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TW201603805A - 醫藥劑量傳送系統 - Google Patents

醫藥劑量傳送系統 Download PDF

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TW201603805A
TW201603805A TW104120362A TW104120362A TW201603805A TW 201603805 A TW201603805 A TW 201603805A TW 104120362 A TW104120362 A TW 104120362A TW 104120362 A TW104120362 A TW 104120362A TW 201603805 A TW201603805 A TW 201603805A
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胡曼 哈佛茲
葛利葛瑞 慕
歐陽潔儀
羅伯特 達克
瑪利亞 胡藍
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波提亞斯數位康健公司
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Abstract

依據本發明用於傳送劑量的醫藥劑量傳送系統包含一載體組件及一經構形用以密封該載體組件之一內部容積的帽蓋，其中該帽蓋包含一產生一獨特電流特徵的裝置。依據本發明之實施例經製備待傳送的劑量在多樣不同應用中有其用途，此等應用包含臨床試驗。

Description

醫藥劑量傳送系統
本發明大體上關於電子裝置，且更特定言之關於身為利用導電作用交流資訊之一通訊系統之一部分的電子裝置。
依據35 U.S.C.§ 119(e)，本申請案主張2009年1月6日申請之臨時專利申請案序號第61/142,861號之申請日的優先權，該臨時專利申請案的內容以引用的方式併入本文中。
處方藥對於許多患者來說在正確使用時係有效的治療手段。但研究顯示平均有大約50%的患者並未遵循處方藥用藥規則。低比率嚴守用藥規則造成每年有大量的人住院及在家看護。僅只在美國，近來經評估由於患者不聽話而造成的花費每年超過千億美金。
患者聽話與否特別重要的一種情況為臨床研究方面。未能嚴格遵循臨床試驗設定條件的遠程後果遠遠超過可能被捲入試驗中的幾百個患者。在沒有修正係數的情況下發生脫軌的話，其結果可能從輕則無法獲得FDA核可到重則必須將建議劑量提高到超過完全遵守用藥規則之人所需的量。此種經加多的劑量可能導致副 作用發生機率提高，從而可能因此使人更進一步不遵守用藥規則。
臨床研究通常登錄患者進行指定藥物治療手段，目標為測試與藥物治療在醫藥相關臨床終點時之作用有關的假設。此等研究舉例來說可能測量有著眾多不同臨床終點之任一者的交替藥物治療之間的關係，此等測量從生理、生化或心理方面的量測到疾病之表現、患者存活時間或生活品質。此外，藥物治療亦必須與任何觀察所得有害事件建立關聯以盡力辨識稀有有害反應或與其他醫藥之交互作用。
可靠地交互關聯極其特定藥物治療手段(包含劑量及投藥方法)與效力和安全性兩者的能力相當大程度取決於確實知道每位患者已依循處方治療手段。因此，患者聽命程度(包含精確投藥時間)的監控對於臨床試驗主持者以及整體上醫藥產業來說有相當高的價值。
因此，需要一種用於追蹤記錄已投送劑量及投藥時間的系統及方法。
本發明之裝置包含一載體組件及一經構形用以密封該載體組件之一內部容積的帽蓋，其中該帽蓋包含一用電流編碼資訊的通訊裝置。該裝置包含一可攝食的事件標記器或一離子發射模組識別器，其利用通過與該裝置接觸之導電流體的導電作用。本發明之裝置在製備一醫藥劑量方面有其用途。本發明之額外觀點包含依據本發明之方法製備的劑量。依據本發明之實施例製備的劑量在多樣不同應用中有其用途，此等應用包含臨床試驗。
10‧‧‧醫藥劑量載體系統
20‧‧‧帽蓋
30‧‧‧醫藥活性劑錠
35‧‧‧填充組合物
37‧‧‧填充組合物
40‧‧‧裝置
50‧‧‧殼體
60‧‧‧開放端
65‧‧‧接合區
70‧‧‧封閉端
80‧‧‧插入部分
90‧‧‧切除部分
92‧‧‧缺口
94‧‧‧缺口
96‧‧‧缺口
98‧‧‧缺口
130‧‧‧醫藥劑量系統
132‧‧‧包覆式帽蓋
134‧‧‧帽蓋
136‧‧‧裝置
140‧‧‧載體組件
圖1A係一依據本發明之醫藥劑量傳送系統的局部切除正面透視圖，在該傳送系統之外部定位有一電流特徵產生裝置。
圖1B係一依據本發明之醫藥劑量傳送系統的局部切除正面透視圖，在該傳送系統之內部定位有一電流特徵產生裝置。
圖2A係一圖1A醫藥劑量傳送系統的分解透視圖。
圖2B係一圖1B醫藥劑量傳送系統的分解透視圖。
圖3A係一用於依據本發明之圖1醫藥劑量的帽蓋的仰視圖。
圖3B係一圖3A帽蓋的側視圖。
圖3C係一圖3A帽蓋的透視圖。
圖4係一依據本發明具備一包覆式帽蓋之醫藥劑量的剖面圖。
本發明之裝置包含一載體組件及一經構形用以密封該載體組件之一內部容積的帽蓋，其中該帽蓋包含一可攝食的事件標記識別器。本發明之裝置在製備一醫藥劑量方面有其用途。本發明之額外觀點包含依據本發明之方法製備的劑量。依據本發明之各觀點製備的劑量在多樣不同應用中有其用途，此等應用包含臨床試驗。
在更詳細說明本發明時，首先探討本發明之裝置及其製備醫藥劑量之使用方法，然後說明此等方法之用途及其涉及之總成和系統。下文亦更詳細探討實行本發明之方法的套組。
如前所概述，提出用於製備醫藥劑量之裝置及其使用方法。“醫藥劑量”一辭係指含有活性劑之一已知量的實體離散結構，其中該活性劑已知量係在一活性劑投送事件已被選擇用於投送給一受者的活性劑已知量。因此，一醫藥劑量含有一醫藥活性劑(文中亦簡稱為“活性劑”)之一預定量。存在於醫藥劑量內之醫藥活性劑的量係經計算足以在一活性劑投送事件中投送給一受者時產生期望效果。藉由本發明之方法產生的醫藥劑量可具有多種不同組態之任一者。因此，醫藥劑量之形狀可為圓柱形、球形或橢圓形，或是任何其他適宜形狀。尤其是具有大致膠囊組態的醫藥劑量，如下文所將詳述。
本發明之裝置包含一載體組件及一經構形用以密封該載體組件之一內部容積的帽蓋，其中該帽蓋包含一可攝食事件標記識別器。該等裝置之組件可有變化，其中這些組件的不同觀點在下文詳述。
本發明之方法包含用一醫藥活性劑組合物裝填一載體組件然後用一帽蓋密封該載體組件以製成醫藥劑量。該載體組件係一盛裝醫藥活性劑組合物之一量的容器。視醫藥活性劑組合物之特定本質而定(詳見下文)，該載體組件可被構形為用以盛裝多種不同類型之組合物，包含液體及固體，譬如粉末、錠體、有塗層的顆粒組合物、丸體、珠粒及小球。雖說載體經構形用以盛裝的活性劑體積可有變化，在一些案例中，載體可經構形用以盛裝0至1克(譬如0至100毫克且包含0至5毫克)範圍的活性劑量。載體組件可有多種不同組態。載體組件之組態的實例包含但不限於部分盒狀、部分球狀、部分卵狀、部分圓錐狀等。
特別引人注意的一種載體組件組態為部分膠囊組態。部分膠囊組態係具有一第一開放端及一第二封閉端的組態，其中該開放端與封閉端以一足以向該載體組件提供一期望內部容積的距離分隔。適用的部分膠囊組態可有多種不同斷面組態，其中斷面組態係在該開放端由該載體組件之壁界定的形狀。特別引人注意的斷面組態包含但不限於圓形、矩形、三角形、方形及卵形，以及不規則的斷面組態。
本發明之部分膠囊組態載體組件可依期望具有不同尺寸。在一些案例中，載體組件之長度在1公釐至50公釐的範圍內，譬如5公釐至30公釐且包含10公釐至20公釐。載體組件之外徑可有變化，在一些案例中為1公釐至30公釐，譬如5公釐至20公釐且包含5公釐至10公釐。載體組件之內徑亦可有變化，從0.5公釐至29.99公釐，譬如3.0公釐至19.99公釐且包含3.0公釐至9.99公釐。載體組件之壁可有變化，前提是其厚度足以承受醫藥活性劑組合物，在一些案例中壁厚範圍為0.01公釐至2公釐，譬如0.01公釐至0.2公釐且包含0.01公釐至0.1公釐。依期望，此等尺寸在載體組件中可為恆定或可變。舉例來說，內徑可為沿著膠囊長度為恆定或者可有變化。
本發明之載體組件譬如部分膠囊組態的載體組件可為利用任何適宜手段由任何適宜材料製成。可用來製造載體組件的材料包含用於習知醫藥膠囊劑量的生理可接受聚合材料。此等材料可為透明或不透明的，且依期望可為有色的。當中尤其令人注意的是剛性材料及彈性材料二者。
適於製造本發明載體組件的合適聚合物包含但不限 於：明膠類，聚乙烯醇(PVA)；天然及合成多醣類，包含支鏈澱粉、紅藻膠、三仙膠、聚葡萄胺糖洋菜膠類，及纖維素材料類，譬如羧甲基纖維素、羥丙基甲基纖維素(HPMC)、甲基纖維素、羥乙基纖維素、羥乙基甲基纖維素、羥丙基纖維素；聚乙二醇類(PEGs)，聚乙烯氧化物類(PEOs)、PEG與PEO之聚合物；丙烯酸及甲基丙烯酸基聚合物類，譬如EUDRAGIT ETM、EUDRAGIT LTM及/或EUDRAGIT STM甲基丙烯酸聚合物類、EUDRAGIT RLTM及/或EUDRAGIT RSTM甲基丙烯酸銨共聚物類；普維酮(聚乙烯氫吡咯酮)、聚乙二醇化甘油酯類(譬如GELUCIRE 44/14TM、GELUCIRE 50/02TM、GELUCIRE 50/13TM及GELUCIRE 53/10TM聚合物類)；羧乙基聚合物類(譬如CARBOPOLTM聚合物類)；聚氧乙烯-聚氧丙烯共聚物類(譬如POLOXAMER188TM聚合物)；及類似物。
載體組件的表面可為平滑的或係由設置成任何圖案的崎嶇及/或溝槽組成。在期望情況，載體組件具有隔間或隔板。載體組件可有多個隔間，致使每一隔間具有不同的活性劑釋放特性，或是含有不同的醫藥活性劑組合物，例如像美國專利第4,738,724號、5,672,359號及5,443,461號所述，該等專利之內容以引用的方式併入本文中。
載體組件可為利用任何適宜手段製造，包含模塑等。製造手段包含但不限於美國專利第5,705,189號、4,576,284號、4,591,475號、4,655,840號、4,738,724號、4,738,817號及4,790,881號所揭示者，該等專利之內容以引用的方式併入本文中。另一選擇，載體組件可為取自販售商譬如Qualicaps Inc.,Whitsett NC。
在本發明的方法中，該載體組件可裝有多種不同類型 的醫藥活性劑組合物。用以裝填該載體組件的協定可因醫藥活性劑組合物的本質而異。舉例來說，可流動的組合物譬如液體及固體(微粒及小球組合物為可流動固體之實例)可被傾注到該載體組件之內部空間內，不管是手動進行、使用一自動化裝置或是二者之組合，以便用該醫藥活性劑組合物裝填該載體組件。不可流動的固體譬如錠體或膠囊可被定位在載體組件之內部容積以內，同樣不管是手動進行、使用一自動化裝置或是二者之組合，以便裝填該載體組件。
如前所述，該醫藥活性劑組合物可為固體或液體組合物。所述固體組合物包含但不限於：粉末、丸體(例如呈小珠或小球之形式)、有塗層的顆粒及錠體。所述液體組合物可為多樣，例如在黏度、顏色等方面有所變化。本發明之醫藥活性劑組合物包含一醫藥活性劑，其係單獨存在或係與一賦形劑組合，其中該賦形劑可包含一或多種不同組份，譬如填充物、黏合劑、著色劑等。
在本文中，“活性劑”一辭包含會在與一活體譬如人類接觸後產生一生理效果例如一有利或有用效果的任何化合物。活性劑可有別於此等賦形劑組份譬如填充物、黏合劑、著色劑等。活性劑可為能夠調整一活受體內之一生物程序的任何分子。在一些案例中，活性劑可為一用於診斷、治療或疾病防制或是當作一藥物之一組份的物質。所述活性劑之廣泛類型包含但不限於：心血管用劑類；痛覺舒緩劑類例如止痛藥類、麻醉藥類、抗炎劑類等；作用於神經的劑類；化療(例如抗腫瘤)劑類等。所述活性劑類進一步揭示於經公開為WO 2006/116718號之PCT專利申請案第US2006/016370號，其完整內容以引用的方式併入本文中。
醫藥活性劑組合物可如前所述進一步包含一賦形劑 組份，賦形劑組份可包含一或多種成分，包含但不限於填充物、黏合劑、崩解劑、著色劑等。所述賦形劑組份進一步見於經公開為WO 2006/116718號之PCT專利申請案第US2006/016370號，其完整內容以引用的方式併入本文中。可存在於本發明之組合物中的組份的額外說明可見Remington’s Pharmaceutical Sciences,Mace Publishing Company,Philadelphia,Pa.,17th ed.(1985)。
在一些案例中，該等方法可包含在該載體組件中提供一獨立於該活性劑組合物之填充組合物。舉例來說，在一些案例中，該載體組件被裝填有一醫藥活性劑組合物及一不同填充組合物，其中該填充組合物可因多種不同目的而被包含。一種所述填充組合物係向醫藥劑量組合物賦予一大於胃液之密度的填充物。據此，所述填充組合物係向醫藥劑量組合物賦予一大於0.8或更高、譬如1.0或更高且包含1.2或更高之密度的填充物。任何適宜材料可用作填充組合物，包含以上所述用作賦形劑組份的材料。
填充物亦可為被包含用以在一裝置或識別器譬如一可攝食事件標記(IEM，其亦被稱為離子發射模組)識別器被放在載體組件內時填滿所出現的任何閒置空間。劑量之識別器組件提供許多好處。識別器的存在允許吾人監測投藥之精確時間及頻率還有患者反應。這些可藉由本發明之方法及劑量之使用而獲得的資訊可被用在許多背景中，例如用來提升臨床研究之整體品質和精度。利用此資訊，吾人可輕易地認出遵守治療規則的臨床試驗對象並排除不守規則的人以便獲得關於一已知活性劑之功效的更精準資料。此資訊亦可與各種生理資料組合以便獲得關於一已知活性劑之效果的更詳盡資料。
本發明之方法亦尋得與藥劑師之用途，藥劑師可製備包含一IEM的患者客製劑量，即便所述活性劑之原始生產者不提供包含一IEM之劑量。IEM係一種經訂定尺寸為可攝食的裝置，且包含一導電率控制模組及一在與導電流體接觸之後變完整的部分電源。由於IEM被訂定尺寸為可攝食的，其大小係被訂為可放入人嘴中被吞嚥。在一些案例中，本發明之IEM的最大尺寸為30公釐或更小，例如20公釐或更小，包含5公釐或更小。因此，當今可取得的任何醫藥組合物可利用本發明之方法及組件與一IEM建立關聯。
在將醫藥活性劑組合物(及依期望之任何任選填充組合物)放入載體組件之內部容積內後，隨後用一帽蓋密封所得已裝填載體組件。帽蓋係一經構形以與一載體組件之開放端匹配成一密封關係的結構物，致使當帽蓋與載體組件之開放端建立關聯時，該載體組件之一內部容積及其內容物(醫藥活性劑組合物)被密封阻絕於由該載體與帽蓋界定之劑量結構之外界環境，致使氣體和液體無法輕易地在該劑量結構的內外環境之間通過。帽蓋可由任何適當材料製成，包含以上關於載體組件所述之材料。在一些案例中，帽蓋係由微晶體纖維素、交聯羧甲基纖維素鈉及硬脂酸鎂。
本發明之帽蓋包含一或多個IEM識別器。該一或多個IEM識別器可存在於帽蓋之多種不同位置，包含內部位置及外部位置。內部位置包含界定於帽蓋內側且經構形用以收納IEM的區域。外部位置包含外表面及內表面。帽蓋之外表面為當帽蓋與載體組件處於一密封關係時面向帽蓋之外界環境的表面。外表面依期望可為帽蓋之一側表面或是帽蓋之一頂表面。帽蓋之內表面為當帽蓋與載體組件處於一密封關係時面向由載體組件及帽蓋界定之內部容積的 表面。一給定帽蓋可包含單一個IEM或是二或更多個IEM，譬如三個或更多個可攝食事件標記器。
該一或多個IEM與帽蓋穩定地相關。因此，該等識別器例如藉由使用一黏著劑而被固定在帽蓋之一位置，譬如帽蓋之一外表面。所述黏著劑包含但不限於：糖及纖維素黏著劑，蛋白質黏著劑譬如玉米蛋白或酪蛋白，聚矽氧黏著劑，聚合物黏著劑、包含丙烯酸及甲基丙烯酸黏著劑，蟲膠，及類似物。
所述IEM為在IEM與一(或多個)目標生理位置接觸後經由一獨特電流特徵之生成來聯絡資訊的識別器，該獨特電流特徵流過一導電環境，譬如一導電流體。IEM可因特定實施例及組合物之預期應用而異，前提是其在與一目標生理位置譬如胃液或腸液接觸後會被激活(起動)。因此，IEM可為一當在一目標部位被激活、例如當IEM接觸一目標身體部位時會產生一經編碼有資訊之獨特電流特徵的識別器。IEM可為能夠在激活後提供一可偵測信號的任何組件或裝置。依據本發明之各觀點的IEM包括一用於產生一獨特電流特徵的控制單元。IEM可經構形為一旦組合物與一生理目標部位發生接觸時產生獨特電流特徵。視實施例而定，目標生理部位或位置可有變化，其中代表性目標生理部位包含但不限於胃腸道中之一位置，譬如嘴、食道、胃、小腸、大腸等。IEM可被構形為在與目標部位之流體譬如胃液接觸後即被激活，與目標部位之特定組合物無關。必要時，識別器可經構形為在組合物與一目標生理部位接觸後被詢問激活。IEM可經構形為在一段指定時間長度之後被激活，其中目標部位係在一段指定時間長度之後抵達。
視一特定應用之需求而定，從IEM取得的資訊可為 一般的，致使該資訊僅確認組合物已接觸目標部位。另一選擇，該資訊可為獨特的，其以某些方式獨特地從一批劑量中之一群或複數個不同標記器當中確認一特定IEM已接觸一目標生理部位。因此，IEM可為當與一批劑量搭配使用時會發出一電流特徵的IEM，其電流特徵係無法與該批之任一其他劑量構件之IEM所發出的電流特徵區別。另一選擇，該批之每一IEM可發出一獨特信號，至少係相對於該批之所有其他IEM。在此等案例中，該批之每一IEM產生一電流特徵，其相對於該批中所有其他IEM獨特地表明該特定IEM。 IEM可發出一係一普及獨特電流特徵的獨特電流特徵(其中此一電流特徵可能類似於人的指紋，其與任一其他個體之任一其他指紋不同且因此在一普及水準上認出一個體)。電流特徵可為直接輸送關於一給定事件的資訊或是提供一識別碼，此識別碼可用於從一資料庫(亦即一鏈結識別碼與組合物)擷取關於事件之資訊。
IEM之電流產生期的持續時間可有變化，依據本發明之教示，從0.1微秒至48小時或更久，譬如從0.1微秒至24小時或更久，譬如0.1微秒至4小時或更久，譬如1秒至4小時，包含1分鐘至10分鐘。視給定實施例而定，IEM可產生編碼於該電流特徵中的相同資訊一次；另一選擇，IEM可經構形以產生具有相同資訊之電流特徵二或更多次，其中離散相同電流特徵之集合可被統稱為冗餘信號。
除了產生一獨特電流特徵，依據本發明之其他觀點，IEM可經構形以產生多種不同類型之信號，其包含但不限於：RF信號，磁信號，音波信號等。
IEM可因特定實施例及組合物之預期應用而異，前提 是其會在與一目標生理位置譬如胃接觸後被激活(亦即起動)。IEM包含一由一導電流體譬如胃酸變完整的部分電源，及一導電率控制單元。不同類型之IEM的實例包含但不限於揭示於下列文獻者：PCT申請案第PCT/US2006/016370號，其被公開為WO/2006/116718號；PCT申請案第PCT/US2007/082563號，其被公開為WO/2008/052136號；PCT申請案第PCT/US2007/024225號，其被公開為WO/2008/063626號；PCT申請案第PCT/US2007/022257號，其被公開為WO/2008/066617號；PCT申請案第PCT/US2008/052845號，其被公開為WO/2008/095183號；PCT申請案第PCT/US2008/053999號，其被公開為WO/2008/101107號；PCT申請案第PCT/US2008/056296號，其被公開為WO/2008/112577號；PCT申請案第PCT/US2008/056299號，其被公開為WO/2008/112578號；PCT申請案第PCT/US2008/077753號；及2009年9月21日申請之美國專利申請案第12/564,017號，該等專利申請案之內容以引用的方式併入本文中。
