IT1284874B1 - Complessi bioadesivi di polycarbophil e farmaci antifungini o antiprotozoari azolici - Google Patents
Complessi bioadesivi di polycarbophil e farmaci antifungini o antiprotozoari azoliciInfo
- Publication number
- IT1284874B1 IT1284874B1 IT96RM000559A ITRM960559A IT1284874B1 IT 1284874 B1 IT1284874 B1 IT 1284874B1 IT 96RM000559 A IT96RM000559 A IT 96RM000559A IT RM960559 A ITRM960559 A IT RM960559A IT 1284874 B1 IT1284874 B1 IT 1284874B1
- Authority
- IT
- Italy
- Prior art keywords
- polycarbophil
- complexes
- antifungal
- bioadhesive
- antiprotozoar
- Prior art date
Links
- 229920000148 Polycarbophil calcium Polymers 0.000 title abstract 5
- 229950005134 polycarbophil Drugs 0.000 title abstract 5
- 229940121375 antifungal agent Drugs 0.000 title abstract 3
- 230000000843 anti-fungal effect Effects 0.000 title abstract 2
- 239000000227 bioadhesive Substances 0.000 title abstract 2
- 229940079593 drug Drugs 0.000 title 1
- 239000003814 drug Substances 0.000 title 1
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 abstract 3
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 abstract 3
- 239000002904 solvent Substances 0.000 abstract 2
- 229920002125 Sokalan® Polymers 0.000 abstract 1
- 230000000845 anti-microbial effect Effects 0.000 abstract 1
- 230000000842 anti-protozoal effect Effects 0.000 abstract 1
- 239000003937 drug carrier Substances 0.000 abstract 1
- 238000001035 drying Methods 0.000 abstract 1
- 238000001704 evaporation Methods 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000003232 mucoadhesive effect Effects 0.000 abstract 1
- 239000000546 pharmaceutical excipient Substances 0.000 abstract 1
- 239000004584 polyacrylic acid Substances 0.000 abstract 1
- 238000010298 pulverizing process Methods 0.000 abstract 1
- 238000007873 sieving Methods 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- 238000013268 sustained release Methods 0.000 abstract 1
- 239000012730 sustained-release form Substances 0.000 abstract 1
- 230000000699 topical effect Effects 0.000 abstract 1
- 150000003852 triazoles Chemical class 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4174—Arylalkylimidazoles, e.g. oxymetazolin, naphazoline, miconazole
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
- A61K31/4164—1,3-Diazoles
- A61K31/4178—1,3-Diazoles not condensed 1,3-diazoles and containing further heterocyclic rings, e.g. pilocarpine, nitrofurantoin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/506—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim not condensed and containing further heterocyclic rings
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
- A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
- A61K47/56—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule
- A61K47/58—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being an organic macromolecular compound, e.g. an oligomeric, polymeric or dendrimeric molecule obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. poly[meth]acrylate, polyacrylamide, polystyrene, polyvinylpyrrolidone, polyvinylalcohol or polystyrene sulfonic acid resin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0034—Urogenital system, e.g. vagina, uterus, cervix, penis, scrotum, urethra, bladder; Personal lubricants
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Epidemiology (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Gynecology & Obstetrics (AREA)
- Reproductive Health (AREA)
- Urology & Nephrology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicinal Preparation (AREA)
Priority Applications (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT96RM000559A IT1284874B1 (it) | 1996-08-02 | 1996-08-02 | Complessi bioadesivi di polycarbophil e farmaci antifungini o antiprotozoari azolici |
| DE69711887T DE69711887D1 (de) | 1996-08-02 | 1997-07-25 | Bioadhaesive komplexe von polycarbophil und azolen mit antifungaler oder antiprotozoen-wirksamkeit |
| AU38632/97A AU3863297A (en) | 1996-08-02 | 1997-07-25 | Bioadhesive complexes of polycarbophil and azole antifungal or antiprotozoal drugs |
