.
Мерк Енд Ко., Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Мерк Енд Ко., Інк., Мерк Енд Ко., Инк. filed Critical Мерк Енд Ко., Інк.
Publication of UA29505C2 publication Critical patent/UA29505C2/uk

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0087—Galenical forms not covered by A61K9/02 - A61K9/7023
    • A61K9/0095—Drinks; Beverages; Syrups; Compositions for reconstitution thereof, e.g. powders or tablets to be dispersed in a glass of water; Veterinary drenches
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/66—Phosphorus compounds
    • A61K31/662—Phosphorus acids or esters thereof having P—C bonds, e.g. foscarnet, trichlorfon
    • A61K31/663—Compounds having two or more phosphorus acid groups or esters thereof, e.g. clodronic acid, pamidronic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Epidemiology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Rheumatology (AREA)
  • Orthopedic Medicine & Surgery (AREA)
  • Pain & Pain Management (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Cosmetics (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

Винахід стосується використання пероральних рідких композицій, що містять алендронат, для пригніченння процесу резорбції кісти в пацієнтів, у яких утруднене ковтання.
UA96124659A 1994-05-17 1995-05-12 Фармацевтична композиція для лікування і/або профілактики розрідження кістки і спосіб лікування і/або профілактики розрідження кістки у ссавців UA29505C2 (uk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US08/245,289 US5462932A (en) 1994-05-17 1994-05-17 Oral liquid alendronate formulations
PCT/US1995/005926 WO1995031203A1 (en) 1994-05-17 1995-05-12 Oral liquid alendronate formulations

Publications (1)

Publication Number Publication Date
UA29505C2 true UA29505C2 (uk) 2000-11-15

Family

ID=22926074

Family Applications (1)

Application Number Title Priority Date Filing Date
UA96124659A UA29505C2 (uk) 1994-05-17 1995-05-12 Фармацевтична композиція для лікування і/або профілактики розрідження кістки і спосіб лікування і/або профілактики розрідження кістки у ссавців

Country Status (34)

Country Link
US (1) US5462932A (uk)
EP (1) EP0759757B1 (uk)
JP (1) JP4111536B2 (uk)
KR (1) KR100372966B1 (uk)
CN (1) CN1079672C (uk)
AT (1) ATE222495T1 (uk)
AU (1) AU691634B2 (uk)
CA (1) CA2190148C (uk)
CO (1) CO4600739A1 (uk)
CY (1) CY2336B1 (uk)
CZ (1) CZ285860B6 (uk)
DE (1) DE69527842T2 (uk)
DK (1) DK0759757T3 (uk)
DZ (1) DZ1884A1 (uk)
ES (1) ES2180646T3 (uk)
FI (1) FI118296B (uk)
HK (1) HK1009245A1 (uk)
HR (1) HRP950293B1 (uk)
HU (1) HU220626B1 (uk)
IL (1) IL113651A (uk)
MX (1) MX9605660A (uk)
MY (1) MY112285A (uk)
NO (1) NO310179B1 (uk)
NZ (1) NZ289231A (uk)
PL (1) PL179634B1 (uk)
PT (1) PT759757E (uk)
RU (1) RU2176507C2 (uk)
SI (1) SI0759757T1 (uk)
SK (1) SK281098B6 (uk)
TW (1) TW402501B (uk)
UA (1) UA29505C2 (uk)
WO (1) WO1995031203A1 (uk)
YU (1) YU49354B (uk)
ZA (1) ZA953960B (uk)

