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SG146638A1 - Pharmaceutical delivery system - Google Patents

Pharmaceutical delivery system

Info

Publication number
SG146638A1
SG146638A1 SG200806828-0A SG2008068280A SG146638A1 SG 146638 A1 SG146638 A1 SG 146638A1 SG 2008068280 A SG2008068280 A SG 2008068280A SG 146638 A1 SG146638 A1 SG 146638A1
Authority
SG
Singapore
Prior art keywords
delivery system
pharmaceutical delivery
active agent
formulation
agent
Prior art date
Application number
SG200806828-0A
Other languages
English (en)
Inventor
Thomas C Riley
R Saul Levinson
Robert C Cuca
Elio Mariani
Original Assignee
Drugtech Corp
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Drugtech Corp filed Critical Drugtech Corp
Publication of SG146638A1 publication Critical patent/SG146638A1/en

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0034Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • A61K9/0036Devices retained in the vagina or cervix for a prolonged period, e.g. intravaginal rings, medicated tampons, medicated diaphragms
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0034Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04Antibacterial agents
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10Antimycotics

Landscapes

  • Health & Medical Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Reproductive Health (AREA)
  • Gynecology & Obstetrics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Urology & Nephrology (AREA)
  • Communicable Diseases (AREA)
  • Endocrinology (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
SG200806828-0A 2003-09-19 2004-09-20 Pharmaceutical delivery system SG146638A1 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US50401703P 2003-09-19 2003-09-19
US50713803P 2003-10-01 2003-10-01

Publications (1)

Publication Number Publication Date
SG146638A1 true SG146638A1 (en) 2008-10-30

Family

ID=34381092

Family Applications (1)

Application Number Title Priority Date Filing Date
SG200806828-0A SG146638A1 (en) 2003-09-19 2004-09-20 Pharmaceutical delivery system

Country Status (11)

Country Link
US (2) US20050095245A1 (zh)
EP (1) EP1667619A4 (zh)
JP (1) JP2007505927A (zh)
CN (1) CN1852690B (zh)
AR (1) AR047108A1 (zh)
AU (1) AU2004274000B2 (zh)
BR (1) BRPI0414500A (zh)
CA (1) CA2540129A1 (zh)
MY (1) MY144021A (zh)
SG (1) SG146638A1 (zh)
WO (1) WO2005027807A1 (zh)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0222522D0 (en) 2002-09-27 2002-11-06 Controlled Therapeutics Sct Water-swellable polymers
US20060140990A1 (en) * 2003-09-19 2006-06-29 Drugtech Corporation Composition for topical treatment of mixed vaginal infections
CN1852690B (zh) 2003-09-19 2010-04-14 制药技术有限公司 药物输送系统
GB0417401D0 (en) 2004-08-05 2004-09-08 Controlled Therapeutics Sct Stabilised prostaglandin composition
JP2008540534A (ja) * 2005-05-09 2008-11-20 ドラッグテック コーポレイション 放出調節薬学組成物
AU2006280002A1 (en) * 2005-08-12 2007-02-22 Drugtech Corporation Estrogen compositions and therapeutic methods of use thereof
EA200870153A1 (ru) * 2006-01-05 2008-12-30 Драгтек Корпорейшн Композиция и способ ее использования
AU2006332520A1 (en) * 2006-01-05 2007-07-12 Drugtech Corporation Drug delivery system for bioadhesion to a vulvovaginal surface
WO2008005783A2 (en) * 2006-06-30 2008-01-10 Drugtech Corporation Treatment of non- infectious inflammatory vulvovaginitis with a bioadhesive clindamycin composition
GB0613333D0 (en) 2006-07-05 2006-08-16 Controlled Therapeutics Sct Hydrophilic polyurethane compositions
GB0613638D0 (en) 2006-07-08 2006-08-16 Controlled Therapeutics Sct Polyurethane elastomers
US20080160065A1 (en) * 2006-07-12 2008-07-03 Janet Anne Halliday Drug delivery polymer with hydrochloride salt of clindamycin
US20080085877A1 (en) * 2006-08-10 2008-04-10 Drugtech Corporation Therapeutic methods of using estrogen compositions
GB0620685D0 (en) 2006-10-18 2006-11-29 Controlled Therapeutics Sct Bioresorbable polymers
WO2008089405A1 (en) * 2007-01-19 2008-07-24 Neurosci, Inc. Composition of multiple hormones delivered vaginally in a single cream
WO2008143889A1 (en) 2007-05-14 2008-11-27 Research Foundation Of State University Of New York Induction of a physiological dispersion response in bacterial cells in a biofilm
US20080287408A1 (en) * 2007-05-14 2008-11-20 Drugtech Corporation Endometriosis treatment
TW200927141A (en) * 2007-11-22 2009-07-01 Bayer Schering Pharma Oy Vaginal delivery system
PT3256138T (pt) 2015-02-10 2022-05-23 Axsome Therapeutics Inc Composições farmacêuticas compreendendo meloxicam
US11207509B2 (en) 2017-06-15 2021-12-28 Wiesman Holdings, LLC Method and device for delivery of a solution into a body orifice
US10285998B1 (en) 2018-04-04 2019-05-14 The Menopause Method, Inc. Composition and method to aid in hormone replacement therapy
USD918388S1 (en) 2018-06-15 2021-05-04 Wiesman Holdings, LLC Solution diffusing head
US10568758B1 (en) * 2018-12-20 2020-02-25 Michael Peikoff Prophylactic device(s)

