[go: up one dir, main page]

SG11202111130SA - Chimeric receptors and methods of use thereof - Google Patents

Chimeric receptors and methods of use thereof

Info

Publication number
SG11202111130SA
SG11202111130SA SG11202111130SA SG11202111130SA SG11202111130SA SG 11202111130S A SG11202111130S A SG 11202111130SA SG 11202111130S A SG11202111130S A SG 11202111130SA SG 11202111130S A SG11202111130S A SG 11202111130SA SG 11202111130S A SG11202111130S A SG 11202111130SA
Authority
SG
Singapore
Prior art keywords
methods
chimeric receptors
chimeric
receptors
Prior art date
Application number
SG11202111130SA
Inventor
Brian Garrison
Jennifer Chien
Kathryn Loving
Russell Gordley
Michelle Hung
Original Assignee
Senti Biosciences Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Senti Biosciences Inc filed Critical Senti Biosciences Inc
Publication of SG11202111130SA publication Critical patent/SG11202111130SA/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06—Animal cells or tissues; Human cells or tissues
    • C12N5/0602—Vertebrate cells
    • C12N5/0634—Cells from the blood or the immune system
    • C12N5/0636—T lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/11—T-cells, e.g. tumour infiltrating lymphocytes [TIL] or regulatory T [Treg] cells; Lymphokine-activated killer [LAK] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/10—Cellular immunotherapy characterised by the cell type used
    • A61K40/15—Natural-killer [NK] cells; Natural-killer T [NKT] cells
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/30—Cellular immunotherapy characterised by the recombinant expression of specific molecules in the cells of the immune system
    • A61K40/31—Chimeric antigen receptors [CAR]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4202—Receptors, cell surface antigens or cell surface determinants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4202—Receptors, cell surface antigens or cell surface determinants
    • A61K40/421—Immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4202—Receptors, cell surface antigens or cell surface determinants
    • A61K40/4214—Receptors for cytokines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4202—Receptors, cell surface antigens or cell surface determinants
    • A61K40/4214—Receptors for cytokines
    • A61K40/4217—Receptors for interleukins [IL]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K40/00—Cellular immunotherapy
    • A61K40/40—Cellular immunotherapy characterised by antigens that are targeted or presented by cells of the immune system
    • A61K40/41—Vertebrate antigens
    • A61K40/42—Cancer antigens
    • A61K40/4254—Adhesion molecules, e.g. NRCAM, EpCAM or cadherins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/52—Cytokines; Lymphokines; Interferons
    • C07K14/53—Colony-stimulating factor [CSF]
    • C07K14/535—Granulocyte CSF; Granulocyte-macrophage CSF
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/7051—T-cell receptor (TcR)-CD3 complex
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70517—CD8
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70503—Immunoglobulin superfamily
    • C07K14/70521—CD28, CD152
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/71—Receptors; Cell surface antigens; Cell surface determinants for growth factors; for growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2851—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the lectin superfamily, e.g. CD23, CD72
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2863—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for growth factors, growth regulators
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2866—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against receptors for cytokines, lymphokines, interferons
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/58—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation
    • A61K2039/585—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation wherein the target is cancer
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/10—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterized by the structure of the chimeric antigen receptor [CAR]
    • A61K2239/17—Hinge-spacer domain
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/27—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterized by targeting or presenting multiple antigens
    • A61K2239/28—Expressing multiple CARs, TCRs or antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/27—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterized by targeting or presenting multiple antigens
    • A61K2239/29—Multispecific CARs
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/31—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterized by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/38—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K40/00
    • A61K2239/46—Indexing codes associated with cellular immunotherapy of group A61K40/00 characterised by the cancer treated
    • A61K2239/48—Blood cells, e.g. leukemia or lymphoma
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/50—Immunoglobulins specific features characterized by immunoglobulin fragments
    • C07K2317/56—Immunoglobulins specific features characterized by immunoglobulin fragments variable (Fv) region, i.e. VH and/or VL
    • C07K2317/565—Complementarity determining region [CDR]
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/02—Fusion polypeptide containing a localisation/targetting motif containing a signal sequence
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/01—Fusion polypeptide containing a localisation/targetting motif
    • C07K2319/03—Fusion polypeptide containing a localisation/targetting motif containing a transmembrane segment
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/33—Fusion polypeptide fusions for targeting to specific cell types, e.g. tissue specific targeting, targeting of a bacterial subspecies
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/40—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation
    • C07K2319/43—Fusion polypeptide containing a tag for immunodetection, or an epitope for immunisation containing a FLAG-tag
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/50—Fusion polypeptide containing protease site
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/60—Fusion polypeptide containing spectroscopic/fluorescent detection, e.g. green fluorescent protein [GFP]
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2510/00—Genetically modified cells

