TWI383753B - 用於增強運動能力的組合物 - Google Patents
用於增強運動能力的組合物 Download PDFInfo
- Publication number
- TWI383753B TWI383753B TW092129416A TW92129416A TWI383753B TW I383753 B TWI383753 B TW I383753B TW 092129416 A TW092129416 A TW 092129416A TW 92129416 A TW92129416 A TW 92129416A TW I383753 B TWI383753 B TW I383753B
- Authority
- TW
- Taiwan
- Prior art keywords
- composition
- vitamin
- epigallocatechin
- quercetin
- aforementioned
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 63
- 230000002708 enhancing effect Effects 0.000 title claims description 6
- XMOCLSLCDHWDHP-IUODEOHRSA-N epi-Gallocatechin Chemical compound C1([C@H]2OC3=CC(O)=CC(O)=C3C[C@H]2O)=CC(O)=C(O)C(O)=C1 XMOCLSLCDHWDHP-IUODEOHRSA-N 0.000 claims abstract description 30
- REFJWTPEDVJJIY-UHFFFAOYSA-N Quercetin Chemical compound C=1C(O)=CC(O)=C(C(C=2O)=O)C=1OC=2C1=CC=C(O)C(O)=C1 REFJWTPEDVJJIY-UHFFFAOYSA-N 0.000 claims abstract description 28
- RYYVLZVUVIJVGH-UHFFFAOYSA-N caffeine Chemical compound CN1C(=O)N(C)C(=O)C2=C1N=CN2C RYYVLZVUVIJVGH-UHFFFAOYSA-N 0.000 claims abstract description 18
- XMOCLSLCDHWDHP-UHFFFAOYSA-N L-Epigallocatechin Natural products OC1CC2=C(O)C=C(O)C=C2OC1C1=CC(O)=C(O)C(O)=C1 XMOCLSLCDHWDHP-UHFFFAOYSA-N 0.000 claims abstract description 15
- DZYNKLUGCOSVKS-UHFFFAOYSA-N epigallocatechin Natural products OC1Cc2cc(O)cc(O)c2OC1c3cc(O)c(O)c(O)c3 DZYNKLUGCOSVKS-UHFFFAOYSA-N 0.000 claims abstract description 15
- ZVOLCUVKHLEPEV-UHFFFAOYSA-N Quercetagetin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=C(O)C(O)=C(O)C=C2O1 ZVOLCUVKHLEPEV-UHFFFAOYSA-N 0.000 claims abstract description 14
- HWTZYBCRDDUBJY-UHFFFAOYSA-N Rhynchosin Natural products C1=C(O)C(O)=CC=C1C1=C(O)C(=O)C2=CC(O)=C(O)C=C2O1 HWTZYBCRDDUBJY-UHFFFAOYSA-N 0.000 claims abstract description 14
- MWDZOUNAPSSOEL-UHFFFAOYSA-N kaempferol Natural products OC1=C(C(=O)c2cc(O)cc(O)c2O1)c3ccc(O)cc3 MWDZOUNAPSSOEL-UHFFFAOYSA-N 0.000 claims abstract description 14
- 235000005875 quercetin Nutrition 0.000 claims abstract description 14
- 229960001285 quercetin Drugs 0.000 claims abstract description 14
- CIWBSHSKHKDKBQ-JLAZNSOCSA-N Ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(=O)C(O)=C1O CIWBSHSKHKDKBQ-JLAZNSOCSA-N 0.000 claims abstract description 12
- LXNHXLLTXMVWPM-UHFFFAOYSA-N pyridoxine Chemical compound CC1=NC=C(CO)C(CO)=C1O LXNHXLLTXMVWPM-UHFFFAOYSA-N 0.000 claims abstract description 12
- PFTAWBLQPZVEMU-ZFWWWQNUSA-N (+)-epicatechin Natural products C1([C@@H]2OC3=CC(O)=CC(O)=C3C[C@@H]2O)=CC=C(O)C(O)=C1 PFTAWBLQPZVEMU-ZFWWWQNUSA-N 0.000 claims abstract description 9
- PFTAWBLQPZVEMU-UKRRQHHQSA-N (-)-epicatechin Chemical compound C1([C@H]2OC3=CC(O)=CC(O)=C3C[C@H]2O)=CC=C(O)C(O)=C1 PFTAWBLQPZVEMU-UKRRQHHQSA-N 0.000 claims abstract description 9
- LPHGQDQBBGAPDZ-UHFFFAOYSA-N Isocaffeine Natural products CN1C(=O)N(C)C(=O)C2=C1N(C)C=N2 LPHGQDQBBGAPDZ-UHFFFAOYSA-N 0.000 claims abstract description 9
- VJEONQKOZGKCAK-UHFFFAOYSA-N caffeine Natural products CN1C(=O)N(C)C(=O)C2=C1C=CN2C VJEONQKOZGKCAK-UHFFFAOYSA-N 0.000 claims abstract description 9
- 229960001948 caffeine Drugs 0.000 claims abstract description 9
- 235000012734 epicatechin Nutrition 0.000 claims abstract description 9
- LPTRNLNOHUVQMS-UHFFFAOYSA-N epicatechin Natural products Cc1cc(O)cc2OC(C(O)Cc12)c1ccc(O)c(O)c1 LPTRNLNOHUVQMS-UHFFFAOYSA-N 0.000 claims abstract description 9
- AUNGANRZJHBGPY-UHFFFAOYSA-N D-Lyxoflavin Natural products OCC(O)C(O)C(O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-UHFFFAOYSA-N 0.000 claims abstract description 6
- ZZZCUOFIHGPKAK-UHFFFAOYSA-N D-erythro-ascorbic acid Natural products OCC1OC(=O)C(O)=C1O ZZZCUOFIHGPKAK-UHFFFAOYSA-N 0.000 claims abstract description 6
- PVNIIMVLHYAWGP-UHFFFAOYSA-N Niacin Chemical compound OC(=O)C1=CC=CN=C1 PVNIIMVLHYAWGP-UHFFFAOYSA-N 0.000 claims abstract description 6
- AUNGANRZJHBGPY-SCRDCRAPSA-N Riboflavin Chemical compound OC[C@@H](O)[C@@H](O)[C@@H](O)CN1C=2C=C(C)C(C)=CC=2N=C2C1=NC(=O)NC2=O AUNGANRZJHBGPY-SCRDCRAPSA-N 0.000 claims abstract description 6
- 229930003451 Vitamin B1 Natural products 0.000 claims abstract description 6
- 229930003779 Vitamin B12 Natural products 0.000 claims abstract description 6
- 229930003471 Vitamin B2 Natural products 0.000 claims abstract description 6
- 229930003537 Vitamin B3 Natural products 0.000 claims abstract description 6
- 229930003268 Vitamin C Natural products 0.000 claims abstract description 6
- FDJOLVPMNUYSCM-WZHZPDAFSA-L cobalt(3+);[(2r,3s,4r,5s)-5-(5,6-dimethylbenzimidazol-1-yl)-4-hydroxy-2-(hydroxymethyl)oxolan-3-yl] [(2r)-1-[3-[(1r,2r,3r,4z,7s,9z,12s,13s,14z,17s,18s,19r)-2,13,18-tris(2-amino-2-oxoethyl)-7,12,17-tris(3-amino-3-oxopropyl)-3,5,8,8,13,15,18,19-octamethyl-2 Chemical compound [Co+3].N#[C-].N([C@@H]([C@]1(C)[N-]\C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C(\C)/C1=N/C([C@H]([C@@]1(CC(N)=O)C)CCC(N)=O)=C\C1=N\C([C@H](C1(C)C)CCC(N)=O)=C/1C)[C@@H]2CC(N)=O)=C\1[C@]2(C)CCC(=O)NC[C@@H](C)OP([O-])(=O)O[C@H]1[C@@H](O)[C@@H](N2C3=CC(C)=C(C)C=C3N=C2)O[C@@H]1CO FDJOLVPMNUYSCM-WZHZPDAFSA-L 0.000 claims abstract description 6
- 229960003512 nicotinic acid Drugs 0.000 claims abstract description 6
- DFPAKSUCGFBDDF-UHFFFAOYSA-N nicotinic acid amide Natural products NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 claims abstract description 6
- RADKZDMFGJYCBB-UHFFFAOYSA-N pyridoxal hydrochloride Natural products CC1=NC=C(CO)C(C=O)=C1O RADKZDMFGJYCBB-UHFFFAOYSA-N 0.000 claims abstract description 6
- 229960002477 riboflavin Drugs 0.000 claims abstract description 6
- 229960003495 thiamine Drugs 0.000 claims abstract description 6
