SG149685A1 - Polymer conjugates of neublastin and methods of using same - Google Patents

Polymer conjugates of neublastin and methods of using same

Info

Publication number: SG149685A1
Authority: SG; Singapore
Prior art keywords: neublastin; methods; same; polymer conjugates; conjugates
Prior art date: 2001-02-01

Application number

SG200504719-6A

Other languages

English (en)

Inventor

Dinah W Y Sah

R Blake Pepinsky

Paula Ann Borjack-Sjodin

Stephan S Miller

Anthony Rossomando

Original Assignee

Biogen Idec Inc

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2001-02-01

Filing date

2002-01-25

Publication date

2009-02-27

2002-01-25 Application filed by Biogen Idec Inc filed Critical Biogen Idec Inc

2009-02-27 Publication of SG149685A1 publication Critical patent/SG149685A1/en

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- C07K14/4756—Neuregulins, i.e. p185erbB2 ligands, glial growth factor, heregulin, ARIA, neu differentiation factor
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/475—Growth factors; Growth regulators
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/59—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes
- A61K47/60—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained otherwise than by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyureas or polyurethanes the organic macromolecular compound being a polyoxyalkylene oligomer, polymer or dendrimer, e.g. PEG, PPG, PEO or polyglycerol
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/12—Drugs for disorders of the urinary system of the kidneys
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/02—Muscle relaxants, e.g. for tetanus or cramps
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/02—Drugs for disorders of the nervous system for peripheral neuropathies
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/14—Drugs for disorders of the nervous system for treating abnormal movements, e.g. chorea, dyskinesia
- A61P25/16—Anti-Parkinson drugs
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
- A61P29/02—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID] without antiinflammatory effect
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide

Landscapes

Health & Medical Sciences (AREA)
Chemical & Material Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Organic Chemistry (AREA)
General Health & Medical Sciences (AREA)
Medicinal Chemistry (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Pharmacology & Pharmacy (AREA)
Animal Behavior & Ethology (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Biomedical Technology (AREA)
Pain & Pain Management (AREA)
Diabetes (AREA)
Genetics & Genomics (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Hematology (AREA)
Obesity (AREA)
Zoology (AREA)
Molecular Biology (AREA)
Toxicology (AREA)
Biochemistry (AREA)
Gastroenterology & Hepatology (AREA)
Urology & Nephrology (AREA)
Biophysics (AREA)
Psychology (AREA)
Orthopedic Medicine & Surgery (AREA)
Physical Education & Sports Medicine (AREA)
Heart & Thoracic Surgery (AREA)
Rheumatology (AREA)
Epidemiology (AREA)
Vascular Medicine (AREA)
Hospice & Palliative Care (AREA)
Endocrinology (AREA)

SG200504719-6A 2001-02-01 2002-01-25 Polymer conjugates of neublastin and methods of using same SG149685A1 (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US26607101P	2001-02-01	2001-02-01

Publications (1)

Publication Number	Publication Date
SG149685A1 true SG149685A1 (en)	2009-02-27

Family

ID=23013042

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SG200504719-6A SG149685A1 (en)	2001-02-01	2002-01-25	Polymer conjugates of neublastin and methods of using same

Country Status (36)