| AT97935751T ATE215815T1 (de) | 1996-08-02 | 1997-07-25 | Bioadhaesive komplexe von polycarbophil und azolen mit antifungaler oder antiprotozoen- wirksamkeit |
| US09/230,863 US6423307B2 (en) | 1996-08-02 | 1997-07-25 | Bioadhesive complexes of polycarbophil and azole antifungal or antiprotozoal drugs |
| PCT/IT1997/000187 WO1998005303A1 (en) | 1996-08-02 | 1997-07-25 | Bioadhesive complexes of polycarbophil and azole antifungal or antiprotozoal drugs |
| EP97935751A EP0918510B1 (en) | 1996-08-02 | 1997-07-25 | Bioadhesive complexes of polycarbophil and azole antifungal or antiprotozoal drugs |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IT96RM000559A IT1284874B1 (it) | 1996-08-02 | 1996-08-02 | Complessi bioadesivi di polycarbophil e farmaci antifungini o antiprotozoari azolici |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| ITRM960559A0 ITRM960559A0 (it) | 1996-08-02 |
| ITRM960559A1 ITRM960559A1 (it) | 1998-02-02 |
| IT1284874B1 true IT1284874B1 (it) | 1998-05-22 |
Family
ID=11404381
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IT96RM000559A IT1284874B1 (it) | 1996-08-02 | 1996-08-02 | Complessi bioadesivi di polycarbophil e farmaci antifungini o antiprotozoari azolici |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US6423307B2 (it) |
| EP (1) | EP0918510B1 (it) |
| AT (1) | ATE215815T1 (it) |
| AU (1) | AU3863297A (it) |
| DE (1) | DE69711887D1 (it) |
| IT (1) | IT1284874B1 (it) |
| WO (1) | WO1998005303A1 (it) |
Families Citing this family (27)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040234606A1 (en) * | 1997-09-12 | 2004-11-25 | Levine Howard L. | Localized vaginal delivery without detrimental blood levels |
| GR980100028A (el) * | 1998-01-15 | 1999-09-30 | Drug Research Hellas ����� | Φαρμακευτικα προιοντα για τοπικη χρηση που περιεχουν φλουκοναζολη σε συγκεντρωσεις μεταξυ 0,2% και 5% |
| NL1008745C2 (nl) * | 1998-03-30 | 1999-10-01 | Stichting Tech Wetenschapp | Therapeutisch werkzame verbinding voor behandeling van gist- en/of schimmelinfecties in de mondholte. |
| DE19850445A1 (de) * | 1998-11-02 | 2000-05-04 | Falk Pharma Gmbh | Arzneimittel zur topischen Behandlung entzündlicher Darmerkrankungen |
| US20030091540A1 (en) * | 2001-10-16 | 2003-05-15 | Nawaz Ahmad | Compositions and methods for delivering antibacterial, antifungal and antiviral ointments to the oral, nasal or vaginal cavity |
| US20080182841A1 (en) * | 2001-10-29 | 2008-07-31 | Levine Howard L | Vaginally administered anti-dysrhythmic agents for treating pelvic pain |
| US8425892B2 (en) * | 2001-10-29 | 2013-04-23 | Columbia Laboratories, Inc. | Extended, controlled-release pharmaceutical compositions using charged polymers |
| MXPA05006505A (es) * | 2002-12-18 | 2005-09-30 | Ferrer Int | Composiciones vaginales de sertaconazol. |
| US20040126369A1 (en) * | 2002-12-30 | 2004-07-01 | Richard Payne | Delivery of peroxide-generating enzymes to the vaginal tract |
| ES2237298B1 (es) | 2003-07-16 | 2006-11-01 | Italfarmaco, S.A. | Formulaciones mucoadhesivas semisolidas. |
| ITMI20031640A1 (it) | 2003-08-08 | 2005-02-09 | Mipharm S P A | Base per gel bioadesivi. |
| BRPI0414500A (pt) | 2003-09-19 | 2006-11-07 | Drugtech Corp | formulação farmacêutica composição para tratar uma infecção vaginal, e, métodos para tratar uma infecção vaginal, para estabilizar uma formulação de clindamicina, para tratar ou prevenir uma recorrência de uma infecção vaginal em uma paciente e para tratar condições vaginais |
| US20060140990A1 (en) * | 2003-09-19 | 2006-06-29 | Drugtech Corporation | Composition for topical treatment of mixed vaginal infections |
| US7279131B2 (en) * | 2004-07-01 | 2007-10-09 | Uop Llc | Method and apparatus for mass analysis of samples |
| US7850771B2 (en) * | 2004-09-10 | 2010-12-14 | Viance, Llc | Emulsion compositions for wood protection |
| DE102004054552A1 (de) * | 2004-11-11 | 2006-05-18 | Hcb Happy Child Birth Holding Ag | Neue Zusammensetzung zur Erleichterung der Humangeburt |
