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SI2252609T1 - Derivati piridin-2-ila kot imunomodulacijska sredstva - Google Patents

Derivati piridin-2-ila kot imunomodulacijska sredstva

Info

Publication number
SI2252609T1
SI2252609T1 SI200930611T SI200930611T SI2252609T1 SI 2252609 T1 SI2252609 T1 SI 2252609T1 SI 200930611 T SI200930611 T SI 200930611T SI 200930611 T SI200930611 T SI 200930611T SI 2252609 T1 SI2252609 T1 SI 2252609T1
Authority
SI
Slovenia
Prior art keywords
pyridin
derivatives
immunomodulating agents
immunomodulating
agents
Prior art date
Application number
SI200930611T
Other languages
English (en)
Inventor
Martin Bolli
Cyrille Lescop
Boris Mathys
Claus Mueller
Oliver Nayler
Beat Steiner
Original Assignee
Actelion Pharmaceuticals Ltd.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=40584746&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SI2252609(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Actelion Pharmaceuticals Ltd. filed Critical Actelion Pharmaceuticals Ltd.
Publication of SI2252609T1 publication Critical patent/SI2252609T1/sl

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A61P11/06—Antiasthmatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/06—Antipsoriatics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
    • A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/06—Immunosuppressants, e.g. drugs for graft rejection

Landscapes

  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Diabetes (AREA)
  • Pulmonology (AREA)
  • Obesity (AREA)
  • Hematology (AREA)
  • Endocrinology (AREA)
  • Transplantation (AREA)
  • Oncology (AREA)
  • Dermatology (AREA)
  • Emergency Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Pyridine Compounds (AREA)
SI200930611T 2008-03-07 2009-02-25 Derivati piridin-2-ila kot imunomodulacijska sredstva SI2252609T1 (sl)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IB2008050848 2008-03-07
PCT/IB2009/050749 WO2009109872A1 (en) 2008-03-07 2009-02-25 Pyridin-2-yl derivatives as immunomodulating agents
EP09716943.7A EP2252609B1 (en) 2008-03-07 2009-02-25 Pyridin-2-yl derivatives as immunomodulating agents

Publications (1)

Publication Number Publication Date
SI2252609T1 true SI2252609T1 (sl) 2013-07-31

Family

ID=40584746

Family Applications (1)

Application Number Title Priority Date Filing Date
SI200930611T SI2252609T1 (sl) 2008-03-07 2009-02-25 Derivati piridin-2-ila kot imunomodulacijska sredstva

Country Status (27)

Country Link
US (1) US8575200B2 (sl)
EP (1) EP2252609B1 (sl)
JP (1) JP5435745B2 (sl)
KR (1) KR101615779B1 (sl)
CN (1) CN102015695B (sl)
AR (1) AR070858A1 (sl)
AU (1) AU2009220861B2 (sl)
BR (1) BRPI0909055A2 (sl)
CA (1) CA2715437C (sl)
CL (1) CL2009000532A1 (sl)
CY (1) CY1114096T1 (sl)
DK (1) DK2252609T3 (sl)
ES (1) ES2414533T3 (sl)
HK (1) HK1150601A1 (sl)
HR (1) HRP20130641T1 (sl)
IL (1) IL207972A (sl)
MA (1) MA32173B1 (sl)
MX (1) MX2010009644A (sl)
MY (1) MY183039A (sl)
NZ (1) NZ588438A (sl)
PL (1) PL2252609T3 (sl)
PT (1) PT2252609E (sl)
RU (1) RU2494099C2 (sl)
SI (1) SI2252609T1 (sl)
TW (1) TWI444377B (sl)
WO (1) WO2009109872A1 (sl)
ZA (1) ZA201007136B (sl)

