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SK287008B6 - Spôsob prípravy citalopramu, citalopram pripravený týmto spôsobom a farmaceutický prostriedok s obsahom citalopramu - Google Patents

Spôsob prípravy citalopramu, citalopram pripravený týmto spôsobom a farmaceutický prostriedok s obsahom citalopramu Download PDF

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Publication number
SK287008B6
SK287008B6 SK322-2003A SK3222003A SK287008B6 SK 287008 B6 SK287008 B6 SK 287008B6 SK 3222003 A SK3222003 A SK 3222003A SK 287008 B6 SK287008 B6 SK 287008B6
Authority
SK
Slovakia
Prior art keywords
formula
alkyl
compound
citalopram
substituted
Prior art date
Application number
SK322-2003A
Other languages
English (en)
Slovak (sk)
Other versions
SK3222003A3 (en
Inventor
Hans Petersen
Haleh Ahmadian
Robert Dancer
Original Assignee
H. Lundbeck A/S
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by H. Lundbeck A/S filed Critical H. Lundbeck A/S
Publication of SK3222003A3 publication Critical patent/SK3222003A3/sk
Publication of SK287008B6 publication Critical patent/SK287008B6/sk

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/77—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D307/87—Benzo [c] furans; Hydrogenated benzo [c] furans
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/24—Antidepressants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/34—Tobacco-abuse

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Psychiatry (AREA)
  • Addiction (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pain & Pain Management (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Heterocyclic Carbon Compounds Containing A Hetero Ring Having Oxygen Or Sulfur (AREA)
  • Furan Compounds (AREA)
  • Steroid Compounds (AREA)
SK322-2003A 2000-08-18 2001-08-14 Spôsob prípravy citalopramu, citalopram pripravený týmto spôsobom a farmaceutický prostriedok s obsahom citalopramu SK287008B6 (sk)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DKPA200001231 2000-08-18
PCT/DK2001/000542 WO2002016342A1 (en) 2000-08-18 2001-08-14 Method for the preparation of citalopram

Publications (2)

Publication Number Publication Date
SK3222003A3 SK3222003A3 (en) 2003-08-05
SK287008B6 true SK287008B6 (sk) 2009-09-07

Family

ID=8159660

Family Applications (2)

Application Number Title Priority Date Filing Date
SK322-2003A SK287008B6 (sk) 2000-08-18 2001-08-14 Spôsob prípravy citalopramu, citalopram pripravený týmto spôsobom a farmaceutický prostriedok s obsahom citalopramu
SK320-2003A SK287236B6 (sk) 2000-08-18 2001-08-14 Spôsob prípravy citalopramu

Family Applications After (1)

Application Number Title Priority Date Filing Date
SK320-2003A SK287236B6 (sk) 2000-08-18 2001-08-14 Spôsob prípravy citalopramu

Country Status (41)

Country Link
US (2) US6426422B1 (no)
EP (2) EP1309581B1 (no)
JP (2) JP2004506730A (no)
KR (2) KR100887206B1 (no)
CN (3) CN1159307C (no)
AR (3) AR029598A1 (no)
AT (4) ATE281447T1 (no)
AU (6) AU7960901A (no)
BE (2) BE1013443A6 (no)
BG (2) BG65965B1 (no)
CA (2) CA2354877C (no)
CH (2) CH691969A5 (no)
CL (2) CL2008002412A1 (no)
CZ (2) CZ294746B6 (no)
DE (4) DE60106932T2 (no)
DK (4) DK200101219A (no)
EA (2) EA005811B1 (no)
ES (4) ES2228920T3 (no)
FI (2) FI20011621A (no)
FR (2) FR2813077B1 (no)
GB (2) GB2365865B (no)
GR (1) GR1004074B (no)
HK (3) HK1044538B (no)
HR (2) HRP20030064A2 (no)
HU (2) HUP0103291A3 (no)
IE (2) IES20010761A2 (no)
IL (2) IL144817A0 (no)
IS (2) IS2121B (no)
ME (2) MEP2308A (no)
MX (2) MXPA03000913A (no)
NL (2) NL1018776C1 (no)
NO (2) NO326570B1 (no)
NZ (2) NZ523853A (no)
PL (2) PL359969A1 (no)
PT (2) PT1309581E (no)
RS (2) RS50258B (no)
SI (2) SI1309582T1 (no)
SK (2) SK287008B6 (no)
UA (2) UA72340C2 (no)
WO (2) WO2002016342A1 (no)
ZA (1) ZA200106683B (no)