Family Cites Families (83)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB1525120A (en) * 1974-12-19 1978-09-20 Nelson Res & Dev Topical antimicrobial compositions
US4018918A (en) * 1975-05-20 1977-04-19 The Upjohn Company Topical clindamycin preparations
JPS6027646B2 (ja) * 1979-10-31 1985-06-29 花王株式会社 化粧料
EP0047804A1 (en) * 1980-09-15 1982-03-24 Unilever Plc Water-in-oil emulsions and process for preparing same
US4342741A (en) * 1981-04-27 1982-08-03 Dental Chemical Co., Ltd. Dentifrice compositions
US4551148A (en) * 1982-09-07 1985-11-05 Kv Pharmaceutical Company Vaginal delivery systems and their methods of preparation and use
US4683243A (en) * 1984-02-08 1987-07-28 Richardson-Vicks, Inc. Analgesic and anti-inflammatory compositions comprising diphenhydramine and methods of using same
ATE68686T1 (de) * 1985-10-31 1991-11-15 Kv Pharm Co System zum freigeben von stoffen in der vagina.
US5266329A (en) * 1985-10-31 1993-11-30 Kv Pharmaceutical Company Vaginal delivery system
AU7031887A (en) * 1986-01-31 1987-08-25 Nelson Research & Development Company Compositions comprising 1-substituted azacycloalkanes and their uses
GB8607159D0 (en) * 1986-03-22 1986-04-30 Smith & Nephew Ass Pharmaceutical composition
US5536743A (en) * 1988-01-15 1996-07-16 Curatek Pharmaceuticals Limited Partnership Intravaginal treatment of vaginal infections with buffered metronidazole compositions
US4943389A (en) * 1988-04-04 1990-07-24 Emulsion Technology, Inc. Emulsifier for water-in-oil emulsions
US5008037A (en) * 1988-04-04 1991-04-16 Emulsion Technology, Inc. Emulsifier for water-in-oil emulsions
US4895934A (en) * 1988-08-22 1990-01-23 E. I. Du Pont De Nemours And Company Process for the preparation of clindamycin phosphate
US5055303A (en) * 1989-01-31 1991-10-08 Kv Pharmaceutical Company Solid controlled release bioadherent emulsions
CA1337279C (en) 1989-06-06 1995-10-10 Robert J. Borgman Intravaginal treatment of vaginal infections with buffered metronidazole compositions
US5143934A (en) * 1990-11-21 1992-09-01 A/S Dumex (Dumex Ltd.) Method and composition for controlled delivery of biologically active agents
US5085856A (en) * 1990-07-25 1992-02-04 Elizabeth Arden Co., Division Of Conopco, Inc. Cosmetic water-in-oil emulsion lipstick comprising a phospholipid and glycerol fatty acid esters emulsifying system
AU1797592A (en) 1991-04-12 1992-11-17 Upjohn Company, The Vaginal drug delivery device
IT1251114B (it) * 1991-07-26 1995-05-04 Farcon Ag Forme farmaceutiche antivirali per applicazione vaginale
IT1253711B (it) * 1991-12-17 1995-08-23 Alfa Wassermann Spa Formulazioni farmaceutiche vaginali contenenti rifaximin e loro uso nel trattamento delle infezioni vaginali
IL101387A (en) * 1992-03-26 1999-11-30 Pharmos Ltd Emulsion with enhanced topical and/or transdermal systemic effect utilizing submicron oil droplets
ZA932947B (en) * 1992-04-28 1993-10-27 Schering Plough Healthcare Applicator for semisolid medications
WO1994008536A1 (en) * 1992-10-21 1994-04-28 Gynetech Laboratories, Inc. Vaginal sponge delivery system
US6113921A (en) * 1993-03-23 2000-09-05 Pharmos Corp. Topical and transdermal delivery system utilizing submicron oil spheres
WO1994023749A1 (en) * 1993-04-19 1994-10-27 Institute For Advanced Skin Research Inc. Microemulsion preparation containing difficultly absorbable substance
GB9318641D0 (en) * 1993-09-08 1993-10-27 Edko Trading Representation Compositions
