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SU514811A1 - The method of obtaining p-phenetidine - Google Patents

The method of obtaining p-phenetidine

Info

Publication number
SU514811A1
SU514811A1 SU1982872A SU1982872A SU514811A1 SU 514811 A1 SU514811 A1 SU 514811A1 SU 1982872 A SU1982872 A SU 1982872A SU 1982872 A SU1982872 A SU 1982872A SU 514811 A1 SU514811 A1 SU 514811A1
Authority
SU
USSR - Soviet Union
Prior art keywords
nitrobenzene
hours
phenetidine
loaded
carried out
Prior art date
Application number
SU1982872A
Other languages
Russian (ru)
Inventor
Валентина Семеновна Ценюга
Татьяна Алексеевна Кругликова
Нина Александровна Надежина
Галина Александровна Чистякова
Иллария Андреевна Смирнова
Нина Егоровна Скуратова
Антонина Африкановна Токнова
Original Assignee
Предприятие П/Я В-8469
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Предприятие П/Я В-8469 filed Critical Предприятие П/Я В-8469
Priority to SU1982872A priority Critical patent/SU514811A1/en
Application granted granted Critical
Publication of SU514811A1 publication Critical patent/SU514811A1/en

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  • Low-Molecular Organic Synthesis Reactions Using Catalysts (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

Claims (3)

3 ной кислоты, 6,6 г диметилсульфоксида (ДМСО), 40 г нитробензола, 0,2 г окиси платины. Восстановление ведут газообразным водородом под давлением 6 ати и температуре 75-80°С в течение 6 час. После прекращени  поглощени  водорода даетс  выдержка в атмосфере азота при давлении 6 ати и температуре 75-80 С в течение 4 час. Выход П -фенетидина на загруженны нитробензол 49,4%. Пример 2.В эмалированный аппа рат емкостью 63 л загружают 31,5 л абс лютированного этанола 2,95 кг серной кислоты, 0,44 кг ДМСО, 2,5 кг нитробензола, 9,5 г piOp. Восстановление ведут при давлении водорода 6 ати и температуре 75-80°С в течение 9 час и выдержке под азотом в течение 4 час. Выход fl -фенетидина на загруженны нитробензол 53,8%, Формула изобретени  1.Способ получени  „-фенетидина восстановлением нитробензола в абсолютированном спирте и в присутствии концентрированной серной кислоты, при нагревании , отличающийс  тем, что, с целью повышени  выхода целевого продукта , процесс восстановлени  ведут каталитически в присутствии катализатора платиновой группы, промотированного диме- тилсу ьфоксидом, с последующей термообработкой полученного продукта в атмосфе ре азота. 3% hydrochloric acid, 6.6 g of dimethyl sulfoxide (DMSO), 40 g of nitrobenzene, 0.2 g of platinum oxide. Recovery lead gaseous hydrogen under a pressure of 6 MPa and a temperature of 75-80 ° C for 6 hours. After the absorption of hydrogen ceases, aging is carried out in a nitrogen atmosphere at a pressure of 6 bar and a temperature of 75-80 ° C for 4 hours. The output of P-phenetidine on the loaded nitrobenzene 49.4%. Example 2. A 63 l enamelled apparatus with a capacity of 63 l is loaded with 31.5 l of absolutized ethanol, 2.95 kg of sulfuric acid, 0.44 kg of DMSO, 2.5 kg of nitrobenzene, 9.5 g of piOp. Recovery is carried out at a hydrogen pressure of 6 MPa and a temperature of 75-80 ° C for 9 hours and aging under nitrogen for 4 hours. Fl-phenetidine yield on nitrobenzene loaded 53.8%, claims 1. Method for producing α-phenetidine by reducing nitrobenzene in absolute alcohol and in the presence of concentrated sulfuric acid, with heating, characterized in that, in order to increase the yield of the target product, lead catalytically in the presence of a platinum group catalyst promoted with dimethyl phosphate, followed by heat treatment of the obtained product in a nitrogen atmosphere. 2.Способ по п. 1, о т л и ч а ю- щ и и с   тем, что в качестве катализатора используют окись платины, 2. The method according to claim 1, about tl and h and y and with the fact that as the catalyst using platinum oxide 3.Способ по пп. 1и2, отлича ющ и и с   тем, что процесс провод т при 50 125°С.3. Method according to paragraphs. 1 and 2, which is also distinguished by the fact that the process is carried out at 50 125 ° C.
SU1982872A 1974-01-03 1974-01-03 The method of obtaining p-phenetidine SU514811A1 (en)

Priority Applications (1)

Application Number Priority Date Filing Date Title
SU1982872A SU514811A1 (en) 1974-01-03 1974-01-03 The method of obtaining p-phenetidine

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
SU1982872A SU514811A1 (en) 1974-01-03 1974-01-03 The method of obtaining p-phenetidine

Publications (1)

Publication Number Publication Date
SU514811A1 true SU514811A1 (en) 1976-05-25

Family

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Family Applications (1)

Application Number Title Priority Date Filing Date
SU1982872A SU514811A1 (en) 1974-01-03 1974-01-03 The method of obtaining p-phenetidine

Country Status (1)

Country Link
SU (1) SU514811A1 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5493055A (en) * 1994-05-06 1996-02-20 Tambour, Ltd. Process for the manufacture of p-phenetidine

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5493055A (en) * 1994-05-06 1996-02-20 Tambour, Ltd. Process for the manufacture of p-phenetidine

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