[go: up one dir, main page]

TW419472B - Process for preparing taxane derivatives - Google Patents

Process for preparing taxane derivatives Download PDF

Info

Publication number
TW419472B
TW419472B TW082108117A TW82108117A TW419472B TW 419472 B TW419472 B TW 419472B TW 082108117 A TW082108117 A TW 082108117A TW 82108117 A TW82108117 A TW 82108117A TW 419472 B TW419472 B TW 419472B
Authority
TW
Taiwan
Prior art keywords
formula
page
group
cns
product
Prior art date
Application number
TW082108117A
Other languages
English (en)
Chinese (zh)
Inventor
Jean-Manuel Mas
Viviane Massonneau
Original Assignee
Rhone Poulenc Rorer Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Rhone Poulenc Rorer Sa filed Critical Rhone Poulenc Rorer Sa
Application granted granted Critical
Publication of TW419472B publication Critical patent/TW419472B/zh

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D263/00—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings
    • C07D263/02—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings
    • C07D263/04—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
    • C07D263/06—Heterocyclic compounds containing 1,3-oxazole or hydrogenated 1,3-oxazole rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members with hydrocarbon radicals, substituted by oxygen atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D305/00—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms
    • C07D305/14—Heterocyclic compounds containing four-membered rings having one oxygen atom as the only ring hetero atoms condensed with carbocyclic rings or ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
    • Y02P20/00—Technologies relating to chemical industry
    • Y02P20/50—Improvements relating to the production of bulk chemicals
    • Y02P20/55—Design of synthesis routes, e.g. reducing the use of auxiliary or protecting groups

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epoxy Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Nitrogen And Oxygen As The Only Ring Hetero Atoms (AREA)
  • Plural Heterocyclic Compounds (AREA)
TW082108117A 1992-10-05 1993-10-02 Process for preparing taxane derivatives TW419472B (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
FR9211741A FR2696458B1 (fr) 1992-10-05 1992-10-05 Procédé de préparation de dérivés du taxane.

Publications (1)

Publication Number Publication Date
TW419472B true TW419472B (en) 2001-01-21

Family

ID=9434119

Family Applications (1)

Application Number Title Priority Date Filing Date
TW082108117A TW419472B (en) 1992-10-05 1993-10-02 Process for preparing taxane derivatives

Country Status (24)

Country Link
US (3) US5616739A (cs)
EP (1) EP0663906B1 (cs)
JP (1) JP3014760B2 (cs)
KR (1) KR100311198B1 (cs)
AT (1) ATE146174T1 (cs)
AU (1) AU689080B2 (cs)
CA (1) CA2146250C (cs)
CZ (1) CZ283261B6 (cs)
DE (1) DE69306591T2 (cs)
DK (1) DK0663906T3 (cs)
ES (1) ES2095081T3 (cs)
FI (1) FI109793B (cs)
FR (1) FR2696458B1 (cs)
GR (1) GR3021997T3 (cs)
HU (1) HU226412B1 (cs)
MX (1) MX9305766A (cs)
NO (1) NO309089B1 (cs)
NZ (1) NZ256445A (cs)
PL (1) PL182284B1 (cs)
RU (1) RU2116303C1 (cs)
SK (1) SK280627B6 (cs)
TW (1) TW419472B (cs)
WO (1) WO1994007877A1 (cs)
ZA (1) ZA937318B (cs)