該帽蓋可有多種不同組態，前提是其經構形為當其與載體組件之開放端建立關聯時密封該載體組件之開放端。帽蓋可有多種不同組態，允許其當其與載體組件之開放端建立關聯時密封該載體組件之開放端。在一些案例中，帽蓋具有聯鎖元件，此等聯鎖元件搭配載體組件之開放端之匹配元件操作以密封載體組件之開放端。聯鎖元件的實例為螺桿螺紋及扣接配合元件。另一選擇，帽蓋可有一區或端經構形以壓入配合載體組件之內側且密封載體組件之內容物。此種組態之一實例為其中帽蓋具有一由剛性材料建構的末端，其中該端之組態略大於載體組件之開放端。在載體組件之開放 端係由一彈性體材料製成的情況，帽蓋之剛性端可藉由拉伸載體之開放端而被壓入配合至載體之開放端內。當任何拉伸力自載體之開放端移除時，載體之開放端隨後會順應帽蓋之剛性端成密封關係。另一選擇，帽蓋可包含一具有某種程度之柔性的可壓縮端。此柔性足以向帽蓋賦予藉由壓縮該可壓縮端產生一壓縮端、將該帽蓋壓縮端放入載體組件開放端內然後移除壓縮力而使帽蓋之柔軟端壓入配合至載體組件之開放端內的能力。當該壓縮端因壓縮力之移除而膨脹時，該壓縮端成一密封關係順應載體組件開放端之組態以將載體組件之內容物密封在載體組件內。
一具有可壓縮端的帽蓋可以多種不同方式提供。一種可壓縮端係一由可壓縮材料製成的末端。所述可壓縮材料為柔性的。另一選擇，該可壓縮端可包含向該可壓縮端提供可壓縮能力的一或多個缺口。
需要時，帽蓋可用一黏著劑固定於載體組件之開放端，合適黏著劑的實例如前所述。因此，帽蓋可被膠黏至載體組件之開放端上以便密封載體組件開放端。
在一些實例中，於載體及/或帽蓋中提供通道或類似結構，此等通過促進劑量形式之液體穿透、載體組件之溶解且/或減低劑量形式之浮力。此等孔若存在則其直徑可為10-3公釐至5公釐，譬如0.1公釐至2公釐。
今參照圖1A和2A，一醫藥劑量載體系統10包含一帽蓋20及殼體或殼體50。系統10之殼體50界定一腔穴且包含一開放端60及一封閉端70。封閉端70有一部分平坦的底座，有側壁從該底座以一向上方向延伸，在開放端60以一開口終結以於其內界 定該腔穴。封閉端70亦可為一圓邊結構，譬如一半球形端壁，還有其他組態，且有一圓錐形組態等。
系統10在殼體50之內壁上包含一接合區65。當帽蓋20以一足以在殼體50與帽蓋20之間產生一密封的方式插入殼體50之開放端60內時，接合區65可與帽蓋20接合。帽蓋20及殼體50的尺寸經選擇致使帽蓋20之外壁與殼體50之接合區65之內壁之間發生接觸。
如前所述，系統10可被裝填一醫藥活性劑組合物及/或一填充組合物。依據本發明之一觀點，系統10被裝填呈錠體之形式的一種醫藥活性劑組合物及兩種填充組合物。因此，殼體50被裝填一種醫藥活性劑錠30及兩種填充組合物35和37。儘管在殼體50所界定的腔穴內以一特定順序顯示，本發明之範圍不受錠體30及填充組合物35和37之相對位置或順序限制。舉例來說，錠體30可如圖1A所示被定位在填充組合物37的位置。此外，錠體30及填充組合物35和37的方位可被翻轉以更好地配合系統10之組裝，如圖1B和2B所示，且本發明之範圍不限於此。填充組合物35和37之至少一者係由一會對整個系統10賦予一密度的材料製成。依據本發明之一觀點，該密度可為大於系統10所進入或被導入之環境譬如胃液之密度。因此，填充組合物35和37之任一者可被用來改變系統10之浮力，另一個填充組合物可被用來阻止錠體30及另一填充組合物在殼體50所界定之腔穴內發生移動。依據本發明之另一觀點，填充組合物二者皆可被用於改變系統10之浮力。依據本發明之教示，填充組合物之任一者可被換成一醫藥製劑，致使系統10包含兩種(或更多種)不同醫藥活性劑，其在不同時間或相同時間釋入周遭 環境內。
今參照圖1A和1B，在組裝系統10時，醫藥活性劑譬如錠體30及兩種填充組合物35和37如圖所示被定位在殼體50內。此定位步驟可為手動完成或藉由自動化方法完成，譬如經由一組裝機、遠端機器人、或其他自動化裝置的使用完成。在將錠體30及填充組合物35和37放入殼體50內後，用帽蓋20密封殼體50之開放端60以密封系統10。利用帽蓋20密封殼體50之開放端60可為手動完成或藉由自動化方法完成，譬如經由一組裝機、遠端機器人、或其他自動化裝置的使用完成。
如圖1A和2A所示，由殼體50界定且容納錠體30及填充組合物35和37的腔穴由帽蓋20密封。帽蓋20可被壓入配合至殼體50之開放端60之內側。依據本發明之另一觀點，帽蓋20可被膠黏至接合區65。
今參照圖1A和2A，帽蓋20在其一頂部外表面上包含一裝置40譬如IEM。裝置40經由一適當固定方法的使用而被固定在帽蓋20之上表面。舉例來說，依據本發明之一觀點，裝置40利用一適當黏著劑膠黏至帽蓋20。另一選擇，如圖1B和2B所示，裝置40可係固定於帽蓋20之一底部內表面，致使當帽蓋20被定位在殼體50之腔穴內時，裝置40被密封於其內且受保護不與系統10所進入之周遭環境接觸，直到帽蓋20脫離殼體50。
依據本發明之另一觀點，裝置40包含一如PCT申請案第PCT/US2008/077753號中揭示之虛擬偶極元件，該申請案之內容以引用的方式併入本文中。依據本發明之另一觀點，裝置40為肉眼不可見。
今參照圖1A及2A，如前所述，帽蓋20包含一塞入殼體50之開放端60內的插入部分80。插入部分80係與裝置40所在表面相對。如圖所示，插入部分80界定至少一切除部分90，該切除部分允許插入部分80被塞入開放端60內。開放端60可為可展延的以張開並壓力配合至插入部分80上並提供一牢固配合。因此，帽蓋20可經捏夾以在用於將插入部分80密封於開放端60內時塞入殼體50之開放端60內。
今參照圖1B和2B，如前所述，帽蓋20包含一塞入殼體50之開放端60內的插入部分80。插入部分80被定位在帽蓋20之底部表面附近。帽蓋20之底部表面經塑形以接納被定位並固定在該底部表面上的裝置40。如圖所示，插入部分80界定複數個切除部分90，該等切除部分允許插入部分80塞入開放端60內。但本發明之範圍不受帽蓋20底部表面之形狀或其上之切除部分數量限制。開放端60可為可展延的以張開並壓入配合至插入部分80上並提供一牢固配合。另一選擇且依據本發明之另一觀點，開放端60可為剛性且為錐形(圖中未示)以匹配地接納帽蓋20之一錐形插入部分(圖中未示)，其中該錐形部分或開放端60與帽蓋20之錐形插入部分被膠黏在一起。因此，帽蓋20可被壓入並膠黏至殼體50之開放端60內以使帽蓋20固定於殼體50。
今參照圖3A、3B及3C，帽蓋20包含插入部分80。依據本發明之一觀點，插入部分80界定四個通道或缺口92、94、96及98。每一缺口具有一近似弦月之形狀，如圖所示。然缺口92、94、96及98可具有促進帽蓋20塞入開放端60內之任何合適形狀，例如多邊形形狀。如圖所示，帽蓋20之插入部分80包含一周向環 狀斜邊脊部。
在一些案例中，固定於殼體50之末端的帽蓋20可被一包覆式帽蓋組件覆蓋。該包覆式帽蓋組件可由多樣材料製造，譬如用於載體組件的任一材料。該包覆式帽蓋可由一不透明材料製造以便隱藏裝置40之存在並且避免在打包及處理期間與周遭環境接觸。該包覆式帽蓋組件可為彈性體的，例如藉此在與載體組件處於密封關係的帽蓋上方提供一牢固配合。
今參照圖4，依據本發明之另一觀點，一醫藥劑量系統130包含一包覆式帽蓋132。醫藥劑量系統130包含一利用一帽蓋134密封的載體組件140。帽蓋134在其一外表面上包含一裝置136譬如一電流特徵產生裝置或IEM。包覆式帽蓋132被定位在帽蓋134上方。包覆式帽蓋132如圖所示固定於載體組件140，這在醫藥劑量系統130被攝食時防止裝置136與導電流體之間發生接觸。一旦包覆式帽蓋132脫離載體組件140，裝置136即與周遭環境發生接觸，且若該環境包含一導電流體譬如胃液，則裝置136被激活並產生一可被偵測及解碼以擷取資訊的電流特徵。
若需要，製備劑量傳送系統的方法可進一步包含製備安慰劑醫藥劑量。安慰劑醫藥劑量可依一類似於包含一醫藥活性劑之劑量之製備的方式製備，差別在於不將醫藥活性劑放入載體組件內。取而代之係將一沒有活性劑(例如如前所述)的賦形劑組合物放入載體組件內然後用帽蓋密封。製備安慰劑劑量的方法包含欲將醫藥劑量用於臨床試驗的方法。
依據本發明之更另一觀點，製備一劑量傳送系統的方法可進一步包含製備在載體內有一裝置的劑量，舉例來說其係單獨 使用或搭配一填充物使用。此等觀點除了其他應用更可經由一獨特電流特徵之產生促進劑量傳送系統之一攝食事件之標記。
依據本發明之另一觀點，可將兩種不同的藥劑放入殼體50內並用一填充組合物分隔。此種實體分隔在不同藥劑必須在溶液中混合才會起作用的案例中為有利。因此，當殼體50被溶解時，兩種獨立藥劑被釋入周遭流體譬如胃液內。這導致兩種原本分開的藥劑發生接觸並結合，藉此允許兩種不同藥劑精準傳送至一目標部位並組合。
本發明之觀點進一步包含使用依據前述方法製造之醫藥劑量的方法。整體而言，本發明之方法會包含將一或多個醫藥劑量投送給一受者，例如使一受者攝食本發明之醫藥劑量。該等劑量可被投送給許多不同類型的受者。一般而言這些受者是“哺乳類動物”，此辭係用來廣泛地描述在哺乳類動物範圍內的生物，包含食肉動物(例如狗和貓)、齧齒動物(例如小鼠、天竺鼠及大鼠)、以及靈長動物(例如人類、猩猩及猴子)。在攝食後，一獨特電流特徵由IEM產生且例如被一接收器偵測，例如見下列文獻：PCT申請案第PCT/US2006/016370號，其被公開為WO/2006/116718號；PCT申請案第PCT/US2007/082563號，其被公開為WO/2008/052136號；PCT申請案第PCT/US2007/024225號，其被公開為WO/2008/063626號；PCT申請案第PCT/US2007/022257號，其被公開為WO/2008/066617號；PCT申請案第PCT/US2008/052845號，其被公開為WO/2008/095183號；PCT申請案第PCT/US2008/053999號，其被公開為WO/2008/101107號；PCT申請案第PCT/US2008/056296號，其被公開為WO/2008/112577號；PCT申請案第 PCT/US2008/056299號，其被公開為WO/2008/112578號；PCT申請案第PCT/US2008/077753號；2009年10月13日申請之美國專利申請案第61/251,088號；及及2009年12月15日申請之PCT專利申請案第PCT/US2009/068128號，該等專利申請案之內容以引用的方式併入本文中。
製備醫藥劑量並將其投送給例如如前所述之受者的方法在許多不同應用有其用途。一種應用為利用該等劑量之識別器當作IEM。本發明之醫藥劑量可用於治療及非治療應用，例如見於下列文獻：PCT申請案第PCT/US2006/016370號，其被公開為WO/2006/116718號；PCT申請案第PCT/US2007/082563號，其被公開為WO/2008/052136號；PCT申請案第PCT/US2007/024225號，其被公開為WO/2008/063626號；PCT申請案第PCT/US2007/022257號，其被公開為WO/2008/066617號；PCT申請案第PCT/US2008/052845號，其被公開為WO/2008/095183號；PCT申請案第PCT/US2008/053999號，其被公開為WO/2008/101107號；PCT申請案第PCT/US2008/056296號，其被公開為WO/2008/112577號；PCT申請案第PCT/US2008/056299號，其被公開為WO/2008/112578號；及PCT申請案第PCT/US2008/077753號，該等專利申請案之內容以引用的方式併入本文中。
所述應用包含實際傳送到體內之藥劑的自動偵測及辨識，其可為依下述方式完成：(1)監控患者對於處方治療規則之遵守程度；(2)基於患者守規矩的程度修改治療規則；(3)監控患者在臨床試驗中的遵守程度；(4)監控受控物質之使用；及類似方式。這些不同例示應用的每一者在下列文獻中有更詳細敘述：PCT 申請案第PCT/US2006/016370號，其被公開為WO/2006/116718號；PCT申請案第PCT/US2007/082563號，其被公開為WO/2008/052136號；PCT申請案第PCT/US2007/024225號，其被公開為WO/2008/063626號；PCT申請案第PCT/US2007/022257號，其被公開為WO/2008/066617號；PCT申請案第PCT/US2008/052845號，其被公開為WO/2008/095183號；PCT申請案第PCT/US2008/053999號，其被公開為WO/2008/101107號；PCT申請案第PCT/US2008/056296號，其被公開為WO/2008/112577號；PCT申請案第PCT/US2008/056299號，其被公開為WO/2008/112578號；及PCT申請案第PCT/US2008/077753號，該等專利申請案之內容以引用的方式併入本文中。
在某些實施例中，本發明之製造醫藥劑量的方法被用在臨床試驗中。採用本發明之方法及組合物的臨床試驗包含多患者研究，此等研究係為了收集一新醫藥活性劑之安全性及效力資料而進行。臨床試驗的實例包含研究者在初期召集健康的志願者及/或患者進行小規模前導研究然後在患者中進行較大規模研究的研究，其通常比較新產品與一當前指定的治療方案。此外，臨床試驗亦可比較所述活性劑與一安慰劑組合物。在這些案例中，安慰劑可依一類似於本發明製造醫藥劑量之方法的方式製備，差別在於不將醫藥活性劑組合物密封於載體組件內。當在一給定臨床試驗中收集到正面的安全性及效力資料，可增加患者之數量。臨床試驗的規模可從一個國家中的單一中心試驗至多個國家中的多中心試驗。
使用依據本發明製備之醫藥劑量進行臨床試驗提供許多好處。其一為臨床試驗管理者(運作此臨床試驗的人)可使用 標準載體組件及帽蓋且依一給定醫藥活性劑組合物之需求訂製這些東西。
本發明亦提出包含一或多個如前所述之本發明醫藥劑量的系統。除了本發明的醫藥劑量，該系統可包含與身體有關聯的信號接收器以偵測代表從依據本發明之教示之醫藥劑量載體收到的編碼資訊之電壓電位的變化。所述與身體有關聯的接收器包含見於下列文獻者：PCT申請案第PCT/US2008/052845號，其被公開為WO/2008/095183號；及PCT申請案第PCT/US2006/016370號，其被公開為WO/2006/116718號，該等申請案的內容以引用的方式併入本文中。如此等相關申請案所述，接收器可被植入患者之體表上。該等系統可進一步包含額外的資料中繼及/或處理組件，譬如無線通信裝置(譬如行動電話)；如可在電腦及資訊系統中找到的資料處理器等。
本發明亦提出用於實行所述方法的套組。套組可包含一或多個如前所述之本發明載體組件及相關帽蓋。套組之載體組件及相關帽蓋會經配備以接收內有密封的一或多種醫藥活性劑組合物之劑量；譬如醫藥活性劑組合物係獨立於所述套組提供。必要時，套組亦可包含一或多個填充組合物。一給定套組可包含足夠的載體組件及帽蓋以製作1或更多、包含5或更多、譬如50或更多、100或更多、1000或更多、5000或更多、或10000或更多的醫藥劑量。
所述套組亦可包含如何利用套組之組件實行本發明之方法的使用指南。使用指南可被記錄在一適當記錄媒體或基體上。舉例來說，使用指南可為印在一基體譬如紙或塑膠等上。因此，使用指南可作為一包裝插入物、套組或其組件之容器之標籤(亦即伴 隨著包裝或次包裝)出現在套組中。在其他實施例中，使用指南係以存在於一適當電腦可讀儲存媒體譬如CD-ROM、磁碟上的電子儲存資料檔案存在。在更其他實施例中，實際的使用指南不存在於套組內，但提供從一遠端源例如經由網際網路獲取使用指南的手段。此實施例之一實例為一包含一網址的套組，吾人可自該網址瀏覽及/或下載使用指南。關於使用指南，此種獲取使用指南的手段係記錄在一適當基體上。
所述套組之一些或所有組件可被打包於適當包裝內以維持無菌。必要時套組之組件係被打包在一套組容納元件內以造出單一易取單元，其中該套組容納元件可為一箱子或類似結構且可以是或不是氣密容器。
應理解到本發明不侷限於所述特定實施例，因為其可有變化。亦應理解到文中所述用語僅係為了描述特地特定實施例，且非意欲設限，因為本發明之範圍將由隨附申請專利範圍限制。
在提出數值範圍時，應理解到除非文中另有明確說明，否則所述範圍上限與下限之間的任何居間數值(至下限之單位的十分之一)及所述範圍中之任何其他明述或居間數值皆涵蓋於本發明內。這些較小範圍的上限及下限可被獨立地包含在此等較小範圍中且同樣在本發明之內，依循所述範圍中之任何指定排他限制值。在所述範圍包含這些極限值之一或二者時，除此等內含極限值之任一者或二者的範圍亦被包含在本發明之內。
除非另有定義，文中所述所有技術性及科學性術語均具有如熟習本發明所屬技藝之人熟知的相同意思。儘管任何類似或等效於文中所述的方法及材料亦可用於本發明之實行或測試，代表 性範例方法及材料如本文所述。
本說明書引用之所有公開案及專利均視同每一個別公開案或專利經明確且個別地表示以引用的方式併入本文中以揭示及明述與所引用公開案有關之方法及/或材料。任何公開案的引用係針對其等在申請日之前的內容且不應解釋為認可本發明未經標明先於此等本質為習知發明的此等公開案。再者，文中提供之公開日期可能異於實際公開日期，這可能需要單獨確認。
應理解到在本說明書及申請專利範圍項中，除非文中另有明確敘述，否則單數形“一”及“該”包含複數個指述對象。更應理解到申請專利範圍項可能經起草以排除任何選用元素。因此，此聲明係欲當作諸如“僅只”、“僅有”及類似排他性用語在與申請專利範圍元素之列舉有關時的使用或“負面”限制的使用之先述基礎。
文中某些範圍已用在數值之前加上“約”字的方式呈現。“約”字係用來為其後精確數字以及靠近或近似所述數字的數字提供字義支援。在判定一數字是否靠近或近似一明確敘述數字時，靠近或近似的未明述數字可為在其出現的內容當中會提供該明確敘述數字之實質等效的數字。
熟習此技藝者在閱讀本說明書之後會理解到，文中所提每一個別實施例具有離散組件和特徵，這些組件和特徵可輕易地從其他幾個實施例之任一者的特徵分開或與其他幾個實施例之任一者的特徵結合而未脫離本發明之範圍或精神。任何明述方法可依文中所述事件順序或是依邏輯上可行之任何其他順序執行。
儘管以上為方便理解已藉由範例和實例詳細說明本 發明，熟習此技藝者從本發明之教示可輕易理解到可對本發明進行某些變化和修改而未脫離隨附申請專利範圍項之精神或範圍。
10‧‧‧醫藥劑量載體系統
20‧‧‧帽蓋
30‧‧‧醫藥活性劑錠
35‧‧‧填充組合物
37‧‧‧填充組合物
40‧‧‧裝置
50‧‧‧殼體
60‧‧‧開放端
65‧‧‧接合區
70‧‧‧封閉端
80‧‧‧插入部分
90‧‧‧切除部分

Claims (53)

  1. 一種用於追蹤傳送參數的醫藥傳送系統，該系統包含：一具有一封閉端及一開放端的載體殼體，其中該載體殼體界定一腔穴；一定位於該載體殼體之腔穴內的藥劑；及一包括一封閉端及一開放端的帽蓋，其中該帽蓋的開放端包含一密封部分，該密封部分與該載體殼體之開放端處於實體聯繫關係以密封容納該藥劑之該腔穴；及一與該系統相關的裝置，其中該裝置產生一可辨識導電性傳輸電流信號(identifiable conductively transmitted current signal)以聯絡資訊；其中該裝置包含：一導電率控制模組，用於產生代表該資訊之導電性傳輸電流信號；及一在與一導電流體接觸之後變完整的部分電源，且其中該導電性傳輸電流信號流過該導電流體，且其中該裝置係固定於該帽蓋的一封閉部分致使該裝置能夠在該載體殼體與周遭環境發生接觸時與周遭環境發生接觸。
