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TR200001081T2 - CDKS inhibitörleri olarak ikame edilmiş 4-amino tiyazol-2-il bileşikleri - Google Patents

CDKS inhibitörleri olarak ikame edilmiş 4-amino tiyazol-2-il bileşikleri

Info

Publication number
TR200001081T2
TR200001081T2 TR2000/01081T TR200001081T TR200001081T2 TR 200001081 T2 TR200001081 T2 TR 200001081T2 TR 2000/01081 T TR2000/01081 T TR 2000/01081T TR 200001081 T TR200001081 T TR 200001081T TR 200001081 T2 TR200001081 T2 TR 200001081T2
Authority
TR
Turkey
Prior art keywords
compounds substituted
amino thiazole
cdks inhibitors
formula
compound
Prior art date
Application number
TR2000/01081T
Other languages
English (en)
Inventor
K. M. Chong Wesley
Song Chu Shao
K. Duvadie Rohit
Li Lin
Xiao Wei
Yang Yi
Original Assignee
Agouron Pharmaceuticals, Inc.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Agouron Pharmaceuticals, Inc. filed Critical Agouron Pharmaceuticals, Inc.
Publication of TR200001081T2 publication Critical patent/TR200001081T2/tr

Links

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
    • C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
    • C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
    • C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
    • C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
    • C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
    • C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D277/00—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings
    • C07D277/02—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings
    • C07D277/20—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D277/32—Heterocyclic compounds containing 1,3-thiazole or hydrogenated 1,3-thiazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D277/38—Nitrogen atoms
    • C07D277/42—Amino or imino radicals substituted by hydrocarbon or substituted hydrocarbon radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings
    • C07D417/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D417/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00
    • C07D417/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing three or more hetero rings

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Thiazole And Isothizaole Compounds (AREA)

Abstract

Bu bulus, CDK1, CDK2, CDK4 ce CDK6 gibi sikline bagli kinazlarin önlenmesi için, formül (I)' e aminotiyazol bilesikleri; veya formül (I)' e ait bir bilesigin farmasötik açidan kabul gören bir tuzu, veya formül (I)' e ait bir bilesigin veya bunun farmasötik açidan kabul gören bir tuzunun bir ön ilaci veya farmasötik açidan aktif bir metaboliti ile ilgilidir.
TR2000/01081T 1997-10-27 1998-10-27 CDKS inhibitörleri olarak ikame edilmiş 4-amino tiyazol-2-il bileşikleri TR200001081T2 (tr)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US6363497P 1997-10-27 1997-10-27
US6366697P 1997-10-28 1997-10-28

Publications (1)

Publication Number Publication Date
TR200001081T2 true TR200001081T2 (tr) 2000-10-23

Family

ID=26743609

Family Applications (1)

Application Number Title Priority Date Filing Date
TR2000/01081T TR200001081T2 (tr) 1997-10-27 1998-10-27 CDKS inhibitörleri olarak ikame edilmiş 4-amino tiyazol-2-il bileşikleri

Country Status (34)

Country Link
US (2) US6569878B1 (tr)
EP (1) EP1056732B1 (tr)
JP (1) JP2004500304A (tr)
KR (1) KR20010082501A (tr)
CN (1) CN1158269C (tr)
AP (1) AP1445A (tr)
AT (2) ATE332896T1 (tr)
AU (1) AU738792B2 (tr)
BG (1) BG64195B1 (tr)
BR (1) BR9815200A (tr)
CA (1) CA2306082A1 (tr)
DE (2) DE69835241T2 (tr)
EA (1) EA003527B1 (tr)
EE (1) EE200000289A (tr)
ES (2) ES2256968T3 (tr)
GE (1) GEP20032896B (tr)
HR (1) HRP20000222A2 (tr)
HU (1) HUP0004512A3 (tr)
ID (1) ID24372A (tr)
IL (1) IL135574A0 (tr)
IS (1) IS5462A (tr)
LT (1) LT4855B (tr)
LV (1) LV12592B (tr)
NO (1) NO20001955L (tr)
NZ (1) NZ503788A (tr)
OA (1) OA11352A (tr)
PL (1) PL342447A1 (tr)
RO (1) RO119463B1 (tr)
SI (1) SI20324A (tr)
SK (1) SK5212000A3 (tr)
TR (1) TR200001081T2 (tr)
UA (1) UA66810C2 (tr)
WO (1) WO1999021845A2 (tr)
YU (1) YU22400A (tr)

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AP2000001795A0 (en) 2000-06-30
LV12592A (en) 2000-12-20
NO20001955D0 (no) 2000-04-14
EE200000289A (et) 2001-06-15
ATE332896T1 (de) 2006-08-15
CN1276789A (zh) 2000-12-13
GEP20032896B (en) 2003-02-25
WO1999021845A3 (en) 1999-08-19
DE69833223T2 (de) 2006-09-14
AU738792B2 (en) 2001-09-27
EP1056732B1 (en) 2006-01-11
DE69835241D1 (de) 2006-08-24
AU1366499A (en) 1999-05-17
HUP0004512A2 (hu) 2002-03-28
EA200000464A1 (ru) 2000-12-25
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SI20324A (sl) 2001-02-28
BG104478A (en) 2001-02-28
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NZ503788A (en) 2002-11-26
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US6569878B1 (en) 2003-05-27
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YU22400A (sh) 2003-08-29
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WO1999021845A2 (en) 1999-05-06
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