Families Citing this family (81)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FR2696464B1 (fr) * 1992-10-05 1994-11-10 Rhone Poulenc Rorer Sa Nouveau procédé d'estérification de la baccatine III et de la désacétyl-10 baccatine III.
FR2697522B1 (fr) * 1992-10-30 1994-11-25 Rhone Poulenc Rorer Sa Procédé de préparation de dérivés du taxane.
FR2698361B1 (fr) * 1992-11-20 1995-01-13 Rhone Poulenc Rorer Sa Procédé de préparation d'un acide oxazolidine-1,3 carboxylique-5.
MX9307777A (es) 1992-12-15 1994-07-29 Upjohn Co 7-HALO-Y 7ß, 8ß-METANO-TAXOLES, USO ANTINEOPLASTICO Y COMPOSICIONES FARMACEUTICAS QUE LOS CONTIENEN.
US5973160A (en) * 1992-12-23 1999-10-26 Poss; Michael A. Methods for the preparation of novel sidechain-bearing taxanes
EP0982302B1 (en) * 1993-06-11 2004-04-14 PHARMACIA & UPJOHN COMPANY Delta 6,7-taxols antineoplastic use and pharmaceutical compositions containing them
FR2706457B1 (fr) * 1993-06-16 1995-07-28 Rhone Poulenc Rorer Sa Procédé de préparation d'un acide oxazolidinecarboxylique utile pour préparer des taxoïdes thérapeutiquement actifs.
US6005120A (en) 1993-07-20 1999-12-21 Florida State University Tricyclic and tetracyclic taxanes
CN1046270C (zh) * 1993-11-12 1999-11-10 法玛西雅厄普约翰美国公司 嘧啶－硫烷基或烷基醚化合物
IL112412A (en) * 1994-01-28 2000-02-29 Upjohn Co Delta 12,13-iso-taxol analogs and antineoplastic pharmaceutical compositions containing them
US5679807A (en) * 1995-01-30 1997-10-21 Hauser, Inc. Preparation of taxol and docetaxel through primary amines
CA2170661A1 (en) * 1995-03-22 1996-09-23 John K. Thottathil Novel methods for the preparation of taxanes using oaxzolidine intermediates
GB9512471D0 (en) * 1995-06-20 1995-08-23 Pharmacia Spa Method for the preparation of taxol and its derivatives
US5688977A (en) * 1996-02-29 1997-11-18 Napro Biotherapeutics, Inc. Method for docetaxel synthesis
NZ332475A (en) * 1996-05-08 2000-05-26 Upjohn Co silylated baccatin derivatives, 3-(substituted amino)-3-phenyl-(2R,3S)-isoserinate derivatives, the oxazolidine ester thereof and other immediates used to prepare baccatin derivatives
US7288665B1 (en) * 1997-08-18 2007-10-30 Florida State University Process for selective derivatization of taxanes
DE69812395T2 (de) 1997-08-21 2004-02-05 Florida State University, Tallahassee Verfahren zur synthese von taxanen
AU1712899A (en) * 1997-12-23 1999-07-12 Bristol-Myers Squibb Company 7-deoxy-6-nitrogen substituted paclitaxels
EP1229934B1 (en) 1999-10-01 2014-03-05 Immunogen, Inc. Compositions and methods for treating cancer using immunoconjugates and chemotherapeutic agents
PL366100A1 (en) 2000-09-22 2005-01-24 Bristol-Myers Squibb Company Method for reducing toxicity of combined chemotherapies
US6891050B2 (en) * 2001-08-10 2005-05-10 Dabur India Limited Process for the preparation of taxanes such as paclitaxel, docetaxel and structurally similar analogs
US6881852B2 (en) * 2002-02-05 2005-04-19 Dabur India Limited Process of purification of paclitaxel and docetaxel
US7247738B2 (en) * 2002-05-07 2007-07-24 Dabur India Limited Method of preparation of anticancer taxanes using 3-[(substituted-2-trialkylsilyl) ethoxycarbonyl]-5-oxazolidine carboxylic acids
US6900342B2 (en) * 2002-05-10 2005-05-31 Dabur India Limited Anticancer taxanes such as paclitaxel, docetaxel and their structural analogs, and a method for the preparation thereof