- DPJRMOMPQZCRJU-UHFFFAOYSA-M thiamine hydrochloride Chemical compound Cl.[Cl-].CC1=C(CCO)SC=[N+]1CC1=CN=C(C)N=C1N DPJRMOMPQZCRJU-UHFFFAOYSA-M 0.000 claims abstract description 6
- 235000010374 vitamin B1 Nutrition 0.000 claims abstract description 6
- 239000011691 vitamin B1 Substances 0.000 claims abstract description 6
- 235000019163 vitamin B12 Nutrition 0.000 claims abstract description 6
- 239000011715 vitamin B12 Substances 0.000 claims abstract description 6
- 235000019164 vitamin B2 Nutrition 0.000 claims abstract description 6
- 239000011716 vitamin B2 Substances 0.000 claims abstract description 6
- 235000019160 vitamin B3 Nutrition 0.000 claims abstract description 6
- 239000011708 vitamin B3 Substances 0.000 claims abstract description 6
- 235000019158 vitamin B6 Nutrition 0.000 claims abstract description 6
- 239000011726 vitamin B6 Substances 0.000 claims abstract description 6
- 235000019154 vitamin C Nutrition 0.000 claims abstract description 6
- 239000011718 vitamin C Substances 0.000 claims abstract description 6
- 229940011671 vitamin b6 Drugs 0.000 claims abstract description 6
- GVJHHUAWPYXKBD-UHFFFAOYSA-N (±)-α-Tocopherol Chemical compound OC1=C(C)C(C)=C2OC(CCCC(C)CCCC(C)CCCC(C)C)(C)CCC2=C1C GVJHHUAWPYXKBD-UHFFFAOYSA-N 0.000 claims description 14
- 244000269722 Thea sinensis Species 0.000 claims description 10
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 claims description 10
- 235000013616 tea Nutrition 0.000 claims description 10
- 229930003427 Vitamin E Natural products 0.000 claims description 7
- -1 gallic acid ester Chemical class 0.000 claims description 7
- WIGCFUFOHFEKBI-UHFFFAOYSA-N gamma-tocopherol Natural products CC(C)CCCC(C)CCCC(C)CCCC1CCC2C(C)C(O)C(C)C(C)C2O1 WIGCFUFOHFEKBI-UHFFFAOYSA-N 0.000 claims description 7
- 235000019165 vitamin E Nutrition 0.000 claims description 7
- 239000011709 vitamin E Substances 0.000 claims description 7
- 229940046009 vitamin E Drugs 0.000 claims description 7
- 229940094952 green tea extract Drugs 0.000 claims description 5
- 235000020688 green tea extract Nutrition 0.000 claims description 5
- 239000001814 pectin Substances 0.000 claims description 5
- 235000010987 pectin Nutrition 0.000 claims description 5
- 229920001277 pectin Polymers 0.000 claims description 5
- 229960003080 taurine Drugs 0.000 claims description 5
- 241000219310 Beta vulgaris subsp. vulgaris Species 0.000 claims description 4
- 235000021536 Sugar beet Nutrition 0.000 claims description 4
- 239000007864 aqueous solution Substances 0.000 claims description 4
- ADRVNXBAWSRFAJ-UHFFFAOYSA-N catechin Natural products OC1Cc2cc(O)cc(O)c2OC1c3ccc(O)c(O)c3 ADRVNXBAWSRFAJ-UHFFFAOYSA-N 0.000 claims description 4
- 235000005487 catechin Nutrition 0.000 claims description 4
- ACTIUHUUMQJHFO-UPTCCGCDSA-N coenzyme Q10 Chemical compound COC1=C(OC)C(=O)C(C\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CC\C=C(/C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UPTCCGCDSA-N 0.000 claims description 4
- PFTAWBLQPZVEMU-DZGCQCFKSA-N (+)-catechin Chemical compound C1([C@H]2OC3=CC(O)=CC(O)=C3C[C@@H]2O)=CC=C(O)C(O)=C1 PFTAWBLQPZVEMU-DZGCQCFKSA-N 0.000 claims description 3
- LSHVYAFMTMFKBA-PZJWPPBQSA-N (+)-catechin-3-O-gallate Chemical compound O([C@H]1CC2=C(O)C=C(C=C2O[C@@H]1C=1C=C(O)C(O)=CC=1)O)C(=O)C1=CC(O)=C(O)C(O)=C1 LSHVYAFMTMFKBA-PZJWPPBQSA-N 0.000 claims description 3
- ACTIUHUUMQJHFO-UHFFFAOYSA-N Coenzym Q10 Natural products COC1=C(OC)C(=O)C(CC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)CCC=C(C)C)=C(C)C1=O ACTIUHUUMQJHFO-UHFFFAOYSA-N 0.000 claims description 3
- 235000015895 biscuits Nutrition 0.000 claims description 3
- 235000019219 chocolate Nutrition 0.000 claims description 3
- 229950001002 cianidanol Drugs 0.000 claims description 3
- 235000017471 coenzyme Q10 Nutrition 0.000 claims description 3
- 229940110767 coenzyme Q10 Drugs 0.000 claims description 3
- 235000016213 coffee Nutrition 0.000 claims description 3
- 235000013353 coffee beverage Nutrition 0.000 claims description 3
- 239000000835 fiber Substances 0.000 claims description 3
- 229930003935 flavonoid Natural products 0.000 claims description 3
- 150000002215 flavonoids Chemical class 0.000 claims description 3
- 235000017173 flavonoids Nutrition 0.000 claims description 3
- 235000011389 fruit/vegetable juice Nutrition 0.000 claims description 3
- LVJJFMLUMNSUFN-UHFFFAOYSA-N gallocatechin gallate Natural products C1=C(O)C=C2OC(C=3C=C(O)C(O)=CC=3)C(O)CC2=C1OC(=O)C1=CC(O)=C(O)C(O)=C1 LVJJFMLUMNSUFN-UHFFFAOYSA-N 0.000 claims description 3
- 235000015243 ice cream Nutrition 0.000 claims description 3
- 235000015110 jellies Nutrition 0.000 claims description 3
- 239000008274 jelly Substances 0.000 claims description 3
- 235000013336 milk Nutrition 0.000 claims description 3
- 239000008267 milk Substances 0.000 claims description 3
- 210000004080 milk Anatomy 0.000 claims description 3
- 210000003205 muscle Anatomy 0.000 claims description 3
- 238000011084 recovery Methods 0.000 claims description 3
- 235000013618 yogurt Nutrition 0.000 claims description 3
- 235000010469 Glycine max Nutrition 0.000 claims description 2
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims description 2
- LNTHITQWFMADLM-UHFFFAOYSA-N anhydrous gallic acid Natural products OC(=O)C1=CC(O)=C(O)C(O)=C1 LNTHITQWFMADLM-UHFFFAOYSA-N 0.000 claims description 2
- 235000013339 cereals Nutrition 0.000 claims description 2
- 239000009429 Ginkgo biloba extract Substances 0.000 claims 1
- 244000068988 Glycine max Species 0.000 claims 1
- 150000001765 catechin Chemical class 0.000 claims 1
- 229940074391 gallic acid Drugs 0.000 claims 1