  2. 如申請專利範圍第1項所述之系統，其中該封閉部分界定至少一通道，該通道用於讓該帽蓋塞入該載體殼體之開放端內以密封該腔穴且其中該至少一通道允許該帽蓋被壓入配合至該載體殼體之開放端內。
  3. 如申請專利範圍第1項所述之系統，其中該密封部分利用一黏著劑固定於該載體殼體之開放端。
  4. 如申請專利範圍第1項所述之系統，進一步包含一固定部分，其被機械地固定於該載體殼體之開放端。
  5. 如申請專利範圍第1項所述之系統，其中該部分電源包含：一電耦接至該導電率控制模組的第一材料；及一電耦接至該導電率控制模組的第二材料，其中該第一材料及該第二材料藉由一不導電材料分隔且經選擇以在與該導電流體發生接觸時產生一電壓電位。
  6. 如申請專利範圍第1項所述之系統，其中該部分電源在該第一材料及該第二材料透過一與之接觸的導電流體電耦接時產生一電壓電位，且該電壓電位被用以激活該導電率控制模組以產生該可辨識導電性傳輸電流信號。
  7. 如申請專利範圍第1項所述之系統，其中該裝置被固定於該帽蓋的封閉端致使該裝置在該載體殼體與該導電流體發生接觸之大約同時與該導電流體發生接觸，且因此該裝置在與該導電流體接觸後被激活。
  8. 如申請專利範圍第1項所述之系統，其中該裝置被固定於該帽蓋的封閉端且其中該載體殼體進一步包含一被定位在該帽蓋之封 閉端上方的包覆式帽蓋，致使該包覆式帽蓋在其溶解之前阻止該導電流體與該裝置接觸，這導致該載體殼體之導入環境之時間與該導電率控制模組之激活之間的一延遲，且藉此延遲該可辨識導電性傳輸電流信號之產生。
  9. 如申請專利範圍第1項所述之系統，其中該裝置被固定於該帽蓋之開放端致使該裝置在該帽蓋脫離該載體殼體之後與周遭環境發生接觸，且藉此延遲該裝置產生該可辨識導電性傳輸電流信號。
  10. 如申請專利範圍第1項所述之系統，其中該帽蓋在該開放端包含一錐形部分且該載體殼體在該開放端包含一錐形部分，致使該等錐形部分公母匹配且膠黏在一起，藉此導致該帽蓋被固定於該載體殼體之開放端以密封該腔穴。
  11. 如申請專利範圍第1項所述之系統，其中該帽蓋被機械地塞入該載體殼體之開放端以密封該載體殼體之腔穴。
  12. 如申請專利範圍第1項所述之系統，其進一步包括一定位於該載體殼體之腔穴內的藥劑。
  13. 如申請專利範圍第1項所述之系統，其中該藥劑具有一向該裝置賦予一大於胃液之密度的組合物。
  14. 如申請專利範圍第1項所述之系統，進一步包含一固定部分，其中該裝置被固定於該固定部分的一底端致使在該載體殼體溶解至該帽蓋脫離時該裝置與該導電流體發生接觸藉此造成延遲產生該可辨識導電性傳輸電流信號。
  15. 如申請專利範圍第1項所述之系統，其中該裝置被放在由該載體殼體界定之腔穴內。
  16. 如申請專利範圍第1項所述之系統，其中該載體殼體進一步包含一定位於由該載體殼體界定之腔穴內的填充組合物以阻止該藥劑及該裝置在由該載體殼體界定之腔穴內發生移動。
  17. 如申請專利範圍第1項所述之系統，其進一步包括一定位於由該載體殼體界定之腔穴內的浮力改變設備。
  18. 一種系統，其包含：一具有一封閉端及一開放端的載體殼體，該載體殼體界定一內部容積，其中該開放端進一步包含一在該載體殼體的一內壁上的接合區；一包含一頂端及一底端的帽蓋，其中該底端包含一經構形以耦接該載體殼體的開放端的接合區之插入部分以密封該載體殼體的內部容積，其中當該帽蓋及該載體殼體裝配時該插入部分及該接合區經構形以密封該載體殼體的內部容積，及在該帽蓋及該載體殼體被攝食後該帽蓋脫離該載體殼體；及 至少一裝置被固定於該帽蓋，其中當該裝置與一電傳導流體(electrically conductive fluid)發生接觸時由於該載體殼體與該傳導流體發生接觸，每一裝置經構形以產生一可辨識電流特徵以聯絡資訊。
  19. 如申請專利範圍第18項所述之系統，其中該帽蓋包含聯鎖元件(interlocking element)，其經構形以在一密封關係(sealing relationship)中操作該載體殼體的開放端的匹配元件(mating elements)。
  20. 如申請專利範圍第19項所述之系統，其中該聯鎖元件係螺桿螺紋，其經構形以將該帽蓋密封接合至該載體殼體。
  21. 如申請專利範圍第19項所述之系統，其中該聯鎖元件係扣接配合元件(snap-fit elements)，其經構形以將該帽蓋密封接合至該載體殼體。
  22. 如申請專利範圍第18項所述之系統，其中該帽蓋的底端經構形以在一密封關係中以壓入配合該載體殼體的封閉端的內側。
  23. 如申請專利範圍第22項所述之系統，其中該帽蓋的底端經構形以壓入配合該載體殼體的開放端內。
  24. 如申請專利範圍第23項所述之系統，其中該帽蓋的底端係由一剛性材料製成，其具有一略大於該載體殼體的開放端的一內直徑之外直徑。
  25. 如申請專利範圍第24項所述之系統，其中該載體殼體的開放端係由一彈性體材料製成。
  26. 如申請專利範圍第18項所述之系統，其中該帽蓋的底端包含一壓縮順應端(compressible compliant end)。
  27. 如申請專利範圍第18項所述之系統，其中該至少一裝置包含：一框架；一導電率控制模組，被固定於該框架且經構形以產生代表該資訊的可辨識電流特徵；一第一材料，被固定於該框架且電耦接至該導電率控制模組；及一第二材料，被固定於該框架且電耦接至該導電率控制模組，其中該第一材料及該第二材料藉由一不導電材料(non-conductive material)分隔且經選擇以在與一導電流體發生接觸時產生一電壓電位。
  28. 如申請專利範圍第18項所述之系統，其中該裝置被固定於該帽蓋的一頂部分。
  29. 如申請專利範圍第18項所述之系統，其中該載體殼體及該帽蓋經構形以接收內有密封的一或多種醫藥活性劑組合物之劑量。
  30. 一種系統，其包含：一具有一封閉端及一開放端的載體殼體，該載體殼體界定一內部容積，其中開放端進一步包含一在該載體殼體的一內壁上的接合區；一定位於藉由該載體殼體所界定之內部容積以改變該載體殼體之浮力的設備；一包含一頂端及一底端的帽蓋，其中該底端包含一經構形以耦接該載體殼體的開放端的接合區之插入部分以密封該載體殼體的內部容積，其中當該帽蓋及該載體殼體裝配時該插入部分及該接合區經構形以密封該內部容積，及在該帽蓋及該載體殼體被攝食後該帽蓋脫離該載體殼體；及至少一裝置被固定於該帽蓋，其中當該裝置與一電傳導流體發生接觸時由於該載體殼體與該傳導流體發生接觸，每一裝置經構形以產生一可辨識電流特徵以聯絡資訊。
  31. 如申請專利範圍第30項所述之系統，其中該帽蓋包含聯鎖元件，其經構形以在一密封關係中操作該載體殼體的開放端的匹配元件。
  32. 如申請專利範圍第31項所述之系統，其中該聯鎖元件係螺桿螺紋，其經構形以將該帽蓋密封接合至該載體殼體。
  33. 如申請專利範圍第31項所述之系統，其中該聯鎖元件係扣接配合元件，其經構形以將該帽蓋密封接合至該載體殼體。
  34. 如申請專利範圍第30項所述之系統，其中該帽蓋的底端經構形以在一密封關係中以壓入配合該載體殼體的封閉端的內側。
  35. 如申請專利範圍第34項所述之系統，其中該帽蓋的底端經構形以壓入配合該載體殼體的開放端內。
  36. 如申請專利範圍第35項所述之系統，其中該帽蓋的底端係由一剛性材料製成，其具有一略大於該載體殼體的開放端的一內直徑之外直徑。
  37. 如申請專利範圍第36項所述之系統，其中該載體殼體的開放端係由一彈性體材料製成。
  38. 如申請專利範圍第30項所述之系統，其中該帽蓋的底端包含一壓縮順應端。
  39. 如申請專利範圍第30項所述之系統，其中該至少一裝置包含： 一框架；一導電率控制模組，被固定於該框架且經構形以產生代表該資訊的可辨識電流特徵；一第一材料，被固定於該框架且電耦接至該導電率控制模組；及一第二材料，被固定於該框架且電耦接至該導電率控制模組，其中該第一材料及該第二材料藉由一不導電材料分隔且經選擇以在與一導電流體發生接觸時產生一電壓電位。
  40. 如申請專利範圍第30項所述之系統，其中該裝置被固定於該帽蓋的一頂部分。
  41. 如申請專利範圍第30項所述之系統，其中該載體殼體及該帽蓋經構形以接收內有密封的一或多種醫藥活性劑組合物之劑量。
  42. 一種系統，其包含：一具有一封閉端及一開放端的可溶解外殼，該可溶解外殼界定一內部容積，其中該開放端進一步包含一在該可溶解外殼的一內壁上的接合區；一包含一頂端及一底端的帽蓋，其中該底端包含一經構形以耦接該可溶解外殼的開放端的接合區之插入部分以密封該可溶解外殼的內部容積，其中當該帽蓋及該可溶解外殼裝配時該插入部分 及該接合區經構形以密封該內部容積，及在該帽蓋及該可溶解外殼被攝食後該帽蓋脫離該可溶解外殼；及至少一裝置被固定於該帽蓋，其中當該裝置與一電傳導流體發生接觸時由於該可溶解外殼與該傳導流體發生接觸，每一裝置經構形以產生一可辨識電流特徵以聯絡資訊。
  43. 如申請專利範圍第42項所述之系統，其中該帽蓋包含聯鎖元件，其經構形以在一密封關係中操作該可溶解外殼的開放端的匹配元件。
  44. 如申請專利範圍第43項所述之系統，其中該聯鎖元件係螺桿螺紋，其經構形以將該帽蓋密封接合至該可溶解外殼。
  45. 如申請專利範圍第43項所述之系統，其中該聯鎖元件係扣接配合元件，其經構形以將該帽蓋密封接合至該可溶解外殼。
  46. 如申請專利範圍第42項所述之系統，其中該帽蓋的底端經構形以在一密封關係中以壓入配合該可溶解外殼的封閉端的內側。
  47. 如申請專利範圍第46項所述之系統，其中該帽蓋的底端經構形以壓入配合該可溶解外殼的開放端內。
  48. 如申請專利範圍第46項所述之系統，其中該帽蓋的底端係由一剛性材料製成，其具有一略大於該載體殼體的開放端的一內直徑之外直徑。
  49. 如申請專利範圍第48項所述之系統，其中該可溶解外殼的開放端係由一彈性體材料製成。
  50. 如申請專利範圍第42項所述之系統，其中該帽蓋的底端包含一壓縮順應端。
  51. 如申請專利範圍第42項所述之系統，其中該至少一裝置包含：一框架；一導電率控制模組，被固定於該框架且經構形以產生代表該資訊的可辨識電流特徵；一第一材料，被固定於該框架且電耦接至該導電率控制模組；及一第二材料，被固定於該框架且電耦接至該導電率控制模組，其中該第一材料及該第二材料藉由一不導電材料分隔且經選擇以在與一導電流體發生接觸時產生一電壓電位。
  52. 如申請專利範圍第42項所述之系統，其中該裝置被固定於該帽蓋的一頂部分。
  53. 如申請專利範圍第42項所述之系統，其中該可溶解外殼及該帽蓋經構形以接收內有密封的一或多種醫藥活性劑組合物之劑量。
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Families Citing this family (59)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8836513B2 (en) 2006-04-28 2014-09-16 Proteus Digital Health, Inc. Communication system incorporated in an ingestible product
US8912908B2 (en) 2005-04-28 2014-12-16 Proteus Digital Health, Inc. Communication system with remote activation
DK1889198T3 (da) 2005-04-28 2015-02-09 Proteus Digital Health Inc Farma-informatiksystem
US8802183B2 (en) 2005-04-28 2014-08-12 Proteus Digital Health, Inc. Communication system with enhanced partial power source and method of manufacturing same
US9198608B2 (en) * 2005-04-28 2015-12-01 Proteus Digital Health, Inc. Communication system incorporated in a container
KR101568660B1 (ko) 2006-05-02 2015-11-12 프로테우스 디지털 헬스, 인코포레이티드 환자 주문형 치료법
SG175681A1 (en) 2006-10-25 2011-11-28 Proteus Biomedical Inc Controlled activation ingestible identifier
US8718193B2 (en) 2006-11-20 2014-05-06 Proteus Digital Health, Inc. Active signal processing personal health signal receivers
US8858432B2 (en) 2007-02-01 2014-10-14 Proteus Digital Health, Inc. Ingestible event marker systems
MY154556A (en) 2007-02-14 2015-06-30 Proteus Digital Health Inc In-body power source having high surface area electrode
US9270025B2 (en) 2007-03-09 2016-02-23 Proteus Digital Health, Inc. In-body device having deployable antenna
EP2124725A1 (en) 2007-03-09 2009-12-02 Proteus Biomedical, Inc. In-body device having a multi-directional transmitter
US8540632B2 (en) 2007-05-24 2013-09-24 Proteus Digital Health, Inc. Low profile antenna for in body device
US8961412B2 (en) 2007-09-25 2015-02-24 Proteus Digital Health, Inc. In-body device with virtual dipole signal amplification
EP3827811A1 (en) 2008-03-05 2021-06-02 Otsuka Pharmaceutical Co., Ltd. Multi-mode communication ingestible event markers and systems
ES2696984T3 (es) 2008-07-08 2019-01-21 Proteus Digital Health Inc Infraestructura de datos de marcadores de eventos de ingestión
EP2313003B1 (en) 2008-08-13 2016-08-03 Proteus Digital Health, Inc. Ingestible circuitry
JP5785097B2 (ja) * 2009-01-06 2015-09-24 プロテウス デジタル ヘルス， インコーポレイテッド 薬学的投薬量送達システム
US9883819B2 (en) 2009-01-06 2018-02-06 Proteus Digital Health, Inc. Ingestion-related biofeedback and personalized medical therapy method and system
GB2480965B (en) 2009-03-25 2014-10-08 Proteus Digital Health Inc Probablistic pharmacokinetic and pharmacodynamic modeling
SG10201810784SA (en) 2009-04-28 2018-12-28 Proteus Digital Health Inc Highly Reliable Ingestible Event Markers And Methods For Using The Same
EP2432458A4 (en) 2009-05-12 2014-02-12 Proteus Digital Health Inc ACCEPTABLE EVENT MARKER WITH SUGAR COMPONENT
TWI517050B (zh) 2009-11-04 2016-01-11 普羅托斯數位健康公司 供應鏈管理之系統
UA109424C2 (uk) 2009-12-02 2015-08-25 Фармацевтичний продукт, фармацевтична таблетка з електронним маркером і спосіб виготовлення фармацевтичної таблетки
SG184494A1 (en) 2010-04-07 2012-11-29 Proteus Biomedical Inc Miniature ingestible device
TWI557672B (zh) 2010-05-19 2016-11-11 波提亞斯數位康健公司 用於從製造商跟蹤藥物直到患者之電腦系統及電腦實施之方法、用於確認將藥物給予患者的設備及方法、患者介面裝置
JP2014504902A (ja) 2010-11-22 2014-02-27 プロテウス デジタル ヘルス， インコーポレイテッド 医薬品を有する摂取可能なデバイス
US9756874B2 (en) 2011-07-11 2017-09-12 Proteus Digital Health, Inc. Masticable ingestible product and communication system therefor
WO2015112603A1 (en) 2014-01-21 2015-07-30 Proteus Digital Health, Inc. Masticable ingestible product and communication system therefor
MX340001B (es) * 2011-07-21 2016-06-20 Proteus Digital Health Inc Dispositivo, sistema y método de comunicación móvil.