Country	Link
EP (2)	EP1862475A1 (zh)
JP (2)	JP4259868B2 (zh)
KR (2)	KR100872807B1 (zh)
CN (1)	CN1500095B (zh)
AR (1)	AR035077A1 (zh)
AT (1)	ATE365748T1 (zh)
AU (1)	AU2002247037B2 (zh)
BG (1)	BG66393B1 (zh)
BR (1)	BR0206852A (zh)
CA (1)	CA2436407C (zh)
CY (1)	CY1106886T1 (zh)
CZ (1)	CZ20032080A3 (zh)
DE (1)	DE60220879T2 (zh)
DK (1)	DK1355936T3 (zh)
EA (1)	EA009771B1 (zh)
EE (1)	EE05537B1 (zh)
ES (1)	ES2289091T3 (zh)
GE (1)	GEP20063916B (zh)
HK (1)	HK1057759A1 (zh)
HU (1)	HU228973B1 (zh)
IL (2)	IL156941A0 (zh)
IS (1)	IS2867B (zh)
MX (1)	MXPA03006805A (zh)
MY (1)	MY143685A (zh)
NO (1)	NO332150B1 (zh)
NZ (1)	NZ527863A (zh)
PL (1)	PL211162B1 (zh)
PT (1)	PT1355936E (zh)
RS (1)	RS50857B (zh)
SG (1)	SG149685A1 (zh)
SI (1)	SI1355936T1 (zh)
SK (1)	SK288123B6 (zh)
TR (1)	TR200301208T2 (zh)
UA (2)	UA82983C2 (zh)
WO (1)	WO2002060929A2 (zh)
ZA (1)	ZA200305733B (zh)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US7442370B2 (en)	2001-02-01	2008-10-28	Biogen Idec Ma Inc.	Polymer conjugates of mutated neublastin
AU2002247037B2 (en) *	2001-02-01	2007-08-16	Biogen Ma Inc.	Polymer conjugates of neublastin and methods of using same
US7276580B2 (en)	2001-03-12	2007-10-02	Biogen Idec Ma Inc.	Neurotrophic factors
EP1395279B1 (en) *	2001-03-28	2011-10-05	Biogen Idec MA Inc.	Use of neublastin polypeptides for treating neuropathic pain
DK1476181T3 (en) *	2002-01-18	2016-05-23	Biogen Ma Inc	POLYALKYLENE POLYMER COMPOUNDS AND USE THEREOF
DK1594436T3 (da) *	2003-01-31	2010-12-13	Biogen Idec Inc	Polymerkonjugater af muteret neublastin
DE602004021648D1 (de)	2003-04-18	2009-07-30	Biogen Idec Inc	Polymerkonjugiertes glycosiliertes Neublastin
ATE423134T1 (de)	2003-06-10	2009-03-15	Nsgene As	Verbesserte sezernierung von neublastin
US7598059B2 (en)	2003-10-02	2009-10-06	Biogen Idec Ma Inc.	Neublastin expression constructs
PL1786454T3 (pl)	2004-08-19	2010-12-31	Biogen Ma Inc	Odmiany neublastyny
CA2577690C (en) *	2004-08-19	2013-08-06	Biogen Idec Ma Inc.	Refolding transforming growth factor beta family proteins
TWI501774B (zh)	2006-02-27	2015-10-01	Biogen Idec Inc	神經性病症之治療
US20100056440A1 (en) *	2006-03-01	2010-03-04	Biogen Idec Ma Inc.	Compositions and methods for administering gdnf ligand family proteins
JP2010503630A (ja)	2006-09-15	2010-02-04	クレアビリス・セラピューティクス・エスピーエー	ＨＭＧＢ１のＢｏｘ−ＡおよびＨＭＧＢ１のＢｏｘ−Ａ変異体のポリマー複合体
TWI445544B (zh) *	2007-05-01	2014-07-21	Biogen Idec Inc	增進血管形成之組合物及方法
US20140301977A1 (en) *	2011-11-02	2014-10-09	Genentech, Inc.	Overload and elute chromatography
RU2488635C1 (ru) *	2012-03-22	2013-07-27	Государственное бюджетное образовательное учреждение высшего профессионального образования Первый Московский государственный медицинский университет им. И.М. Сеченова Министерства здравоохранения и социального развития Российской Федерации (ГБОУ ВПО Первый МГМУ им. И.М. Сеченова Минздравсоцразвития	Способ получения рекомбинантного антиангиогенного полипептида

Citations (1)

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Publication number	Priority date	Publication date	Assignee	Title
WO2000001815A2 (en) *	1998-07-06	2000-01-13	Nsgene A/S	Neurotrophic factors

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US6472178B1 (en) *	1998-02-27	2002-10-29	Regeneron Pharmaceuticals, Inc.	Nucleic acids encoding a modified ciliary neurotrophic factor and method of making thereof
US5770577A (en) *	1994-11-14	1998-06-23	Amgen Inc.	BDNF and NT-3 polypeptides selectively linked to polyethylene glycol
EP1137774A2 (en) *	1998-12-09	2001-10-04	Amgen Inc.	Grnf4, a gdnf-related neurotrophic factor
AU2002247037B2 (en) *	2001-02-01	2007-08-16	Biogen Ma Inc.	Polymer conjugates of neublastin and methods of using same

