SI2197880T1 - Biciklične heterociklične spojine kot inhibitorji protein tirozin kinaze - Google Patents
Biciklične heterociklične spojine kot inhibitorji protein tirozin kinazeInfo
- Publication number
- SI2197880T1 SI2197880T1 SI200831563T SI200831563T SI2197880T1 SI 2197880 T1 SI2197880 T1 SI 2197880T1 SI 200831563 T SI200831563 T SI 200831563T SI 200831563 T SI200831563 T SI 200831563T SI 2197880 T1 SI2197880 T1 SI 2197880T1
- Authority
- SI
- Slovenia
- Prior art keywords
- tyrosine kinase
- kinase inhibitors
- heterocyclic compounds
- protein tyrosine
- bicyclic heterocyclic
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D471/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00
- C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
- C07D471/04—Ortho-condensed systems
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A61P35/02—Antineoplastic agents specific for leukemia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/04—Ortho-condensed systems
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Oncology (AREA)
- Hematology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US97955507P | 2007-10-12 | 2007-10-12 | |
| GBGB0720041.3A GB0720041D0 (en) | 2007-10-12 | 2007-10-12 | New Compounds |
| US6117808P | 2008-06-13 | 2008-06-13 | |
| PCT/GB2008/003418 WO2009047506A1 (en) | 2007-10-12 | 2008-10-10 | Bicyclic heterocyclic compounds as protein tyrosine kinase inhibitors |
| EP08806556.0A EP2197880B1 (en) | 2007-10-12 | 2008-10-10 | Bicyclic heterocyclic compounds as protein tyrosine kinase inhibitors |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| SI2197880T1 true SI2197880T1 (sl) | 2016-04-29 |
Family
ID=38788133
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| SI200831563T SI2197880T1 (sl) | 2007-10-12 | 2008-10-10 | Biciklične heterociklične spojine kot inhibitorji protein tirozin kinaze |
Country Status (18)
| Country | Link |
|---|---|
| US (2) | US8076354B2 (sl) |
| EP (1) | EP2197880B1 (sl) |
| JP (1) | JP5497648B2 (sl) |
| AU (1) | AU2008309418B2 (sl) |
| CA (1) | CA2701865C (sl) |
| CY (1) | CY1117139T1 (sl) |
| DK (1) | DK2197880T3 (sl) |
| ES (1) | ES2559685T3 (sl) |
| GB (1) | GB0720041D0 (sl) |
| HK (1) | HK1145495A1 (sl) |
| HR (1) | HRP20160002T1 (sl) |
| HU (1) | HUE026275T2 (sl) |
| ME (1) | ME02373B (sl) |
| PL (1) | PL2197880T3 (sl) |
| PT (1) | PT2197880E (sl) |
| RS (1) | RS54518B1 (sl) |
| SI (1) | SI2197880T1 (sl) |
| WO (1) | WO2009047506A1 (sl) |
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| GB0720041D0 (en) | 2007-10-12 | 2007-11-21 | Astex Therapeutics Ltd | New Compounds |
| GB0720038D0 (en) | 2007-10-12 | 2007-11-21 | Astex Therapeutics Ltd | New compounds |
| GB0810902D0 (en) | 2008-06-13 | 2008-07-23 | Astex Therapeutics Ltd | New compounds |
| GB0906470D0 (en) | 2009-04-15 | 2009-05-20 | Astex Therapeutics Ltd | New compounds |
| GB0906472D0 (en) | 2009-04-15 | 2009-05-20 | Astex Therapeutics Ltd | New compounds |
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| ES2984771T3 (es) | 2012-06-13 | 2024-10-31 | Incyte Holdings Corp | Compuestos tricíclicos sustituidos como inhibidores de FGFR |
| WO2014026125A1 (en) | 2012-08-10 | 2014-02-13 | Incyte Corporation | Pyrazine derivatives as fgfr inhibitors |
| US9266892B2 (en) | 2012-12-19 | 2016-02-23 | Incyte Holdings Corporation | Fused pyrazoles as FGFR inhibitors |
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| DK2986610T5 (en) | 2013-04-19 | 2018-12-10 | Incyte Holdings Corp | BICYCLIC HETEROCYCLES AS FGFR INHIBITORS |
| CA2956270C (en) | 2014-08-18 | 2022-08-09 | Eisai R&D Management Co., Ltd. | Salt of monocyclic pyridine derivative and crystal thereof |