US9235683B2 (en) 2011-11-09 2016-01-12 Proteus Digital Health, Inc. Apparatus, system, and method for managing adherence to a regimen
US20130129869A1 (en) 2011-11-23 2013-05-23 Hooman Hafezi Compositions comprising a shelf-life stability component
US8752728B2 (en) 2012-03-26 2014-06-17 Orbital Innovations, Llc Portable, time-release dosage form dispensing assembly
KR20150038038A (ko) 2012-07-23 2015-04-08 프로테우스 디지털 헬스, 인코포레이티드 섭취 가능한 부품을 포함하는 섭취 가능한 이벤트 마커를 제조하기 위한 기술
US11737896B2 (en) 2012-07-31 2023-08-29 Purdue Research Foundation Wirelessly-powered implantable EMG recording system
JP5869736B2 (ja) 2012-10-18 2016-02-24 プロテウス デジタル ヘルス， インコーポレイテッド 通信デバイス用の電源において電力消失およびブロードキャスト電力を適応的に最適化するための装置、システム、および方法
US9610225B2 (en) 2012-12-19 2017-04-04 Otsuka Pharmaceutical Co., Ltd. Medical tablet, and manufacturing method and manufacturing apparatus for medical tablet
JP2016508529A (ja) 2013-01-29 2016-03-22 プロテウス デジタル ヘルス， インコーポレイテッド 高度に膨張可能なポリマーフィルムおよびこれを含む組成物
US10175376B2 (en) 2013-03-15 2019-01-08 Proteus Digital Health, Inc. Metal detector apparatus, system, and method
JP6511439B2 (ja) 2013-06-04 2019-05-15 プロテウス デジタル ヘルス， インコーポレイテッド データ収集および転帰の査定のためのシステム、装置、および方法
US9796576B2 (en) 2013-08-30 2017-10-24 Proteus Digital Health, Inc. Container with electronically controlled interlock
US10084880B2 (en) 2013-11-04 2018-09-25 Proteus Digital Health, Inc. Social media networking based on physiologic information
WO2015154092A2 (en) 2014-04-04 2015-10-08 Towerview Health, Inc. Apparatus and associated methods for tracking and increasing medication adherence for patients
US11051543B2 (en) 2015-07-21 2021-07-06 Otsuka Pharmaceutical Co. Ltd. Alginate on adhesive bilayer laminate film
USD787811S1 (en) 2015-10-06 2017-05-30 Towerview Health, Inc. Tray for a pillbox
USD787812S1 (en) 2015-10-06 2017-05-30 Towerview Health, Inc. Pillbox
RU2711058C1 (ru) 2016-07-22 2020-01-14 Протеус Диджитал Хелс, Инк. Электромагнитное зондирование и обнаружение проглатываемых маркеров событий
IL265827B2 (en) 2016-10-26 2023-03-01 Proteus Digital Health Inc Methods for producing capsules with ingestible event markers
DE202017102645U1 (de) * 2017-05-03 2018-08-06 Romaco Kilian Gmbh Ablaufvorrichtung für Presslinge einer Rundläufer-Tablettenpresse sowie Rundläufer-Tablettenpresse mit Ablaufvorrichtung
CN110785157B (zh) 2017-05-17 2022-11-04 麻省理工学院 自扶正系统及相关组件和方法
US11541015B2 (en) 2017-05-17 2023-01-03 Massachusetts Institute Of Technology Self-righting systems, methods, and related components
CN108814536B (zh) * 2018-03-09 2020-10-09 中北大学 一种用于结肠诊查的可变径履带式机器人机构
WO2019222570A1 (en) 2018-05-17 2019-11-21 Massachusetts Institute Of Technology Systems for electrical stimulation
FR3093419B1 (fr) 2019-03-08 2021-06-18 Univ Grenoble Alpes Composition et procédé associé de mesure de l’observance thérapeutique
KR102344420B1 (ko) * 2019-10-11 2021-12-29 원광대학교산학협력단 확장형 구조를 갖는 위체류 약물전달장치 및 이의 제조 방법
US11485568B2 (en) 2019-12-11 2022-11-01 TW3 Properties LLC Portable, reusable medication dispensing assembly which has communication capability to improve medication adherence
US11357705B2 (en) 2019-12-11 2022-06-14 TW3 Properties LLC Portable, reusable dispensing assembly having multiple operating modes
KR102426727B1 (ko) * 2020-04-17 2022-07-28 성균관대학교산학협력단 방출 속도 조절 경구용 약물 전달 장치 및 방출 속도 조절 경구용 약물 전달 장치의 제조 방법
TWI842626B (zh) * 2023-09-14 2024-05-11 國立勤益科技大學 一種胃電刺激系統

Family Cites Families (656)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3799802A (en) 1966-06-28 1974-03-26 F Schneble Plated through hole printed circuit boards
US3607788A (en) 1967-11-20 1971-09-21 Robert J Adolph Liquid electrode material
US3589943A (en) 1968-08-29 1971-06-29 Gen Electric Electrochemical battery
US3642008A (en) 1968-09-25 1972-02-15 Medical Plastics Inc Ground electrode and test circuit
US3679480A (en) 1969-05-08 1972-07-25 Dow Chemical Co Electrical cell assembly
US3682160A (en) 1969-10-16 1972-08-08 Matsushita Electric Ind Co Ltd Physiological signal transmitter for use inside the body
US3719183A (en) 1970-03-05 1973-03-06 H Schwartz Method for detecting blockage or insufficiency of pancreatic exocrine function
US3837339A (en) 1972-02-03 1974-09-24 Whittaker Corp Blood glucose level monitoring-alarm system and method therefor
US3828766A (en) 1972-08-14 1974-08-13 Jet Medical Prod Inc Disposable medical electrode
US3989050A (en) 1972-09-19 1976-11-02 Gilbert Buchalter Process for utilizing certain gel compositions for electrical stimulation
US3944064A (en) 1973-10-26 1976-03-16 Alza Corporation Self-monitored device for releasing agent at functional rate
US4106348A (en) 1974-02-20 1978-08-15 U.S. Philips Corporation Device for examination by means of ultrasonic vibrations
US3893111A (en) 1974-03-14 1975-07-01 Albert Albert F System and method for remote monitoring of animal temperature
US3967202A (en) 1974-07-25 1976-06-29 Northern Illinois Gas Company Data transmission system including an RF transponder for generating a broad spectrum of intelligence bearing sidebands
US4090752A (en) 1974-10-07 1978-05-23 Baxter Travenol Laboratories, Inc. Diagnostic electrode assembly
US4077397A (en) 1974-10-07 1978-03-07 Baxter Travenol Laboratories, Inc. Diagnostic electrode assembly
ZA755785B (en) 1974-10-07 1976-08-25 Baxter Laboratories Inc Diagnostic electrode assembly
US4062750A (en) 1974-12-18 1977-12-13 James Francis Butler Thin film electrochemical electrode and cell
US4055178A (en) 1976-03-10 1977-10-25 Harrigan Roy Major Drug delivery device for preventing contact of undissolved drug with the stomach lining
US4017856A (en) 1976-03-10 1977-04-12 Westinghouse Electric Corporation Self-calibrating microwave transponder
US4129125A (en) 1976-12-27 1978-12-12 Camin Research Corp. Patient monitoring system
GB1594214A (en) 1977-01-21 1981-07-30 Cardio Tech Body electrodes
US4082087A (en) 1977-02-07 1978-04-04 Isis Medical Instruments Body contact electrode structure for deriving electrical signals due to physiological activity
JPS5475284A (en) 1977-11-29 1979-06-15 Asahi Chemical Ind Threeeterminal magnetic reluctance effect element
US4239046A (en) 1978-09-21 1980-12-16 Ong Lincoln T Medical electrode
US4345588A (en) 1979-04-23 1982-08-24 Northwestern University Method of delivering a therapeutic agent to a target capillary bed
US4269189A (en) 1979-07-09 1981-05-26 Consolidated Medical Equipment Inc. Skin conducting electrode assembly
DE2928477C3 (de) 1979-07-14 1982-04-15 Battelle-Institut E.V., 6000 Frankfurt Vorrichtung zur Freisetzung von Substanzen an definierten Orten des Verdauungstraktes
US4331654A (en) 1980-06-13 1982-05-25 Eli Lilly And Company Magnetically-localizable, biodegradable lipid microspheres
US4418697A (en) 1981-08-17 1983-12-06 Francine Tama Electrode attachment method
US4494950A (en) 1982-01-19 1985-01-22 The Johns Hopkins University Plural module medication delivery system
US4439196A (en) 1982-03-18 1984-03-27 Merck & Co., Inc. Osmotic drug delivery system
US4790881A (en) 1982-03-26 1988-12-13 Warner-Lambert Company Molded hydrophilic polymer
US4655840A (en) 1982-03-26 1987-04-07 Warner-Lambert Company Hydrophilic polymer compositions for injection molding
EG16028A (en) 1982-03-26 1986-12-30 Warner Lambert Co Apparatus and method for molding capsules
GB8322007D0 (en) 1983-08-16 1983-09-21 Wellcome Found Pharmaceutical delivery system
US4576284A (en) 1983-12-02 1986-03-18 Warner-Lambert Company Closing of filled capsules
US4738724A (en) 1983-11-04 1988-04-19 Warner-Lambert Company Method for forming pharmaceutical capsules from starch compositions
US4738817A (en) 1983-11-17 1988-04-19 Warner-Lambert Company Method for forming pharmaceutical capsules from hydrophilic polymers
US4559950A (en) 1983-11-25 1985-12-24 Graphic Controls Corporation Disposable biomedical and diagnostic electrode
US5000957A (en) 1984-03-19 1991-03-19 Alza Corporation Dispenser comprising hydrophilic osmopolymer
GB8422876D0 (en) 1984-09-11 1984-10-17 Secr Defence Silicon implant devices
US4654165A (en) 1985-04-16 1987-03-31 Micro Tracers, Inc. Microingredient containing tracer
US4767627A (en) 1985-05-29 1988-08-30 Merck & Co., Inc. Drug delivery device which can be retained in the stomach for a controlled period of time
US4763659A (en) 1985-08-21 1988-08-16 Spring Creek Institute, Inc. Dry electrode system for detection of biopotentials
US4669479A (en) 1985-08-21 1987-06-02 Spring Creek Institute, Inc. Dry electrode system for detection of biopotentials
US4635641A (en) 1985-10-16 1987-01-13 Murray Electronics Associates Limited Multi-element electrode
US4663250A (en) 1986-03-12 1987-05-05 Institute Of Gas Technology Reduction of electrode dissolution
US4725997A (en) 1986-08-22 1988-02-16 Aprex Corporation Contingent dosing device
US4784162A (en) 1986-09-23 1988-11-15 Advanced Medical Technologies Portable, multi-channel, physiological data monitoring system
US4896261A (en) 1986-11-24 1990-01-23 Motorola Inc. System for scheduling serial message transmission on a bus which is adoptable for rescheduling prioritized messages using a doubly-linked list
US4876093A (en) 1987-07-02 1989-10-24 Alza Corporation Dispenser with dispersing member for delivering beneficial agent
DE3723310A1 (de) 1987-07-15 1989-01-26 John Urquhart Pharmazeutisches praeparat und verfahren zu seiner herstellung
US5002772A (en) 1988-05-31 1991-03-26 Pfizer Inc. Gastric retention system for controlled drug release
CA1327838C (fr) 1988-06-13 1994-03-15 Fred Zacouto Dispositif implantable de protection contre les affections liees a la coagulation sanguine
US4975230A (en) 1988-06-17 1990-12-04 Vapor Technologies Inc. Method of making an open pore structure
US4844076A (en) 1988-08-26 1989-07-04 The Johns Hopkins University Ingestible size continuously transmitting temperature monitoring pill
EP0392032B1 (de) 1989-04-10 1995-01-25 Pacesetter AB Implantierbares medizinisches Gerät mit Mitteln zum telemetrischen Übertragen von Daten
CA2016517C (en) 1989-05-11 1999-01-12 Dale R. Shackle Solid state electrochemical cell having microroughened current collector
US5281287A (en) 1989-07-21 1994-01-25 Iomed, Inc. Method of making a hydratable bioelectrode
US4987897A (en) 1989-09-18 1991-01-29 Medtronic, Inc. Body bus medical device communication system
US6749122B1 (en) 1990-05-25 2004-06-15 Broadcom Corporation Multi-level hierarchial radio-frequency system communication system
US6359872B1 (en) 1997-10-28 2002-03-19 Intermec Ip Corp. Wireless personal local area network
US5167626A (en) * 1990-10-02 1992-12-01 Glaxo Inc. Medical capsule device actuated by radio-frequency (RF) signal
US5279607A (en) * 1991-05-30 1994-01-18 The State University Of New York Telemetry capsule and process
US5395366A (en) * 1991-05-30 1995-03-07 The State University Of New York Sampling capsule and process
US5176626A (en) 1992-01-15 1993-01-05 Wilson-Cook Medical, Inc. Indwelling stent
US5634468A (en) 1992-04-03 1997-06-03 Micromedical Industries Limited Sensor patch and system for physiological monitoring
US5263481A (en) 1992-05-21 1993-11-23 Jens Axelgaard Electrode system with disposable gel
US5283136A (en) 1992-06-03 1994-02-01 Ramot University Authority For Applied Research And Industrial Development Ltd. Rechargeable batteries
US5318557A (en) 1992-07-13 1994-06-07 Elan Medical Technologies Limited Medication administering device
US5261402A (en) 1992-07-20 1993-11-16 Graphic Controls Corporation Snapless, tabless, disposable medical electrode with low profile
US5338625A (en) 1992-07-29 1994-08-16 Martin Marietta Energy Systems, Inc. Thin film battery and method for making same
US7758503B2 (en) 1997-01-27 2010-07-20 Lynn Lawrence A Microprocessor system for the analysis of physiologic and financial datasets
US5757326A (en) 1993-03-29 1998-05-26 Seiko Epson Corporation Slot antenna device and wireless apparatus employing the antenna device
US5394882A (en) 1993-07-21 1995-03-07 Respironics, Inc. Physiological monitoring system
AU7966694A (en) 1993-07-21 1996-05-02 University Of Kentucky Research Foundation, The A multicompartment hard capsule with control release properties
US5458141A (en) 1993-08-04 1995-10-17 Quinton Instrument Company Abrasive skin electrode
US5443461A (en) 1993-08-31 1995-08-22 Alza Corporation Segmented device for simultaneous delivery of multiple beneficial agents
DE4329898A1 (de) 1993-09-04 1995-04-06 Marcus Dr Besson Kabelloses medizinisches Diagnose- und Überwachungsgerät
US6390088B1 (en) 1993-12-13 2002-05-21 Boehringer Ingelheim Kg Aerosol inhaler
AU3197295A (en) 1994-03-21 1997-02-26 Dusa Pharmaceuticals, Inc. Patch, controller, and method for the photodynamic therapy of a dermal lesion
US5600548A (en) 1994-08-11 1997-02-04 Sundstrand Corporation DC content control for an inverter
IE70735B1 (en) 1994-08-15 1996-12-11 Elan Med Tech Orally administrable delivery device
DE9414065U1 (de) * 1994-08-31 1994-11-03 Röhm GmbH & Co. KG, 64293 Darmstadt Thermoplastischer Kunststoff für darmsaftlösliche Arznei-Umhüllungen
IL111396A (en) 1994-10-25 1997-07-13 Ness Neuromuscular Electrical Stimulation Systems Ltd Electrode system
US5485841A (en) 1995-02-14 1996-01-23 Univ Mcgill Ultrasonic lung tissue assessment
US5778882A (en) 1995-02-24 1998-07-14 Brigham And Women's Hospital Health monitoring system
US6374670B1 (en) 1995-03-13 2002-04-23 University Of Washington Non-invasive gut motility monitor
US5845265A (en) 1995-04-26 1998-12-01 Mercexchange, L.L.C. Consignment nodes
US5645063A (en) 1995-06-05 1997-07-08 Quinton Instrument Company Skin electrode having multiple conductive center members
US5738708A (en) 1995-06-07 1998-04-14 The Regents Of The University Of California Office Of Technology Transfer Composite metal membrane
US5802467A (en) 1995-09-28 1998-09-01 Innovative Intelcom Industries Wireless and wired communications, command, control and sensing system for sound and/or data transmission and reception
US6076016A (en) 1995-10-19 2000-06-13 Feierbach; Gary F. Galvanic transdermal conduction communication system and method
GB9522872D0 (en) 1995-11-08 1996-01-10 Oxford Medical Ltd Improvements relating to physiological monitoring
US8092224B2 (en) 1995-11-22 2012-01-10 James A. Jorasch Systems and methods for improved health care compliance
SE9504258D0 (sv) 1995-11-28 1995-11-28 Pacesetter Ab Device and method for generating a synthesized ECG
US5596302A (en) 1996-01-17 1997-01-21 Lucent Technologies Inc. Ring oscillator using even numbers of differential stages with current mirrors
US5868136A (en) 1996-02-20 1999-02-09 Axelgaard Manufacturing Co. Ltd. Medical electrode
US20010044588A1 (en) 1996-02-22 2001-11-22 Mault James R. Monitoring system
US5833603A (en) 1996-03-13 1998-11-10 Lipomatrix, Inc. Implantable biosensing transponder
WO1997036646A1 (fr) * 1996-04-01 1997-10-09 Valery Ivanovich Kobozev Stimulateur electrique des voies gastro-intestinales
US5864578A (en) 1996-04-29 1999-01-26 Golden Bridge Technology, Inc. Matched filter-based handoff method and apparatus
US5800421A (en) 1996-06-12 1998-09-01 Lemelson; Jerome H. Medical devices using electrosensitive gels
DE19780856D2 (de) 1996-08-16 1999-09-23 Roche Diagnostics Gmbh Kontrollsystem für die Überwachung der regelmäßigen Einnahme eines Medikamentes
CA2264250C (en) 1996-08-29 2005-07-05 Synthelabo Tablet with controlled release of alfuzosin hydrochloride
US5792048A (en) 1996-09-03 1998-08-11 Schaefer; Guenter Indentification pill with integrated microchip: smartpill, smartpill with integrated microchip and microprocessor for medical analyses and a smartpill, smartbox, smartplague, smartbadge or smartplate for luggage control on commercial airliners