Families Citing this family (26)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AR022329A1 (es) 1999-01-29 2002-09-04 Lundbeck & Co As H Metodo para la preparacion de 5-cianoftalida
HU227473B1 (en) * 1999-04-14 2011-07-28 Lundbeck & Co As H Method for preparation of citalopram
ITMI991581A1 (it) * 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ATE277032T1 (de) 1999-10-25 2004-10-15 Lundbeck & Co As H Verfahren zur herstellung von citalopram
AR026063A1 (es) 1999-11-01 2002-12-26 Lundbeck & Co As H Metodo para la preparacion de 5-carboxiftalida.
CZ20022213A3 (cs) 1999-12-28 2002-09-11 H. Lundbeck A/S Způsob výroby citalopramu
KR100653141B1 (ko) 1999-12-30 2006-12-01 하. 룬트벡 아크티에 셀스카브 시탈로프람의 제조 방법
AU3033700A (en) * 2000-01-14 2001-07-24 H. Lundbeck A/S Method for the preparation of 5-cyanophthalide
NL1017417C1 (nl) 2000-03-03 2001-03-16 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
BR0109176A (pt) 2000-03-13 2003-04-22 Lundbeck & Co As H Método para preparação de citalopram e composto da fórmula
NL1017500C1 (nl) 2000-03-13 2001-04-26 Lundbeck & Co As H Werkwijze voor de bereiding van Citalopram.
PL357022A1 (en) * 2000-03-13 2004-07-12 H.Lundbeck A/S Stepwise alkylation of 5-substituted 1-(4-fluorophenyl)-1,3-dihydroisobenzofurans
BR0109268A (pt) 2000-03-14 2002-12-03 Lundbeck & Co As H Método de preparação de citalopram, composto e citaplopram
EA200200982A1 (ru) * 2000-03-16 2003-02-27 Х.Лундбекк А/С Способ получения 5-циано-1-(4-фторфенил)-1,3-дигидроизобензофуранов
AR032455A1 (es) 2000-05-12 2003-11-12 Lundbeck & Co As H Metodo para la preparacion de citalopram, un intermediario empleado en el metodo, un metodo para la preparacion del intermediario empleado en el metodo y composicion farmaceutica antidepresiva
CA2354877C (en) 2000-08-18 2006-05-02 H. Lundbeck A/S Method for the preparation of citalopram
ES2228824T3 (es) 2000-12-22 2005-04-16 H. Lundbeck A/S Metodo de preparacion de citalopram puro.
US7148364B2 (en) * 2002-01-07 2006-12-12 Sun Pharmaceutical Industries Process for the preparation of 1-[3-(dimethylamino)propyl]-1-(4-fluorophenyl)-1,3-dihydro-5-isobenzofuran carbonitrile
TWI306846B (en) * 2002-08-12 2009-03-01 Lundbeck & Co As H Method for the separation of intermediates which may be used for the preparation of escitalopram
AU2003223105A1 (en) * 2003-03-24 2004-10-18 Hetero Drugs Limited Novel crystalline forms of (s)-citalopram oxalate
US20050143350A1 (en) * 2003-11-19 2005-06-30 Seed John C. Combination drug therapy to treat obesity
CN100569765C (zh) 2003-12-19 2009-12-16 杭州民生药业集团有限公司 西酞普兰中间体晶体碱
US9339500B2 (en) * 2008-03-04 2016-05-17 Intra-Cellular Therapies, Inc. Methods of treating vasomotor symptoms
US20100087664A1 (en) * 2008-10-07 2010-04-08 Ravindra Vedantham Preparation of citalopram and salts thereof
JP6222973B2 (ja) * 2013-04-19 2017-11-01 日本テルペン化学株式会社 ジベンジルトリチオカーボネート誘導体
CN103936702A (zh) * 2014-05-07 2014-07-23 成都诺维尔生物医药有限公司 艾司西酞普兰杂质j的合成方法