Families Citing this family (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
BRPI0716171B8 (pt) * 2006-09-07 2021-05-25 Actelion Pharmaceuticals Ltd composto, composição farmacêutica e uso de um composto
JP5253400B2 (ja) * 2006-09-08 2013-07-31 アクテリオン ファーマシューティカルズ リミテッド 免疫調節薬としてのピリジン−３−イル誘導体
EP2069318B1 (en) * 2006-09-21 2012-09-12 Actelion Pharmaceuticals Ltd. Phenyl derivatives and their use as immunomodulators
MX2009009597A (es) * 2007-03-16 2009-09-16 Actelion Pharmaceuticals Ltd Derivados de amino-piridina como agonistas del receptor s1p1/edg1.
MY153975A (en) * 2007-08-17 2015-04-30 Actelion Pharmaceuticals Ltd Pyridine derivatives as s1p1/edg1 receptor modulators
RU2010121969A (ru) * 2007-11-01 2011-12-10 Актелион Фармасьютиклз Лтд (Ch) Новые производные пиримидина
SI2454255T1 (sl) 2009-07-16 2014-01-31 Actelion Pharmaceuticals Ltd. Derivati piridin-4-ila kot agonisti s1p1/edg1
JP5778755B2 (ja) * 2010-04-15 2015-09-16 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ ヒドロキノンの製造方法
TWI546300B (zh) 2011-01-19 2016-08-21 艾克泰聯製藥有限公司 ２－甲氧基－吡啶－４－基衍生物
PL2970236T3 (pl) 2013-03-15 2018-01-31 Idorsia Pharmaceuticals Ltd Pochodne pirydyn-4-ylowe
MA42107B1 (fr) 2015-05-20 2020-02-28 Idorsia Pharmaceuticals Ltd Forme cristalline du composé (s)-3-{4-[5-(2-cyclopentyl-6-méthoxy-pyridin-4-yl)-[1,2,4]oxadiazol-3-yl]-2-éthyl-6-méthyl-phénoxy}-propane-1,2-diol

Family Cites Families (40)

* Cited by examiner, † Cited by third party
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CA2051494C (en) 1990-09-20 2006-03-14 Robert J. Dinerstein 1-aryl-3-pyridinyl-2-propene-1-ones as calcium uptake inhibitors
DE4429465A1 (de) * 1994-08-19 1996-02-22 Bayer Ag Verfahren zur Herstellung von 2-Halogenpyridinaldehyden und neue 2-Halogenpyridinaldehyde
JP2003034684A (ja) * 2001-06-29 2003-02-07 Biofor Inc 新規な種類の抗真菌剤
WO2003105771A2 (en) * 2002-06-17 2003-12-24 Merck & Co., Inc. 1-((5-aryl-1,2,4-oxadiazol-3-yl)benzyl)azetidine-3-carboxylates and 1-((5-aryl-1,2,4-oxadiazol-3-yl)benzyl)pyrrolidine-3-carboxylates as edg receptor agonists
DE10237883A1 (de) 2002-08-19 2004-03-04 Merckle Gmbh Chem.-Pharm. Fabrik Substituierte Isoxazolderivate und ihre Verwendung in der Pharmazie
AU2003279915A1 (en) * 2002-10-15 2004-05-04 Merck And Co., Inc. Process for making azetidine-3-carboxylic acid
AU2004277947A1 (en) * 2003-10-01 2005-04-14 Merck & Co., Inc. 3,5-aryl, heteroaryl or cycloalkyl substituted-1,2,4-oxadiazoles as S1P receptor agonists
EP1697333A4 (en) * 2003-12-17 2009-07-08 Merck & Co Inc 3,4-DISUSBSTITUTED PROPANOIC CARBOXYLATES AS S1P RECEPTOR AGONISTS (EDG)
JP5315611B2 (ja) * 2004-06-23 2013-10-16 小野薬品工業株式会社 Ｓ１ｐ受容体結合能を有する化合物およびその用途
WO2006010379A1 (en) * 2004-07-29 2006-02-02 Actelion Pharmaceuticals Ltd. Novel thiophene derivatives as immunosuppressive agents
PT1826197E (pt) * 2004-12-13 2012-03-06 Ono Pharmaceutical Co Derivado de ácido aminocarboxílico e sua utilização medicinal
ES2370791T3 (es) * 2005-03-23 2011-12-22 Actelion Pharmaceuticals Ltd. Nuevos derivados de tiofeno como agonistas del receptor de esfingosina-1-fosfato-1.
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KR101382733B1 (ko) * 2005-03-23 2014-04-14 액테리온 파마슈티칼 리미티드 면역조절물질로서의 수첨 벤조(ｃ) 티오펜 유도체
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RU2007147940A (ru) * 2005-06-08 2009-07-20 Новартис АГ (CH) Полициклические оксадиазолы или изоксазолы и их применение в качестве лигандов s1p рецептора
US20070043104A1 (en) * 2005-06-10 2007-02-22 Luthman Ingrid K UII-modulating compounds and their use
MX2007016505A (es) * 2005-06-24 2008-03-07 Actelion Pharmaceuticals Ltd Nuevos derivados de tiofeno.
AR057894A1 (es) * 2005-11-23 2007-12-26 Actelion Pharmaceuticals Ltd Derivados de tiofeno
TWI404706B (zh) * 2006-01-11 2013-08-11 Actelion Pharmaceuticals Ltd 新穎噻吩衍生物
BRPI0706725A2 (pt) * 2006-01-24 2011-04-05 Actelion Pharmaceuticals Ltda Composto de sais do mesmo , composição farmacêutica , e , uso de um composto
WO2007132307A1 (en) * 2006-05-09 2007-11-22 Pfizer Products Inc. Cycloalkylamino acid derivatives and pharmaceutical compositions thereof
AR061841A1 (es) * 2006-09-07 2008-09-24 Actelion Pharmaceuticals Ltd Derivados de tiofen-oxadiazoles, agonistas del receptor s1p1/edg1, composiciones farmaceuticas que los contienen y usos como agentes inmunomoduladores.
BRPI0716171B8 (pt) * 2006-09-07 2021-05-25 Actelion Pharmaceuticals Ltd composto, composição farmacêutica e uso de um composto
JP5253400B2 (ja) * 2006-09-08 2013-07-31 アクテリオン ファーマシューティカルズ リミテッド 免疫調節薬としてのピリジン−３−イル誘導体
EP2069318B1 (en) * 2006-09-21 2012-09-12 Actelion Pharmaceuticals Ltd. Phenyl derivatives and their use as immunomodulators
US20100087491A1 (en) * 2006-09-29 2010-04-08 Rainer Albert Polycyclic compounds
JP2008120794A (ja) 2006-10-16 2008-05-29 Daiichi Sankyo Co Ltd ヘテロ環化合物を含有する医薬組成物
JP2010513283A (ja) * 2006-12-15 2010-04-30 アボット・ラボラトリーズ 新規なオキサジアゾール化合物
MX2009009597A (es) * 2007-03-16 2009-09-16 Actelion Pharmaceuticals Ltd Derivados de amino-piridina como agonistas del receptor s1p1/edg1.
MY153975A (en) * 2007-08-17 2015-04-30 Actelion Pharmaceuticals Ltd Pyridine derivatives as s1p1/edg1 receptor modulators
RU2010121969A (ru) * 2007-11-01 2011-12-10 Актелион Фармасьютиклз Лтд (Ch) Новые производные пиримидина
AU2008334297A1 (en) * 2007-12-10 2009-06-18 Actelion Pharmaceuticals Ltd Thiophene derivatives as agonists of S1P1/EDG1
CA2714614A1 (en) * 2008-03-06 2009-09-11 Actelion Pharmaceuticals Ltd Novel pyrimidine-pyridine derivatives
CA2714665A1 (en) * 2008-03-06 2009-09-11 Actelion Pharmaceuticals Ltd Pyridine compounds
WO2009109904A1 (en) * 2008-03-07 2009-09-11 Actelion Pharmaceuticals Ltd Novel aminomethyl benzene derivatives
SI2454255T1 (sl) * 2009-07-16 2014-01-31 Actelion Pharmaceuticals Ltd. Derivati piridin-4-ila kot agonisti s1p1/edg1