US5963132A (en) 1996-10-11 1999-10-05 Avid Indentification Systems, Inc. Encapsulated implantable transponder
US6364834B1 (en) 1996-11-13 2002-04-02 Criticare Systems, Inc. Method and system for remotely monitoring multiple medical parameters in an integrated medical monitoring system
US8734339B2 (en) 1996-12-16 2014-05-27 Ip Holdings, Inc. Electronic skin patch for real time monitoring of cardiac activity and personal health management
US5974124A (en) 1997-01-21 1999-10-26 Med Graph Method and system aiding medical diagnosis and treatment
US6122351A (en) 1997-01-21 2000-09-19 Med Graph, Inc. Method and system aiding medical diagnosis and treatment
WO1998041279A1 (en) 1997-03-17 1998-09-24 Nims, Inc. Physiologic signs feedback system
DE19717023C2 (de) 1997-04-23 2003-02-06 Micronas Gmbh Vorrichtung zum Behandeln von malignen, tumorösen Gewebebereichen
US5981166A (en) 1997-04-23 1999-11-09 Pharmaseq, Inc. Screening of soluble chemical compounds for their pharmacological properties utilizing transponders
US6288629B1 (en) 1997-05-23 2001-09-11 Intermec Ip Corp. Method of using write—ok flag for radio frequency (RF) transponders (RF Tags)
US5984875A (en) 1997-08-22 1999-11-16 Innotek Pet Products, Inc. Ingestible animal temperature sensor
US5948227A (en) 1997-12-17 1999-09-07 Caliper Technologies Corp. Methods and systems for performing electrophoretic molecular separations
US6099259A (en) 1998-01-26 2000-08-08 Bristol Compressors, Inc. Variable capacity compressor
US6097927A (en) 1998-01-27 2000-08-01 Symbix, Incorporated Active symbolic self design method and apparatus
US6038464A (en) 1998-02-09 2000-03-14 Axelgaard Manufacturing Co., Ltd. Medical electrode
US7542878B2 (en) 1998-03-03 2009-06-02 Card Guard Scientific Survival Ltd. Personal health monitor and a method for health monitoring
US6141592A (en) 1998-03-06 2000-10-31 Intermedics Inc. Data transmission using a varying electric field
US6579231B1 (en) 1998-03-27 2003-06-17 Mci Communications Corporation Personal medical monitoring unit and system
US6091975A (en) 1998-04-01 2000-07-18 Alza Corporation Minimally invasive detecting device
US6175752B1 (en) 1998-04-30 2001-01-16 Therasense, Inc. Analyte monitoring device and methods of use
US6949816B2 (en) 2003-04-21 2005-09-27 Motorola, Inc. Semiconductor component having first surface area for electrically coupling to a semiconductor chip and second surface area for electrically coupling to a substrate, and method of manufacturing same
ATE245937T1 (de) 1998-05-13 2003-08-15 Cygnus Therapeutic Systems Überwachung physiologischer analyte
US6477424B1 (en) 1998-06-19 2002-11-05 Medtronic, Inc. Medical management system integrated programming apparatus for communication with an implantable medical device
US6704602B2 (en) 1998-07-02 2004-03-09 Medtronic, Inc. Implanted medical device/external medical instrument communication utilizing surface electrodes
US7548787B2 (en) 2005-08-03 2009-06-16 Kamilo Feher Medical diagnostic and communication system
US6558320B1 (en) 2000-01-20 2003-05-06 Medtronic Minimed, Inc. Handheld personal data assistant (PDA) with a medical device and method of using the same
US6333699B1 (en) 1998-08-28 2001-12-25 Marathon Oil Company Method and apparatus for determining position in a pipe
BR9913610A (pt) 1998-09-04 2001-10-09 Wolfe Res Pty Ltd Sistema de implante médico
FI116957B (fi) 1998-10-29 2006-04-13 Nokia Corp Menetelmä langattoman laitteen ja elektroniikkalaitteen välistä tiedonsiirtoa varten ja tiedonsiirtolaite
US6708060B1 (en) 1998-11-09 2004-03-16 Transpharma Ltd. Handheld apparatus and method for transdermal drug delivery and analyte extraction
US6217744B1 (en) 1998-12-18 2001-04-17 Peter Crosby Devices for testing fluid
EP1140210B1 (en) 1998-12-21 2003-07-02 Sequella, Inc. Methods and compositions comprising monitoring devices
US6115636A (en) 1998-12-22 2000-09-05 Medtronic, Inc. Telemetry for implantable devices using the body as an antenna
US6269058B1 (en) 1999-01-04 2001-07-31 Texas Instruments Incorporated Wide capture range circuitry
US6358202B1 (en) 1999-01-25 2002-03-19 Sun Microsystems, Inc. Network for implanted computer devices
US8636648B2 (en) 1999-03-01 2014-01-28 West View Research, Llc Endoscopic smart probe
US6285897B1 (en) 1999-04-07 2001-09-04 Endonetics, Inc. Remote physiological monitoring system
US6755783B2 (en) 1999-04-16 2004-06-29 Cardiocom Apparatus and method for two-way communication in a device for monitoring and communicating wellness parameters of ambulatory patients
US6290646B1 (en) 1999-04-16 2001-09-18 Cardiocom Apparatus and method for monitoring and communicating wellness parameters of ambulatory patients
US6200265B1 (en) 1999-04-16 2001-03-13 Medtronic, Inc. Peripheral memory patch and access method for use with an implantable medical device
ATE256421T1 (de) 1999-05-25 2004-01-15 Medicotest As Hautelektrode
EP1246414B1 (en) 1999-05-26 2012-05-23 Johnson Controls Technology Company Wireless communications system and method therefor
US6366206B1 (en) 1999-06-02 2002-04-02 Ball Semiconductor, Inc. Method and apparatus for attaching tags to medical and non-medical devices
EP1060704A3 (en) 1999-06-18 2002-09-18 Agilent Technologies, Inc. (a Delaware corporation) Multi-parameter capability transmitter for wireless telemetry systems
JP3402267B2 (ja) 1999-06-23 2003-05-06 ソニーケミカル株式会社 電子素子の実装方法
DE19929328A1 (de) 1999-06-26 2001-01-04 Daimlerchrysler Aerospace Ag Vorrichtung zur medizinischen Langzeitüberwachung von Personen
US6287252B1 (en) 1999-06-30 2001-09-11 Monitrak Patient monitor
US6307468B1 (en) 1999-07-20 2001-10-23 Avid Identification Systems, Inc. Impedance matching network and multidimensional electromagnetic field coil for a transponder interrogator
HN2000000165A (es) 1999-08-05 2001-07-09 Dimensional Foods Corp Productos holograficos comestibles, particularmente farmaceuticos, y metodos y aparatos para producirlos.
US6428809B1 (en) 1999-08-18 2002-08-06 Microdose Technologies, Inc. Metering and packaging of controlled release medication
US6206702B1 (en) 1999-08-24 2001-03-27 Deborah A. Hayden Methods and devices for treating unilateral neglect
US6526034B1 (en) 1999-09-21 2003-02-25 Tantivy Communications, Inc. Dual mode subscriber unit for short range, high rate and long range, lower rate data communications
US6533733B1 (en) 1999-09-24 2003-03-18 Ut-Battelle, Llc Implantable device for in-vivo intracranial and cerebrospinal fluid pressure monitoring
US6990082B1 (en) 1999-11-08 2006-01-24 Intel Corporation Wireless apparatus having a transceiver equipped to support multiple wireless communication protocols
CA2386673A1 (en) 1999-10-07 2001-04-12 Anthony R. Montgomery Physiological signal monitoring apparatus and method
US6852084B1 (en) 2000-04-28 2005-02-08 Peter V. Boesen Wireless physiological pressure sensor and transmitter with capability of short range radio frequency transmissions
US6426863B1 (en) 1999-11-25 2002-07-30 Lithium Power Technologies, Inc. Electrochemical capacitor
US6612984B1 (en) 1999-12-03 2003-09-02 Kerr, Ii Robert A. System and method for collecting and transmitting medical data
GB9930000D0 (en) 1999-12-21 2000-02-09 Phaeton Research Ltd An ingestible device
US6294999B1 (en) 1999-12-29 2001-09-25 Becton, Dickinson And Company Systems and methods for monitoring patient compliance with medication regimens
US8002700B2 (en) 1999-12-30 2011-08-23 Medtronic, Inc. Communications system for an implantable medical device and a delivery device
EP1119137B1 (en) 2000-01-20 2006-08-16 Lucent Technologies Inc. Interoperability for bluetooth/IEEE 802.11
AR026148A1 (es) 2000-01-21 2003-01-29 Osmotica Argentina S A Dispositivo osmotico con pasaje preformado que aumenta de tamano
US7039453B2 (en) 2000-02-08 2006-05-02 Tarun Mullick Miniature ingestible capsule
JP4619608B2 (ja) 2000-03-08 2011-01-26 ギブン イメージング リミテッド インビボ撮像のための装置およびシステム
US6526315B1 (en) 2000-03-17 2003-02-25 Tanita Corporation Portable bioelectrical impedance measuring instrument
DE10014588A1 (de) 2000-03-27 2001-10-04 Basf Ag Wirkstoffhaltige Schwimmformen enthaltend Polyvinylacetat und Polyvinylpyrrolidon, deren Verwendung und Herstellung
US6622050B2 (en) 2000-03-31 2003-09-16 Medtronic, Inc. Variable encryption scheme for data transfer between medical devices and related data management systems
US6757523B2 (en) 2000-03-31 2004-06-29 Zeus Wireless, Inc. Configuration of transmit/receive switching in a transceiver
US6922592B2 (en) 2000-04-04 2005-07-26 Medtronic, Inc. Implantable medical device controlled by a non-invasive physiological data measurement device
US6654638B1 (en) 2000-04-06 2003-11-25 Cardiac Pacemakers, Inc. Ultrasonically activated electrodes
US6441747B1 (en) 2000-04-18 2002-08-27 Motorola, Inc. Wireless system protocol for telemetry monitoring
US6496705B1 (en) 2000-04-18 2002-12-17 Motorola Inc. Programmable wireless electrode system for medical monitoring
US6836862B1 (en) 2000-04-24 2004-12-28 3Com Corporation Method of indicating wireless connection integrity
US7231451B2 (en) 2000-05-08 2007-06-12 Microtune (San Diego), Inc. Transmit-only and receive-only Bluetooth apparatus and method
US6432292B1 (en) 2000-05-16 2002-08-13 Metallic Power, Inc. Method of electrodepositing metal on electrically conducting particles
DE60144299D1 (de) 2000-05-19 2011-05-05 Welch Allyn Protocol Inc Vorrichtung zur überwachung von patienten
US6680923B1 (en) 2000-05-23 2004-01-20 Calypso Wireless, Inc. Communication system and method
ATE279879T1 (de) 2000-05-29 2004-11-15 Medicotest As Elektrode zur herstellung eines elektrischen kontakts mit der haut
IL163684A0 (en) 2000-05-31 2005-12-18 Given Imaging Ltd Measurement of electrical characteristics of tissue
GB0014854D0 (en) 2000-06-16 2000-08-09 Isis Innovation System and method for acquiring data
US7261690B2 (en) 2000-06-16 2007-08-28 Bodymedia, Inc. Apparatus for monitoring health, wellness and fitness
US6605038B1 (en) 2000-06-16 2003-08-12 Bodymedia, Inc. System for monitoring health, wellness and fitness
US20060122474A1 (en) 2000-06-16 2006-06-08 Bodymedia, Inc. Apparatus for monitoring health, wellness and fitness
GB0014855D0 (en) 2000-06-16 2000-08-09 Isis Innovation Combining measurements from different sensors
US7009946B1 (en) 2000-06-22 2006-03-07 Intel Corporation Method and apparatus for multi-access wireless communication
GB0016561D0 (en) 2000-07-05 2000-08-23 Rolls Royce Plc Health monitoring
EP1301123B1 (en) 2000-07-19 2004-12-08 Medicotest A/S A skin electrode with a by-pass element
JP2004516863A (ja) 2000-07-24 2004-06-10 モトローラ・インコーポレイテッド 摂取可能な電子カプセル
US6564079B1 (en) 2000-07-27 2003-05-13 Ckm Diagnostics, Inc. Electrode array and skin attachment system for noninvasive nerve location and imaging device
JP4428835B2 (ja) 2000-08-09 2010-03-10 昭和電工株式会社 磁気記録媒体及びその製造方法
US20020026111A1 (en) 2000-08-28 2002-02-28 Neil Ackerman Methods of monitoring glucose levels in a subject and uses thereof
US7685005B2 (en) 2000-08-29 2010-03-23 Medtronic, Inc. Medical device systems implemented network scheme for remote patient management
DE60102331T2 (de) 2000-09-08 2005-03-17 Matsushita Electric Works, Ltd., Kadoma Datenübertragungssystem unter Verwendung eines menschlichen Körpers als Signalübertragungsweg
US6720923B1 (en) 2000-09-14 2004-04-13 Stata Labs, Llc Antenna design utilizing a cavity architecture for global positioning system (GPS) applications
US6572636B1 (en) 2000-09-19 2003-06-03 Robert Sean Hagen Pulse sensing patch and associated methods
WO2002027659A2 (en) 2000-09-26 2002-04-04 Advantage 3D Llc Method and system for generation, storage and distribution of omni-directional object views
US6773429B2 (en) 2000-10-11 2004-08-10 Microchips, Inc. Microchip reservoir devices and facilitated corrosion of electrodes
US7024248B2 (en) 2000-10-16 2006-04-04 Remon Medical Technologies Ltd Systems and methods for communicating with implantable devices
WO2002034331A2 (en) 2000-10-26 2002-05-02 Medtronic, Inc. Externally worn transceiver for use with an implantable medical device
US6929636B1 (en) 2000-11-08 2005-08-16 Hewlett-Packard Development Company, L.P. Internal drug dispenser capsule medical device
US6632175B1 (en) 2000-11-08 2003-10-14 Hewlett-Packard Development Company, L.P. Swallowable data recorder capsule medical device
US6689117B2 (en) 2000-12-18 2004-02-10 Cardiac Pacemakers, Inc. Drug delivery system for implantable medical device
US6879810B2 (en) 2000-12-20 2005-04-12 Nokia Corporation Control of short range RF communication
JP2002263185A (ja) 2001-03-12 2002-09-17 Sanyo Electric Co Ltd 投薬システム及び方法及び投薬装置
JP2002290212A (ja) 2001-03-27 2002-10-04 Nec Corp 電圧制御発振器
US6342774B1 (en) 2001-03-27 2002-01-29 Motorola, Inc. Battery having user charge capacity control
EP1383575A4 (en) 2001-03-28 2010-01-20 Televital Inc SYSTEM AND METHOD FOR REAL-TIME MONITORING, INVESTIGATION, ANALYSIS, RECOVERY AND STORAGE OF PHYSIOLOGICAL DATA OVER A WIDE-FUTURE NETWORK (WAN)
US6595929B2 (en) 2001-03-30 2003-07-22 Bodymedia, Inc. System for monitoring health, wellness and fitness having a method and apparatus for improved measurement of heat flow
ATE324068T1 (de) 2001-04-02 2006-05-15 N I Medical Ltd Gerät zur bestimmung des hämodynamischen zustands
EP1379167A1 (en) 2001-04-06 2004-01-14 Medic4all Inc. A physiological monitoring system for a computational device of a human subject
US6694161B2 (en) 2001-04-20 2004-02-17 Monsanto Technology Llc Apparatus and method for monitoring rumen pH
US6801137B2 (en) 2001-04-23 2004-10-05 Cardionet, Inc. Bidirectional communication between a sensor unit and a monitor unit in patient monitoring
US6782290B2 (en) 2001-04-27 2004-08-24 Medtronic, Inc. Implantable medical device with rechargeable thin-film microbattery power source
US20050182389A1 (en) 2001-04-30 2005-08-18 Medtronic, Inc Implantable medical device and patch system and method of use
KR20030092120A (ko) 2001-05-03 2003-12-03 텔쥬트 테크놀로지스, 인크. 무선 의료용 모니터링 장치 및 시스템
US7039033B2 (en) 2001-05-07 2006-05-02 Ixi Mobile (Israel) Ltd. System, device and computer readable medium for providing a managed wireless network using short-range radio signals
AU2002304269A1 (en) * 2001-05-20 2002-12-03 Given Imaging Ltd. A floatable in vivo sensing device
GB0113212D0 (en) 2001-05-31 2001-07-25 Oxford Biosignals Ltd Patient condition display
US20020192159A1 (en) 2001-06-01 2002-12-19 Reitberg Donald P. Single-patient drug trials used with accumulated database: flowchart
JP2004538053A (ja) 2001-06-19 2004-12-24 デジタル スポーツ メディア 生理学的モニタリングおよびシステム
US7160258B2 (en) 2001-06-26 2007-01-09 Entrack, Inc. Capsule and method for treating or diagnosing the intestinal tract
US7044911B2 (en) 2001-06-29 2006-05-16 Philometron, Inc. Gateway platform for biological monitoring and delivery of therapeutic compounds
CA2452883C (en) 2001-07-11 2012-01-03 Cns Response, Inc. Electroencephalography based systems and methods for selecting therapies and predicting outcomes
ES2501142T3 (es) 2001-07-12 2014-10-01 Given Imaging Ltd. Dispositivo para examinar una cavidad interna corporal
US20030017826A1 (en) 2001-07-17 2003-01-23 Dan Fishman Short-range wireless architecture
WO2003009920A1 (en) 2001-07-25 2003-02-06 Biosource, Inc. Electrode array for use in electrochemical cells
US6951536B2 (en) 2001-07-30 2005-10-04 Olympus Corporation Capsule-type medical device and medical system
US6747556B2 (en) 2001-07-31 2004-06-08 Medtronic Physio-Control Corp. Method and system for locating a portable medical device
US20030065536A1 (en) 2001-08-13 2003-04-03 Hansen Henrik Egesborg Portable device and method of communicating medical data information