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Zoology (AREA)
  • Cell Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Toxicology (AREA)
  • Biomedical Technology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
  • Hematology (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Developmental Biology & Embryology (AREA)
  • Virology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
SG11202111130SA 2019-04-30 2020-04-30 Chimeric receptors and methods of use thereof SG11202111130SA (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201962841128P 2019-04-30 2019-04-30
US201962854151P 2019-05-29 2019-05-29
US201962893106P 2019-08-28 2019-08-28
PCT/US2020/030640 WO2020223445A1 (en) 2019-04-30 2020-04-30 Chimeric receptors and methods of use thereof

Publications (1)

Publication Number Publication Date
SG11202111130SA true SG11202111130SA (en) 2021-11-29

Family

ID=73029309

Family Applications (1)

Application Number Title Priority Date Filing Date
SG11202111130SA SG11202111130SA (en) 2019-04-30 2020-04-30 Chimeric receptors and methods of use thereof

Country Status (11)

Country Link
US (2) US12005081B2 (en)
EP (1) EP3962527A4 (en)
JP (2) JP7711945B2 (en)
KR (1) KR20220016083A (en)
CN (1) CN114007642A (en)
AU (1) AU2020265679A1 (en)
CA (1) CA3133333A1 (en)
IL (1) IL287407A (en)
SG (1) SG11202111130SA (en)
TW (1) TW202110873A (en)
WO (1) WO2020223445A1 (en)

Families Citing this family (23)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SG11202111130SA (en) 2019-04-30 2021-11-29 Senti Biosciences Inc Chimeric receptors and methods of use thereof
US20220289842A1 (en) * 2019-08-20 2022-09-15 Senti Biosciences, Inc. Chimeric inhibitory receptor
WO2022051727A2 (en) * 2020-09-04 2022-03-10 Immpact-Bio Ltd. BICISTRONIC INHIBITORY CHIMERIC ANTIGEN RECEPTOR (iCAR)/ACTIVATING CHIMERIC ANTIGEN RECEPTOR (aCAR) CONSTRUCTS FOR USE IN CANCER THERAPIES
AU2021361993A1 (en) * 2020-10-16 2023-06-15 Senti Biosciences, Inc. Chimeric receptors and methods of use thereof
WO2022104109A1 (en) * 2020-11-13 2022-05-19 Catamaran Bio, Inc. Genetically modified natural killer cells and methods of use thereof
CA3199739A1 (en) * 2020-11-24 2022-06-02 Brian Scott GARRISON Chimeric receptors and methods of use thereof
US11661459B2 (en) 2020-12-03 2023-05-30 Century Therapeutics, Inc. Artificial cell death polypeptide for chimeric antigen receptor and uses thereof
MX2023006395A (en) 2020-12-03 2023-06-15 Century Therapeutics Inc GENETICALLY DESIGNED CELLS AND USES OF THESE.
WO2022133169A1 (en) 2020-12-18 2022-06-23 Century Therapeutics, Inc. Chimeric antigen receptor systems with adaptable receptor specificity
JP2024516713A (en) * 2021-05-07 2024-04-16 センティ バイオサイエンシズ インコーポレイテッド Chimeric receptors and methods of use thereof
US20250114452A1 (en) 2021-08-04 2025-04-10 The Regents Of The University Of Colorado, A Body Corporate Lat activating chimeric antigen receptor t cells and methods of use thereof
CN113893338A (en) * 2021-11-04 2022-01-07 苏州大学附属第一医院 Application of CD38 CAR-T cells in acute myelopathy of chronic myelocytic leukemia
CN113980907B (en) * 2021-12-24 2022-03-15 山东兴瑞生物科技有限公司 anti-FLT 3 chimeric antigen receptor modified T cell and application thereof in preparation of AML (AML) treatment drug
CA3247450A1 (en) * 2022-04-21 2023-10-26 Senti Biosciences, Inc. Multicistronic chimeric protein expression systems
CN114645022B (en) * 2022-05-13 2022-09-02 首都医科大学宣武医院 CD 5-targeted CAR-gamma delta T cell and preparation method and application thereof
CN114989310B (en) * 2022-06-20 2024-11-19 深圳先进技术研究院 Chimeric antigen receptor, macrophage expressing chimeric antigen receptor and application thereof
CN115212299A (en) * 2022-06-21 2022-10-21 深圳先进技术研究院 Application of CAR-T and CAR-M combination in preparation of antitumor drugs
CN116064620B (en) * 2022-12-06 2025-06-17 上海恩凯细胞技术有限公司 Preparation and application of CAR-NK cells with enhanced infiltration ability into tumor sites
WO2025090749A1 (en) * 2023-10-25 2025-05-01 St. Jude Children's Research Hospital, Inc. Chimeric antigen receptors targeting leucine rich repeat containing 15 (lrrc15)
WO2025098508A1 (en) * 2023-11-10 2025-05-15 贝达药业股份有限公司 Label polypeptide, therapeutic agent and use thereof
TW202540400A (en) * 2023-11-16 2025-10-16 美商聖堤生物科技股份有限公司 Methods of enhancing engineered immune cell cytotoxicity
WO2025189046A2 (en) * 2024-03-06 2025-09-12 The Johns Hopkins University Pantigen specific cytokine receptor stimulation of immune cell function
CN118667016B (en) * 2024-05-29 2025-07-01 深圳豪石生物科技有限公司 CD20 single domain antibody and humanized antibody F11 thereof