Family Cites Families (27)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1143702A (no) 1965-03-18
GB1526331A (en) * 1976-01-14 1978-09-27 Kefalas As Phthalanes
GB8419963D0 (en) 1984-08-06 1984-09-12 Lundbeck & Co As H Intermediate compound and method
GB8814057D0 (en) 1988-06-14 1988-07-20 Lundbeck & Co As H New enantiomers & their isolation
DE3926765A1 (de) 1989-08-12 1991-02-14 Hoechst Ag Verfahren zur verminderung von primaerem und sekundaerem amin in einem tertiaeren amin
US5296507A (en) 1990-09-06 1994-03-22 H.Lundbeck A/S Treatment of cerbrovascular disorders
DK213290D0 (da) 1990-09-06 1990-09-06 Lundbeck & Co As H Treatment of cerebrovascular disorders
DE19626659A1 (de) 1996-07-03 1998-01-08 Basf Ag Verfahren zur Herstellung von Phthaliden
DE19627697A1 (de) 1996-07-10 1998-01-15 Basf Ag Verfahren zur Herstellung von Phthaliden
ZA9711376B (en) 1996-12-20 1998-07-21 Lundbeck & Co As H Indole or dihydroindole derivatives
JP3526581B2 (ja) 1997-07-08 2004-05-17 ハー・ルンドベック・アクティーゼルスカブ シタロプラムの製造方法
UA62985C2 (en) * 1997-11-10 2004-01-15 Lunnbeck As H A method for the preparation of citalopram
AU738359B2 (en) * 1997-11-11 2001-09-13 H. Lundbeck A/S Method for the preparation of citalopram
WO2000023431A1 (en) 1998-10-20 2000-04-27 H. Lundbeck A/S Method for the preparation of citalopram
AU764161B2 (en) 1998-12-23 2003-08-14 H. Lundbeck A/S Method for the preparation of 5-cyanophthalide
AR022329A1 (es) 1999-01-29 2002-09-04 Lundbeck & Co As H Metodo para la preparacion de 5-cianoftalida
HU227473B1 (en) 1999-04-14 2011-07-28 Lundbeck & Co As H Method for preparation of citalopram
ITMI991581A1 (it) 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
ITMI991579A1 (it) * 1999-06-25 2001-01-15 Lundbeck & Co As H Metodo per la preparazione di citalopram
GB2360281B (en) 1999-10-25 2002-01-16 Lundbeck & Co As H Method for the preparation of citalopram
US6310222B1 (en) 1999-11-01 2001-10-30 Sumika Fine Chemicals Co., Ltd. Production method of 5-phthalancarbonitrile compound, intermediate therefor and production method of the intermediate
FR2805812A1 (fr) 2000-02-24 2001-09-07 Lundbeck & Co As H Procede de preparation du citalopram
IES20010143A2 (en) 2000-02-24 2001-07-25 Lundbeck & Co As H Method for the preparation of citalopram
GB0005477D0 (en) * 2000-03-07 2000-04-26 Resolution Chemicals Limited Process for the preparation of citalopram
CA2354877C (en) 2000-08-18 2006-05-02 H. Lundbeck A/S Method for the preparation of citalopram
ES2228824T3 (es) 2000-12-22 2005-04-16 H. Lundbeck A/S Metodo de preparacion de citalopram puro.
DE60100016T2 (de) 2000-12-28 2003-04-17 H. Lundbeck A/S, Valby Verfahren zur herstellung von reinem citalopram