- 235000004515 gallic acid Nutrition 0.000 claims 1
- 229940068052 ginkgo biloba extract Drugs 0.000 claims 1
- 235000020686 ginkgo biloba extract Nutrition 0.000 claims 1
- 235000011888 snacks Nutrition 0.000 claims 1
- WMBWREPUVVBILR-WIYYLYMNSA-N (-)-Epigallocatechin-3-o-gallate Chemical compound O([C@@H]1CC2=C(O)C=C(C=C2O[C@@H]1C=1C=C(O)C(O)=C(O)C=1)O)C(=O)C1=CC(O)=C(O)C(O)=C1 WMBWREPUVVBILR-WIYYLYMNSA-N 0.000 abstract description 6
- WMBWREPUVVBILR-UHFFFAOYSA-N GCG Natural products C=1C(O)=C(O)C(O)=CC=1C1OC2=CC(O)=CC(O)=C2CC1OC(=O)C1=CC(O)=C(O)C(O)=C1 WMBWREPUVVBILR-UHFFFAOYSA-N 0.000 abstract description 6
- 229940030275 epigallocatechin gallate Drugs 0.000 abstract description 6
- LSHVYAFMTMFKBA-TZIWHRDSSA-N (-)-epicatechin-3-O-gallate Chemical compound O([C@@H]1CC2=C(O)C=C(C=C2O[C@@H]1C=1C=C(O)C(O)=CC=1)O)C(=O)C1=CC(O)=C(O)C(O)=C1 LSHVYAFMTMFKBA-TZIWHRDSSA-N 0.000 abstract description 5
- LSHVYAFMTMFKBA-UHFFFAOYSA-N ECG Natural products C=1C=C(O)C(O)=CC=1C1OC2=CC(O)=CC(O)=C2CC1OC(=O)C1=CC(O)=C(O)C(O)=C1 LSHVYAFMTMFKBA-UHFFFAOYSA-N 0.000 abstract description 5
- 241000700159 Rattus Species 0.000 description 24
- 229940088594 vitamin Drugs 0.000 description 10
- 229930003231 vitamin Natural products 0.000 description 10
- 235000013343 vitamin Nutrition 0.000 description 10
- 239000011782 vitamin Substances 0.000 description 10
- 239000004615 ingredient Substances 0.000 description 8
- 235000013361 beverage Nutrition 0.000 description 7
- 210000004369 blood Anatomy 0.000 description 7
- 239000008280 blood Substances 0.000 description 7
- 210000001995 reticulocyte Anatomy 0.000 description 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 6
- 238000000034 method Methods 0.000 description 6
- 230000002354 daily effect Effects 0.000 description 5
- 239000000284 extract Substances 0.000 description 5
- 235000013305 food Nutrition 0.000 description 5
- 239000003826 tablet Substances 0.000 description 5
- 244000194101 Ginkgo biloba Species 0.000 description 4
- 230000037396 body weight Effects 0.000 description 4
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 4
- 235000015872 dietary supplement Nutrition 0.000 description 4
- 208000035475 disorder Diseases 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 description 4
- 150000008442 polyphenolic compounds Chemical class 0.000 description 4
- 235000013824 polyphenols Nutrition 0.000 description 4
- 239000000047 product Substances 0.000 description 4
- 235000020357 syrup Nutrition 0.000 description 4
- 239000006188 syrup Substances 0.000 description 4
- 238000012360 testing method Methods 0.000 description 4
- 235000011201 Ginkgo Nutrition 0.000 description 3
- 235000008100 Ginkgo biloba Nutrition 0.000 description 3
- GUBGYTABKSRVRQ-QKKXKWKRSA-N Lactose Natural products OC[C@H]1O[C@@H](O[C@H]2[C@H](O)[C@@H](O)C(O)O[C@@H]2CO)[C@H](O)[C@@H](O)[C@H]1O GUBGYTABKSRVRQ-QKKXKWKRSA-N 0.000 description 3
- 229930006000 Sucrose Natural products 0.000 description 3
- CZMRCDWAGMRECN-UGDNZRGBSA-N Sucrose Chemical compound O[C@H]1[C@H](O)[C@@H](CO)O[C@@]1(CO)O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 CZMRCDWAGMRECN-UGDNZRGBSA-N 0.000 description 3
- 239000002775 capsule Substances 0.000 description 3
- 210000003743 erythrocyte Anatomy 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 239000008101 lactose Substances 0.000 description 3
- 230000002503 metabolic effect Effects 0.000 description 3
- 239000000843 powder Substances 0.000 description 3
- 150000003244 quercetin derivatives Chemical class 0.000 description 3
- 235000019204 saccharin Nutrition 0.000 description 3
- CVHZOJJKTDOEJC-UHFFFAOYSA-N saccharin Chemical compound C1=CC=C2C(=O)NS(=O)(=O)C2=C1 CVHZOJJKTDOEJC-UHFFFAOYSA-N 0.000 description 3
- 229940081974 saccharin Drugs 0.000 description 3
- 239000000901 saccharin and its Na,K and Ca salt Substances 0.000 description 3
- 150000003431 steroids Chemical class 0.000 description 3
- 239000005720 sucrose Substances 0.000 description 3
- 150000003722 vitamin derivatives Chemical class 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- FBPFZTCFMRRESA-FSIIMWSLSA-N D-Glucitol Natural products OC[C@H](O)[C@H](O)[C@@H](O)[C@H](O)CO FBPFZTCFMRRESA-FSIIMWSLSA-N 0.000 description 2
- FBPFZTCFMRRESA-JGWLITMVSA-N D-glucitol Chemical compound OC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO FBPFZTCFMRRESA-JGWLITMVSA-N 0.000 description 2
- FVQOMEDMFUMIMO-UHFFFAOYSA-N Hyperosid Natural products OC1C(O)C(O)C(CO)OC1OC1C(=O)C2=C(O)C=C(O)C=C2OC1C1=CC=C(O)C(O)=C1 FVQOMEDMFUMIMO-UHFFFAOYSA-N 0.000 description 2
- 206010028980 Neoplasm Diseases 0.000 description 2
- 240000008042 Zea mays Species 0.000 description 2
- 235000005824 Zea mays ssp. parviglumis Nutrition 0.000 description 2
- 235000002017 Zea mays subsp mays Nutrition 0.000 description 2
- 150000001413 amino acids Chemical class 0.000 description 2
- 239000003263 anabolic agent Substances 0.000 description 2
- 229940070021 anabolic steroids Drugs 0.000 description 2
- 230000008901 benefit Effects 0.000 description 2
- 230000036772 blood pressure Effects 0.000 description 2
- 235000012000 cholesterol Nutrition 0.000 description 2
- 235000005822 corn Nutrition 0.000 description 2
- 201000010099 disease Diseases 0.000 description 2
- 229940079593 drug Drugs 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 229930182470 glycoside Natural products 0.000 description 2
- 230000012010 growth Effects 0.000 description 2
- 229910052500 inorganic mineral Inorganic materials 0.000 description 2
- 201000007270 liver cancer Diseases 0.000 description 2