Family Cites Families (179)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB8308235D0 (en) 1983-03-25 1983-05-05 Celltech Ltd Polypeptides
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
GB8422238D0 (en) 1984-09-03 1984-10-10 Neuberger M S Chimeric proteins
US5225539A (en) 1986-03-27 1993-07-06 Medical Research Council Recombinant altered antibodies and methods of making altered antibodies
GB8607679D0 (en) 1986-03-27 1986-04-30 Winter G P Recombinant dna product
US4946778A (en) 1987-09-21 1990-08-07 Genex Corporation Single polypeptide chain binding molecules
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
US20040049014A1 (en) 1988-12-28 2004-03-11 Protein Design Labs, Inc. Humanized immunoglobulins
IL162181A (en) 1988-12-28 2006-04-10 Pdl Biopharma Inc A method of producing humanized immunoglubulin, and polynucleotides encoding the same
US5703055A (en) 1989-03-21 1997-12-30 Wisconsin Alumni Research Foundation Generation of antibodies through lipid mediated DNA delivery
US5399346A (en) 1989-06-14 1995-03-21 The United States Of America As Represented By The Department Of Health And Human Services Gene therapy
EP0519596B1 (en) 1991-05-17 2005-02-23 Merck & Co. Inc. A method for reducing the immunogenicity of antibody variable domains
IL104570A0 (en) 1992-03-18 1993-05-13 Yeda Res & Dev Chimeric genes and cells transformed therewith
US5635388A (en) 1994-04-04 1997-06-03 Genentech, Inc. Agonist antibodies against the flk2/flt3 receptor and uses thereof
US5773001A (en) 1994-06-03 1998-06-30 American Cyanamid Company Conjugates of methyltrithio antitumor agents and intermediates for their synthesis
EP0787188A1 (en) 1994-11-01 1997-08-06 Targeted Genetics Corporation Chimeric receptors for the generation of selectively-activatable t h?-independent cytotoxic t cells
US5712149A (en) 1995-02-03 1998-01-27 Cell Genesys, Inc. Chimeric receptor molecules for delivery of co-stimulatory signals
US6103521A (en) 1995-02-06 2000-08-15 Cell Genesys, Inc. Multispecific chimeric receptors
DE19608769C1 (en) 1996-03-07 1997-04-10 Univ Eberhard Karls Monoclonal antibody BV10A4H2 specific for human FLT3/FLK2 receptor
DE69839147T2 (en) 1997-06-12 2009-02-19 Novartis International Pharmaceutical Ltd. ARTIFICIAL ANTIBODY POLYPEPTIDE
DE19727814C1 (en) 1997-06-30 1998-10-01 Univ Eberhard Karls Monoclonal antibody specific for human tyrosine kinase receptor protein
WO2001029058A1 (en) 1999-10-15 2001-04-26 University Of Massachusetts Rna interference pathway genes as tools for targeted genetic interference
GB9925854D0 (en) 1999-11-01 1999-12-29 Celltech Therapeutics Ltd Biological products
GB9925853D0 (en) 1999-11-01 1999-12-29 Celltech Therapeutics Ltd Biological products
US6326193B1 (en) 1999-11-05 2001-12-04 Cambria Biosciences, Llc Insect control agent
WO2001096584A2 (en) 2000-06-12 2001-12-20 Akkadix Corporation Materials and methods for the control of nematodes
US7183385B2 (en) 2002-02-20 2007-02-27 Cell Signaling Technology, Inc. Phospho-specific antibodies to Flt3 and uses thereof