| US10851105B2 (en) | 2014-10-22 | 2020-12-01 | Incyte Corporation | Bicyclic heterocycles as FGFR4 inhibitors |
| PE20171514A1 (es) | 2015-02-20 | 2017-10-20 | Incyte Corp | Heterociclos biciclicos como inhibidores de fgfr |
| US9580423B2 (en) | 2015-02-20 | 2017-02-28 | Incyte Corporation | Bicyclic heterocycles as FGFR4 inhibitors |
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| US10550126B2 (en) | 2015-10-16 | 2020-02-04 | Abbvie Inc. | Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-A]pyrrolo[2,3-e]-pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof |
| US11365198B2 (en) | 2015-10-16 | 2022-06-21 | Abbvie Inc. | Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-N-(2,2,2-trifluoroethyl)pyrrolidine-1-carboxamide and solid state forms thereof |
| MX2018004605A (es) | 2015-10-16 | 2018-11-29 | Abbvie Inc | Procesos para la preparacion de (3s,4r)-3-etil-4-(3h-imidazo-[1,2- a]-pirrolo-[2,3-e]-pirazin-8-il)-n-(2,2,2-trifluoroetil)-pirrolid in-1-carboxamida y formas en estado solido de la misma. |
| US11780848B2 (en) | 2015-10-16 | 2023-10-10 | Abbvie Inc. | Processes for the preparation of (3S,4R)-3-ethyl-4-(3H-imidazo[1,2-a]pyrrolo[2,3-e]-pyrazin-8-yl)-n-(2,2,2-trifluoroethyl)pyrrolidine-1- carboxamide and solid state forms thereof |
| AR111960A1 (es) | 2017-05-26 | 2019-09-04 | Incyte Corp | Formas cristalinas de un inhibidor de fgfr y procesos para su preparación |
| MX2020003341A (es) * | 2017-10-18 | 2020-09-17 | Jubilant Epipad LLC | Compuestos de imidazo-piridina como inhibidores de pad. |
| CN111225917A (zh) * | 2017-10-24 | 2020-06-02 | 拜耳股份公司 | 取代咪唑并吡啶酰胺及其用途 |
| US11219619B2 (en) | 2018-03-28 | 2022-01-11 | Eisai R&D Management Co., Ltd. | Therapeutic agent for hepatocellular carcinoma |
| CR20200591A (es) | 2018-05-04 | 2021-03-31 | Incyte Corp | Sales de un inhibidor de fgfr |
| BR112020022392A2 (pt) | 2018-05-04 | 2021-02-02 | Incyte Corporation | formas sólidas de um inibidor de fgfr e processos para preparação das mesmas |
| WO2020185532A1 (en) | 2019-03-08 | 2020-09-17 | Incyte Corporation | Methods of treating cancer with an fgfr inhibitor |
| WO2020216669A1 (de) | 2019-04-23 | 2020-10-29 | Bayer Aktiengesellschaft | Phenylsubstituierte imidazopyridinamide und ihre verwendung |
| US11591329B2 (en) | 2019-07-09 | 2023-02-28 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
| CA3145680C (en) | 2019-07-26 | 2024-03-12 | Zhengxia CHEN | Pyridine derivative as fgfr and vegfr dual inhibitors |
| US12122767B2 (en) | 2019-10-01 | 2024-10-22 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
| CN115835908A (zh) | 2019-10-14 | 2023-03-21 | 因赛特公司 | 作为fgfr抑制剂的双环杂环 |
| US11566028B2 (en) | 2019-10-16 | 2023-01-31 | Incyte Corporation | Bicyclic heterocycles as FGFR inhibitors |
| JP2023505257A (ja) | 2019-12-04 | 2023-02-08 | インサイト・コーポレイション | Ｆｇｆｒ阻害剤の誘導体 |
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| EP2004626A4 (en) | 2006-03-23 | 2010-10-27 | Synta Pharmaceuticals Corp | BENZIMIDAZOLYL-PYRIDINE COMPOUNDS FOR THE TREATMENT OF INFLAMMATION AND IMMUNE DISORDERS |
| ITVA20060041A1 (it) | 2006-07-05 | 2008-01-06 | Dialectica Srl | Uso di composti derivati amminotiazolici, di loro composizioni farmaceutiche, nel trattamento di malattie caratterizzate dalla anormale repressione della trascrizione genica, particolarmente il morbo di huntington |
| TW200811134A (en) | 2006-07-12 | 2008-03-01 | Irm Llc | Compounds and compositions as protein kinase inhibitors |
| EP1882475A1 (en) | 2006-07-26 | 2008-01-30 | Novartis AG | Method of treating disorders mediated by the fibroblast growth factor receptor |