Families Citing this family (57)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5780455A (en) * 1994-08-24 1998-07-14 Merck & Co., Inc. Intravenous alendronate formulations
EP0809502A4 (en) * 1995-02-17 2001-12-05 Merck & Co Inc PROCESS FOR REDUCING THE RISK OF BONE FRACTURES OTHER THAN VERTEBRAL FRACTURES
US5914099A (en) * 1995-05-12 1999-06-22 Merck & Co., Inc. Prevention of tooth loss by the administration of alendronate or its salts
IL118422A0 (en) * 1995-06-02 1996-09-12 Merck & Co Inc Use of alendronate for the prevention of osteoporosis
WO1996039150A1 (en) * 1995-06-06 1996-12-12 Merck & Co., Inc. Bisphosphonate therapy for bone loss associated with rheumatoid arthritis
US5616571A (en) * 1995-06-06 1997-04-01 Merck & Co., Inc. Bisphosphonates prevent bone loss associated with immunosuppressive therapy
IL120270A0 (en) * 1996-02-28 1997-06-10 Pfizer Combination therapy to treat osteoporosis
US6100301A (en) * 1996-02-28 2000-08-08 Pfizer Inc Combination therapy to treat osteoporosis-polyphosphonates and estrogen agonists
EA001213B1 (ru) * 1996-10-04 2000-12-25 Мерк Энд Ко., Инк. Композиции жидкого алендроната
US6376477B2 (en) 1996-11-25 2002-04-23 Merck & Co., Inc. Combination of an agent that binds to the androgen receptor and a bisphosphonic acid in the prevention and/or treatment of diseases involving calcium or phosphate metabolism
US6080779A (en) * 1996-12-13 2000-06-27 Osteoscreen, Inc. Compositions and methods for stimulating bone growth
US6376476B1 (en) 1996-12-13 2002-04-23 Zymogenetics Corporation Isoprenoid pathway inhibitors for stimulating bone growth
FI104901B (fi) 1997-10-20 2000-04-28 Leiras Oy Uudet metyleenibisfosfonihappojohdannaiset
GB9802617D0 (en) * 1998-02-07 1998-04-01 Knoll Ag Pharmaceutical formulation
US6331533B1 (en) 1998-11-16 2001-12-18 Merck & Co., Inc. Method for inhibiting dental resorptive lesions
US6194469B1 (en) * 1998-12-11 2001-02-27 Board Of Trustees Operating Michigan State Univeristy Method for inhibiting cyclooxygenase and inflammation using cherry bioflavonoids
EP1188441A4 (en) * 1999-06-02 2004-01-28 Procter & Gamble ORAL PREPARATIONS OF DINATRIUM ETIDRONATE
US6677320B2 (en) * 2000-01-20 2004-01-13 Hoffmann-La Roches Inc. Parenteral bisphosphonate composition with improved local tolerance
US6468559B1 (en) 2000-04-28 2002-10-22 Lipocine, Inc. Enteric coated formulation of bishosphonic acid compounds and associated therapeutic methods
CN1224423C (zh) * 2000-07-17 2005-10-26 山之内制药株式会社 改善口服吸收的医药组合物
US7560490B2 (en) * 2001-01-23 2009-07-14 Gador S.A. Composition comprising bisphosphonates for prevention and/or treatment of metabolic diseases of bones, process for preparing such composition and use thereof
US8197561B2 (en) 2001-10-10 2012-06-12 River Basin Energy, Inc. Process for drying coal
US7537622B2 (en) * 2001-10-10 2009-05-26 Fmi Newcoal, Inc. Process for drying coal
US7695535B2 (en) 2001-10-10 2010-04-13 River Basin Energy, Inc. Process for in-situ passivation of partially-dried coal
EP1458400A1 (en) * 2001-12-13 2004-09-22 Merck & Co., Inc. Liquid bisphosphonate formulations for bone disorders
WO2003055496A1 (en) * 2001-12-21 2003-07-10 The Procter & Gamble Company Method for the treatment of bone disorders
PT1506041E (pt) * 2002-05-10 2007-12-28 Hoffmann La Roche Ácido ibandrónico para o tratamento e a prevenção da osteoporose
ITTO20020406A1 (it) * 2002-05-13 2003-11-13 Chiesi Farma Spa Formulazioni di bisfosfonati ad uso iniettabile.
US7041309B2 (en) * 2002-06-13 2006-05-09 Neuropro Technologies, Inc. Spinal fusion using an HMG-CoA reductase inhibitor
GR1004331B (el) * 2002-10-07 2003-09-05 Verisfield (Uk) Ltd Νεες φαρμακευτικες συνθεσεις που περιεχουν αλας αλενδρονικου οξεος
EP1790347B1 (en) * 2002-12-20 2014-12-24 F. Hoffmann-La Roche AG High dose ibandronate formulation
US20050101605A1 (en) * 2003-11-07 2005-05-12 Ahmed Salah U. Oral liquid formulations of methotrexate
US20080287400A1 (en) * 2004-05-24 2008-11-20 Richard John Dansereau Low Dosage Forms Of Risedronate Or Its Salts
MXPA06013575A (es) * 2004-05-24 2007-02-08 Procter & Gamble Forma enterica de dosificacion solida por via oral de bifosfonato que contiene un agente quelante.
US7645459B2 (en) 2004-05-24 2010-01-12 The Procter & Gamble Company Dosage forms of bisphosphonates
US7645460B2 (en) * 2004-05-24 2010-01-12 The Procter & Gamble Company Dosage forms of risedronate
US20080286359A1 (en) * 2004-05-24 2008-11-20 Richard John Dansereau Low Dosage Forms Of Risedronate Or Its Salts
US20080032959A1 (en) * 2004-06-23 2008-02-07 Alves Stephen E Estrogen Receptor Modulators
US20060069069A1 (en) * 2004-07-15 2006-03-30 Nanobac Pharmaceuticals, Inc. Methods and compositions for the administration of calcium chelators, bisphosponates and/or citrate compounds and their pharmaceutical uses
WO2006020009A1 (en) * 2004-07-23 2006-02-23 The Procter & Gamble Company Solid oral dosage form of a bisphosphonate containing a chelating agent
WO2007109585A2 (en) * 2006-03-17 2007-09-27 The Board Of Trustees Of The University Of Illinois Bisphosphonate compounds and methods
WO2008128056A1 (en) * 2004-10-08 2008-10-23 The Board Of Trustees Of The University Of Illinois Bisphosphonate compounds and methods with enhanced potency for multiple targets including fpps, ggpps, and dpps
US7358361B2 (en) * 2004-10-08 2008-04-15 The Board Of Trustees Of The University Of Illinois Biophosphonate compounds and methods for bone resorption diseases, cancer, bone pain, immune disorders, and infectious diseases
US20060134190A1 (en) * 2004-12-16 2006-06-22 Banner Pharmacaps Inc. Formulations of bisphosphonate drugs with improved bioavailability
WO2007095161A2 (en) * 2006-02-14 2007-08-23 New York University Methods and compositions for treating disorders associated with increased bone turnover and osteopenia
PL1894557T3 (pl) * 2006-09-04 2011-07-29 Gador Sa Płynna kompozycja do zapobiegania i/lub leczenia różnych metabolicznych chorób kości, jej zastosowanie, oraz sposób jej wytwarzania
ZA200900603B (en) * 2006-11-21 2010-05-26 Teikoku Pharma Usa Inc Biphosphonate inhalant formulations and methods for using the same
US8974801B2 (en) * 2006-12-21 2015-03-10 Amphastar Pharmaceuticals Inc. Long term sustained release pharmaceutical composition containing aqueous suspension of bisphosphonate
US20090170815A1 (en) * 2007-12-28 2009-07-02 Roxane Laboratories Incorporated. Alendronate oral liquid formulations
CN101932306A (zh) * 2008-02-05 2010-12-29 阿特维斯集团公司 阿仑膦酸盐制剂、其制备方法和使用方法
US20100034752A1 (en) * 2008-08-11 2010-02-11 Toru Hibi Inhalant formulations comprising a bisphosphonate and a pyrazolone derivative and methods for using the same
US8956426B2 (en) 2010-04-20 2015-02-17 River Basin Energy, Inc. Method of drying biomass
US9057037B2 (en) 2010-04-20 2015-06-16 River Basin Energy, Inc. Post torrefaction biomass pelletization
US9889225B2 (en) * 2010-08-20 2018-02-13 Kaohsiung Medical University Method for bone formation by administering poly(lactic-co-glycolic acid) cross-linked alendronate
ES2716525T3 (es) 2010-12-06 2019-06-13 Effrx Pharmaceuticals Sa Formulaciones de bisfosfonatos efervescentes estables con características de solubilización rápida
CN103070824B (zh) * 2013-01-24 2014-07-16 天津红日药业股份有限公司 一种含有伊班膦酸钠的注射液
CA2926424C (en) * 2013-10-08 2018-01-09 Innopharma, Inc. Aprepitant oral liquid formulations

