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TR200003087T2 - Yeni CD19 X CD3 Spesifik polipeptidler ve kullanımları - Google Patents

Yeni CD19 X CD3 Spesifik polipeptidler ve kullanımları

Info

Publication number
TR200003087T2
TR200003087T2 TR2000/03087T TR200003087T TR200003087T2 TR 200003087 T2 TR200003087 T2 TR 200003087T2 TR 2000/03087 T TR2000/03087 T TR 2000/03087T TR 200003087 T TR200003087 T TR 200003087T TR 200003087 T2 TR200003087 T2 TR 200003087T2
Authority
TR
Turkey
Prior art keywords
polypeptides
polynucleotides
vectors
new
specific polypeptides
Prior art date
Application number
TR2000/03087T
Other languages
English (en)
Inventor
D�Rken Bernd
Riethm�Ller Gert
Kufer Peter
Lutterbse Ralf
Bargou Ralf
L�Ffler Anja
Original Assignee
Micromet Ag
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=8231795&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=TR200003087(T2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Micromet Ag filed Critical Micromet Ag
Publication of TR200003087T2 publication Critical patent/TR200003087T2/tr

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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10Cells modified by introduction of foreign genetic material
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2809Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against the T-cell receptor (TcR)-CD3 complex
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00Antineoplastic agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00Drugs for immunological or allergic disorders
    • A61P37/02Immunomodulators
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K16/00Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00Medicinal preparations containing antigens or antibodies
    • A61K2039/505Medicinal preparations containing antigens or antibodies comprising antibodies
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K48/00Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2317/00Immunoglobulins specific features
    • C07K2317/30Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/34Identification of a linear epitope shorter than 20 amino acid residues or of a conformational epitope defined by amino acid residues
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K2319/00Fusion polypeptide

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Genetics & Genomics (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Biochemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Wood Science & Technology (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Zoology (AREA)
  • Veterinary Medicine (AREA)
  • Microbiology (AREA)
  • Cell Biology (AREA)
  • General Engineering & Computer Science (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Macromolecular Compounds Obtained By Forming Nitrogen-Containing Linkages In General (AREA)

Abstract

Sirasiyla CD19 ve CD3 antijenlerine spesifik, en azindan iki baglanma yerinden olusan yeni tek zincirli, çok fonksiyonlu polipeptidleri anlatilmistir. yukarida açiklanan polipeptidin en azindan daha önce saptanmis baska bir fonksiyon domaininden olustugu polipeptidler de saglanmistir. Ayrica sözü edilen polipeptidleri kodlayan polinükleotidler ve sözü edilen polinükleotidlerden olusan vektörlerle bunlarin aktarildigi (transforme) konak hücreler ve bunlarin sözü edilen polipeptidlerin üretiminde kullanilmasi da açiklanmistir. Ayrica bulus yukarida açiklanan polipeptidler, polinükleotidler veya vektörlerden olusan tercihen farmasötik ve diagnostik kompozisyonlar da saglanmistir. yukarda belirtilen polipeptidlerin, polinükleotidlerin ve vektörlerin tercihen non-Hodgkin lemfoma gibi B-hücresi habisliklerine karsi immünoterapi için kullanilan farmasötik kompozisyonlarin hazirlanmasina yönelik kullanimi açiklanmistir.
TR2000/03087T 1998-04-21 1999-04-21 Yeni CD19 X CD3 Spesifik polipeptidler ve kullanımları TR200003087T2 (tr)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
EP98107269 1998-04-21

Publications (1)

Publication Number Publication Date
TR200003087T2 true TR200003087T2 (tr) 2001-02-21

Family

ID=8231795

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2000/03087T TR200003087T2 (tr) 1998-04-21 1999-04-21 Yeni CD19 X CD3 Spesifik polipeptidler ve kullanımları

Country Status (29)

Country Link
US (2) US7112324B1 (tr)
EP (2) EP1348715A3 (tr)
JP (1) JP4169478B2 (tr)
KR (1) KR100508289B1 (tr)
CN (1) CN1302103C (tr)
AT (1) ATE244758T1 (tr)
AU (1) AU761587B2 (tr)
BR (1) BRPI9909860B8 (tr)
CA (1) CA2326389C (tr)
CU (1) CU23252B7 (tr)
CZ (1) CZ302070B6 (tr)
DE (1) DE69909459T2 (tr)
DK (1) DK1071752T3 (tr)
ES (1) ES2203141T3 (tr)
HK (1) HK1037674A1 (tr)
HR (1) HRP20000714B1 (tr)
HU (1) HU229039B1 (tr)
ID (1) ID27512A (tr)
IL (2) IL138857A0 (tr)
NO (1) NO326523B1 (tr)
NZ (1) NZ507381A (tr)
PL (1) PL199747B1 (tr)
PT (1) PT1071752E (tr)
RU (1) RU2228202C2 (tr)
SI (1) SI1071752T1 (tr)
SK (1) SK286683B6 (tr)
TR (1) TR200003087T2 (tr)
WO (1) WO1999054440A1 (tr)
ZA (1) ZA200005866B (tr)

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