2002
- 2002-01-25 AU AU2002247037A patent/AU2002247037B2/en not_active Ceased
- 2002-01-25 DK DK02714792T patent/DK1355936T3/da active
- 2002-01-25 HU HU0500637A patent/HU228973B1/hu not_active IP Right Cessation
- 2002-01-25 SI SI200230580T patent/SI1355936T1/sl unknown
- 2002-01-25 KR KR1020037010127A patent/KR100872807B1/ko not_active IP Right Cessation
- 2002-01-25 PT PT02714792T patent/PT1355936E/pt unknown
- 2002-01-25 PL PL372101A patent/PL211162B1/pl unknown
- 2002-01-25 AR ARP020100279A patent/AR035077A1/es not_active Application Discontinuation
- 2002-01-25 UA UA2003088104A patent/UA82983C2/ru unknown
- 2002-01-25 RS YUP-610/03A patent/RS50857B/sr unknown
- 2002-01-25 KR KR1020087022638A patent/KR100960063B1/ko not_active IP Right Cessation
- 2002-01-25 EP EP07110666A patent/EP1862475A1/en not_active Withdrawn
- 2002-01-25 EP EP02714792A patent/EP1355936B1/en not_active Expired - Lifetime
- 2002-01-25 AT AT02714792T patent/ATE365748T1/de active
- 2002-01-25 BR BR0206852-4A patent/BR0206852A/pt not_active Application Discontinuation
- 2002-01-25 CZ CZ20032080A patent/CZ20032080A3/cs unknown
- 2002-01-25 CN CN028077539A patent/CN1500095B/zh not_active Expired - Fee Related
- 2002-01-25 SK SK971-2003A patent/SK288123B6/sk not_active IP Right Cessation
- 2002-01-25 DE DE60220879T patent/DE60220879T2/de not_active Expired - Lifetime
- 2002-01-25 EE EEP200300355A patent/EE05537B1/xx not_active IP Right Cessation
- 2002-01-25 WO PCT/US2002/002319 patent/WO2002060929A2/en active IP Right Grant
- 2002-01-25 IL IL15694102A patent/IL156941A0/xx unknown
- 2002-01-25 TR TR2003/01208T patent/TR200301208T2/xx unknown
- 2002-01-25 GE GE5240A patent/GEP20063916B/en unknown
- 2002-01-25 ES ES02714792T patent/ES2289091T3/es not_active Expired - Lifetime
- 2002-01-25 EA EA200300852A patent/EA009771B1/ru not_active IP Right Cessation
- 2002-01-25 UA UAA200802148A patent/UA100967C2/ru unknown
- 2002-01-25 JP JP2002561497A patent/JP4259868B2/ja not_active Expired - Fee Related
- 2002-01-25 MX MXPA03006805A patent/MXPA03006805A/es active IP Right Grant
- 2002-01-25 NZ NZ527863A patent/NZ527863A/en not_active IP Right Cessation
- 2002-01-25 SG SG200504719-6A patent/SG149685A1/en unknown
- 2002-01-25 CA CA2436407A patent/CA2436407C/en not_active Expired - Fee Related
- 2002-02-04 MY MYPI20020368A patent/MY143685A/en unknown
2003
- 2003-07-15 IL IL156941A patent/IL156941A/en not_active IP Right Cessation
- 2003-07-17 IS IS6879A patent/IS2867B/is unknown
- 2003-07-24 ZA ZA2003/05733A patent/ZA200305733B/en unknown
- 2003-08-01 NO NO20033441A patent/NO332150B1/no not_active IP Right Cessation
- 2003-08-19 BG BG108111A patent/BG66393B1/bg unknown
- 2003-11-21 HK HK03108539A patent/HK1057759A1/xx not_active IP Right Cessation
2007
- 2007-09-21 CY CY20071101225T patent/CY1106886T1/el unknown
2008
- 2008-10-28 JP JP2008277469A patent/JP4423338B2/ja not_active Expired - Fee Related

Patent Citations (1)

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Publication number	Priority date	Publication date	Assignee	Title
WO2000001815A2 (en) *	1998-07-06	2000-01-13	Nsgene A/S	Neurotrophic factors

Non-Patent Citations (2)