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IT1187828B (it) * 1985-05-24 1987-12-23 Gentili Ist Spa Composizione farmaceutica a base di difosfonati per il trattamento dell aretrosi
GB8618259D0 (en) * 1986-07-25 1986-09-03 Leo Pharm Prod Ltd Pharmaceutical compositions
DE3822650A1 (de) * 1988-07-05 1990-02-01 Boehringer Mannheim Gmbh Neue diphosphonsaeurederivate, verfahren zu deren herstellung und diese verbindungen enthaltende arzneimittel
US4922007A (en) * 1989-06-09 1990-05-01 Merck & Co., Inc. Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid or salts thereof
FI83421C (fi) * 1989-06-21 1991-07-10 Huhtamaeki Oy Foerfarande foer framstaellning av farmakologiskt anvaendbara metylenbisfosfonsyraderivat.
US5227506A (en) * 1989-09-06 1993-07-13 Merck & Co., Inc. Acyloxymethyl esters of bisphosphonic acids as bone resorption inhibitors
CA2035179C (en) * 1990-01-31 2001-08-14 Gerald S. Brenner Pharmaceutical compositions containing insoluble salts of bisphosphonic acids
US5356887A (en) * 1990-01-31 1994-10-18 Merck & Co., Inc. Pharmaceutical compositions containing insoluble calcium salts of amino-hydroxybutylidene bisphoshonic acids
US5019651A (en) * 1990-06-20 1991-05-28 Merck & Co., Inc. Process for preparing 4-amino-1-hydroxybutylidene-1,1-bisphosphonic acid (ABP) or salts thereof
US5270365A (en) * 1991-12-17 1993-12-14 Merck & Co., Inc. Prevention and treatment of periodontal disease with alendronate
FR2703590B1 (fr) * 1993-04-05 1995-06-30 Sanofi Elf Utilisation de derives d'acide bisphosphonique pour la preparation de medicaments destines a favoriser la reparation osseuse .