US7351542B2 (en) 2002-05-20 2008-04-01 The Regents Of The University Of California Methods of modulating tubulin deacetylase activity
EP1530465B2 (en) 2002-06-26 2015-12-16 MediGene AG Method of producing a cationic liposomal preparation comprising a lipophilic compound
JP2006513152A (ja) * 2002-10-09 2006-04-20 ファイトジェン ライフ サイエンシズ インコーポレイテッド 新規タキサンならびにその使用および調製に関する方法
US6838569B2 (en) 2002-12-16 2005-01-04 Dabur India Limited Process for preparation of paclitaxel trihydrate and docetaxel trihydrate
CA2525647A1 (en) 2003-05-16 2005-02-24 Intermune, Inc. Synthetic chemokine receptor ligands and methods of use thereof
US7407973B2 (en) * 2003-10-24 2008-08-05 Intermune, Inc. Use of pirfenidone in therapeutic regimens
US7202370B2 (en) * 2003-10-27 2007-04-10 Conor Medsystems, Inc. Semi-synthesis of taxane intermediates from 9-dihydro-13-acetylbaccatin III
JP2008513356A (ja) * 2004-08-09 2008-05-01 アリオス バイオファーマ インク． 合成高度糖鎖付加プロテアーゼ耐性ポリペプチド変異体、それを使用する経口製剤および方法
US7597884B2 (en) * 2004-08-09 2009-10-06 Alios Biopharma, Inc. Hyperglycosylated polypeptide variants and methods of use
EP1647552A1 (en) * 2004-10-08 2006-04-19 INDENA S.p.A. Semisynthesis process for the preparation of 10-deacetyl-n-debenzoyl-paclitaxel
EP1712552A1 (en) * 2005-04-11 2006-10-18 INDENA S.p.A. Semisynthesis process for the preparation of 10-deacetyl-n-debenzoyl-paclitaxel
US7446126B2 (en) 2004-10-08 2008-11-04 Indena S.P.A. Semisynthesis process for the preparation of 10-deacetyl-N-debenzoyl-paclitaxel
US8691780B2 (en) * 2005-02-17 2014-04-08 The Board Of Trustees Of The Leland Stanford Junior University Txr1 and enhanced taxane sensitivity based on the modulation of a pathway mediated thereby
KR20080100264A (ko) * 2006-03-21 2008-11-14 닥터 레디스 레보러터리즈 리미티드 도세탁셀의 다형체와 그 제조방법
AU2007228984B2 (en) 2006-03-22 2012-05-03 Syncore Biotechnology Co., Ltd Treatment of triple receptor negative breast cancer
ITMI20062479A1 (it) * 2006-12-21 2008-06-22 Indena Spa Processo per la preparazione di secotassani
KR100942093B1 (ko) * 2007-05-30 2010-02-12 미쓰비시덴키 가부시키가이샤 전기차의 브레이크 제어 장치
US9198893B2 (en) 2008-05-22 2015-12-01 Galera Labs, Llc Combination antitumor therapy
KR101003822B1 (ko) 2008-06-20 2010-12-27 주식회사 셀트리온화학연구소 도세탁셀의 제조방법 및 도세탁셀의 제조를 위한 신규한중간체
EP2310507A4 (en) 2008-07-08 2013-03-20 David Gladstone Inst METHOD AND COMPOSITIONS FOR ANGIOGENIC MODULATION
CN101735179B (zh) * 2008-11-19 2012-09-12 上海百灵医药科技有限公司 一种多烯紫杉醇的制备方法，其中间体及制备方法
WO2010059916A2 (en) * 2008-11-20 2010-05-27 Dr. Reddy's Laboratories Ltd. Preparation of docetaxel
PL388144A1 (pl) 2009-05-29 2010-12-06 Przedsiębiorstwo Produkcyjno-Wdrożeniowe Ifotam Spółka Z Ograniczoną Odpowiedzialnością Solwaty (2R,3S)-3-tert-butoksykarbonylamino-2-hydroksy-3-fenylopropionianu 4-acetoksy-2α-benzoiloksy -5β,20-epoksy-1,7β,10β-trihydroksy-9-okso-taks-11-en-13α-ylu, sposób ich otrzymywania i zastosowanie
CN104582717B (zh) 2012-07-19 2018-03-13 雷德伍德生物科技股份有限公司 对cd22有特异性的抗体及其使用方法
CN104884056A (zh) 2012-11-12 2015-09-02 雷德伍德生物科技股份有限公司 用于制备缀合物的化合物和方法
DK3300745T3 (da) 2013-02-15 2019-11-04 Univ California Kimærisk antigenreceptor og fremgangsmåder til anvendelse deraf
EP2970124B1 (en) 2013-03-14 2019-05-22 The Board of Trustees of the Leland Stanford Junior University Mitochondrial aldehyde dehydrogenase-2 modulators and methods of use thereof
US9493413B2 (en) 2013-11-27 2016-11-15 Redwood Bioscience, Inc. Hydrazinyl-pyrrolo compounds and methods for producing a conjugate
