TR200001018T2 - Alzheimer hastalığının tedavi yöntemi. - Google Patents
Alzheimer hastalığının tedavi yöntemi.Info
- Publication number
- TR200001018T2 TR200001018T2 TR2000/01018T TR200001018T TR200001018T2 TR 200001018 T2 TR200001018 T2 TR 200001018T2 TR 2000/01018 T TR2000/01018 T TR 2000/01018T TR 200001018 T TR200001018 T TR 200001018T TR 200001018 T2 TR200001018 T2 TR 200001018T2
- Authority
- TR
- Turkey
- Prior art keywords
- carbon atoms
- hydrogen
- alzheimer
- disease
- treatment method
- Prior art date
Links
- 208000024827 Alzheimer disease Diseases 0.000 title abstract 2
- 238000000034 method Methods 0.000 title abstract 2
- 125000004432 carbon atom Chemical group C* 0.000 abstract 6
- 229910052739 hydrogen Inorganic materials 0.000 abstract 5
- 239000001257 hydrogen Substances 0.000 abstract 5
- 125000004435 hydrogen atom Chemical group [H]* 0.000 abstract 5
- 125000000217 alkyl group Chemical group 0.000 abstract 2
- 125000004390 alkyl sulfonyl group Chemical group 0.000 abstract 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 abstract 2
- 229910052760 oxygen Inorganic materials 0.000 abstract 2
- 239000001301 oxygen Substances 0.000 abstract 2
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 abstract 1
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 abstract 1
- PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 abstract 1
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 abstract 1
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical compound [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 abstract 1
- 206010002022 amyloidosis Diseases 0.000 abstract 1
- 125000003435 aroyl group Chemical group 0.000 abstract 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 abstract 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 abstract 1
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 abstract 1
- 229910052794 bromium Inorganic materials 0.000 abstract 1
- 239000000460 chlorine Substances 0.000 abstract 1
- 229910052801 chlorine Inorganic materials 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 229910052731 fluorine Inorganic materials 0.000 abstract 1
- 239000011737 fluorine Substances 0.000 abstract 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 abstract 1
- 125000001038 naphthoyl group Chemical group C1(=CC=CC2=CC=CC=C12)C(=O)* 0.000 abstract 1
- 125000001624 naphthyl group Chemical group 0.000 abstract 1
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 abstract 1
- 125000000286 phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 abstract 1
- 125000004344 phenylpropyl group Chemical group 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- 229910052717 sulfur Inorganic materials 0.000 abstract 1
- 239000011593 sulfur Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/403—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil condensed with carbocyclic rings, e.g. carbazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- General Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Psychiatry (AREA)
- Hospice & Palliative Care (AREA)
- Endocrinology (AREA)
- Zoology (AREA)
- Gastroenterology & Hepatology (AREA)
- Organic Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Indole Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Nitrogen- Or Sulfur-Containing Heterocyclic Ring Compounds With Rings Of Six Or More Members (AREA)