Also Published As

Publication number Publication date
BE1013443A6 (fr) 2002-01-15
AU2001279609B2 (en) 2007-09-06
CA2354880C (en) 2003-06-03
GB2365865B (en) 2002-07-17
ES2170735A1 (es) 2002-08-01
ZA200106683B (en) 2002-08-05
DE60106932T2 (de) 2005-11-03
EP1309582B1 (en) 2004-11-03
BE1013444A6 (fr) 2002-01-15
NO20013943L (no) 2002-02-19
AU2001100278B4 (en) 2001-11-29
US6426422B1 (en) 2002-07-30
HRP20030065A2 (en) 2005-02-28
IL144817A0 (en) 2002-06-30
CL2008002673A1 (es) 2009-01-02
US6509483B2 (en) 2003-01-21
AU7960801A (en) 2002-03-04
PT1309581E (pt) 2005-03-31
UA71676C2 (en) 2004-12-15
AR029597A1 (es) 2003-07-10
CZ20012959A3 (cs) 2002-04-17
AU2001100278A4 (en) 2001-09-13
AU2001279608B2 (en) 2006-10-05
KR100887207B1 (ko) 2009-03-06
ATE281447T1 (de) 2004-11-15
SI1309582T1 (en) 2005-06-30
MEP2308A (xx) 2010-02-10
NZ523877A (en) 2004-08-27
ES2230347T3 (es) 2005-05-01
DK1309582T3 (da) 2005-03-14
GB2365865A (en) 2002-02-27
FI20011621A (fi) 2002-02-19
HUP0103291A3 (en) 2003-02-28
CN1339436A (zh) 2002-03-13
AU2001100271B4 (en) 2001-11-29
NO20013942D0 (no) 2001-08-14
AU7960901A (en) 2002-03-04
CZ20012958A3 (cs) 2002-04-17
SI1309581T1 (en) 2005-04-30
HU0103291D0 (en) 2001-10-28
HK1047086A1 (en) 2003-02-07
CL2008002412A1 (es) 2009-01-02
CN1222517C (zh) 2005-10-12
AR029598A1 (es) 2003-07-10
BG107583A (bg) 2004-01-30
BG65965B1 (bg) 2010-07-30
HK1068069A1 (en) 2005-04-22
AU2001100271A4 (en) 2001-09-13
FR2813077A1 (fr) 2002-02-22
EA200300279A1 (ru) 2003-08-28
DE60106932D1 (de) 2004-12-09
IS2121B (is) 2006-06-15
NO326570B1 (no) 2009-01-12
EA005811B1 (ru) 2005-06-30
IL144816A0 (en) 2002-06-30
NO20013942L (no) 2002-02-19
GB2362647A (en) 2001-11-28
ES2170735B2 (es) 2003-09-16
FI20011621A0 (fi) 2001-08-09
ATE281448T1 (de) 2004-11-15
MEP2208A (xx) 2010-02-10
EP1309581B1 (en) 2004-11-03
GR20010100398A (el) 2002-05-24
GB2362647B (en) 2002-09-18
GB0119733D0 (en) 2001-10-03
HK1044538B (zh) 2006-07-07
SK287236B6 (sk) 2010-04-07
AT4946U1 (de) 2002-01-25
CN1239490C (zh) 2006-02-01
EA200300277A1 (ru) 2003-08-28
DE60106933D1 (de) 2004-12-09
IS6048A (is) 2001-10-19
GR1004074B (el) 2002-11-26
EP1309582A1 (en) 2003-05-14
EP1309581A1 (en) 2003-05-14
FR2813078B1 (fr) 2004-04-02
HUP0103291A2 (hu) 2002-05-29
HUP0103295A3 (en) 2005-01-28
IS6047A (is) 2001-10-20
CZ294746B6 (cs) 2005-03-16
UA72340C2 (uk) 2005-02-15
JP2004506729A (ja) 2004-03-04
DK200101219A (da) 2002-02-19
SK3202003A3 (en) 2003-08-05
GB0119734D0 (en) 2001-10-03
US20020025982A1 (en) 2002-02-28
RS50287B (sr) 2009-09-08
YU6903A (sh) 2006-05-25
US20020026062A1 (en) 2002-02-28
AT5026U1 (de) 2002-02-25
ES2170734A1 (es) 2002-08-01
DE60106933T2 (de) 2005-12-01
BG65964B1 (bg) 2010-07-30
NL1018775C1 (nl) 2001-10-24
FI20011622A (fi) 2002-02-19
ES2170734B2 (es) 2003-09-16
AR066694A2 (es) 2009-09-09
CA2354877A1 (en) 2002-02-18
DE10140029A1 (de) 2002-05-02
CA2354877C (en) 2006-05-02
CN1159307C (zh) 2004-07-28
NL1018776C1 (nl) 2001-10-24
KR20030022385A (ko) 2003-03-15
CN1515564A (zh) 2004-07-28
FI20011622A0 (fi) 2001-08-09
CN1339435A (zh) 2002-03-13
KR100887206B1 (ko) 2009-03-06
HK1044538A1 (en) 2002-10-25
SK3222003A3 (en) 2003-08-05
JP2004506730A (ja) 2004-03-04
NO20013943D0 (no) 2001-08-14
DE10140028A1 (de) 2002-04-18
DK1309581T3 (da) 2005-03-14
IL144816A (en) 2005-09-25
YU11503A (sh) 2006-05-25
CZ295863B6 (cs) 2005-11-16
FR2813077B1 (fr) 2004-08-20
WO2002016341A1 (en) 2002-02-28
PL359969A1 (en) 2004-09-06
RS50258B (sr) 2009-07-15
KR20030022378A (ko) 2003-03-15
IS2120B (is) 2006-06-15
CH691968A5 (de) 2001-12-14
NO326772B1 (no) 2009-02-16
MXPA03001329A (es) 2003-06-06
MXPA03000913A (es) 2003-06-24
CH691969A5 (de) 2001-12-14
HK1047086B (zh) 2005-04-22
IES20010760A2 (en) 2002-02-20
EA005946B1 (ru) 2005-08-25
HUP0103295A2 (hu) 2002-05-29
ES2228920T3 (es) 2005-04-16
PT1309582E (pt) 2005-03-31
BG107584A (bg) 2004-01-30
DK200101216A (da) 2002-02-19
CA2354880A1 (en) 2002-01-22
HRP20030064A2 (en) 2005-02-28
IES20010761A2 (en) 2002-02-20
PL359825A1 (en) 2004-09-06
FR2813078A1 (fr) 2002-02-22
WO2002016342A1 (en) 2002-02-28
NZ523853A (en) 2004-07-30

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Legal Events

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MM4A Patent lapsed due to non-payment of maintenance fees

Effective date: 20100814