- 208000014018 liver neoplasm Diseases 0.000 description 2
- 235000019359 magnesium stearate Nutrition 0.000 description 2
- 239000000845 maltitol Substances 0.000 description 2
- VQHSOMBJVWLPSR-WUJBLJFYSA-N maltitol Chemical compound OC[C@H](O)[C@@H](O)[C@@H]([C@H](O)CO)O[C@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O VQHSOMBJVWLPSR-WUJBLJFYSA-N 0.000 description 2
- 235000010449 maltitol Nutrition 0.000 description 2
- 229940035436 maltitol Drugs 0.000 description 2
- 239000011707 mineral Substances 0.000 description 2
- 229930014626 natural product Natural products 0.000 description 2
- 235000015205 orange juice Nutrition 0.000 description 2
- BBFYUPYFXSSMNV-UHFFFAOYSA-N quercetin-7-o-galactoside Natural products OC1C(O)C(O)C(CO)OC1OC1=CC(O)=C2C(=O)C(O)=C(C=3C=C(O)C(O)=CC=3)OC2=C1 BBFYUPYFXSSMNV-UHFFFAOYSA-N 0.000 description 2
- 235000009561 snack bars Nutrition 0.000 description 2
- 239000000600 sorbitol Substances 0.000 description 2
- 238000005303 weighing Methods 0.000 description 2
- 206010001488 Aggression Diseases 0.000 description 1
- JMGZEFIQIZZSBH-UHFFFAOYSA-N Bioquercetin Natural products CC1OC(OCC(O)C2OC(OC3=C(Oc4cc(O)cc(O)c4C3=O)c5ccc(O)c(O)c5)C(O)C2O)C(O)C(O)C1O JMGZEFIQIZZSBH-UHFFFAOYSA-N 0.000 description 1
- 206010006187 Breast cancer Diseases 0.000 description 1
- 208000026310 Breast neoplasm Diseases 0.000 description 1
- 206010009944 Colon cancer Diseases 0.000 description 1
- 206010010774 Constipation Diseases 0.000 description 1
- 229920002261 Corn starch Polymers 0.000 description 1
- 241001427367 Gardena Species 0.000 description 1
- 102000015779 HDL Lipoproteins Human genes 0.000 description 1
- 108010010234 HDL Lipoproteins Proteins 0.000 description 1
- 208000032843 Hemorrhage Diseases 0.000 description 1
- OVSQVDMCBVZWGM-SJWGPRHPSA-N Hyperin Natural products O[C@H]1[C@H](O)[C@@H](O)[C@@H](CO)O[C@H]1OC1=C(C=2C=C(O)C(O)=CC=2)OC2=CC(O)=CC(O)=C2C1=O OVSQVDMCBVZWGM-SJWGPRHPSA-N 0.000 description 1
- 206010061218 Inflammation Diseases 0.000 description 1
- 208000008839 Kidney Neoplasms Diseases 0.000 description 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 206010037549 Purpura Diseases 0.000 description 1
- 241001672981 Purpura Species 0.000 description 1
- QJTYCCFDQWFJHU-UHFFFAOYSA-N Quercetin-5-O-beta-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1=CC(O)=CC2=C1C(=O)C(O)=C(C=1C=C(O)C(O)=CC=1)O2 QJTYCCFDQWFJHU-UHFFFAOYSA-N 0.000 description 1
- 206010038389 Renal cancer Diseases 0.000 description 1
- CZMRCDWAGMRECN-UHFFFAOYSA-N Rohrzucker Natural products OCC1OC(CO)(OC2OC(CO)C(O)C(O)C2O)C(O)C1O CZMRCDWAGMRECN-UHFFFAOYSA-N 0.000 description 1
- 229920002472 Starch Polymers 0.000 description 1
- 239000004376 Sucralose Substances 0.000 description 1
- 239000004480 active ingredient Substances 0.000 description 1
- 239000013543 active substance Substances 0.000 description 1
- 230000016571 aggressive behavior Effects 0.000 description 1
- 208000012761 aggressive behavior Diseases 0.000 description 1
- 235000019728 animal nutrition Nutrition 0.000 description 1
- 150000008425 anthrones Chemical class 0.000 description 1
- 239000003963 antioxidant agent Substances 0.000 description 1
- 230000003078 antioxidant effect Effects 0.000 description 1
- 235000006708 antioxidants Nutrition 0.000 description 1
- 206010003246 arthritis Diseases 0.000 description 1
- 230000037147 athletic performance Effects 0.000 description 1
- 235000013527 bean curd Nutrition 0.000 description 1
- 230000000740 bleeding effect Effects 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 230000001684 chronic effect Effects 0.000 description 1
- 208000029742 colonic neoplasm Diseases 0.000 description 1
- 239000000470 constituent Substances 0.000 description 1
- 239000008120 corn starch Substances 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 206010012601 diabetes mellitus Diseases 0.000 description 1
- 235000005911 diet Nutrition 0.000 description 1
- 230000037213 diet Effects 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 239000003085 diluting agent Substances 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 230000002996 emotional effect Effects 0.000 description 1
- 239000003623 enhancer Substances 0.000 description 1
- 230000003203 everyday effect Effects 0.000 description 1
- 230000001605 fetal effect Effects 0.000 description 1
- 235000019264 food flavour enhancer Nutrition 0.000 description 1
- 235000015203 fruit juice Nutrition 0.000 description 1
- 239000000499 gel Substances 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 150000002303 glucose derivatives Chemical class 0.000 description 1
- 235000009569 green tea Nutrition 0.000 description 1
- 150000003278 haem Chemical class 0.000 description 1
- 238000003306 harvesting Methods 0.000 description 1
- 230000036541 health Effects 0.000 description 1
- 201000005787 hematologic cancer Diseases 0.000 description 1
- 208000024200 hematopoietic and lymphoid system neoplasm Diseases 0.000 description 1
- 239000012676 herbal extract Substances 0.000 description 1
- NQYPTLKGQJDGTI-FCVRJVSHSA-N hyperoside Natural products OC[C@H]1O[C@@H](OC2=C(Oc3cc(O)cc(O)c3[C@H]2O)c4ccc(O)c(O)c4)[C@H](O)[C@@H](O)[C@H]1O NQYPTLKGQJDGTI-FCVRJVSHSA-N 0.000 description 1
- 238000000338 in vitro Methods 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 230000004054 inflammatory process Effects 0.000 description 1
- 238000001802 infusion Methods 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 230000000968 intestinal effect Effects 0.000 description 1
- 238000007917 intracranial administration Methods 0.000 description 1