| WO2006121979A2 (en) * | 2005-05-09 | 2006-11-16 | Drugtech Corporation | Modified-release pharmaceutical compositions |
| BRPI0620908A2 (pt) * | 2006-01-05 | 2011-11-29 | Drugtech Corp | composição farmacêutica, sistema de distribuição antibacteriana e antifúngica vaginal e uso da composição farmacêutica |
| WO2008067991A2 (en) * | 2006-12-08 | 2008-06-12 | Antares Pharma Ipl Ag | Skin-friendly drug complexes for transdermal administration |
| ES2344673B1 (es) | 2008-08-07 | 2011-05-03 | Italfarmaco, S.A. | Uso de estriol en la preparacion de una formulacion farmaceutica parael tratamiento de atrofia vaginal en mujeres con riesgo de potologiatumoral. |
| WO2010047831A1 (en) * | 2008-10-23 | 2010-04-29 | Nycomed Us Inc. | Stable metronidazole gel formulations |
| ES2344675B1 (es) | 2008-12-19 | 2011-04-28 | Italfarmaco, S.A. | Uso de estriol en la preparacion de una formulacion farrmaceutica para el tratamiento de atrofia vaginal en mujeres con riesgo de patologiacardiovascular. |
| CA3054236A1 (en) | 2011-06-28 | 2013-01-03 | Chemo Research Sl | High dosage mucoadhesive metronidazole aqueous-based gel formulations and their use to treat bacterial vaginosis |
| US9446024B2 (en) | 2013-06-25 | 2016-09-20 | UNIVERSITé LAVAL | Formulations for the treatment of vaginal disorders |
| US20190141991A1 (en) * | 2017-11-14 | 2019-05-16 | Ralph Waldo Emerson | Anti-pest guardian barrier including an article/substrate protecting drying oil |
| GB201808567D0 (en) * | 2018-05-24 | 2018-07-11 | Douglas Pharmaceuticals Ltd | Pharmaceutical compositions |
| CN114264808B (zh) * | 2021-12-28 | 2022-09-30 | 南京岚煜生物科技有限公司 | 基于抗原检测试剂的抗原中和当量的确定方法 |
Family Cites Families (9)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3244027A1 (de) | 1982-11-27 | 1984-05-30 | Bayer Ag, 5090 Leverkusen | Antimykotische mittel mit hoher wirkstoff-freisetzung in form von gelsystemen |
| JPH0830004B2 (ja) * | 1983-11-14 | 1996-03-27 | コロンビア ラボラトリーズ インコーポレイテッド | 生物接着性組成物およびそれにより治療する方法 |
| US4837378A (en) | 1986-01-15 | 1989-06-06 | Curatek Pharmaceuticals, Inc. | Topical metronidazole formulations and therapeutic uses thereof |
| US5536743A (en) | 1988-01-15 | 1996-07-16 | Curatek Pharmaceuticals Limited Partnership | Intravaginal treatment of vaginal infections with buffered metronidazole compositions |
| JPH03275619A (ja) | 1990-03-23 | 1991-12-06 | Nitsusui Seiyaku Kk | 外用剤組成物 |
| DE69119217T2 (de) * | 1990-08-21 | 1996-10-31 | Theratech Inc | Zusammensetzungen zur kontrollierten freigabe |
| US5658956A (en) * | 1991-03-01 | 1997-08-19 | Warner-Lambert Company | Bioadhesive-wound healing compositions and methods for preparing and using same |
| IT1275816B1 (it) | 1995-10-27 | 1997-10-17 | Montefarmaco Spa | Composizioni farmaceutiche solide per uso vaginale |
| US5955096A (en) * | 1996-06-25 | 1999-09-21 | Brown University Research Foundation | Methods and compositions for enhancing the bioadhesive properties of polymers using organic excipients |
-
1996
- 1996-08-02 IT IT96RM000559A patent/IT1284874B1/it active IP Right Grant
-
1997
- 1997-07-25 WO PCT/IT1997/000187 patent/WO1998005303A1/en active IP Right Grant
- 1997-07-25 AT AT97935751T patent/ATE215815T1/de not_active IP Right Cessation
- 1997-07-25 EP EP97935751A patent/EP0918510B1/en not_active Expired - Lifetime
- 1997-07-25 DE DE69711887T patent/DE69711887D1/de not_active Expired - Lifetime
- 1997-07-25 US US09/230,863 patent/US6423307B2/en not_active Expired - Fee Related
- 1997-07-25 AU AU38632/97A patent/AU3863297A/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| AU3863297A (en) | 1998-02-25 |
| US6423307B2 (en) | 2002-07-23 |
| ITRM960559A1 (it) | 1998-02-02 |
| EP0918510B1 (en) | 2002-04-10 |
| WO1998005303A1 (en) | 1998-02-12 |
| US20020012674A1 (en) | 2002-01-31 |
| ATE215815T1 (de) | 2002-04-15 |
| EP0918510A1 (en) | 1999-06-02 |
| ITRM960559A0 (it) | 1996-08-02 |
| DE69711887D1 (de) | 2002-05-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 0001 | Granted |