EP0717674B1 (de) 1993-09-10 1997-07-16 Battenfeld Kunststoffmaschinen Ges.m.b.H. Holmlose kunststoff-spritzgiessmaschine
JP3566739B2 (ja) * 1993-09-30 2004-09-15 三省製薬株式会社 皮膚外用剤の安定化方法
US6228383B1 (en) * 1994-03-03 2001-05-08 Gs Development Ab Use of fatty acid esters as bioadhesive substances
JP3487633B2 (ja) 1994-04-28 2004-01-19 祐徳薬品工業株式会社 皮膚疾患治療乳剤
TW438601B (en) * 1994-05-18 2001-06-07 Janssen Pharmaceutica Nv New mucoadhesive emulsion compositions and a process for the preparation thereof
US5554380A (en) * 1994-08-04 1996-09-10 Kv Pharmaceutical Company Bioadhesive pharmaceutical delivery system
US5589177A (en) * 1994-12-06 1996-12-31 Helene Curtis, Inc. Rinse-off water-in-oil-in-water compositions
US5618522A (en) * 1995-01-20 1997-04-08 The Procter & Gamble Company Emulsion compositions
DE19536504C2 (de) * 1995-09-29 1999-09-23 H Meinert Verwendung fluorierter Alkane
US6267895B1 (en) * 1996-05-14 2001-07-31 Germiphene Corporation Catalytic dental water apparatus
GB9610359D0 (en) 1996-05-17 1996-07-24 Edko Trading Representation Pharmaceutical compositions
IT1284874B1 (it) * 1996-08-02 1998-05-22 Farmigea Spa Complessi bioadesivi di polycarbophil e farmaci antifungini o antiprotozoari azolici
US5993856A (en) * 1997-01-24 1999-11-30 Femmepharma Pharmaceutical preparations and methods for their administration
US6416778B1 (en) * 1997-01-24 2002-07-09 Femmepharma Pharmaceutical preparations and methods for their regional administration
US6416779B1 (en) * 1997-06-11 2002-07-09 Umd, Inc. Device and method for intravaginal or transvaginal treatment of fungal, bacterial, viral or parasitic infections
US6150400A (en) * 1997-06-30 2000-11-21 Presutti Laboratories Method for treating vulvar vestibulitis
US20040234606A1 (en) * 1997-09-12 2004-11-25 Levine Howard L. Localized vaginal delivery without detrimental blood levels
US5888523A (en) * 1997-09-22 1999-03-30 Biocontrol, Inc. Topical non-steroidal anti-inflammatory drug composition
ES2165139T3 (es) * 1998-04-30 2002-03-01 Vesely Renata Maria Cavaliere Composiciones farmaceuticas que contienen lactobacillus brevis y lactobacillus salivarius para el tratamiento de infecciones vaginales.
EP1109563A4 (en) * 1998-08-04 2009-07-22 Madash Llp HEAT-SENSITIVE HYDROGELS WITH MODIFIED TERMINATION
AU1239100A (en) * 1998-11-03 2000-05-22 Bristol-Myers Squibb Company Skin moisturizer compositions containing a sebum control agent
US6316433B1 (en) * 1998-12-18 2001-11-13 Kaneka Corporation Method for treatment of bacterial infections with once or twice-weekly administered rifalazil
US6267985B1 (en) * 1999-06-30 2001-07-31 Lipocine Inc. Clear oil-containing pharmaceutical compositions
FR2792642B1 (fr) * 1999-04-21 2001-06-08 Oreal Composition cosmetique contenant des particules de resine de melamine-formaldehyde ou d'uree-formaldehyde et ses utilisations
DE19934943B4 (de) * 1999-07-26 2007-08-02 Beiersdorf Ag Kosmetische und dermatologische Zubereitungen auf der Grundlage von O/W-Emulsionen
TWI232111B (en) 1999-08-06 2005-05-11 Upjohn Co Intravaginal clindamycin ovule composition
US6479545B1 (en) * 1999-09-30 2002-11-12 Drugtech Corporation Formulation for menopausal women
JP2001151662A (ja) * 1999-11-25 2001-06-05 Lion Corp 乾燥性皮膚疾患治療薬
FR2802097B1 (fr) * 1999-12-14 2002-12-13 Invest S Therapeutiques Essais Composition sous forme de gel prevue pour recevoir un principe actif en solution ou en suspension, notamment pour application sur une muqueuse et procede de fabrication