- GXMWXESSGGEWEM-UHFFFAOYSA-N isoquercitrin Natural products OCC(O)C1OC(OC2C(Oc3cc(O)cc(O)c3C2=O)c4ccc(O)c(O)c4)C(O)C1O GXMWXESSGGEWEM-UHFFFAOYSA-N 0.000 description 1
- 235000014058 juice drink Nutrition 0.000 description 1
- 201000010982 kidney cancer Diseases 0.000 description 1
- 235000021374 legumes Nutrition 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 208000019423 liver disease Diseases 0.000 description 1
- 239000000314 lubricant Substances 0.000 description 1
- 201000005202 lung cancer Diseases 0.000 description 1
- 208000020816 lung neoplasm Diseases 0.000 description 1
- 238000002483 medication Methods 0.000 description 1
- 230000036651 mood Effects 0.000 description 1
- 230000003387 muscular Effects 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 239000002674 ointment Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 208000020016 psychiatric disease Diseases 0.000 description 1
- OVSQVDMCBVZWGM-DTGCRPNFSA-N quercetin 3-O-beta-D-galactopyranoside Chemical compound O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@H]1OC1=C(C=2C=C(O)C(O)=CC=2)OC2=CC(O)=CC(O)=C2C1=O OVSQVDMCBVZWGM-DTGCRPNFSA-N 0.000 description 1
- OVSQVDMCBVZWGM-QSOFNFLRSA-N quercetin 3-O-beta-D-glucopyranoside Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C(C=2C=C(O)C(O)=CC=2)OC2=CC(O)=CC(O)=C2C1=O OVSQVDMCBVZWGM-QSOFNFLRSA-N 0.000 description 1
- QPHXPNUXTNHJOF-XNFUJFQVSA-N quercetin 7-O-alpha-L-rhamnopyranoside Chemical compound O[C@@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@H]1OC1=CC(O)=C2C(=O)C(O)=C(C=3C=C(O)C(O)=CC=3)OC2=C1 QPHXPNUXTNHJOF-XNFUJFQVSA-N 0.000 description 1
- BBFYUPYFXSSMNV-HMGRVEAOSA-N quercetin 7-O-beta-D-glucoside Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=CC(O)=C2C(=O)C(O)=C(C=3C=C(O)C(O)=CC=3)OC2=C1 BBFYUPYFXSSMNV-HMGRVEAOSA-N 0.000 description 1
- SZDMSNWMQAMVTJ-UHFFFAOYSA-N quercetin-3-O-glucoside Natural products OC1OC(COC2=C(C(=O)c3cc(O)cc(O)c3O2)c4ccc(O)c(O)c4)C(O)C(O)C1O SZDMSNWMQAMVTJ-UHFFFAOYSA-N 0.000 description 1
- FZKBNCDAGYDHTP-UHFFFAOYSA-N quercetin-3-O-glycoside Natural products OC1C(O)C(O)C(O)OC1COC1=C(C=2C=C(O)C(O)=CC=2)OC2=CC(O)=CC(O)=C2C1=O FZKBNCDAGYDHTP-UHFFFAOYSA-N 0.000 description 1
- GXLQUHPXGLZNGE-UHFFFAOYSA-N quercetin-3-O-rhamnoside-7-O-rhamnoside Natural products OC1C(O)C(O)C(C)OC1OC1=CC(O)=C2C(=O)C(OC3C(C(O)C(O)C(C)O3)O)=C(C=3C=C(O)C(O)=CC=3)OC2=C1 GXLQUHPXGLZNGE-UHFFFAOYSA-N 0.000 description 1
- QPHXPNUXTNHJOF-UHFFFAOYSA-N quercetin-7-O-beta-L-rhamnopyranoside Natural products OC1C(O)C(O)C(C)OC1OC1=CC(O)=C2C(=O)C(O)=C(C=3C=C(O)C(O)=CC=3)OC2=C1 QPHXPNUXTNHJOF-UHFFFAOYSA-N 0.000 description 1
- VKPZUISEBPQDMQ-UHFFFAOYSA-N quercetin-7-O-glucoside Natural products OC1OC(COc2cc(O)c3OC(=C(C(=O)c3c2)c4ccc(O)c(O)c4)O)C(O)C(O)C1O VKPZUISEBPQDMQ-UHFFFAOYSA-N 0.000 description 1
- 230000035484 reaction time Effects 0.000 description 1
- 210000004994 reproductive system Anatomy 0.000 description 1
- IKGXIBQEEMLURG-BKUODXTLSA-N rutin Chemical compound O[C@H]1[C@H](O)[C@@H](O)[C@H](C)O[C@@H]1OC[C@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](OC=2C(C3=C(O)C=C(O)C=C3OC=2C=2C=C(O)C(O)=CC=2)=O)O1 IKGXIBQEEMLURG-BKUODXTLSA-N 0.000 description 1
- 229960004555 rutoside Drugs 0.000 description 1
- 239000012056 semi-solid material Substances 0.000 description 1
- 208000012201 sexual and gender identity disease Diseases 0.000 description 1
- 208000015891 sexual disease Diseases 0.000 description 1
- 239000011343 solid material Substances 0.000 description 1
- 239000000243 solution Substances 0.000 description 1
- 235000003687 soy isoflavones Nutrition 0.000 description 1
- 238000001228 spectrum Methods 0.000 description 1
- 238000010561 standard procedure Methods 0.000 description 1
- 239000008107 starch Substances 0.000 description 1
- 235000019698 starch Nutrition 0.000 description 1
- 238000007920 subcutaneous administration Methods 0.000 description 1
- 235000019408 sucralose Nutrition 0.000 description 1
- BAQAVOSOZGMPRM-QBMZZYIRSA-N sucralose Chemical compound O[C@@H]1[C@@H](O)[C@@H](Cl)[C@@H](CO)O[C@@H]1O[C@@]1(CCl)[C@@H](O)[C@H](O)[C@@H](CCl)O1 BAQAVOSOZGMPRM-QBMZZYIRSA-N 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 230000009897 systematic effect Effects 0.000 description 1
- DKVBOUDTNWVDEP-NJCHZNEYSA-N teicoplanin aglycone Chemical compound N([C@H](C(N[C@@H](C1=CC(O)=CC(O)=C1C=1C(O)=CC=C2C=1)C(O)=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)OC=1C=C3C=C(C=1O)OC1=CC=C(C=C1Cl)C[C@H](C(=O)N1)NC([C@H](N)C=4C=C(O5)C(O)=CC=4)=O)C(=O)[C@@H]2NC(=O)[C@@H]3NC(=O)[C@@H]1C1=CC5=CC(O)=C1 DKVBOUDTNWVDEP-NJCHZNEYSA-N 0.000 description 1
- 230000001225 therapeutic effect Effects 0.000 description 1
- 230000008467 tissue growth Effects 0.000 description 1
- 238000012549 training Methods 0.000 description 1
- 230000004584 weight gain Effects 0.000 description 1
- 235000019786 weight gain Nutrition 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Preparation or treatment thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L2/00—Non-alcoholic beverages; Dry compositions or concentrates therefor; Preparation or treatment thereof
- A23L2/02—Non-alcoholic beverages; Dry compositions or concentrates therefor; Preparation or treatment thereof containing fruit or vegetable juices
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/105—Plant extracts, their artificial duplicates or their derivatives
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES, NOT OTHERWISE PROVIDED FOR; PREPARATION OR TREATMENT THEREOF
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/15—Vitamins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