Also Published As

Publication number Publication date
CL2009000532A1 (es) 2010-04-09
CY1114096T1 (el) 2016-07-27
RU2010140854A (ru) 2012-04-20
PT2252609E (pt) 2013-06-24
MY183039A (en) 2021-02-08
CA2715437A1 (en) 2009-09-11
CN102015695A (zh) 2011-04-13
WO2009109872A1 (en) 2009-09-11
RU2494099C2 (ru) 2013-09-27
KR101615779B1 (ko) 2016-04-26
DK2252609T3 (da) 2013-06-24
AU2009220861B2 (en) 2014-05-29
TW200940532A (en) 2009-10-01
TWI444377B (zh) 2014-07-11
EP2252609A1 (en) 2010-11-24
NZ588438A (en) 2012-05-25
HK1150601A1 (en) 2012-01-06
IL207972A0 (en) 2010-12-30
PL2252609T3 (pl) 2013-09-30
ES2414533T3 (es) 2013-07-19
IL207972A (en) 2016-03-31
JP5435745B2 (ja) 2014-03-05
AU2009220861A1 (en) 2009-09-11
MX2010009644A (es) 2010-09-22
BRPI0909055A2 (pt) 2019-02-26
KR20100137493A (ko) 2010-12-30
EP2252609B1 (en) 2013-04-17
US8575200B2 (en) 2013-11-05
JP2011513381A (ja) 2011-04-28
CA2715437C (en) 2016-05-24
MA32173B1 (fr) 2011-03-01
CN102015695B (zh) 2014-08-27
HRP20130641T1 (en) 2013-08-31
ZA201007136B (en) 2014-03-26
AR070858A1 (es) 2010-05-12
US20100331372A1 (en) 2010-12-30

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