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Title
BALOH R H ET AL: "ARTEMIN, A NOVEL MEMBER OF THE GDNF LIGAND FAMILY, SUPPORTS PERIPHERAL AND CENTRAL NEURONS AND SIGNALS THROUGH THE GFRALPHA3- RET RECEPTOR COMPLEX" *
BALOH ROBERT H ET AL: "Functional mapping of receptor specificity domains of glial cell line-derived neurotrophic factor (GDNF) family ligands and production of GFRalpha1 RET-specific agonists." *

Also Published As

Publication number	Publication date
YU61003A (sh)	2006-05-25
DE60220879D1 (de)	2007-08-09
BR0206852A (pt)	2005-05-03
AR035077A1 (es)	2004-04-14
AU2002247037B2 (en)	2007-08-16
GEP20063916B (en)	2006-09-11
HU228973B1 (en)	2013-07-29
SK9712003A3 (en)	2004-01-08
EE05537B1 (et)	2012-04-16
NZ527863A (en)	2006-09-29
KR100960063B1 (ko)	2010-05-31
PL372101A1 (en)	2005-07-11
WO2002060929A3 (en)	2003-03-06
ATE365748T1 (de)	2007-07-15
WO2002060929A2 (en)	2002-08-08
NO20033441D0 (no)	2003-08-01
KR20080098662A (ko)	2008-11-11
EE200300355A (et)	2003-10-15
UA82983C2 (ru)	2008-06-10
EP1355936A2 (en)	2003-10-29
CN1500095B (zh)	2010-06-16
EA009771B1 (ru)	2008-04-28
IS2867B (is)	2014-02-15
EP1862475A1 (en)	2007-12-05
JP2009039135A (ja)	2009-02-26
UA100967C2 (ru)	2013-02-25
TR200301208T2 (tr)	2005-05-23
MY143685A (en)	2011-06-30
HK1057759A1 (en)	2004-04-16
SK288123B6 (sk)	2013-09-03
SI1355936T1 (sl)	2007-12-31
NO20033441L (no)	2003-10-01
KR100872807B1 (ko)	2008-12-09
PT1355936E (pt)	2007-09-28
JP4259868B2 (ja)	2009-04-30
BG108111A (bg)	2004-12-30
RS50857B (sr)	2010-08-31
EP1355936B1 (en)	2007-06-27
CZ20032080A3 (cs)	2003-10-15
IS6879A (is)	2003-07-17
CN1500095A (zh)	2004-05-26
DK1355936T3 (da)	2007-10-29
CA2436407A1 (en)	2002-08-08
CA2436407C (en)	2011-08-30
JP2005503763A (ja)	2005-02-10
PL211162B1 (pl)	2012-04-30
MXPA03006805A (es)	2003-11-13
IL156941A0 (en)	2004-02-08
HUP0500637A3 (en)	2010-01-28
NO332150B1 (no)	2012-07-09
ZA200305733B (en)	2005-02-23
DE60220879T2 (de)	2008-03-06
EA200300852A1 (ru)	2004-06-24
CY1106886T1 (el)	2012-09-26
IL156941A (en)	2008-11-03
ES2289091T3 (es)	2008-02-01
BG66393B1 (bg)	2013-11-29
JP4423338B2 (ja)	2010-03-03
KR20030074766A (ko)	2003-09-19
HUP0500637A2 (hu)	2005-09-28

Publication	Publication Date	Title
SG149685A1 (en)	2009-02-27	Polymer conjugates of neublastin and methods of using same
EP1196444B8 (en)	2003-08-06	Exendin-4 conjugates and their medical use
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LTC2599503I2 (lt)	2019-06-25	Interferono beta-1A polimero konjugatai ir jų panaudojimas
TR200101867T2 (tr)	2001-11-21	CCR5 modülatörleri olarak piperidinler
WO2003049699A3 (en)	2004-12-29	Novel monofunctional polyethylene glycol aldehydes
PT1107793E (pt)	2005-02-28	Conjugados de dextrano-leptina, composicoes farmaceuticas e processos relacionados
ATE331730T1 (de)	2006-07-15	Neue depsipeptid-verbindung
RS20050585A (en)	2007-11-15	Polymer conjugates of mutated neublastin
WO2003040119A8 (fr)	2003-11-27	Inhibiteurs de l'angiogenese
AU2002354872A1 (en)	2003-03-03	Novel chelating agents and conjugates thereof, their synthesis and use as diagnostic and therapeutic agents