- A61K31/352—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom condensed with carbocyclic rings, e.g. methantheline
- A61K31/353—3,4-Dihydrobenzopyrans, e.g. chroman, catechin
- A61K31/355—Tocopherols, e.g. vitamin E
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
- A61K31/365—Lactones
- A61K31/375—Ascorbic acid, i.e. vitamin C; Salts thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/4415—Pyridoxine, i.e. Vitamin B6
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
- A61K31/51—Thiamines, e.g. vitamin B1
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7135—Compounds containing heavy metals
- A61K31/714—Cobalamins, e.g. cyanocobalamin, i.e. vitamin B12
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Epidemiology (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Nutrition Science (AREA)
- Mycology (AREA)
- Molecular Biology (AREA)
- Botany (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Coloring Foods And Improving Nutritive Qualities (AREA)
- Medicines Containing Plant Substances (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
- Compositions Of Macromolecular Compounds (AREA)
- Non-Alcoholic Beverages (AREA)
- Diaphragms For Electromechanical Transducers (AREA)
- Crystals, And After-Treatments Of Crystals (AREA)
- Paper (AREA)
- Organic Insulating Materials (AREA)
- Mechanical Treatment Of Semiconductor (AREA)
Description
本發明係關於一種用於增強身體機能之組合物及一種使用前述組合物以增強身體機能之方法。
達到身體機能的顛峰長久以來一直是運動競技及自我改善的目標。改善身體機能的方法包含有系統的延長運動、控制飲食及使用藥物如代謝類固醇。代謝類固醇(anabolic steroids)是一種睪酮衍生物，能促進組織成長，增加肌肉質量、血液量及血紅素含量，並改善整體強健度。無論如何，適用代謝類固醇經常造成嚴重的併發症，如降低血液中高密度脂蛋白含量、使再生系統失調或導致肝臟失調疾病，包含肝癌或紫斑性肝炎。這些併發症進一步導致女性雄性化、打斷孩童成長或胎兒缺陷。使用代謝類固醇也會造成精神上的失調，如不可預期的情緒變化及侵略行為。因此，需要一種安全的藥物或飲食補充劑來增進身體機能。
本發明係關於一種包含槲皮素(quercetin)及一些其他天然產物之組合物。該組合物可用於增強身體機能，換言之，可用於改善運動能力如速度、肌力、力量、耐力、彈性、靈活度、平衡感、集中協調性、反應時間及疲勞恢復能力。
本發明之另一方面係關於一種含槲皮素(quercetin)之組成物，包含維他命B3、維他命C或其兩者。在一實施態樣中，該組合物進一步包含一種或多種下列成份：維他命B1、維他命B2、維他命B6及維他命B12。在另一實施態樣中，該組合物可進一步包含一種或多種下列成分：咖啡因、表沒食子兒茶素酸酯(epigallocatechin gallate)、表兒茶素(epicatechin)、兒茶素沒食子酸酯(epicatechin gallate)、表沒食子兒茶素(epigallocatechin)及茶
多酚(polyphernon E)。該組合物也可包含其他成分，如維他命E、輔酶Q10(CoQ-10)、黃豆類黃酮素(soy isoflavones)、牛磺酸(taurine)、甜菜果膠纖維(sugar beet pectin fiber)或銀杏萃取物(ginko biloba extract)。前述組合物並可進一步視需要添加糖精以提高甜度，前述糖精例如山梨醇(sorbitol)、麥芽糖醇(maltitol)、蔗糖、高乳糖玉米糖漿或其他相似糖精。前述組成物也可包含胺基酸、礦物質、增味劑或增色劑。綠茶的樹葉已知包含表沒食子兒茶素酸酯(epigallocatechin gallate)、表兒茶素(epicatechin)、兒茶素沒食子酸酯(epicatechin gallate)、表沒食子兒茶素(epigallocatechin)及茶多酚(polyphernon E)，因此前述五種成份適合由綠茶萃取物提供。
本發明之組合物係可為乾燥型態(如粉末或藥片)或水溶液型態(如飲料或糖漿)，其可為飲食補充劑或藥劑，亦可為飲料或食品，例如：茶(如茶飲料或茶包成份)、汽水、果汁(如水果萃取物或果汁飲料)、牛奶、咖啡、果凍、冰淇淋、優格、餅乾、麥片、巧克力及點心棒。本發明之組合物在任何前述形式下皆可用於增強身體機能。本發明之範圍亦包含以本發明之組合物作為活性劑及使用該組合物製造藥劑以增強身體機能。
本發明係關於一種增強身體機能之方法。該方法包含提供一有效量之前述組合物給一需要增強身體機能之對象。藉由如下列實施方式之方法適當提供該組合物，可增強身體機能並且沒有以藥物方式增強身體機能產生的副作用，如代謝類固醇(anabolic steroids)。
本發明之詳細實施例係依循前述之目的詳述於實施方式中，其他本發明之特徵、目的及優點係說明於實施方式及申請專利範圍中。
本發明之一部份係基於一項超出預期的發現，槲皮素(quercetin)，一種抗氧化物，及一些其他天然產物具有增進健康的功效，包含增進目標對象之身體機能。
舉例來說，本發明係關於一種含槲皮素(quercetin)之組成物，包含維他命B3、維他命C或其兩者。該組合物進一步包含一種或多種下列成份：維他命B1、維他命B2、維他命B6及維他命B12。該組合物亦可進一步包含一種或多種下列成分：咖啡因、表沒食子兒茶素酸酯(epigallocatechin gallate)、表兒茶素(epicatechin)、兒茶素沒食子酸酯(epicatechin gallate)、表沒食子兒茶素(epigallocatechin)及茶多酚(polyphernon E)。綠茶萃取物適合用於提供表沒食子兒茶素酸酯(epigallocatechin gallate)、表兒茶素(epicatechin)、兒茶素沒食子酸酯(epicatechin gallate)、表沒食子兒茶素(epigallocatechin)及茶多酚(polyphernon E)。
前述組成物之示範性組成成份含量係為：0.1-50mg維他命B1、0.1-150mg維他命B2、0.1-2000mg維他命B3、0.1-200mg維他命B6，5-150μg維他命B12、50-2000mg維他命C、50-1500mg咖啡因、20-2000mg槲皮素(quercetin)、10-500mg表沒食子兒茶素酸酯(epigallocatechin gallate)、10-500mg表兒茶素(epicatechin)、10-500mg兒茶素沒食子酸酯(epicatechin gallate)、10-500mg表沒食子兒茶素(epigallocatechin)及10-500mg茶多酚(polyphernon E)，其中前述組成成份係可溶解或分散於1L水溶液中。前述組成成份之含量係可為與前述含量相同之相對比率。前述名詞”槲皮素”係指槲皮素配糖甘基(quercetin aglycon)及槲皮素衍生物，例如：槲皮素-3-O-葡萄糖甘(quercetin-3-O-glucoside)、槲皮素-5-O-葡萄糖甘(quercetin-5-O-glucoside)、槲皮素-7-O-葡萄糖甘(quercetin-7-O-glucoside)、槲皮素-9-O-葡萄糖甘(quercetin-9-O-glucoside)、槲皮素-3-O-芸香甘
(quercetin-3-O-rutinoside)、槲皮素-3-O-[α-鼠李糖-(1→2)-α-鼠李糖-(1→6)]-β-葡萄糖甘(quercetin-3-O-[α-rhamnosyl-(1→2)-α-rhamnosyl-(1→6)]-β-glucoside)、槲皮素-3-O-半乳糖甘(quercetin-3-O-galactoside)、槲皮素-7-O-半乳糖甘(quercetin-7-O-galactoside)、槲皮素-3-O-鼠李糖甘(quercetin-3-O-rhamnoside)及槲皮素-7-O-鼠李糖甘(quercetin-7-O-rhamnoside)。在消化後，槲皮素衍生物會轉化為槲皮素配糖甘基，一可被身體吸收的活性型態。前述之槲皮素含量係指槲皮素配糖甘基或槲皮素衍生物中槲皮素部分。例如：每日使用的組成物係可為1L水溶液，該水溶液中包含1000mg槲皮素、30mg維他命B1、85mg維他命B2、1g維他命B3、100mg維他命B6，120μg維他命B12、1200mg維他命C、1000IU維他命E、1000mg咖啡因及包含120mg表沒食子兒茶素酸酯、140mg表兒茶素、360mg兒茶素沒食子酸酯、360mg表沒食子兒茶素及120mg茶多酚(polyphernon E)的綠茶萃取物。
前述組成物也可包含一種或多種其他活性組成成份，如維他命E、輔酶Q10、黃豆類黃酮素、牛磺酸、甜菜果膠纖維及銀杏萃取物。這些組成成份的示範性含量為：3-1000 IU維他命E、10-400mg輔酶Q10、20-600mg黃豆類黃酮素、10-1000mg牛磺酸、1-15g甜菜果膠纖維及50-500mg銀杏萃取物(乾重)。前述組成物並可進一步視需要藉由添加糖精來提高甜度，添加糖精例如為山梨醇、麥芽糖醇、氫化葡萄糖漿、氫化澱粉水解物、高乳糖玉米糖漿、蔗糖、甜菜糖、果膠及蔗糖素(sucralose)。
前述組成物的一個例子係為粉末形式，該粉末狀之組成物適合用於製備飲料，如茶或果汁。前述粉末組成物亦可用於製備軟膏、凝膠、膠囊或藥片。乳糖及玉米澱粉一般在膠囊中作為稀釋物或在藥片中作為載體；一般可加入潤滑劑，如硬脂酸鎂
(magnesium stearate)，以形成藥片。
本發明之組成物係可為飲食補充劑或藥劑。作為飲食補充劑時，該組成物包含額外的營養物，如礦物質或氨基酸。前述組成物亦可為飲料或食品。在本說明書中，名詞”飲料”及”食物”廣泛地指所有種類的液體及固體/半固體材料，各自可提供動物營養及維持正常或加速動物(包含人類)的成長。飲料產品的例子包含，但不限於，茶飲料、果汁、咖啡及牛奶。食物產品的例子包含果凍、餅乾、麥片、巧克力、點心棒、草本萃取物、日常產品(如冰淇淋及優格)、豆類產品(如豆腐)及米製產品。
本發明之組合物在任何前述形式下皆可用於增強身體機能，如改善整體的力量、平衡感、疲勞恢復力、身體鍛鍊強度及對活動的耐力。該組合物也可用於治療疾病或失調症狀，如關節炎、腫瘤、糖尿病、性障礙、慢性便秘、腸發炎等疾病；並改善注意力或心情；及降低膽固醇或血壓。名詞”腫瘤”係指良性腫瘤及惡性腫瘤(白血癌、結腸癌、腎臟癌、肝癌、乳癌或肺癌)。
名詞”治療”、”改善”及”降低”係指提供有效量之本發明組合物給予需要增強身體機能、或具有一種或多種之前述失調症狀、或具有一種或多種前述疾病之徵候或傾向之對象，其目的在改善身體機能或治療、減輕、減緩、醫治或改善一種或多種之前述失調症狀或前述失調症狀之徵候或傾向。名詞”服用”包含以口服或非口服方式提供任何適當型式之本發明組合物給一對象，如食品、飲料、藥片、膠囊、懸浮液及溶液。名詞”非口服”係指皮下、皮膚、靜脈、肌肉、關節、動脈、滑液、胸骨、囊內、椎管內、或顱內注射，及不同的注入方法。名詞”有效量”係指組合物之劑量足夠提供身體好處(如改善耐力)或治療療效(如降低膽固醇量或血壓)。體內及體外研究可用於推論決定最佳服用路徑及劑量。