US7446190B2 (en) 2002-05-28 2008-11-04 Sloan-Kettering Institute For Cancer Research Nucleic acids encoding chimeric T cell receptors
US8546541B2 (en) 2002-06-20 2013-10-01 Washington University Compositions and methods for modulating lymphocyte activity
US7304149B2 (en) 2002-06-20 2007-12-04 Washington University In St. Louis BTLA nucleic acids
GB0225279D0 (en) 2002-10-30 2002-12-11 Celltech R&D Ltd Biological products
BR0316101A (en) 2002-11-07 2005-09-27 Immunogen Inc Anticd33 antibodies and process for treating acute meloid leukemia using the same.
AU2004251890B2 (en) * 2003-06-25 2010-09-23 Crucell Holland B.V. Binding molecules for the treatment of myeloid cell malignancies
US20050113564A1 (en) 2003-11-05 2005-05-26 St. Jude Children's Research Hospital Chimeric receptors with 4-1BB stimulatory signaling domain
JP2010509234A (en) 2006-11-02 2010-03-25 シアトル ジェネティックス， インコーポレイテッド Methods for treating neoplastic diseases, autoimmune diseases and inflammatory diseases
US8389282B2 (en) 2007-03-30 2013-03-05 Memorial Sloan-Kettering Cancer Center Constitutive expression of costimulatory ligands on adoptively transferred T lymphocytes
AR071891A1 (en) * 2008-05-30 2010-07-21 Imclone Llc ANTI-FLT3 HUMAN ANTIBODIES (THIROSINE KINASE 3 RECEPTOR HUMAN FMS TYPE)
PL3006459T3 (en) 2008-08-26 2022-01-17 City Of Hope Method and compositions for enhanced anti-tumor effector functioning of t cells
DE102009045006A1 (en) 2009-09-25 2011-04-14 Technische Universität Dresden Anti-CD33 antibodies and their use for immuno-targeting in the treatment of CD33-associated diseases
US9023996B2 (en) 2009-12-23 2015-05-05 Synimmune Gmbh Anti-FLT3 antibodies
ES2602743T3 (en) 2010-09-08 2017-02-22 Chemotherapeutisches Forschungsinstitut Georg-Speyer-Haus Chimeric antigen receptors with an optimized hinge region
UA112062C2 (en) 2010-10-04 2016-07-25 Бьорінгер Інгельхайм Інтернаціональ Гмбх CD33-Binding Agent
PH12013501201A1 (en) 2010-12-09 2013-07-29 Univ Pennsylvania Use of chimeric antigen receptor-modified t cells to treat cancer
ES2872077T3 (en) 2011-04-08 2021-11-02 Us Health Chimeric antigen receptor anti-variant III epidermal growth factor receptor and use of the same for the treatment of cancer
JP6850528B2 (en) 2012-02-13 2021-03-31 シアトル チルドレンズ ホスピタル ドゥーイング ビジネス アズ シアトル チルドレンズ リサーチ インスティテュート Bispecific chimeric antigen receptor and its therapeutic use
US20130280220A1 (en) 2012-04-20 2013-10-24 Nabil Ahmed Chimeric antigen receptor for bispecific activation and targeting of t lymphocytes
US20130309223A1 (en) 2012-05-18 2013-11-21 Seattle Genetics, Inc. CD33 Antibodies And Use Of Same To Treat Cancer
AR092745A1 (en) 2012-10-01 2015-04-29 Univ Pennsylvania COMPOSITIONS THAT INCLUDE AN ANTI-FAP UNION DOMAIN AND METHODS TO MAKE WHITE IN STROMAL CELLS FOR THE TREATMENT OF CANCER
NZ746914A (en) 2012-10-02 2020-03-27 Memorial Sloan Kettering Cancer Center Compositions and methods for immunotherapy
US10117896B2 (en) 2012-10-05 2018-11-06 The Trustees Of The University Of Pennsylvania Use of a trans-signaling approach in chimeric antigen receptors