WO2015127137A1 (en) 2014-02-19 2015-08-27 Aldea Pharmaceuticals, Inc. Mitochondrial aldehyde dehydrogenase 2 (aldh2) binding polycyclic amides and their use for the treatment of cancer
RU2016141267A (ru) 2014-03-21 2018-04-24 Эббви Инк. Антитела против egfr и конъюгаты антитело-лекарственное средство
EP3373977A4 (en) 2015-11-12 2019-07-17 The Board of Trustees of the Leland Stanford Junior University CELL-PENETRATING, GUANIDINIUM-LICH OLIGOPHOSPHOTRIESTER FOR ACTIVE AND SPILL-RELIEF
TWI760319B (zh) 2015-12-30 2022-04-11 杏國新藥股份有限公司 乳癌治療
EP3231421A1 (en) 2016-04-11 2017-10-18 Greenaltech, S.L. Uses of a carotenoid in the treatment or prevention of stress induced conditions
AU2017257504A1 (en) 2016-04-26 2018-10-25 R.P. Scherer Technologies, Llc Antibody conjugates and methods of making and using the same
WO2018017190A2 (en) 2016-06-01 2018-01-25 Baxalta Incorporated Formulations of polyalkylene oxide-asparaginase and methods of making and using the same
WO2017214322A1 (en) 2016-06-08 2017-12-14 Abbvie Inc. Anti-b7-h3 antibodies and antibody drug conjugates
CN109562169A (zh) 2016-06-08 2019-04-02 艾伯维公司 抗cd98抗体及抗体药物偶联物
EP3468599A2 (en) 2016-06-08 2019-04-17 AbbVie Inc. Anti-cd98 antibodies and antibody drug conjugates
EP3469000A1 (en) 2016-06-08 2019-04-17 AbbVie Inc. Anti-b7-h3 antibodies and antibody drug conjugates
SG10201914119TA (en) 2016-06-08 2020-02-27 Abbvie Inc Anti-b7-h3 antibodies and antibody drug conjugates
TWI852903B (zh) 2017-01-05 2024-08-21 杏國新藥股份有限公司 胰臟癌治療
CN110177808A (zh) 2017-01-18 2019-08-27 F1肿瘤医学公司 针对axl或ror2的嵌合抗原受体及其使用方法
EP3388082A1 (en) 2017-04-13 2018-10-17 Galera Labs, LLC Combination cancer immunotherapy with pentaaza macrocyclic ring complex
EP3630189A4 (en) 2017-05-24 2021-06-23 The Board of Regents of The University of Texas System Linkers for antibody drug conjugates
SG11202007317XA (en) 2018-01-31 2020-08-28 Galera Labs Llc Combination cancer therapy with pentaaza macrocyclic ring complex and platinum-based anticancer agent
CN112368011A (zh) 2018-04-11 2021-02-12 俄亥俄州创新基金会 缓释微粒用于眼用药物递送的方法和组合物
EP3823674A4 (en) 2018-07-18 2022-12-28 Manzanita Pharmaceuticals, Inc. CONJUGATES FOR DELIVERING AN ANTI-CANCER AGENT TO NERVE CELLS, METHODS OF USE AND METHODS OF PRODUCTION THEREOF
CN113692413A (zh) 2019-04-02 2021-11-23 肯乔克蒂生物技术股份有限公司 外排泵-癌症抗原多特异性抗体以及与其相关的组合物、试剂、试剂盒和方法
EP4097134A1 (en) 2020-01-29 2022-12-07 Kenjockety Biotechnology, Inc. Anti-mdr1 antibodies and uses thereof
CA3182969A1 (en) 2020-06-04 2021-12-09 Kenjockety Biotechnology, Inc. Abcg2 efflux pump-cancer antigen multi-specific antibodies and compositions, reagents, kits and methods related thereto
AU2021284240A1 (en) 2020-06-04 2022-12-08 Kenjockety Biotechnology, Inc. Anti-ABCG2 antibodies and uses thereof
CN116490522A (zh) 2020-09-02 2023-07-25 肯乔克蒂生物技术股份有限公司 抗abcc1抗体及其应用
WO2022103603A1 (en) 2020-11-13 2022-05-19 Kenjockety Biotechnology, Inc. Anti-mrp4 (encoded by abcc4 gene) antibodies and uses thereof
EP4247829A1 (en) 2020-11-20 2023-09-27 R.P. Scherer Technologies, LLC Glycoside dual-cleavage linkers for antibody-drug conjugates
AR124681A1 (es) 2021-01-20 2023-04-26 Abbvie Inc Conjugados anticuerpo-fármaco anti-egfr
KR20240116829A (ko) 2021-12-13 2024-07-30 윌리엄 로버트 아라툰 리빙 트러스트 데이티드 어거스트 29, 2016 항-abcb1 항체
WO2023159220A1 (en) 2022-02-18 2023-08-24 Kenjockety Biotechnology, Inc. Anti-cd47 antibodies