下列實施例係僅用於進一步瞭解本發明，並非用於限制本發
明之揭露範圍。任何熟悉本技術領域之人士係可依本說明書揭露之內容，不需進一步闡述，進一步利用本發明使其發揮最大效用。本說明書中引述之所有文獻係藉由參考全文方式併入本說明書中。
組合物A(1000ml)之製備係在室溫下混合下列成分：1000ml柳橙汁、1000mg槲皮素、30mg維他命B1、85mg維他命B2、1000mg維他命B3、100mg維他命B6、120μg維他命B12、1000IU維他命E及1000mg咖啡因。所有組成成份係可自Spectrum Laboratory Products,Inc.,Gardena,CA；sigma,St.Louis,MO，及Aldrich,Milwaukee,WI.獲得。
從Charles River Lab(Boston,MA)獲得重量240-250g之雄性Spregue-Dawley大鼠，將其分為第1及第2組(每組5隻)。第2組之大鼠藉由胃內灌食方式提供前述組合物，每日劑量8ml/大鼠(30ml/Kg體重)，持續48天。第1組之大鼠僅提供水。
在提供組合物0、14、28及42天後，藉由眼窩放血從大鼠身上收集血液樣本並依標準方法決定不同的血液參數。結果整理於下列表一及表二中。
如表一及表二所示，提供組合物A(第2組)之大鼠的網織紅細胞數量高於提供水(第1組)之大鼠的網織紅細胞數量。例如，在第42天，第2組大鼠的平均網織紅細胞數量(6.58%)高於第1組大鼠的網織紅細胞數量(4.78%)37.7%。在另一方面，兩組大鼠的其他血液參數並沒有顯著的不同。參考表一。此一結果指出組合物A能增加網織紅細胞數量但無法影響其他血液參數。網織紅細胞是一種不成熟、有核的紅血球細胞(RBCs)。網織紅細胞數量的增加及其他血液參數沒有變化，顯示組合物A能改善紅血球重建。
在實驗期間，每日監測大鼠的體重。兩組間沒有統計學上的差異。
組合物B(1000ml)之製備係在室溫下混合下列成分：1000ml柳橙汁、1000mg槲皮素、30mg維他命B1、85mg維他命B2、1000mg維他命B3、100mg維他命B6、120μg維他命B12、1000IU維他命E及1000mg咖啡因、500mg表沒食子兒茶素酸酯、
500mg表兒茶素、500mg兒茶素沒食子酸酯、500mg表沒食子兒茶素及500mg茶多酚(polyphernon E)。
從Charles River Lab(Boston,MA)獲得重量240-250g之雄性Spregue-Dawley大鼠，將其分為第1及第2組(每組5隻)。第2組之大鼠藉由胃內灌食方式提供組合物B，每日劑量14ml/大鼠(30ml/Kg體重)，持續95天。第1組之大鼠僅提供水。
從提供組合物第92天開始，每隻大鼠在Rota-Rod採步機上訓練(Model 57750,Stoelting Co.,Wood dale,Illinois)2小時。在第95天額外訓練20分鐘後，每隻大鼠放在採步機上行走。紀錄每隻大鼠在採步機上從行走至掉下來的時間，並獲得第1組及第2組大鼠的平均行走時間。重複此一實驗3次(“測試A”、”測試B”及”測試C”)。實驗結果整理於表三。
如表三所示，當實驗持續進行，大鼠開始習慣運動並能在採
步機上行走較長的時間。在所有測試中，提供組合物B的大鼠在採步機上行走的時間較未提供組合物B的大鼠長。此一結果顯示組合物B能增強大鼠身體機能。在提供組合物B的95天期間，每日監測大鼠的體重，第1組及第2組間沒有出現統計學上的差異。此一結果表示第2組大鼠身體機能的增強並非是由於體重增加的緣故。
所有本說明書所揭露之特徵皆可以任何形式與其他方法合併使用。本說明書中所揭露之特徵可以具有相同、相等或相似目的的特徵所取代。因此，除了明確強調的部分之外，所有本說明書中揭露的特徵僅為眾多相等或相似特徵中的一個實施例。
根據本說明書所揭露的內容，任何一位熟習本技術領域的人士可輕易明確瞭解本發明之重要特色，在不脫離本發明之精神與範圍下，係可對本發明做不同的改變與修飾使其符合不同的使用目的與情況。因此，其他實施態樣亦包含在下列申請專利範圍內。
Claims (8)
- 一種使用於增強運動之整體肌力、疲勞恢復能力、平衡感和耐力的組合物，係包含0.1-2000 mg的維他命B3、50-2000 mg的維他命C、20-2000 mg的槲皮素、0.1-50mg維他命B1、0.1-150mg維他命B2、0.1-200mg維他命B6，5-150μg維他命B12、3-1000 IU維他命E、及至少一種之選自咖啡因、表沒食子兒茶素酸酯、表兒茶素、兒茶素沒食子酸酯、及表沒食子兒茶素所組成之群組的成分。
- 如申請專利範圍第1項所述之組合物，其中前述組合物進一步包含綠茶萃取物，前述綠茶萃取物包含咖啡因、表沒食子兒茶素酸酯、表兒茶素、兒茶素沒食子酸酯、及表沒食子兒茶素之至少一種。
- 如申請專利範圍第1項所述之組合物，其中前述組合物進一步包含輔酶Q10、黃豆類黃酮素、甜菜果膠纖維及銀杏萃取物之至少一種。
- 如申請專利範圍第1項所述之組合物，其中前述組合物包含一水溶液。
- 如申請專利範圍第1項所述之組合物，其中前述組合物係為乾燥形式。
- 如申請專利範圍第1項所述之組合物，其中前述組合物係為茶、汽水、果汁、牛奶、咖啡、果凍、冰淇淋、優格、餅乾、麥片、巧克力或點心棒。
- 如申請專利範圍第1項所述之組合物，其中前述組合物進一步包含牛磺酸。
- 如申請專利範圍第7項所述之組合物，其中前述牛磺酸的含量為10-1000 mg。
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US42098602P | 2002-10-23 | 2002-10-23 | |
| US10/302,544 US6821536B2 (en) | 2002-11-22 | 2002-11-22 | Antioxidative compositions |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| TW200409601A TW200409601A (en) | 2004-06-16 |
| TWI383753B true TWI383753B (zh) | 2013-02-01 |
Family
ID=32658824
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW092129007A TWI337066B (en) | 2002-10-23 | 2003-10-20 | Dietary supplement |
| TW092129416A TWI383753B (zh) | 2002-10-23 | 2003-10-23 | 用於增強運動能力的組合物 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TW092129007A TWI337066B (en) | 2002-10-23 | 2003-10-20 | Dietary supplement |
Country Status (13)
| Country | Link |
|---|---|
| EP (2) | EP1562447B1 (zh) |
| JP (3) | JP2006507283A (zh) |
| KR (2) | KR101186898B1 (zh) |
| AT (2) | ATE416629T1 (zh) |
| AU (2) | AU2003282829B2 (zh) |
| CA (2) | CA2503363C (zh) |
| DE (2) | DE60325265D1 (zh) |
| DK (2) | DK1562447T3 (zh) |
| ES (1) | ES2322577T3 (zh) |
| HK (1) | HK1086725A1 (zh) |
| NZ (1) | NZ540165A (zh) |
| PT (2) | PT1562447E (zh) |
| TW (2) | TWI337066B (zh) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| ATE416629T1 (de) * | 2002-10-23 | 2008-12-15 | Quercegen Holdings Llc | Antioxidative zusammensetzungen |
| KR101154616B1 (ko) * | 2004-12-31 | 2012-06-08 | (주)아모레퍼시픽 | 캄페롤 및 퀘르세틴을 함유하는 히알루론산 생성 촉진용조성물 |
| JP4601570B2 (ja) * | 2006-03-20 | 2010-12-22 | 株式会社ロッテ | 抗酸化剤及びその製造方法並びに該抗酸化剤を含有する飲食品 |
| US7745486B2 (en) * | 2006-07-17 | 2010-06-29 | Quercegen Pharma Llc | Quercetin-containing compositions |
| JP5399864B2 (ja) * | 2008-11-10 | 2014-01-29 | 花王株式会社 | 精製茶抽出物 |
| CN102802626B (zh) * | 2009-06-11 | 2015-11-25 | 帝斯曼知识产权资产管理有限公司 | 作为肌肉刺激剂的烟酸和/或葫芦巴碱 |
| JP5688234B2 (ja) * | 2010-03-12 | 2015-03-25 | 株式会社ヤマノホールディングス | Ｌ‐アスコルビン酸含有粉の製造方法 |
| MX2013001906A (es) * | 2010-09-17 | 2013-07-05 | Stokely Van Camp Inc | Metodos para reducir la concentracion de lactato en la sangre. |
| JP2012085568A (ja) * | 2010-10-18 | 2012-05-10 | Kao Corp | ゼリー状食品 |
| US20130129680A1 (en) * | 2011-11-23 | 2013-05-23 | Thomas Christian Lines | Method for treating hepatitis c virus infection using quercetin-containing compositions |
| JP6093343B2 (ja) * | 2012-03-09 | 2017-03-08 | 武田薬品工業株式会社 | 内服用液剤 |
| US20150283144A1 (en) * | 2012-11-01 | 2015-10-08 | Rijksuniversiteit Groningen | Methods and compositions for stimulating beneficial bacteria in the gastrointestinal tract |
| JP6752012B2 (ja) * | 2015-11-13 | 2020-09-09 | 太陽化学株式会社 | テルペノイド減少抑制剤 |
| CN106278991B (zh) * | 2016-08-03 | 2018-10-26 | 沅江华龙催化科技有限公司 | 一种由nhpi与含苄基化合物在非金属催化下直接偶联制备pino衍生物的方法 |
| CN106349149B (zh) * | 2016-08-03 | 2018-12-18 | 沅江华龙催化科技有限公司 | 一种由nhpi与酮类化合物直接偶联制备pino衍生物的方法 |
| CN106306887A (zh) * | 2016-08-19 | 2017-01-11 | 朱路 | 一种可以缓解婴儿吐奶不适性的植物维生素滴剂 |
| WO2020112828A1 (en) | 2018-11-30 | 2020-06-04 | Zwicker Jeffrey I | Compositions and methods for reducing major thrombotic events in cancer patients |
| CN112021573A (zh) * | 2020-05-26 | 2020-12-04 | 上海轻姿健康管理有限公司 | 一种提高耐力的运动营养组合物 |
| WO2022131063A1 (ja) * | 2020-12-18 | 2022-06-23 | サントリーホールディングス株式会社 | 筋肉の柔軟性改善用組成物 |
| WO2024101207A1 (ja) * | 2022-11-07 | 2024-05-16 | サントリーホールディングス株式会社 | ケルセチン又はその配糖体を含有する認知機能の低下抑制又は改善用組成物 |
Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5846569A (en) * | 1997-06-20 | 1998-12-08 | Creative Labs, Inc. | Colostrum supplement |
| TW200412863A (en) * | 2002-10-23 | 2004-08-01 | New Sun Nutrition Company | Antioxidative compositions |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP3130327B2 (ja) * | 1991-03-29 | 2001-01-31 | 日鉱金属株式会社 | 肝機能障害予防剤及び肝機能障害予防作用を有する機能性食品 |
| AT407942B (de) * | 1997-04-16 | 2001-07-25 | Husz Georg Bela | Getränk, konzentrat-kombination sowie verfahren zur herstellung eines getränkes |
| JP2002523456A (ja) * | 1998-08-27 | 2002-07-30 | メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフトング | アスコルビン酸塩−イソケルセチン組成物 |
| US6261589B1 (en) * | 1999-03-02 | 2001-07-17 | Durk Pearson | Dietary supplement nutrient soft drink composition with psychoactive effect |
| US6210701B1 (en) * | 1999-04-30 | 2001-04-03 | Healthcomm International, Inc. | Medical food for treating inflammation-related diseases |
| US6299925B1 (en) * | 1999-06-29 | 2001-10-09 | Xel Herbaceuticals, Inc. | Effervescent green tea extract formulation |
| US6579544B1 (en) * | 2000-05-31 | 2003-06-17 | Nutriex, L.L.C. | Method for supplementing the diet |
| JP2002051732A (ja) * | 2000-06-12 | 2002-02-19 | Access Business Group Llc | 食事による植物性化学物質欠乏症を矯正する組成物及び方法 |
| AU2001277940A1 (en) * | 2000-07-20 | 2002-02-05 | Bradford D. Pitman | Dietary supplement compositions |
| JP4043194B2 (ja) * | 2001-02-15 | 2008-02-06 | 株式会社大貴 | 不織布及び該不織布の製造方法 |
| WO2003028747A1 (en) * | 2001-10-04 | 2003-04-10 | Harris Dennis H | Ingestible nerve and circulatory nutritional formulation |
-
2003
- 2003-10-14 AT AT03774827T patent/ATE416629T1/de active
- 2003-10-14 EP EP03774827A patent/EP1562447B1/en not_active Expired - Lifetime
- 2003-10-14 KR KR1020057007030A patent/KR101186898B1/ko not_active IP Right Cessation
- 2003-10-14 PT PT03774827T patent/PT1562447E/pt unknown
- 2003-10-14 JP JP2004546861A patent/JP2006507283A/ja active Pending
- 2003-10-14 CA CA2503363A patent/CA2503363C/en not_active Expired - Fee Related
- 2003-10-14 DE DE60325265T patent/DE60325265D1/de not_active Expired - Lifetime
- 2003-10-14 ES ES03774827T patent/ES2322577T3/es not_active Expired - Lifetime
- 2003-10-14 DK DK03774827T patent/DK1562447T3/da active
- 2003-10-14 AU AU2003282829A patent/AU2003282829B2/en not_active Ceased
- 2003-10-20 TW TW092129007A patent/TWI337066B/zh not_active IP Right Cessation
- 2003-10-23 KR KR1020057007029A patent/KR20050103268A/ko not_active Application Discontinuation
- 2003-10-23 NZ NZ540165A patent/NZ540165A/en not_active IP Right Cessation
- 2003-10-23 AT AT03779239T patent/ATE500747T1/de active
- 2003-10-23 TW TW092129416A patent/TWI383753B/zh not_active IP Right Cessation
- 2003-10-23 DE DE60336336T patent/DE60336336D1/de not_active Expired - Lifetime
- 2003-10-23 JP JP2004547143A patent/JP2006503896A/ja active Pending
- 2003-10-23 EP EP03779239A patent/EP1562449B1/en not_active Expired - Lifetime
- 2003-10-23 CA CA2503373A patent/CA2503373C/en not_active Expired - Fee Related
- 2003-10-23 AU AU2003284919A patent/AU2003284919A1/en not_active Abandoned
- 2003-10-23 DK DK03779239.7T patent/DK1562449T3/da active
- 2003-10-23 PT PT03779239T patent/PT1562449E/pt unknown
-
2006
- 2006-06-14 HK HK06106781A patent/HK1086725A1/xx not_active IP Right Cessation
-
2011
- 2011-03-09 JP JP2011052092A patent/JP2011157366A/ja active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5846569A (en) * | 1997-06-20 | 1998-12-08 | Creative Labs, Inc. | Colostrum supplement |
| TW200412863A (en) * | 2002-10-23 | 2004-08-01 | New Sun Nutrition Company | Antioxidative compositions |
Also Published As
| Publication number | Publication date |
|---|---|
| TW200409601A (en) | 2004-06-16 |
| HK1086725A1 (en) | 2006-09-29 |
| DE60336336D1 (de) | 2011-04-21 |
| ES2322577T3 (es) | 2009-06-23 |
| ATE500747T1 (de) | 2011-03-15 |
| PT1562449E (pt) | 2011-06-16 |
| CA2503363A1 (en) | 2004-05-06 |
| DK1562447T3 (da) | 2009-04-06 |
| JP2006503896A (ja) | 2006-02-02 |
| EP1562449A1 (en) | 2005-08-17 |
| AU2003282829A1 (en) | 2004-05-13 |
| KR20050088994A (ko) | 2005-09-07 |
| EP1562447B1 (en) | 2008-12-10 |
| CA2503363C (en) | 2012-01-17 |
| JP2011157366A (ja) | 2011-08-18 |
| TWI337066B (en) | 2011-02-11 |
| AU2003284919A1 (en) | 2004-05-13 |
| CA2503373C (en) | 2013-01-15 |
| EP1562447A4 (en) | 2006-04-12 |
| PT1562447E (pt) | 2009-03-17 |
| DE60325265D1 (de) | 2009-01-22 |
| KR101186898B1 (ko) | 2012-10-02 |
| JP2006507283A (ja) | 2006-03-02 |
| AU2003282829B2 (en) | 2010-07-22 |
| EP1562449B1 (en) | 2011-03-09 |
| NZ540165A (en) | 2008-10-31 |
| DK1562449T3 (da) | 2011-06-06 |
| ATE416629T1 (de) | 2008-12-15 |
| TW200412863A (en) | 2004-08-01 |
| EP1562447A1 (en) | 2005-08-17 |
| CA2503373A1 (en) | 2004-05-06 |
| EP1562449A4 (en) | 2008-02-20 |
| KR20050103268A (ko) | 2005-10-28 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| TWI383753B (zh) | 用於增強運動能力的組合物 | |
| JP6936932B2 (ja) | フラボノイド組成物及び使用方法 | |
| US8318225B2 (en) | Composition for enhancing physical performance | |
| AU2010202435B2 (en) | Composition for enhancing physical performance | |
| US8901109B2 (en) | Quercetin-containing compositions | |
| CN100361599C (zh) | 抗氧化组合物 | |
| US8440704B2 (en) | Quercetin-containing compositions | |
| JP5121308B2 (ja) | メタボリックシンドロームの予防、改善または治療組成物 | |
| CN101505748A (zh) | 含斛皮素组合物 | |
| JP2009107987A (ja) | 筋力向上剤 | |
| JP2002265359A (ja) | カイニン酸型グルタミン酸受容体遮蔽剤、ａｍｐａ型グルタミン酸受容体遮蔽剤、脳保護剤及び脳保護機能を備えた飲食物 | |
| JP2009533433A (ja) | ピルビン酸アルキルエステルを含む組成物とその使用 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Annulment or lapse of patent due to non-payment of fees |