DK2906248T3 (en) * 2012-10-12 2019-03-04 Medimmune Ltd Pyrrolobenzodiazepines and their conjugates
KR102466666B1 (en) 2013-03-15 2022-11-15 메모리얼 슬로안 케터링 캔서 센터 Compositions and methods for immunotherapy
EP3623380B1 (en) 2013-03-15 2025-10-22 Novartis AG Targeting cytotoxic cells with chimeric receptors for adoptive immunotherapy
WO2015075470A1 (en) 2013-11-21 2015-05-28 Ucl Business Plc Cell
SG11201604784XA (en) 2013-12-13 2016-07-28 Genentech Inc Anti-cd33 antibodies and immunoconjugates
CN106163547A (en) 2014-03-15 2016-11-23 诺华股份有限公司 Use Chimeric antigen receptor treatment cancer
CN106795221B (en) 2014-04-03 2022-06-07 塞勒克提斯公司 CD 33-specific chimeric antigen receptor for cancer immunotherapy
KR102211120B1 (en) 2014-05-15 2021-02-03 내셔널 유니버시티 오브 싱가포르 Modified natural killer cells and uses thereof
BR112017001242A2 (en) 2014-07-21 2017-12-05 Novartis Ag cancer treatment using a cd33 chimeric antigen receptor
EP3660042B1 (en) * 2014-07-31 2023-01-11 Novartis AG Subset-optimized chimeric antigen receptor-containing t-cells
CN105384823A (en) 2014-08-26 2016-03-09 中国人民解放军总医院 Chimeric antigen receptor and gene and recombinant expression vector thereof, engineered CD33 targeting NKT cell and application thereof
ES2688035T3 (en) 2014-08-29 2018-10-30 Gemoab Monoclonals Gmbh Universal antigen receptor that expresses immune cells for addressing multiple multiple antigens, procedure for manufacturing it and using it for the treatment of cancer, infections and autoimmune diseases
MX2017003645A (en) 2014-09-17 2017-05-30 Novartis Ag Targeting cytotoxic cells with chimeric receptors for adoptive immunotherapy.
MA41538A (en) 2014-10-17 2017-12-26 Baylor College Medicine BIPARTITE AND TRIPARTITE IMMUNE CELLS OF SIGNALING
CA2967222C (en) 2014-11-12 2023-10-31 Rinat Neuroscience Corp. Inhibitory chimeric antigen receptors
EP3233095A2 (en) 2014-12-17 2017-10-25 Cellectis INHIBITORY CHIMERIC ANTIGEN RECEPTOR (iCAR OR N-CAR) EXPRESSING NON-T CELL TRANSDUCTION DOMAIN
IL252295B2 (en) 2014-12-19 2023-10-01 Dana Farber Cancer Inst Inc Chimeric antigen receptors and methods of use thereof
HK1246180A1 (en) 2014-12-31 2018-09-07 Celgene Corporation Methods of treating hematological disorders, solid tumors, or infectious diseases using natural killer cells
ES3007649T3 (en) 2015-01-29 2025-03-20 Univ Minnesota Chimeric antigen receptors, compositions, and methods
WO2016126608A1 (en) 2015-02-02 2016-08-11 Novartis Ag Car-expressing cells against multiple tumor antigens and uses thereof
WO2016141357A1 (en) 2015-03-05 2016-09-09 Fred Hutchinson Cancer Research Center Immunomodulatory fusion proteins and uses thereof
MX382481B (en) 2015-03-09 2025-03-13 Agensys Inc ANTIBODY-DRUG CONJUGATES (ADC) THAT BIND TO FLT3 PROTEINS.
GB201507119D0 (en) 2015-04-27 2015-06-10 Ucl Business Plc Nucleic Acid Construct
GB201507115D0 (en) 2015-04-27 2015-06-10 Ucl Business Plc Nucleic Acid Construct