BR0007360A (pt) 1999-12-23 2001-08-14 Johnson & Johnson Composição de liberação controlada
DE10015463B4 (de) 2000-03-29 2008-01-10 Heide, Peter Edgar, Dr. Creme in Form einer überwässerten Wasser-in-Öl-Emulsion
US6387383B1 (en) * 2000-08-03 2002-05-14 Dow Pharmaceutical Sciences Topical low-viscosity gel composition
US6660306B2 (en) * 2000-10-12 2003-12-09 Mickey L. Peshoff Wound healing compound
US20020197314A1 (en) * 2001-02-23 2002-12-26 Rudnic Edward M. Anti-fungal composition
US8093446B2 (en) * 2001-04-11 2012-01-10 Playtex Products, Inc. Fibrous absorbent articles having malodor counteractant
ATE502657T1 (de) * 2001-05-01 2011-04-15 Av Topchiev Inst Petrochemical Zweiphasige, wasserabsorbierende bioadhäsive zusammenstezung
ITMI20010913A1 (it) 2001-05-04 2002-11-04 Univ Pavia Composizioni a rilascio controllato di acido lattico a livello vaginale
US20030083286A1 (en) * 2001-08-22 2003-05-01 Ching-Leou Teng Bioadhesive compositions and methods for enhanced intestinal drug absorption
DE10143963A1 (de) * 2001-09-07 2003-03-27 Basf Ag Kosmetische und dermatologische Zubereitungen in Form von W/O-Emulsionen, enthaltend ein aminosubstituiertes Hydroxybenzophenon
US20030091540A1 (en) * 2001-10-16 2003-05-15 Nawaz Ahmad Compositions and methods for delivering antibacterial, antifungal and antiviral ointments to the oral, nasal or vaginal cavity
US6998384B2 (en) * 2001-12-12 2006-02-14 The Penn State Research Foundation Surfactant prevention of lung complications from cancer chemotherapy
JP2003212747A (ja) * 2002-01-15 2003-07-30 Nisshin Oillio Ltd 油中水型乳化皮膚外用剤
US6899890B2 (en) 2002-03-20 2005-05-31 Kv Pharmaceutical Company Bioadhesive drug delivery system
JP2005531570A (ja) * 2002-05-23 2005-10-20 ユーエムディー, インコーポレイテッド 貫粘膜薬物送達及び凍結保護のための組成物及び方法
US20030219465A1 (en) * 2002-05-23 2003-11-27 Suresh Kumar Gidwani Composition for delivery of dithranol
US20040167223A1 (en) * 2002-09-03 2004-08-26 Popp Karl F. Topical antibacterial formulations
BR0315194A (pt) * 2002-10-31 2005-08-23 Umd Inc Composições terapêuticas para liberação de droga para a, e através da, cobertura epitelial
US20040121003A1 (en) * 2002-12-19 2004-06-24 Acusphere, Inc. Methods for making pharmaceutical formulations comprising deagglomerated microparticles
CA2523859C (en) 2003-04-29 2011-08-02 The General Hospital Corporation Methods and devices for the sustained release of multiple drugs
ES2237298B1 (es) 2003-07-16 2006-11-01 Italfarmaco, S.A. Formulaciones mucoadhesivas semisolidas.
WO2005013906A2 (en) 2003-08-08 2005-02-17 Sri International pH-RESPONSIVE FILM FOR INTRAVAGINAL DELIVERY OF A BENEFICIAL AGENT
CN1852690B (zh) 2003-09-19 2010-04-14 制药技术有限公司 药物输送系统
JP3983218B2 (ja) * 2003-10-23 2007-09-26 株式会社神戸製鋼所 延性に優れた極細高炭素鋼線およびその製造方法
GB0405406D0 (en) 2004-03-10 2004-04-21 Edko Pazarlama Tanitim Ltd Sti Anti-vaginitis compositions
JP4500365B2 (ja) * 2009-12-08 2010-07-14 株式会社ナビタイムジャパン 情報処理装置および経路処理方法

Also Published As

Publication number Publication date
US9789057B2 (en) 2017-10-17
AU2004274000A1 (en) 2005-03-31
CN1852690B (zh) 2010-04-14
MY144021A (en) 2011-07-29
EP1667619A4 (en) 2007-10-10
EP1667619A1 (en) 2006-06-14
AU2004274000B2 (en) 2009-07-30
CA2540129A1 (en) 2005-03-31
WO2005027807A1 (en) 2005-03-31
BRPI0414500A (pt) 2006-11-07
US20050095245A1 (en) 2005-05-05
AR047108A1 (es) 2006-01-11
CN1852690A (zh) 2006-10-25
JP2007505927A (ja) 2007-03-15
US20130102548A1 (en) 2013-04-25

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