- Plural Heterocyclic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Alzheimer hastaliginin tedavisinde ve amiloid hastaliklarin tedavisinde kullanilan, farmasötik olarak kabul edilebilir bir tuz olan bilesik ile tedavi yöntemi olup Formül (I):R7-R13 bagimsiz olarak -H veya -OH; ve A ise H, -OH veya formül (II)' nin bir parçasi olup R1 hidrojen, 6 karbon atomuna kadar allcanoil veya benzoil ve naftoil' den seçilmis aroil olup; R2 hidrojen, 6 karbonatomuna kadar alt alkil veya benzil, feniletil ve fenilpropil' den seçilmis arialkil; R3 hidrojen veya 6 karbon atomuna kadar alt alkil; R4 hidrojen veya 6 hidrojen atomuna kadar alt dahil, veya X' in oksijen oldugu halde, R4 ve R5 birlikte -CH2-O-' yu temsil edebilir; X bir deger bagi ise, -CH2, oksijen veya kükürt, Ar ise fenil, naftil, idanil ve tetrahidroaftil' den seçilmis; R5 ve R6 münferit olarak hidrojen, flor, klor, brom, hidroksil, 6 karbon atomuna kadar alt dahil, bir-CONH2- grubu, 6 karbon atomuna kadar alt alkisulfinil ve 6 karbon atomuna kadar alt alkilsulfonil; veya DEVAMI VAR.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6236697P | 1997-10-15 | 1997-10-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| TR200001018T2 true TR200001018T2 (tr) | 2000-08-21 |
Family
ID=22042015
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| TR2000/01018T TR200001018T2 (tr) | 1997-10-15 | 1998-10-15 | Alzheimer hastalığının tedavi yöntemi. |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US6358990B1 (tr) |
| EP (1) | EP1024697A4 (tr) |
| JP (1) | JP2001519364A (tr) |
| KR (1) | KR100573352B1 (tr) |
| CN (1) | CN1281334A (tr) |
| AU (1) | AU751526B2 (tr) |
| BR (1) | BR9814075A (tr) |
| CA (1) | CA2305262A1 (tr) |
| HU (1) | HUP0100024A3 (tr) |
| IL (1) | IL135584A (tr) |
| NO (1) | NO20001869L (tr) |
| NZ (1) | NZ504419A (tr) |
| PL (1) | PL339910A1 (tr) |
| TR (1) | TR200001018T2 (tr) |
| WO (1) | WO1999018794A1 (tr) |
| ZA (1) | ZA989365B (tr) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE10142175A1 (de) * | 2001-10-09 | 2003-03-27 | Eucro Europe Contract Res Gmbh | Verwendung von ß-Adrenozeptor-Agonisten zur Behandlung von neurodegenerativen Erkrankungen |
| US8101209B2 (en) * | 2001-10-09 | 2012-01-24 | Flamel Technologies | Microparticulate oral galenical form for the delayed and controlled release of pharmaceutical active principles |
| JP2006500320A (ja) * | 2002-04-30 | 2006-01-05 | エスビー・ファルムコ・プエルト・リコ・インコーポレイテッド | カルベジロール一クエン酸塩一水和物 |
| CA2492084A1 (en) * | 2002-06-27 | 2004-01-08 | Sb Pharmco Puerto Rico Inc. | Carvedilol hydobromide |
| CN103254114A (zh) * | 2002-06-27 | 2013-08-21 | 史密斯克莱.比奇曼（科克）有限公司 | 卡维地洛磷酸盐和/或其溶剂合物相应的组合物和/或治疗方法 |
| US20050169994A1 (en) * | 2003-11-25 | 2005-08-04 | Burke Matthew D. | Carvedilol free base, salts, anhydrous forms or solvates thereof, corresponding pharmaceutical compositions, controlled release formulations, and treatment or delivery methods |
| WO2005051322A2 (en) * | 2003-11-25 | 2005-06-09 | Sb Pharmco Puerto Rico Inc. | Controlled release pharmaceutical formulations comprising carvedilol, free based and its salts |
| EP1686986A4 (en) * | 2003-11-25 | 2009-05-27 | Sb Pharmco Inc | CARVEDILOL SALTS, CORRESPONDING COMPOSITIONS, METHODS OF ADMINISTRATION AND / OR TREATMENT |
| CN1991364A (zh) * | 2005-12-26 | 2007-07-04 | 中国科学院上海生命科学研究院 | 预防和治疗阿尔兹海默症的g蛋白偶联受体拮抗剂 |
| EP2007385A4 (en) * | 2006-03-23 | 2010-08-18 | Sinai School Medicine | CARDIOVASCULAR COMPOSITION AND ITS USE FOR THE TREATMENT OF MORBUS ALZHEIMER |
| WO2008021552A2 (en) * | 2006-08-18 | 2008-02-21 | Duke University | Biased ligands and methods of identifying same |
| US20090076116A1 (en) * | 2007-09-13 | 2009-03-19 | Protia, Llc | Deuterium-enriched carvediolo |
| US20110046378A1 (en) | 2008-02-14 | 2011-02-24 | Siemens Medical Solutions Usa, Inc. | Novel Imaging Agents for Detecting Neurological Dysfunction |
| US8932557B2 (en) | 2008-02-14 | 2015-01-13 | Eli Lilly And Company | Imaging agents for detecting neurological dysfunction |
| CN103172643B (zh) * | 2011-12-26 | 2016-03-02 | 中国医学科学院药物研究所 | 黄皮咔唑生物碱及其制备方法和其药物组合物与用途 |
| CN102816107B (zh) * | 2012-08-20 | 2015-06-03 | 东南大学 | 咔唑衍生物及其制备方法与用途 |
| KR20160026897A (ko) | 2013-06-27 | 2016-03-09 | 세다르스-신나이 메디칼 센터 | 신경퇴행성 질환의 예방 및 치료를 위한 아드레날린 수용체 길항제 |
| CA3192905A1 (en) * | 2020-09-17 | 2022-06-23 | Sui Rong Wayne CHEN | Methods of treating and/or preventing alzheimer's disease with r-carvedilol |