WO2003015890A1 (en) 2001-08-20 2003-02-27 President And Fellows Of Harvard College Fluidic arrays and method of using
JP3962250B2 (ja) 2001-08-29 2007-08-22 株式会社レアメタル 生体内情報検出システム及びこれに用いるタグ装置、中継装置
US6650191B2 (en) 2001-09-07 2003-11-18 Texas Instruments Incorporated Low jitter ring oscillator architecture
US20050137480A1 (en) 2001-10-01 2005-06-23 Eckhard Alt Remote control of implantable device through medical implant communication service band
US6840904B2 (en) 2001-10-11 2005-01-11 Jason Goldberg Medical monitoring device and system
US7357891B2 (en) 2001-10-12 2008-04-15 Monosol Rx, Llc Process for making an ingestible film
US6745082B2 (en) 2001-10-22 2004-06-01 Jens Axelgaard Current-controlling electrode with adjustable contact area
US20030152622A1 (en) 2001-10-25 2003-08-14 Jenny Louie-Helm Formulation of an erodible, gastric retentive oral diuretic
US20030083559A1 (en) 2001-10-31 2003-05-01 Thompson David L. Non-contact monitor
US6643541B2 (en) 2001-12-07 2003-11-04 Motorola, Inc Wireless electromyography sensor and system
US20030107487A1 (en) 2001-12-10 2003-06-12 Ronen Korman Method and device for measuring physiological parameters at the wrist
GB0130010D0 (en) 2001-12-14 2002-02-06 Isis Innovation Combining measurements from breathing rate sensors
US7016648B2 (en) 2001-12-18 2006-03-21 Ixi Mobile (Israel) Ltd. Method, system and computer readable medium for downloading a software component to a device in a short distance wireless network
US7729776B2 (en) 2001-12-19 2010-06-01 Cardiac Pacemakers, Inc. Implantable medical device with two or more telemetry systems
US7877273B2 (en) 2002-01-08 2011-01-25 Fredric David Abramson System and method for evaluating and providing nutrigenomic data, information and advice
CA2472226A1 (en) 2002-01-11 2003-07-24 Hexalog Sa Systems and methods for medication monitoring
US7519416B2 (en) 2002-02-04 2009-04-14 Heartview, Llc Diagnostic method utilizing standard lead ECG signals
FR2835730B1 (fr) 2002-02-11 2004-12-10 C T M Ct De Transfert Des Micr Dispositif pour la delivrance de substances et le prelevement intracorporel
US6958034B2 (en) 2002-02-11 2005-10-25 Given Imaging Ltd. Self propelled device
US6935560B2 (en) 2002-02-26 2005-08-30 Safety Syringes, Inc. Systems and methods for tracking pharmaceuticals within a facility
US20030162556A1 (en) 2002-02-28 2003-08-28 Libes Michael A. Method and system for communication between two wireless-enabled devices
US7043305B2 (en) 2002-03-06 2006-05-09 Cardiac Pacemakers, Inc. Method and apparatus for establishing context among events and optimizing implanted medical device performance
US6968153B1 (en) 2002-03-13 2005-11-22 Nokia Corporation Apparatus, method and system for a Bluetooth repeater
US6957107B2 (en) 2002-03-13 2005-10-18 Cardionet, Inc. Method and apparatus for monitoring and communicating with an implanted medical device
US7188767B2 (en) 2002-03-18 2007-03-13 Precision Dynamics Corporation Physical condition or environmental threat detection appliance system
JP3869291B2 (ja) 2002-03-25 2007-01-17 オリンパス株式会社 カプセル型医療装置
US6850788B2 (en) 2002-03-25 2005-02-01 Masimo Corporation Physiological measurement communications adapter
US7376435B2 (en) 2002-04-01 2008-05-20 Intel Corporation Transferring multiple data units over a wireless communication link
US7797033B2 (en) * 2002-04-08 2010-09-14 Smart Pill Corporation Method of using, and determining location of, an ingestible capsule
US6960617B2 (en) 2002-04-22 2005-11-01 Purdue Research Foundation Hydrogels having enhanced elasticity and mechanical strength properties
KR101124876B1 (ko) 2002-04-22 2012-03-28 마시오 마크 아우렐리오 마틴스 애브리우 생물학적 파라미터 측정 장치 및 방법
US7424268B2 (en) 2002-04-22 2008-09-09 Cisco Technology, Inc. System and method for management of a shared frequency band
EP1356762A1 (de) 2002-04-22 2003-10-29 UbiCom Gesellschaft für Telekommunikation mbH Geräteanordnung zur Fernüberwachung von Körperfunktionen
US20030216622A1 (en) 2002-04-25 2003-11-20 Gavriel Meron Device and method for orienting a device in vivo
US7368190B2 (en) 2002-05-02 2008-05-06 Abbott Diabetes Care Inc. Miniature biological fuel cell that is operational under physiological conditions, and associated devices and methods
US7901939B2 (en) 2002-05-09 2011-03-08 University Of Chicago Method for performing crystallization and reactions in pressure-driven fluid plugs
JP2003325439A (ja) 2002-05-15 2003-11-18 Olympus Optical Co Ltd カプセル型医療装置
US20030216729A1 (en) 2002-05-20 2003-11-20 Marchitto Kevin S. Device and method for wound healing and uses therefor
US6847844B2 (en) 2002-06-06 2005-01-25 University Of Pittsburgh Of The Commonwealth System Of Higher Education Method of data communication with implanted device and associated apparatus
US8003179B2 (en) 2002-06-20 2011-08-23 Alcan Packaging Flexible France Films having a desiccant material incorporated therein and methods of use and manufacture
US20040008123A1 (en) 2002-07-15 2004-01-15 Battelle Memorial Institute System and method for tracking medical devices
US6909878B2 (en) 2002-08-20 2005-06-21 Ixi Mobile (Israel) Ltd. Method, system and computer readable medium for providing an output signal having a theme to a device in a short distance wireless network
US7619819B2 (en) 2002-08-20 2009-11-17 Illumina, Inc. Method and apparatus for drug product tracking using encoded optical identification elements
US7020508B2 (en) 2002-08-22 2006-03-28 Bodymedia, Inc. Apparatus for detecting human physiological and contextual information
US7294105B1 (en) 2002-09-03 2007-11-13 Cheetah Omni, Llc System and method for a wireless medical communication system
US7102508B2 (en) 2002-09-09 2006-09-05 Persephone, Inc. Method and apparatus for locating and tracking persons
US20040049245A1 (en) 2002-09-09 2004-03-11 Volker Gass Autonomous patch for communication with an implantable device, and medical kit for using said patch
GB2393356B (en) 2002-09-18 2006-02-01 E San Ltd Telemedicine system
US7388903B2 (en) 2002-09-18 2008-06-17 Conexant, Inc. Adaptive transmission rate and fragmentation threshold mechanism for local area networks
US7118531B2 (en) 2002-09-24 2006-10-10 The Johns Hopkins University Ingestible medical payload carrying capsule with wireless communication
US6842636B2 (en) 2002-09-27 2005-01-11 Axelgaard Manufacturing Co., Ltd. Medical electrode
US7736309B2 (en) 2002-09-27 2010-06-15 Medtronic Minimed, Inc. Implantable sensor method and system
US7209790B2 (en) 2002-09-30 2007-04-24 Medtronic, Inc. Multi-mode programmer for medical device communication
US7686762B1 (en) 2002-10-03 2010-03-30 Integrated Sensing Systems, Inc. Wireless device and system for monitoring physiologic parameters
US20040073454A1 (en) 2002-10-10 2004-04-15 John Urquhart System and method of portal-mediated, website-based analysis of medication dosing
US6959217B2 (en) 2002-10-24 2005-10-25 Alfred E. Mann Foundation For Scientific Research Multi-mode crystal oscillator system selectively configurable to minimize power consumption or noise generation
US7027871B2 (en) 2002-10-31 2006-04-11 Medtronic, Inc. Aggregation of data from external data sources within an implantable medical device
US20030126593A1 (en) 2002-11-04 2003-07-03 Mault James R. Interactive physiological monitoring system
EP1437784B1 (en) 2002-11-08 2012-05-30 Honda Motor Co., Ltd. Electrode for solid polymer fuel cell
US20040092801A1 (en) 2002-11-13 2004-05-13 Budimir Drakulic System for, and method of, acquiring physiological signals of a patient
WO2004049947A2 (en) 2002-11-29 2004-06-17 Given Imaging Ltd. Methods device and system for in vivo diagnosis
AU2003283688A1 (en) 2002-12-11 2004-06-30 Pfizer Products Inc. Controlled-release of an active substance into a high fat environment
US20040167226A1 (en) 2002-12-16 2004-08-26 Serafini Tito A. Methods for the treatment of pain and traumatic injury using benzamides and compositions containing the same
US20060155174A1 (en) 2002-12-16 2006-07-13 Arkady Glukhovsky Device, system and method for selective activation of in vivo sensors
US7009511B2 (en) 2002-12-17 2006-03-07 Cardiac Pacemakers, Inc. Repeater device for communications with an implantable medical device
EP1590039A1 (en) 2002-12-19 2005-11-02 Koninklijke Philips Electronics N.V. An electrode assembly and a system with impedance control
US7127300B2 (en) 2002-12-23 2006-10-24 Cardiac Pacemakers, Inc. Method and apparatus for enabling data communication between an implantable medical device and a patient management system
US6975174B1 (en) 2002-12-31 2005-12-13 Radioframe Networks, Inc. Clock oscillator
US20060142648A1 (en) 2003-01-07 2006-06-29 Triage Data Networks Wireless, internet-based, medical diagnostic system
US7396330B2 (en) 2003-01-07 2008-07-08 Triage Data Networks Wireless, internet-based medical-diagnostic system
US7512448B2 (en) 2003-01-10 2009-03-31 Phonak Ag Electrode placement for wireless intrabody communication between components of a hearing system
KR100873683B1 (ko) 2003-01-25 2008-12-12 한국과학기술연구원 인체통신방법, 인체통신시스템 및 이에 사용되는 캡슐형 내시경
KR100522132B1 (ko) 2003-01-25 2005-10-18 한국과학기술연구원 인체통신시스템에서의 데이터 수신방법 및 수신장치
CN1774239A (zh) 2003-01-29 2006-05-17 埃-皮尔制药公司 用于胃肠道的有效药物递送
US7002476B2 (en) 2003-01-30 2006-02-21 Leap Of Faith Technologies, Inc. Medication compliance system
EP1443780B1 (en) 2003-01-30 2013-05-29 Accenture Global Services Limited Event data acquisition and transmission system
US7149581B2 (en) 2003-01-31 2006-12-12 Medtronic, Inc. Patient monitoring device with multi-antenna receiver
US7215660B2 (en) 2003-02-14 2007-05-08 Rearden Llc Single transceiver architecture for a wireless network
US7392015B1 (en) 2003-02-14 2008-06-24 Calamp Corp. Calibration methods and structures in wireless communications systems
US7155232B2 (en) 2003-03-05 2006-12-26 Conexant Systems, Inc. Transmit request signaling between transceivers
US7653031B2 (en) 2003-03-05 2010-01-26 Timothy Gordon Godfrey Advance notification of transmit opportunities on a shared-communications channel
US7321920B2 (en) 2003-03-21 2008-01-22 Vocel, Inc. Interactive messaging system
JP2006520657A (ja) 2003-03-21 2006-09-14 ウェルチ・アリン・インコーポレーテッド 個人状態生理学的監視システム及び構造、及びモニタリング方法
GB0306642D0 (en) * 2003-03-22 2003-04-30 Dca Design Int Ltd Improvements in and relating to an injector for a medical product
US20040193446A1 (en) 2003-03-27 2004-09-30 Mayer Steven Lloyd System and method for managing a patient treatment program including a prescribed drug regimen
GB0308114D0 (en) 2003-04-08 2003-05-14 Glaxo Group Ltd Novel compounds
GB0308467D0 (en) 2003-04-11 2003-05-21 Rolls Royce Plc Method and system for analysing tachometer and vibration data from an apparatus having one or more rotary components
JP4593083B2 (ja) 2003-04-11 2010-12-08 オリンパス株式会社 検査データ管理方法
US7972616B2 (en) 2003-04-17 2011-07-05 Nanosys, Inc. Medical device applications of nanostructured surfaces
FI116117B (fi) 2003-04-17 2005-09-30 Polar Electro Oy Mittalaite ja menetelmä sykkeen mittaamiseksi sekä mittalaitteen valmistusmenetelmä
WO2004096023A1 (ja) 2003-04-25 2004-11-11 Olympus Corporation 無線型被検体内情報取得システムおよび被検体外部装置
US20040218683A1 (en) 2003-05-01 2004-11-04 Texas Instruments Incorporated Multi-mode wireless devices having reduced-mode receivers
US20040225199A1 (en) 2003-05-08 2004-11-11 Evanyk Shane Walter Advanced physiological monitoring systems and methods
TWI226761B (en) 2003-05-08 2005-01-11 Ind Tech Res Inst Dual band transceiver architecture for wireless application
US7031745B2 (en) 2003-05-12 2006-04-18 Shen Ein-Yiao Cellular phone combined physiological condition examination and processing device
JP4402655B2 (ja) 2003-05-14 2010-01-20 オリンパス株式会社 カプセル型医療装置
KR100542101B1 (ko) 2003-06-02 2006-01-11 삼성전자주식회사 전송 파워 제어 방법 및 이를 이용한 블루투스 장치
US7313163B2 (en) 2003-06-17 2007-12-25 Motorola, Inc. Fast synchronization for half duplex digital communications
US20040260154A1 (en) 2003-06-18 2004-12-23 Boris Sidelnik Human physiological and chemical monitoring system
US20050043634A1 (en) 2003-06-24 2005-02-24 Olympus Corporation Communication system for capsule type medical apparatus capsule type medical apparatus, and information receiver
WO2005006968A1 (en) 2003-07-16 2005-01-27 Koninklijke Philips Electronics N.V. A portable electronic device and a health management system arranged for monitoring a physiological condition of an individual
WO2005007223A2 (en) 2003-07-16 2005-01-27 Sasha John Programmable medical drug delivery systems and methods for delivery of multiple fluids and concentrations
US7554452B2 (en) 2003-07-18 2009-06-30 Cary Cole Ingestible tracking and locating device
US7653350B2 (en) 2003-07-24 2010-01-26 Sony Ericsson Mobile Communications Ab Wireless terminals and methods for communicating over cellular and enhanced mode bluetooth communication links
JP4038575B2 (ja) 2003-07-25 2008-01-30 独立行政法人産業技術総合研究所 バイオセンサ、バイオセンサ装置またはバイオセンサの保存方法
US7243118B2 (en) 2003-07-30 2007-07-10 Broadcom Corporation Method and apparatus for efficient derivation of modulo arithmetic for frequency selection
WO2005016558A2 (en) 2003-08-04 2005-02-24 Microchips, Inc. Methods for accelerated release of material from a reservoir device
ATE413902T1 (de) 2003-08-18 2008-11-15 Cardiac Pacemakers Inc Patientenüberwachungssystem
JP5449647B2 (ja) 2003-08-20 2014-03-19 フィロメトロン，インコーポレイティド ハイドレーションモニタリング
US8346482B2 (en) 2003-08-22 2013-01-01 Fernandez Dennis S Integrated biosensor and simulation system for diagnosis and therapy
JP4398204B2 (ja) 2003-08-29 2010-01-13 オリンパス株式会社 被検体内導入装置および無線型被検体内情報取得システム
JP4332152B2 (ja) 2003-09-02 2009-09-16 富士通株式会社 薬服用状況管理方法及び薬剤
US20050062644A1 (en) 2003-09-08 2005-03-24 Leci Jonathan Ilan Capsule device to identify the location of an individual
JP3993546B2 (ja) 2003-09-08 2007-10-17 オリンパス株式会社 被検体内導入装置および無線型被検体内情報取得システム
CA2852974C (en) 2003-09-11 2017-06-27 Theranos, Inc. Medical device for analyte monitoring and drug delivery
US7499674B2 (en) 2003-09-12 2009-03-03 Nokia Corporation Method and system for repeat request in hybrid ultra wideband-bluetooth radio
US7813809B2 (en) 2004-06-10 2010-10-12 Medtronic, Inc. Implantable pulse generator for providing functional and/or therapeutic stimulation of muscles and/or nerves and/or central nervous system tissue
US7352998B2 (en) 2003-09-12 2008-04-01 Nokia Corporation Method and system for establishing a wireless communications link
JP4153852B2 (ja) 2003-09-18 2008-09-24 オリンパス株式会社 エネルギー供給用コイルおよびこれを用いた無線型被検体内情報取得システム
KR100784072B1 (ko) 2003-09-22 2007-12-10 김형윤 구조물의 건전성 감시용 센서 및 시스템
US20090157358A1 (en) 2003-09-22 2009-06-18 Hyeung-Yun Kim System for diagnosing and monitoring structural health conditions
US7218967B2 (en) 2003-09-26 2007-05-15 Medtronic, Inc. System and method for real-time remote monitoring of implantable medical devices
JP4503979B2 (ja) * 2003-10-22 2010-07-14 オリンパス株式会社 体内装置および医療機器
US20050096514A1 (en) 2003-11-01 2005-05-05 Medtronic, Inc. Gastric activity notification
US6892590B1 (en) 2003-11-04 2005-05-17 Andermotion Technologies Llc Single-balanced shield electrode configuration for use in capacitive displacement sensing systems and methods
US7101343B2 (en) 2003-11-05 2006-09-05 Temple University Of The Commonwealth System Of Higher Education Implantable telemetric monitoring system, apparatus, and method
US20050101843A1 (en) 2003-11-06 2005-05-12 Welch Allyn, Inc. Wireless disposable physiological sensor
US7415242B1 (en) 2003-11-10 2008-08-19 Sprint Spectrum L.P. Method and system for proximity detection for an in-building wireless repeater
DE102004032812B4 (de) 2003-11-11 2006-07-20 Dräger Safety AG & Co. KGaA Kombinationssensor für physiologische Messgrößen