| US7737149B2 (en) | 2006-12-21 | 2010-06-15 | Astrazeneca Ab | N-[5-[2-(3,5-dimethoxyphenyl)ethyl]-2H-pyrazol-3-yl]-4-(3,5-dimethylpiperazin-1-yl)benzamide and salts thereof |
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| WO2008078100A2 (en) | 2006-12-22 | 2008-07-03 | Astex Therapeutics Limited | Tricyclic amine derivatives as protein tyrosine kinase inhibitors |
| US8131527B1 (en) | 2006-12-22 | 2012-03-06 | Astex Therapeutics Ltd. | FGFR pharmacophore compounds |
| US7977336B2 (en) | 2006-12-28 | 2011-07-12 | Banyu Pharmaceutical Co. Ltd | Aminopyrimidine derivatives as PLK1 inhibitors |
| RS52862B (en) | 2007-04-03 | 2013-12-31 | Array Biopharma Inc. | IMIDASO [1,2-A] Pyridine Compounds as Tyrosine Kinase Receptor Inhibitors |
| TWI426068B (zh) | 2007-06-12 | 2014-02-11 | Achaogen Inc | 抗菌劑 |
| US20090005374A1 (en) | 2007-06-26 | 2009-01-01 | Melvin Jr Lawrence S | Imidazopyridinyl thiazolyl histone deacetylase inhibitors |
| GB0720038D0 (en) | 2007-10-12 | 2007-11-21 | Astex Therapeutics Ltd | New compounds |
| GB0720041D0 (en) | 2007-10-12 | 2007-11-21 | Astex Therapeutics Ltd | New Compounds |
| GB0810902D0 (en) | 2008-06-13 | 2008-07-23 | Astex Therapeutics Ltd | New compounds |
| GB0906470D0 (en) | 2009-04-15 | 2009-05-20 | Astex Therapeutics Ltd | New compounds |
| GB0906472D0 (en) | 2009-04-15 | 2009-05-20 | Astex Therapeutics Ltd | New compounds |
-
2007
- 2007-10-12 GB GBGB0720041.3A patent/GB0720041D0/en not_active Ceased
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2008
- 2008-10-10 ES ES08806556.0T patent/ES2559685T3/es active Active
- 2008-10-10 US US12/682,508 patent/US8076354B2/en active Active
- 2008-10-10 AU AU2008309418A patent/AU2008309418B2/en not_active Ceased
- 2008-10-10 WO PCT/GB2008/003418 patent/WO2009047506A1/en active Application Filing
- 2008-10-10 PT PT88065560T patent/PT2197880E/pt unknown
- 2008-10-10 PL PL08806556T patent/PL2197880T3/pl unknown
- 2008-10-10 EP EP08806556.0A patent/EP2197880B1/en active Active
- 2008-10-10 JP JP2010528478A patent/JP5497648B2/ja not_active Expired - Fee Related
- 2008-10-10 ME MEP-2016-3A patent/ME02373B/me unknown
- 2008-10-10 SI SI200831563T patent/SI2197880T1/sl unknown
- 2008-10-10 HU HUE08806556A patent/HUE026275T2/en unknown
- 2008-10-10 CA CA2701865A patent/CA2701865C/en active Active
- 2008-10-10 RS RS20160029A patent/RS54518B1/en unknown
- 2008-10-10 DK DK08806556.0T patent/DK2197880T3/en active
-
2010
- 2010-12-21 HK HK10111952.1A patent/HK1145495A1/zh not_active IP Right Cessation
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2011
- 2011-10-18 US US13/275,786 patent/US8859583B2/en active Active
-
2016
- 2016-01-04 HR HRP20160002TT patent/HRP20160002T1/hr unknown
- 2016-01-18 CY CY20161100043T patent/CY1117139T1/el unknown
Also Published As
| Publication number | Publication date |
|---|---|
| US20100331296A1 (en) | 2010-12-30 |
| RS54518B1 (en) | 2016-06-30 |
| CY1117139T1 (el) | 2017-04-05 |
| ES2559685T3 (es) | 2016-02-15 |
| US8859583B2 (en) | 2014-10-14 |
| US20120035153A1 (en) | 2012-02-09 |
| JP5497648B2 (ja) | 2014-05-21 |
| AU2008309418A1 (en) | 2009-04-16 |
| CA2701865A1 (en) | 2009-04-16 |
| CA2701865C (en) | 2016-01-26 |
| JP2011500544A (ja) | 2011-01-06 |
| GB0720041D0 (en) | 2007-11-21 |
| DK2197880T3 (en) | 2016-01-25 |
| EP2197880B1 (en) | 2015-12-23 |
| AU2008309418B2 (en) | 2014-04-17 |
| PT2197880E (pt) | 2016-02-23 |
| EP2197880A1 (en) | 2010-06-23 |
| US8076354B2 (en) | 2011-12-13 |
| WO2009047506A1 (en) | 2009-04-16 |
| HRP20160002T1 (hr) | 2016-03-11 |
| HK1145495A1 (zh) | 2011-04-21 |
| HUE026275T2 (en) | 2016-06-28 |
| PL2197880T3 (pl) | 2016-07-29 |
| ME02373B (me) | 2016-06-20 |
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