Also Published As

Publication number Publication date
YU31795A (sh) 1999-06-15
WO1995031203A1 (en) 1995-11-23
CA2190148C (en) 2006-02-14
TW402501B (en) 2000-08-21
CN1079672C (zh) 2002-02-27
SK281098B6 (sk) 2000-11-07
NZ289231A (en) 1998-04-27
CZ285860B6 (cs) 1999-11-17
CY2336B1 (en) 2004-02-06
FI118296B (fi) 2007-09-28
HUT76317A (en) 1997-08-28
JP4111536B2 (ja) 2008-07-02
ATE222495T1 (de) 2002-09-15
CA2190148A1 (en) 1995-11-23
FI964593A0 (fi) 1996-11-15
HU220626B1 (hu) 2002-03-28
JPH10504020A (ja) 1998-04-14
EP0759757A1 (en) 1997-03-05
PT759757E (pt) 2002-11-29
HU9603162D0 (en) 1997-01-28
DK0759757T3 (da) 2002-10-07
HRP950293A2 (en) 1997-04-30
SI0759757T1 (en) 2002-12-31
MX9605660A (es) 1998-02-28
KR970703151A (ko) 1997-07-03
CZ336796A3 (en) 1997-06-11
FI964593A (fi) 1996-11-15
NO964864D0 (no) 1996-11-15
NO310179B1 (no) 2001-06-05
NO964864L (no) 1996-11-15
ZA953960B (en) 1996-01-19
KR100372966B1 (ko) 2003-05-12
AU691634B2 (en) 1998-05-21
DZ1884A1 (fr) 2002-02-17
PL179634B1 (pl) 2000-10-31
HRP950293B1 (en) 2003-08-31
MY112285A (en) 2001-05-31
YU49354B (sh) 2005-09-19
CN1148341A (zh) 1997-04-23
US5462932A (en) 1995-10-31
AU2901095A (en) 1995-12-05
IL113651A0 (en) 1995-08-31
CO4600739A1 (es) 1998-05-08
ES2180646T3 (es) 2003-02-16
RU2176507C2 (ru) 2001-12-10
SK147796A3 (en) 1997-07-09
DE69527842D1 (de) 2002-09-26
DE69527842T2 (de) 2003-04-10
PL320614A1 (en) 1997-10-13
HK1009245A1 (en) 1999-05-28
EP0759757B1 (en) 2002-08-21
IL113651A (en) 1999-08-17

Similar Documents

Publication Publication Date Title
UA29505C2 (uk) Фармацевтична композиція для лікування і/або профілактики розрідження кістки і спосіб лікування і/або профілактики розрідження кістки у ссавців
ATE289199T1 (de) Formulierungen mit dem wasserfreien mononatriumsalz von alendronat und deren verwendung zur behandlung von knochenkrankheiten
ES2160643T3 (es) Composiciones que contienen g-csf y proteina de union al tnf.
EP0347899A3 (en) Pharmaceutical compositions on egg shell basis and their preparation and use
HK1055080A1 (en) Apoptotic entities for use in treatment of neurodegenerative and other neurological disorders
CA2308532A1 (en) Use of bisphosphonates for the treatment of osteogenesis imperfecta
Krorner The case for ostectomy--a time-tested therapeutic modality in selected periodontitis sites.
El-Mofty Unilateral loss of the ramus of the mandible
TW374085B (en) Novel piperidine derivatives, their preparation, pharmaceutical formulation and medical use
FI953514A0 (fi) Uusi osteoblastien proliferaatiotekijä
TW224943B (en) The pharmaceutical composition for the stimulation of bone formation
IL103499A0 (en) Pharmaceutical compositions for treating anxiety in benzodiazepine withdrawn patients
IT1244714B (it) Uso della benzidamina per il trattamento della placca dentaria
UA33571A (uk) Спосіб лікування травматичного перелому нижньої щелепи
BG52004B2 (en) Medicament for the treatment of inflammatory impairments of the alveolar bone and the oral mucous membrane
FR2635006B1 (fr) Medicament destine a regulariser les secretions hormonales et a traiter la sterilite
UA28417A (uk) Спосіб допоміжного рефлекторного знеболювання