JP2005158770A (ja) 2003-11-20 2005-06-16 Matsushita Electric Ind Co Ltd 積層基板とその製造方法及び前記積層基板を用いたモジュールの製造方法とその製造装置
US6987691B2 (en) 2003-12-02 2006-01-17 International Business Machines Corporation Easy axis magnetic amplifier
US7427266B2 (en) 2003-12-15 2008-09-23 Hewlett-Packard Development Company, L.P. Method and apparatus for verification of ingestion
US8306592B2 (en) 2003-12-19 2012-11-06 Olympus Corporation Capsule medical device
JP2005185567A (ja) 2003-12-25 2005-07-14 Olympus Corp 医療用カプセル装置
JP4198045B2 (ja) 2003-12-25 2008-12-17 オリンパス株式会社 被検体内位置検出システム
US7392091B2 (en) 2003-12-30 2008-06-24 Cochlear Limited Implanted antenna and radio communications link
JP2005193535A (ja) 2004-01-07 2005-07-21 Alps Electric Co Ltd サーマルヘッド及びその製造方法、並びにサーマルヘッドのドットアスペクト比調整方法
JP2005192821A (ja) 2004-01-07 2005-07-21 Olympus Corp カプセル型医療装置
US7176784B2 (en) 2004-01-21 2007-02-13 Battelle Memorial Institute K1-53 Multi-mode radio frequency device
US7342895B2 (en) 2004-01-30 2008-03-11 Mark Serpa Method and system for peer-to-peer wireless communication over unlicensed communication spectrum
US7647112B2 (en) 2004-02-11 2010-01-12 Ethicon, Inc. System and method for selectively stimulating different body parts
US20050187789A1 (en) 2004-02-25 2005-08-25 Cardiac Pacemakers, Inc. Advanced patient and medication therapy management system and method
CN100444784C (zh) 2004-02-27 2008-12-24 皇家飞利浦电子股份有限公司 用于监测、分析和通信生理状态的可佩带的无线装置
CN1284505C (zh) 2004-02-28 2006-11-15 重庆金山科技（集团）有限公司 医用无线电胶囊式内窥系统
US7406105B2 (en) 2004-03-03 2008-07-29 Alfred E. Mann Foundation For Scientific Research System and method for sharing a common communication channel between multiple systems of implantable medical devices
DE602004024227D1 (de) 2004-03-04 2009-12-31 Olympus Corp Medizinisches system vom kapseltyp
GB0405798D0 (en) 2004-03-15 2004-04-21 E San Ltd Medical data display
JP4520198B2 (ja) 2004-04-07 2010-08-04 オリンパス株式会社 被検体内位置表示システム
US20050234307A1 (en) 2004-04-15 2005-10-20 Nokia Corporation Physiological event handling system and method
US8512219B2 (en) 2004-04-19 2013-08-20 The Invention Science Fund I, Llc Bioelectromagnetic interface system
US9011329B2 (en) 2004-04-19 2015-04-21 Searete Llc Lumenally-active device
JP2005304880A (ja) 2004-04-23 2005-11-04 Hitachi Ltd 非接触ｉｃタグを利用した体内物体管理システム
CA2564977C (en) 2004-04-24 2014-08-12 Inrange Systems, Inc. Integrated, non-sequential, remote medication management and compliance system
US20050245794A1 (en) 2004-04-29 2005-11-03 Medtronic, Inc. Communication with implantable monitoring probe
GB0410248D0 (en) 2004-05-07 2004-06-09 Isis Innovation Signal analysis method
WO2005110238A1 (en) 2004-05-16 2005-11-24 Medic4All A.G Method and device for measuring physiological parameters at the hand
US20050261559A1 (en) 2004-05-18 2005-11-24 Mumford John R Wireless physiological monitoring system
US7575005B2 (en) 2004-05-18 2009-08-18 Excel-Tech Ltd. Mask assembly with integrated sensors
US7125382B2 (en) 2004-05-20 2006-10-24 Digital Angel Corporation Embedded bio-sensor system
KR100592934B1 (ko) 2004-05-21 2006-06-23 한국전자통신연구원 착용형 생체신호 검출모듈 및 이를 포함한 측정장치
US20050259768A1 (en) 2004-05-21 2005-11-24 Oki Techno Centre (Singapore) Pte Ltd Digital receiver and method for processing received signals
US7653542B2 (en) 2004-05-26 2010-01-26 Verizon Business Global Llc Method and system for providing synthesized speech
US20050267556A1 (en) 2004-05-28 2005-12-01 Allan Shuros Drug eluting implants to prevent cardiac apoptosis
CA2567688C (en) 2004-05-28 2016-08-02 Jan De Geest Communication unit for a person's skin
US7289855B2 (en) 2004-06-09 2007-10-30 Medtronic, Inc. Implantable medical device package antenna
US7697994B2 (en) 2004-06-18 2010-04-13 Medtronic, Inc. Remote scheduling for management of an implantable medical device
JP2006006377A (ja) 2004-06-22 2006-01-12 Elquest Corp 薬剤包装用の薬包紙
KR100615431B1 (ko) 2004-06-22 2006-08-25 한국전자통신연구원 생체신호 검출모듈, 다채널 커넥터 모듈 및 이를 포함한생체신호 검출장치
US20050285746A1 (en) 2004-06-25 2005-12-29 Sengupta Uttam K Radio frequency identification based system to track consumption of medication
US7206630B1 (en) 2004-06-29 2007-04-17 Cleveland Medical Devices, Inc Electrode patch and wireless physiological measurement system and method
US20070027383A1 (en) 2004-07-01 2007-02-01 Peyser Thomas A Patches, systems, and methods for non-invasive glucose measurement
US20060001496A1 (en) 2004-07-02 2006-01-05 Abrosimov Igor A Array oscillator and polyphase clock generator
JP4462614B2 (ja) 2004-07-05 2010-05-12 ソニー・エリクソン・モバイルコミュニケーションズ株式会社 近距離無線通信システム、携帯端末装置および無線通信装置
US7343186B2 (en) 2004-07-07 2008-03-11 Masimo Laboratories, Inc. Multi-wavelength physiological monitor
WO2006006158A1 (en) 2004-07-09 2006-01-19 Aerotel Medical Systems (1998) Ltd. Wearable device, system and method for measuring vital parameters
US20080027679A1 (en) 2004-07-21 2008-01-31 Dror Shklarski Wearable Device, System and Method for Measuring Physiological and/or Environmental Parameters
CN100459614C (zh) 2004-07-22 2009-02-04 华为技术有限公司 一种手机外设装置与方法
US20080045843A1 (en) 2004-08-12 2008-02-21 Tomoharu Tsuji Via-Human-Body Information Transmission System and Transmitter-Receiver
US7317378B2 (en) 2004-08-17 2008-01-08 Tagent Corporation Product identification tag device and reader
US7253716B2 (en) 2004-08-17 2007-08-07 Tagent Corporation Trackable pills with electronic ID tags
US20060058602A1 (en) 2004-08-17 2006-03-16 Kwiatkowski Krzysztof C Interstitial fluid analyzer
CN101010114B (zh) 2004-08-27 2010-05-26 皇家飞利浦电子股份有限公司 电子遥控药丸和用于供应至少一种药物的系统
WO2006026741A1 (en) 2004-08-31 2006-03-09 Lifescan Scotland Limited Wearable sensor device and system
KR100727817B1 (ko) 2004-09-07 2007-06-13 한국전자통신연구원 인체를 매질로 이용한 통신장치 및 그 방법
EP1788933A1 (en) 2004-09-08 2007-05-30 Alertis Medical AS Sensor
KR20060023228A (ko) 2004-09-09 2006-03-14 이기방 다공질물질을 가지는 배터리와 배터리제조방법
GB2418144A (en) 2004-09-17 2006-03-22 Psimedica Ltd Medical device for delivery of beneficial substance
US20060065713A1 (en) 2004-09-24 2006-03-30 John Russell Kingery System and method for monitored administration of medical products to patients
US7618374B2 (en) 2004-09-27 2009-11-17 Siemens Medical Solutions Usa, Inc. Image plane sensing methods and systems for intra-patient probes
US7341560B2 (en) 2004-10-05 2008-03-11 Rader, Fishman & Grauer Pllc Apparatuses and methods for non-invasively monitoring blood parameters
US20060078765A1 (en) 2004-10-12 2006-04-13 Laixia Yang Nano-structured ion-conducting inorganic membranes for fuel cell applications
US7917199B2 (en) 2004-11-02 2011-03-29 Medtronic, Inc. Patient event marking in combination with physiological signals
US8478417B2 (en) 2004-11-02 2013-07-02 Medtronic, Inc. Techniques for data reporting in an implantable medical device
IL171772A (en) 2004-11-04 2009-11-18 Given Imaging Ltd Device and method for selecting and integrating the absorption device
KR20060040500A (ko) 2004-11-06 2006-05-10 삼성전자주식회사 생체신호 측정 장치 및 방법
US7414534B1 (en) 2004-11-09 2008-08-19 Pacesetter, Inc. Method and apparatus for monitoring ingestion of medications using an implantable medical device
US7214107B2 (en) 2004-11-22 2007-05-08 Cardiodynamics International Corporation Electrical connector apparatus and methods
US8374693B2 (en) 2004-12-03 2013-02-12 Cardiac Pacemakers, Inc. Systems and methods for timing-based communication between implantable medical devices
US7154071B2 (en) 2004-12-07 2006-12-26 Dräger Safety AG & Co. KGaA Device for transmitting an electric signal detected by contact with the skin surface
JP5317476B2 (ja) 2004-12-13 2013-10-16 コーニンクレッカ フィリップス エヌ ヴェ モバイルモニタリング
WO2006064502A2 (en) 2004-12-14 2006-06-22 E-Pill Pharma, Ltd. Local delivery of drugs or substances using electronic permeability increase
US20060136266A1 (en) 2004-12-20 2006-06-22 E-San Limited Medicinal product order processing system
US7249212B2 (en) 2004-12-22 2007-07-24 International Business Machines Corporation Bluetooth association based on docking connection
US7146449B2 (en) 2004-12-22 2006-12-05 International Business Machines Corporation Bluetooth association with simple power connection
DE602005007847D1 (de) 2004-12-30 2008-08-14 Given Imaging Ltd System zur Lokalisation einer in-Vivo Signalquelle
US20060148254A1 (en) 2005-01-05 2006-07-06 Mclean George Y Activated iridium oxide electrodes and methods for their fabrication
WO2006075016A1 (en) 2005-01-17 2006-07-20 Novo Nordisk A/S Fluide delivery device with integrated monitoring of physiological characteristics
US20080121825A1 (en) 2005-01-18 2008-05-29 Koninklijke Philips Electronics, N.V. Electronically Controlled Capsule For Releasing Radiation
WO2006077529A2 (en) 2005-01-18 2006-07-27 Koninklijke Philips Electronics, N.V. System for controlling traversal of an ingested capsule
CN101208039A (zh) 2005-01-18 2008-06-25 皇家飞利浦电子股份有限公司 用于对消化道中的流体采样的可摄入电控胶囊
EP1841490A2 (en) 2005-01-18 2007-10-10 Koninklijke Philips Electronics N.V. Electronically controlled capsule
JP4099484B2 (ja) 2005-02-09 2008-06-11 株式会社カイザーテクノロジー 通信システム。
JP4731936B2 (ja) 2005-02-09 2011-07-27 本田技研工業株式会社 回転式可変抵抗器
AU2006212007A1 (en) 2005-02-11 2006-08-17 The University Court Of The University Of Glasgow Sensing device, apparatus and system, and method for operating the same
US7850645B2 (en) 2005-02-11 2010-12-14 Boston Scientific Scimed, Inc. Internal medical devices for delivery of therapeutic agent in conjunction with a source of electrical power
US7504954B2 (en) * 2005-03-17 2009-03-17 Spaeder Jeffrey A Radio frequency identification pharmaceutical tracking system and method
CN101180093B (zh) 2005-03-21 2012-07-18 雅培糖尿病护理公司 用于提供结合的药剂输液以及分析物监测系统的方法和系统
ATE407508T1 (de) 2005-03-22 2008-09-15 Koninkl Philips Electronics Nv Adressierungsschema für intelligente drahtlose sensoren-netzwerke zum medizinischen gebrauch
US20060216603A1 (en) 2005-03-26 2006-09-28 Enable Ipc Lithium-ion rechargeable battery based on nanostructures
EP1893282A1 (en) 2005-04-07 2008-03-05 St. Jude Medical AB System and method for radio communication between an implantable medical device and an external base unit
US7270633B1 (en) 2005-04-22 2007-09-18 Cardiac Pacemakers, Inc. Ambulatory repeater for use in automated patient care and method thereof
US20060247505A1 (en) 2005-04-28 2006-11-02 Siddiqui Waqaas A Wireless sensor system
DK1889198T3 (da) 2005-04-28 2015-02-09 Proteus Digital Health Inc Farma-informatiksystem
US9198608B2 (en) * 2005-04-28 2015-12-01 Proteus Digital Health, Inc. Communication system incorporated in a container
US20120024889A1 (en) * 2005-04-28 2012-02-02 Timothy Robertson Polypharmacy Co-Packaged Medication Dosing Unit Including Communication System Therefor
US7414543B2 (en) 2005-04-28 2008-08-19 Honeywell International Inc. Multiple miniature avionic displays
US7359674B2 (en) 2005-05-10 2008-04-15 Nokia Corporation Content distribution & communication system for enhancing service distribution in short range radio environment
US20070222556A1 (en) 2005-05-17 2007-09-27 Robbins Gene A Tracking system for distributable objects which are marked in single laser shot events with dynamically variable images
JP4933538B2 (ja) * 2005-05-20 2012-05-16 ダウ グローバル テクノロジーズ エルエルシー 無線周波識別標識を用いた経口薬服薬履行監視
US8285205B2 (en) 2005-05-26 2012-10-09 Broadcom Corporation Method and system for a single chip integrated Bluetooth and FM transceiver and baseband processor
US20060273882A1 (en) 2005-06-01 2006-12-07 Intel Corporation RFID tag with separate transmit and receive clocks and related method
US20060276702A1 (en) 2005-06-03 2006-12-07 Mcginnis William Neurophysiological wireless bio-sensor
US7387607B2 (en) 2005-06-06 2008-06-17 Intel Corporation Wireless medical sensor system
EP1904173B8 (en) 2005-06-09 2016-06-08 Medtronic, Inc. Implantable medical device with electrodes on multiple housing surfaces
US20060282001A1 (en) 2005-06-09 2006-12-14 Michel Noel Physiologic sensor apparatus
WO2006130988A1 (en) 2005-06-10 2006-12-14 Telecommunications Research Laboratories Wireless communication system
ITTO20050407A1 (it) 2005-06-13 2006-12-14 Ist Superiore Mario Boella Sistema di monitoraggio remoto di parametri fisiologici di un individuo, procedimento e prodotto informatico
US7782189B2 (en) 2005-06-20 2010-08-24 Carestream Health, Inc. System to monitor the ingestion of medicines
US7616111B2 (en) 2005-06-20 2009-11-10 Carestream Health, Inc. System to monitor the ingestion of medicines
WO2007002697A2 (en) 2005-06-28 2007-01-04 Mayo Foundation For Medical Education And Research System for monitoring a physical parameter of a subject
FI20055366A0 (fi) 2005-06-30 2005-06-30 Gen Electric Elektrodi biopotentiaalisignaalin saamiseksi
US20070016089A1 (en) 2005-07-15 2007-01-18 Fischell David R Implantable device for vital signs monitoring
EP3424421A3 (en) 2005-07-20 2019-03-06 Neil R. Euliano Electronic pill for monitoring medication compliance
CN100471445C (zh) 2005-08-01 2009-03-25 周常安 贴片式生理监测装置
US20090142853A1 (en) 2005-08-11 2009-06-04 Eksigent Technologies, Llc Microfluidic system and methods
US20090124871A1 (en) 2005-08-22 2009-05-14 Khalil Arshak Tracking system
US8116809B2 (en) 2005-08-29 2012-02-14 Intel Corporation Method and apparatus of multiple entity wireless communication adapter
US8827904B2 (en) 2005-08-31 2014-09-09 Medtronic, Inc. Automatic parameter status on an implantable medical device system
EP1920418A4 (en) 2005-09-01 2010-12-29 Proteus Biomedical Inc IMPLANTABLE WIRELESS COMMUNICATION SYSTEMS
JP2007068622A (ja) 2005-09-05 2007-03-22 Olympus Corp 被検体内情報取得システム
EP1931237A2 (en) 2005-09-14 2008-06-18 Neoguide Systems, Inc. Methods and apparatus for performing transluminal and other procedures
WO2007031973A2 (en) 2005-09-15 2007-03-22 Visible Assets, Inc. Active low frequency radio tag and patch drug delivery system
US7673679B2 (en) 2005-09-19 2010-03-09 Schlumberger Technology Corporation Protective barriers for small devices
US20080058614A1 (en) 2005-09-20 2008-03-06 Triage Wireless, Inc. Wireless, internet-based system for measuring vital signs from a plurality of patients in a hospital or medical clinic
GB0519836D0 (en) 2005-09-29 2005-11-09 Smartlife Technology Ltd Contact sensors
GB0519837D0 (en) 2005-09-29 2005-11-09 Smartlife Technology Ltd Knitting techniques
GB0519945D0 (en) 2005-09-30 2005-11-09 Cambridge Silicon Radio Ltd Communication in dual protocol environments
US20070078324A1 (en) 2005-09-30 2007-04-05 Textronics, Inc. Physiological Monitoring Wearable Having Three Electrodes
CN100466966C (zh) 2005-10-08 2009-03-11 周常安 呼吸气流生理信号提取和监测装置及系统
US7733224B2 (en) 2006-06-30 2010-06-08 Bao Tran Mesh network personal emergency response appliance
US9154616B2 (en) 2005-10-18 2015-10-06 Oia Intellectuals, Inc. Wearable capture and communication
US7720036B2 (en) 2005-10-26 2010-05-18 Intel Corporation Communication within a wireless network using multiple frequency bands
US7499739B2 (en) 2005-10-27 2009-03-03 Smiths Medical Pm, Inc. Single use pulse oximeter
US8515348B2 (en) 2005-10-28 2013-08-20 Electro Industries/Gauge Tech Bluetooth-enable intelligent electronic device
US9067047B2 (en) * 2005-11-09 2015-06-30 The Invention Science Fund I, Llc Injectable controlled release fluid delivery system
GB0523447D0 (en) 2005-11-17 2005-12-28 E San Ltd System and method for communicating environmentally-based medical support advice
US8016776B2 (en) 2005-12-02 2011-09-13 Medtronic, Inc. Wearable ambulatory data recorder
US8295932B2 (en) 2005-12-05 2012-10-23 Metacure Limited Ingestible capsule for appetite regulation
NL1030608C2 (nl) 2005-12-06 2007-06-07 Patrick Antonius Hendri Meeren Blisterverpakking, samenstel van een blisterverpakking en een houder, alsmede werkwijze voor het verpakken van objecten.