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5175315A (en) * 1989-05-31 1992-12-29 Florida State University Method for preparation of taxol using β-lactam
US5136060A (en) * 1989-11-14 1992-08-04 Florida State University Method for preparation of taxol using an oxazinone
US5015744A (en) * 1989-11-14 1991-05-14 Florida State University Method for preparation of taxol using an oxazinone
MX9102128A (es) * 1990-11-23 1992-07-08 Rhone Poulenc Rorer Sa Derivados de taxano,procedimiento para su preparacion y composicion farmaceutica que los contiene
US5319112A (en) * 1992-08-18 1994-06-07 Virgnia Tech Intellectual Properties, Inc. Method for the conversion of cephalomannine to taxol and for the preparation of N-acyl analogs of taxol

Also Published As

Publication number Publication date
ATE146174T1 (de) 1996-12-15
CA2146250C (fr) 2003-03-11
FI951595L (fi) 1995-04-04
JPH08501788A (ja) 1996-02-27
NO951201D0 (no) 1995-03-29
JP3014760B2 (ja) 2000-02-28
NZ256445A (en) 1997-01-29
DE69306591T2 (de) 1997-04-17
US5677462A (en) 1997-10-14
DE69306591D1 (de) 1997-01-23
FR2696458A1 (fr) 1994-04-08
PL182284B1 (pl) 2001-12-31
FR2696458B1 (fr) 1994-11-10
US5869680A (en) 1999-02-09
SK280627B6 (sk) 2000-05-16
ES2095081T3 (es) 1997-02-01
GR3021997T3 (en) 1997-03-31
CZ84195A3 (en) 1995-09-13
RU95113717A (ru) 1996-12-27
MX9305766A (es) 1995-01-31
AU689080B2 (en) 1998-03-26
CA2146250A1 (fr) 1994-04-14
NO951201L (no) 1995-03-29
EP0663906B1 (fr) 1996-12-11
EP0663906A1 (fr) 1995-07-26
RU2116303C1 (ru) 1998-07-27
FI109793B (fi) 2002-10-15
US5616739A (en) 1997-04-01
SK43695A3 (en) 1995-08-09
HU9500971D0 (en) 1995-06-28
FI951595A0 (fi) 1995-04-04
AU5115093A (en) 1994-04-26
HUT72679A (en) 1996-05-28
DK0663906T3 (da) 1996-12-30
ZA937318B (en) 1994-04-25
HU226412B1 (en) 2008-11-28
CZ283261B6 (cs) 1998-02-18
WO1994007877A1 (fr) 1994-04-14
KR100311198B1 (ko) 2002-04-24
KR950703546A (ko) 1995-09-20
NO309089B1 (no) 2000-12-11
PL308241A1 (en) 1995-07-24