| CN115487297A (zh) * | 2021-06-17 | 2022-12-20 | 清华大学 | 治疗神经元蜡样质脂褐质沉积症的方法和药物 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2815926A1 (de) * | 1978-04-13 | 1979-10-18 | Boehringer Mannheim Gmbh | Neue carbazolyl-(4)-oxy-propanolamin-derivate, verfahren zu ihrer herstellung und diese verbindungen enthaltende arzneimittel |
| DE3319027A1 (de) * | 1983-05-26 | 1984-11-29 | Boehringer Mannheim Gmbh, 6800 Mannheim | Verfahren zur herstellung von optisch aktiven carbazol-derivaten, neue r- und s-carbazol-derivate, sowie arzneimittel, die diese verbindungen enthalten |
| AU618520B2 (en) * | 1986-12-17 | 1992-01-02 | Glaxo Group Limited | Medicaments |
| US4868190A (en) * | 1988-12-27 | 1989-09-19 | Hoechst-Roussel Pharmaceuticals, Inc. | N-pyridinyl-9H-carbazol-9-amines |
| US4983608A (en) * | 1989-09-05 | 1991-01-08 | Hoechst-Roussell Pharmaceuticals, Inc. | N-substituted-4-pyrimidinamines and pyrimidinediamines |
| JPH0558998A (ja) * | 1991-09-06 | 1993-03-09 | Taisho Pharmaceut Co Ltd | カルバゾール誘導体 |
| WO1996003377A1 (en) * | 1994-07-27 | 1996-02-08 | Sankyo Company, Limited | Heterocyclic compounds, useful as allosteric effectors at muscarinic receptors |
| FR2724933A1 (fr) * | 1994-09-22 | 1996-03-29 | Pf Medicament | Nouveaux ethers aromatiques derives d'indoles utiles comme medicaments |
| US5760069A (en) * | 1995-02-08 | 1998-06-02 | Boehringer Mannheim Pharmaceuticals Corporation-Smithkline Beecham Corporation Limited Partnership #1 | Method of treatment for decreasing mortality resulting from congestive heart failure |
| FR2731222A1 (fr) * | 1995-03-02 | 1996-09-06 | Pf Medicament | Nouveaux derives de piperazine aminoindoles cycliques, leur procede de preparation et leur utilisation a titre de medicaments |
| JPH11505526A (ja) * | 1995-05-01 | 1999-05-21 | ユニヴァーシティ・オヴ・ピッツバーグ | アルツハイマー病の死前診断ならびにアミロイド沈着のイン・ビボのイメージ化及び予防のためのアゾ化合物 |
-
1998
- 1998-10-14 ZA ZA989365A patent/ZA989365B/xx unknown
- 1998-10-15 US US09/529,526 patent/US6358990B1/en not_active Expired - Fee Related
- 1998-10-15 HU HU0100024A patent/HUP0100024A3/hu unknown
- 1998-10-15 WO PCT/US1998/021789 patent/WO1999018794A1/en not_active Application Discontinuation
- 1998-10-15 CN CN98812171A patent/CN1281334A/zh active Pending
- 1998-10-15 CA CA002305262A patent/CA2305262A1/en not_active Abandoned
- 1998-10-15 EP EP98953558A patent/EP1024697A4/en not_active Withdrawn
- 1998-10-15 JP JP2000515438A patent/JP2001519364A/ja active Pending
- 1998-10-15 KR KR1020007003990A patent/KR100573352B1/ko not_active Expired - Fee Related
- 1998-10-15 IL IL13558498A patent/IL135584A/en not_active IP Right Cessation
- 1998-10-15 PL PL98339910A patent/PL339910A1/xx unknown
- 1998-10-15 BR BR9814075-2A patent/BR9814075A/pt not_active IP Right Cessation
- 1998-10-15 NZ NZ504419A patent/NZ504419A/xx unknown
- 1998-10-15 TR TR2000/01018T patent/TR200001018T2/tr unknown
- 1998-10-15 AU AU10897/99A patent/AU751526B2/en not_active Ceased
-
2000
- 2000-04-11 NO NO20001869A patent/NO20001869L/no unknown
Also Published As
| Publication number | Publication date |
|---|---|
| HUP0100024A2 (hu) | 2001-07-30 |
| AU751526B2 (en) | 2002-08-22 |
| JP2001519364A (ja) | 2001-10-23 |
| IL135584A (en) | 2005-12-18 |
| KR20010031108A (ko) | 2001-04-16 |
| EP1024697A4 (en) | 2007-05-02 |
| CA2305262A1 (en) | 1999-04-22 |
| NO20001869D0 (no) | 2000-04-11 |
| NO20001869L (no) | 2000-06-14 |
| IL135584A0 (en) | 2001-05-20 |
| CN1281334A (zh) | 2001-01-24 |
| KR100573352B1 (ko) | 2006-04-25 |
| ZA989365B (en) | 1999-04-15 |
| US6358990B1 (en) | 2002-03-19 |
| BR9814075A (pt) | 2000-09-26 |
| NZ504419A (en) | 2002-11-26 |
| WO1999018794A1 (en) | 1999-04-22 |
| PL339910A1 (en) | 2001-01-15 |
| EP1024697A1 (en) | 2000-08-09 |
| AU1089799A (en) | 1999-05-03 |
| HUP0100024A3 (en) | 2002-12-28 |
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