CN1985752A (zh) 2005-12-19 2007-06-27 周常安 分布式生理信号监测设备
US20070156016A1 (en) 2005-12-29 2007-07-05 Ido Betesh Method and system for communication with an ingestible imaging device
US7678043B2 (en) 2005-12-29 2010-03-16 Given Imaging, Ltd. Device, system and method for in-vivo sensing of a body lumen
BRPI0620863A8 (pt) 2005-12-29 2018-01-16 Osmotica Kereskedelmi Es Szolgaltato Kft comprimido em camadas com combinação de liberação tripla
US8301254B2 (en) 2006-01-09 2012-10-30 Greatbatch Ltd. Cross-band communications in an implantable device
US20070162089A1 (en) 2006-01-09 2007-07-12 Transoma Medical, Inc. Cross-band communications in an implantable device
US8078278B2 (en) 2006-01-10 2011-12-13 Remon Medical Technologies Ltd. Body attachable unit in wireless communication with implantable devices
EP1979040B1 (en) 2006-01-23 2009-09-02 Koninklijke Philips Electronics N.V. Improved biomedical electrode for extended patient wear featuring a tap, or snap, which is isolated from the retention seal
US20070185393A1 (en) 2006-02-03 2007-08-09 Triage Wireless, Inc. System for measuring vital signs using an optical module featuring a green light source
US7809399B2 (en) 2006-02-10 2010-10-05 Syntek International Holding Ltd. Method and device for providing multiple communication protocols with a single transceiver
WO2007101141A2 (en) 2006-02-24 2007-09-07 Hmicro, Inc. A medical signal processing system with distributed wireless sensors
US20090023391A1 (en) 2006-02-24 2009-01-22 Koninklijke Philips Electronics N. V. Wireless body sensor network
US8200320B2 (en) 2006-03-03 2012-06-12 PhysioWave, Inc. Integrated physiologic monitoring systems and methods
WO2007104152A2 (en) 2006-03-14 2007-09-20 Jamie Hackett Long-range radio frequency receiver-controller module and wireless control system comprising same
US8920343B2 (en) 2006-03-23 2014-12-30 Michael Edward Sabatino Apparatus for acquiring and processing of physiological auditory signals
US8389003B2 (en) 2006-03-29 2013-03-05 Eatlittle Inc. Ingestible implement for weight control
CN102323984A (zh) 2006-03-30 2012-01-18 陶氏环球技术有限责任公司 用于监控并分析体内用药方案的依从的方法与系统
TW200738212A (en) 2006-04-12 2007-10-16 Guo Terry Bo Jau Miniature wireless apparatus for collecting physiological signals of animals
EP2012664A2 (en) * 2006-04-25 2009-01-14 Dow Global Technologies Inc. Oral drug compliance monitoring using magnetic-field sensors
US7912537B2 (en) 2006-04-27 2011-03-22 Medtronic, Inc. Telemetry-synchronized physiological monitoring and therapy delivery systems
GB0608829D0 (en) 2006-05-04 2006-06-14 Husheer Shamus L G In-situ measurement of physical parameters
WO2007128165A1 (fr) 2006-05-09 2007-11-15 Fangen Xiong Systèmes de réseaux sans fil courte portée et procédé de montage consistant à attribuer des créneaux temporels avec un émetteur-récepteur rf multivoie
US20080051647A1 (en) 2006-05-11 2008-02-28 Changwang Wu Non-invasive acquisition of large nerve action potentials (NAPs) with closely spaced surface electrodes and reduced stimulus artifacts
US7558622B2 (en) 2006-05-24 2009-07-07 Bao Tran Mesh network stroke monitoring appliance
EP2018741B1 (en) 2006-05-15 2013-02-20 Nokia Corporation Contactless programming and testing of memory elements
US7539533B2 (en) 2006-05-16 2009-05-26 Bao Tran Mesh network monitoring appliance
US20080119716A1 (en) 2006-05-17 2008-05-22 Olga Boric-Lubecke Determining presence and/or physiological motion of one or more subjects with quadrature doppler radar receiver systems
CN101073494B (zh) 2006-05-18 2010-09-08 周常安 非侵入式生命迹象监测设备、系统及方法
US20070279217A1 (en) 2006-06-01 2007-12-06 H-Micro, Inc. Integrated mobile healthcare system for cardiac care
AU2007256872B2 (en) 2006-06-01 2013-03-14 Resmed Sensor Technologies Limited Apparatus, system, and method for monitoring physiological signs
DE502006004740D1 (de) 2006-06-14 2009-10-15 Paul Mueller Gmbh & Co Kg Spindel mit Zugstange und Stromleiter
US7346380B2 (en) 2006-06-16 2008-03-18 Axelgaard Manufacturing Co., Ltd. Medical electrode
US20080046038A1 (en) 2006-06-26 2008-02-21 Hill Gerard J Local communications network for distributed sensing and therapy in biomedical applications
US7949404B2 (en) 2006-06-26 2011-05-24 Medtronic, Inc. Communications network for distributed sensing and therapy in biomedical applications
US20080020037A1 (en) 2006-07-11 2008-01-24 Robertson Timothy L Acoustic Pharma-Informatics System
US7962174B2 (en) 2006-07-12 2011-06-14 Andrew Llc Transceiver architecture and method for wireless base-stations
US20080021521A1 (en) 2006-07-18 2008-01-24 Cardiac Pacemakers, Inc. Implantable Medical Device Communication System
DE102007020583B4 (de) 2006-07-19 2012-10-11 Erbe Elektromedizin Gmbh Elektrodeneinrichtung mit einerImnpedanz-Messeinrichtung und Verfahren zum Herstellen einer derartigen Elektrodeneinrichtung
EP2051615A4 (en) 2006-08-10 2011-03-23 Given Imaging Ltd SYSTEM AND METHOD FOR IN VIVO IMAGING
US20080097549A1 (en) 2006-09-01 2008-04-24 Colbaugh Michael E Electrode Assembly and Method of Using Same
US7756573B2 (en) 2006-09-05 2010-07-13 Cardiac Pacemakers, Inc. Implantable medical device diagnostic data acquisition and storage
US8512241B2 (en) 2006-09-06 2013-08-20 Innurvation, Inc. Methods and systems for acoustic data transmission
WO2008030480A2 (en) 2006-09-06 2008-03-13 Innurvation, Inc. Ingestible low power sensor device and system for communicating with same
CN101516256A (zh) 2006-09-18 2009-08-26 皇家飞利浦电子股份有限公司 基于ip的监测和报警
US20080077028A1 (en) 2006-09-27 2008-03-27 Biotronic Crm Patent Personal health monitoring and care system
US20080077184A1 (en) 2006-09-27 2008-03-27 Stephen Denker Intravascular Stimulation System With Wireless Power Supply
CN101522094B (zh) 2006-09-29 2013-12-18 皇家飞利浦电子股份有限公司 微型化阈值传感器
US20080091114A1 (en) 2006-10-11 2008-04-17 Pacesetter, Inc. Techniques for Correlating Thoracic Impedance with Physiological Status
US20080091089A1 (en) 2006-10-12 2008-04-17 Kenneth Shane Guillory Single use, self-contained surface physiological monitor
US8054140B2 (en) 2006-10-17 2011-11-08 Proteus Biomedical, Inc. Low voltage oscillator for medical devices
US20080097917A1 (en) 2006-10-24 2008-04-24 Kent Dicks Systems and methods for wireless processing and medical device monitoring via remote command execution
SG175681A1 (en) 2006-10-25 2011-11-28 Proteus Biomedical Inc Controlled activation ingestible identifier
US20080119705A1 (en) 2006-11-17 2008-05-22 Medtronic Minimed, Inc. Systems and Methods for Diabetes Management Using Consumer Electronic Devices
US8718193B2 (en) 2006-11-20 2014-05-06 Proteus Digital Health, Inc. Active signal processing personal health signal receivers
CN101541237A (zh) 2006-11-21 2009-09-23 皇家飞利浦电子股份有限公司 可摄取电子胶囊以及体内给药或诊断系统
GB0624081D0 (en) 2006-12-01 2007-01-10 Oxford Biosignals Ltd Biomedical signal analysis method
GB0624085D0 (en) 2006-12-01 2007-01-10 Oxford Biosignals Ltd Biomedical signal analysis method
US20080137566A1 (en) 2006-12-06 2008-06-12 Bojko Marholev Method and System for Shared High-Power Transmit Path for a Multi-Protocol Transceiver
US20080146889A1 (en) 2006-12-13 2008-06-19 National Yang-Ming University Method of monitoring human physiological parameters and safty conditions universally
US8157730B2 (en) 2006-12-19 2012-04-17 Valencell, Inc. Physiological and environmental monitoring systems and methods
TWI334747B (en) 2006-12-22 2010-12-11 Unimicron Technology Corp Circuit board structure having embedded electronic components
EP2127349A4 (en) 2007-01-10 2011-03-30 Camillo Ricordi MOBILE EMERGENCY ALARM SYSTEM
JP5461999B2 (ja) 2007-01-16 2014-04-02 ダウ グローバル テクノロジーズ エルエルシー 通信デバイスを組込む経口薬物カプセル構成材
WO2008091838A2 (en) 2007-01-22 2008-07-31 Intelliject, Inc. Medical injector with compliance tracking and monitoring
WO2008091683A2 (en) 2007-01-25 2008-07-31 Senior Vitals, Inc. System and method for physiological data readings, transmission and presentation
US20080183245A1 (en) 2007-01-31 2008-07-31 Van Oort Geeske Telemetry of external physiological sensor data and implantable medical device data to a central processing system
US8858432B2 (en) 2007-02-01 2014-10-14 Proteus Digital Health, Inc. Ingestible event marker systems
US20080214985A1 (en) 2007-02-02 2008-09-04 Activatek, Inc. Active transdermal medicament patch
MY154556A (en) 2007-02-14 2015-06-30 Proteus Digital Health Inc In-body power source having high surface area electrode
EP2124725A1 (en) 2007-03-09 2009-12-02 Proteus Biomedical, Inc. In-body device having a multi-directional transmitter
US9270025B2 (en) 2007-03-09 2016-02-23 Proteus Digital Health, Inc. In-body device having deployable antenna
US20080303638A1 (en) 2007-03-24 2008-12-11 Hap Nguyen Portable patient devices, systems, and methods for providing patient aid and preventing medical errors, for monitoring patient use of ingestible medications, and for preventing distribution of counterfeit drugs
WO2008120128A2 (en) 2007-03-30 2008-10-09 Koninklijke Philips Electronics N.V. System and method for pill communication and control
KR100895297B1 (ko) 2007-04-30 2009-05-07 한국전자통신연구원 다양한 생체 신호의 동시 측정을 위한 다채널 전극센서장치
US20100256461A1 (en) 2007-05-01 2010-10-07 Urodynamix Technologies Ltd. Apparatus and methods for evaluating physiological conditions of tissue
GB0709248D0 (en) 2007-05-14 2007-06-20 T & Medical Ltd System for monitoring chemotherapy associated adverse drug reactions
US8412293B2 (en) 2007-07-16 2013-04-02 Optiscan Biomedical Corporation Systems and methods for determining physiological parameters using measured analyte values
US8540632B2 (en) * 2007-05-24 2013-09-24 Proteus Digital Health, Inc. Low profile antenna for in body device
US20080300572A1 (en) 2007-06-01 2008-12-04 Medtronic Minimed, Inc. Wireless monitor for a personal medical device system
US8060175B2 (en) 2007-06-15 2011-11-15 General Electric Company System and apparatus for collecting physiological signals from a plurality of electrodes
US20080311852A1 (en) 2007-06-15 2008-12-18 Broadcom Corporation Multiple communication link coordination for shared data transmissions
GB2450517A (en) 2007-06-27 2008-12-31 Smartlife Technology Ltd Electrical resistance of yarn or fabric changes with temperature
JP5065780B2 (ja) 2007-07-03 2012-11-07 株式会社日立製作所 Ｒｆｉｄタグ実装基板
US20090009332A1 (en) * 2007-07-03 2009-01-08 Endotronix, Inc. System and method for monitoring ingested medication via rf wireless telemetry
JP4520491B2 (ja) 2007-07-09 2010-08-04 オリンパス株式会社 カプセル型医療システム
WO2009010970A2 (en) * 2007-07-16 2009-01-22 Mabat Chemical Systems Ltd. Modular chemical delivery unit
US8340750B2 (en) 2007-07-19 2012-12-25 Medtronic, Inc. Mechanical function marker channel for cardiac monitoring and therapy control
GB0714807D0 (en) 2007-07-30 2007-09-12 Oxford Biosignals Ltd Method and apparatus for measuring breathing rate
KR101080423B1 (ko) 2007-08-03 2011-11-04 삼성전자주식회사 멀티모듈결합형 휴대전자장치
KR100863064B1 (ko) 2007-08-03 2008-10-13 한국전자통신연구원 생체 신호 측정용 의복 및 그 제조 방법
US20090048498A1 (en) 2007-08-17 2009-02-19 Frank Riskey System and method of monitoring an animal
US20090062670A1 (en) 2007-08-30 2009-03-05 Gary James Sterling Heart monitoring body patch and system
JP5602629B2 (ja) 2007-09-07 2014-10-08 フローレ，インゴ 診断用センサユニット
US20090069642A1 (en) 2007-09-11 2009-03-12 Aid Networks, Llc Wearable Wireless Electronic Patient Data Communications and Physiological Monitoring Device
WO2009036334A1 (en) 2007-09-14 2009-03-19 Corventis, Inc. Adherent multi-sensor device with empathic monitoring
WO2009036333A1 (en) 2007-09-14 2009-03-19 Corventis, Inc. Dynamic pairing of patients to data collection gateways
US8961412B2 (en) 2007-09-25 2015-02-24 Proteus Digital Health, Inc. In-body device with virtual dipole signal amplification
US20090087483A1 (en) 2007-09-27 2009-04-02 Sison Raymundo A Oral dosage combination pharmaceutical packaging
US20090088618A1 (en) 2007-10-01 2009-04-02 Arneson Michael R System and Method for Manufacturing a Swallowable Sensor Device
US20090105561A1 (en) 2007-10-17 2009-04-23 Searete Llc, A Limited Liability Corporation Of The State Of Delaware Medical or veterinary digestive tract utilization systems and methods
US8134459B2 (en) 2007-10-19 2012-03-13 Smiths Medical Asd, Inc. Wireless telecommunications system adaptable for patient monitoring
US20090105567A1 (en) 2007-10-19 2009-04-23 Smiths Medical Pm, Inc. Wireless telecommunications network adaptable for patient monitoring
US8139225B2 (en) 2007-10-24 2012-03-20 Siemens Medical Solutions Usa, Inc. System for processing patient monitoring power and data signals
GB0721117D0 (en) 2007-10-26 2007-12-05 T & Medical Ltd system for assisting in drug dose optimisaion
US20090112626A1 (en) 2007-10-30 2009-04-30 Cary Talbot Remote wireless monitoring, processing, and communication of patient data
WO2009063377A1 (en) 2007-11-13 2009-05-22 Koninklijke Philips Electronics N.V. Ingestible electronic capsule
DK2215726T3 (en) 2007-11-27 2018-04-09 Proteus Digital Health Inc Transbody communication modules with communication channels
US20090157113A1 (en) 2007-12-18 2009-06-18 Ethicon Endo-Surgery, Inc. Wearable elements for implantable restriction systems
US9011327B2 (en) 2007-12-20 2015-04-21 Koninklijke Philips N.V. Capacitive sensing and communicating
JP5091657B2 (ja) 2007-12-21 2012-12-05 株式会社東芝 無線通信装置及び無線通信方法
US20090171180A1 (en) 2007-12-28 2009-07-02 Trevor Pering Method and apparatus for configuring wearable sensors
US8401659B2 (en) 2008-01-15 2013-03-19 Cardiac Pacemakers, Inc. Implantable medical device with wireless communications
US7844341B2 (en) 2008-01-15 2010-11-30 Cardiac Pacemakers, Inc. Implantable medical device with antenna
US20090182207A1 (en) 2008-01-16 2009-07-16 Tenxsys Inc. Ingestible animal health sensor
GB2456567B (en) 2008-01-18 2010-05-05 Oxford Biosignals Ltd Novelty detection
JP5132335B2 (ja) 2008-01-29 2013-01-30 富士フイルム株式会社 カプセル内視鏡及びカプセル内視鏡システム
JP5156427B2 (ja) 2008-02-13 2013-03-06 富士フイルム株式会社 カプセル内視鏡システム
EP3827811A1 (en) 2008-03-05 2021-06-02 Otsuka Pharmaceutical Co., Ltd. Multi-mode communication ingestible event markers and systems
EP2249919B1 (en) 2008-03-06 2019-05-22 Stryker Corporation Foldable, implantable electrode array assembly
US20090243833A1 (en) 2008-03-31 2009-10-01 Ching Ching Huang Monitoring system and method for patient care
ATE542468T1 (de) 2008-04-03 2012-02-15 Olympus Medical Systems Corp Antenneneinheit und empfangsvorrichtung für medizinische kapselvorrichtung
US8690769B2 (en) 2008-04-21 2014-04-08 Philometron, Inc. Metabolic energy monitoring system
WO2009154707A2 (en) 2008-06-18 2009-12-23 The Smartpill Corporation System and method of evaluating a subject with an ingestible capsule
US20090318303A1 (en) 2008-06-20 2009-12-24 International Business Machines Corporation Microfluidic selection of library elements
US9014778B2 (en) 2008-06-24 2015-04-21 Biosense Webster, Inc. Disposable patch and reusable sensor assembly for use in medical device localization and mapping systems
CH699071A2 (fr) 2008-07-02 2010-01-15 Flakes S A Dispositif de freinage et/ou de blocage mécanique.
AU2009268734A1 (en) 2008-07-07 2010-01-14 Mario W. Cardullo Dynamically distributable nano RFID device and related method
ES2696984T3 (es) 2008-07-08 2019-01-21 Proteus Digital Health Inc Infraestructura de datos de marcadores de eventos de ingestión
EP2313003B1 (en) 2008-08-13 2016-08-03 Proteus Digital Health, Inc. Ingestible circuitry
US20100056878A1 (en) 2008-08-28 2010-03-04 Partin Dale L Indirectly coupled personal monitor for obtaining at least one physiological parameter of a subject
US9943644B2 (en) 2008-08-31 2018-04-17 Abbott Diabetes Care Inc. Closed loop control with reference measurement and methods thereof
US20100063841A1 (en) 2008-09-05 2010-03-11 Vital Data Technology, Llc System and method of notifying designated entities of access to personal medical records
US20100069002A1 (en) 2008-09-16 2010-03-18 Vcan Sports, Inc. Method and apparatus for a wireless communication device utilizing bluetooth technology
US8036748B2 (en) 2008-11-13 2011-10-11 Proteus Biomedical, Inc. Ingestible therapy activator system and method
TWI503101B (zh) 2008-12-15 2015-10-11 Proteus Digital Health Inc 與身體有關的接收器及其方法
JP5785097B2 (ja) * 2009-01-06 2015-09-24 プロテウス デジタル ヘルス， インコーポレイテッド 薬学的投薬量送達システム
US8395521B2 (en) 2009-02-06 2013-03-12 University Of Dayton Smart aerospace structures
US8073401B2 (en) 2009-02-17 2011-12-06 Rfaxis, Inc. Multi mode radio frequency transceiver front end circuit with inter-stage matching circuit
CA2789521A1 (en) 2009-02-25 2010-09-02 Xanthia Global Limited Wireless physiology monitor
US8452366B2 (en) 2009-03-16 2013-05-28 Covidien Lp Medical monitoring device with flexible circuitry
US8805528B2 (en) 2009-03-31 2014-08-12 Medtronic, Inc. Channel assessment and selection for wireless communication between medical devices
SG10201810784SA (en) 2009-04-28 2018-12-28 Proteus Digital Health Inc Highly Reliable Ingestible Event Markers And Methods For Using The Same
EP2432458A4 (en) 2009-05-12 2014-02-12 Proteus Digital Health Inc ACCEPTABLE EVENT MARKER WITH SUGAR COMPONENT
US20110230732A1 (en) 2009-09-14 2011-09-22 Philometron, Inc. System utilizing physiological monitoring and electronic media for health improvement
WO2011112972A2 (en) 2010-03-11 2011-09-15 Philometron, Inc. Physiological monitor system for determining medication delivery and outcome
WO2011133799A1 (en) 2010-04-21 2011-10-27 Northwestern University Medical evaluation system and method using sensors in mobile devices
CN106296226A (zh) 2010-06-14 2017-01-04 特鲁塔格科技公司 用于生产具有标识符的包装物品的系统
JP5709987B2 (ja) 2010-06-14 2015-04-30 トルタグ・テクノロジーズ・インコーポレーテッドＴｒｕｔａｇ Ｔｅｃｈｎｏｌｏｇｉｅｓ Ｉｎｃｏｒｐｏｒａｔｅｄ パッケージのなかの商品を検証するためのシステム
EP2580688A4 (en) 2010-06-14 2017-05-10 Trutag Technologies, Inc. Labeling and verifying an item with an identifier
CN103189855B (zh) 2010-06-14 2016-10-19 特鲁塔格科技公司 用于使用数据库验证包装中的物品的系统
KR101450493B1 (ko) 2010-09-13 2014-10-13 노키아 코포레이션 햅틱 통신

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