Similar Documents

Publication Publication Date Title
TW419472B (en) Process for preparing taxane derivatives
TW393474B (en) Process for the preparation of taxane derivatives
JP3064419B2 (ja) バッカチン▲ｉｉｉ▼及び１０−デアセチルバッカチン▲ｉｉｉ▼のエステル化のための新規な方法
CZ20001789A3 (cs) Nový způsob přípravy derivátů ze skupiny taxoidů
KR100206457B1 (ko) 탁산 유도체의 제조 방법, 이로써 얻어진 신규한 유도체 및 이를 함유하는 제약학적 조성물
JPS6330479A (ja) タキソ−ル誘導体類、それらの製造およびそれらを含有する製薬学的組成物
JP3014761B2 (ja) タキサン誘導体の製造法
JP3085710B2 (ja) バッカチン▲ｉｉｉ▼および１０−デアセチルバッカチン▲ｉｉｉ▼の誘導体類の製造方法
AU2007245085A1 (en) A convergent process for the synthesis of taxane derivatives
JPH07503472A (ja) タキサン誘導体の製造方法
JPH07503477A (ja) バッカチン３および１０‐デアセチルバッカチン３の新規誘導体，それらの製造およびそれらを含有する医薬組成物
JP3633619B2 (ja) β−フェニルイソセリン誘導体の製造法
JPH07504425A (ja) β−フェニルイソセリン及びその類似体の製造法
FI115970B (fi) Menetelmä 7-trialkyylisilyylibakkatiini III:n valmistamiseksi
Qi et al. Efficient synthesis of β-oxoalkyl carbamates from carbon dioxide, internal propargylic alcohols, and secondary amines catalyzed by silver salts and DBU
MXPA06012606A (es) Un metodo facil para sintetizar compuestos de bacatina iii.
LT4186B (en) Processfor the preparation of 7-hydroxy taxanes
El-Kadri et al. Synthesis, structure, properties, volatility, and thermal stability of molybdenum (II) and tungsten (II) complexes containing allyl, carbonyl, and pyrazolate or amidinate ligands
WO2023237651A1 (en) Method for the preparation of a 3,6-dihydro-2h-1,3,4-oxadiazin-2-one
JP2000159757A (ja) ７−デオキシタキソール誘導体の製造方法
JPH06508851A (ja) １３α−シンナモイルバッカチンＩＩＩまたは−１０−デアセチルバッカチンＩＩＩの製造方法
CZ283542B6 (cs) Nové anhydridy kyselin, způsob jejich přípravy a jejich použití
Sekhar et al. Alternative synthesis and the determination of absolute configuration of Docetaxel, an anticancer drug
WO2007137513A1 (fr) NOUVEAU TYPE DE COMPOSÉS 2'-α-HYDROXYALKYL TAXEL ET LEURS PROCÉDÉS DE PRÉPARATION
US9284327B2 (en) Taxane compounds, compositions and methods

Legal Events

Date Code Title Description
GD4A Issue of patent certificate for granted invention patent
MK4A Expiration of patent term of an invention patent