WO2016174652A1 (en) 2015-04-30 2016-11-03 Technion Research & Development Foundation Limited Chimeric antigen receptors and methods of their use
WO2016179319A1 (en) 2015-05-04 2016-11-10 Cellerant Therapeutics, Inc. Chimeric antigen receptors with ctla4 signal transduction domains
CN104829733B (en) 2015-05-25 2018-06-05 广州百暨基因科技有限公司 The Chimeric antigen receptor and preparation method and application that antigen-binding unit is stablized
HK1252675A1 (en) 2015-06-12 2019-05-31 Alector Llc Anti-cd33 antibodies and methods of use thereof
AU2016276981B2 (en) 2015-06-12 2022-10-06 Alector Llc Anti-CD33 antibodies and methods of use thereof
CN107849112B (en) * 2015-06-25 2022-04-01 美商生物细胞基因治疗有限公司 Chimeric Antigen Receptors (CAR), compositions and methods of use thereof
US11173179B2 (en) 2015-06-25 2021-11-16 Icell Gene Therapeutics Llc Chimeric antigen receptor (CAR) targeting multiple antigens, compositions and methods of use thereof
CN104877032B (en) 2015-06-26 2018-12-11 中国医学科学院血液病医院（血液学研究所） CD33 specific chimeric antigen receptor and its application
MA42895A (en) 2015-07-15 2018-05-23 Juno Therapeutics Inc MODIFIED CELLS FOR ADOPTIVE CELL THERAPY
JP2018521069A (en) 2015-07-16 2018-08-02 プロスペクト チャーターケア アールダブリュエムシー，エルエルシー ディ／ビー／エイ ロジャー ウィリアムズ メディカル センターＰｒｏｓｐｅｃｔ Ｃｈａｒｔｅｒｃａｒｅ Ｒｗｍｃ，Ｌｌｃ Ｄ／Ｂ／Ａ Ｒｏｇｅｒ Ｗｉｌｌｉａｍｓ Ｍｅｄｉｃａｌ Ｃｅｎｔｅｒ Compositions and methods for treating peritoneal cancer
GB201513540D0 (en) 2015-07-31 2015-09-16 King S College London Therapeutic agents
TWI829617B (en) 2015-07-31 2024-01-21 德商安美基研究（慕尼黑）公司 Antibody constructs for flt3 and cd3
CA2994829A1 (en) 2015-08-07 2017-02-16 Seattle Children's Hospital (dba Seattle Children's Research Institute) Bispecific car t-cells for solid tumor targeting
CN105384825B (en) 2015-08-11 2018-06-01 南京传奇生物科技有限公司 A kind of bispecific chimeric antigen receptor and its application based on single domain antibody
AU2016326721C1 (en) 2015-09-23 2021-06-03 Cytoimmune Therapeutics, Inc. FLT3 directed car cells for immunotherapy
US20180291080A1 (en) 2015-09-28 2018-10-11 Trustees Of Dartmouth College Chimeric antigen receptor, regulatory cells and methods of use
GB201518817D0 (en) 2015-10-23 2015-12-09 Autolus Ltd Cell
GB201521389D0 (en) 2015-12-03 2016-01-20 Ucb Biopharma Sprl Method
WO2017143076A1 (en) 2016-02-16 2017-08-24 Dana-Farber Cancer Institute, Inc. Chimeric antigen receptors and methods of use thereof
AU2017225733A1 (en) * 2016-03-04 2018-09-27 Novartis Ag Cells expressing multiple chimeric antigen receptor (CAR) molecules and uses therefore
IL296966A (en) 2016-04-01 2022-12-01 Amgen Inc Chimeric flt-3 receptors and methods of using them
TWI691596B (en) 2016-04-01 2020-04-21 美商凱特製藥公司 Chimeric antigen and t cell receptors and methods of use
EP3439699A4 (en) 2016-04-04 2019-11-20 Hemogenyx LLC METHOD FOR REMOVAL OF HEMATOPOIETIC STEM CELLS / HEMATOPOIETIC PROGENITORS (CSH / PH) IN A PATIENT USING BISPECIFIC ANTIBODIES
WO2017180587A2 (en) 2016-04-11 2017-10-19 Obsidian Therapeutics, Inc. Regulated biocircuit systems
CN105820255B (en) 2016-04-12 2019-06-28 上海优卡迪生物医药科技有限公司 Anti-CD 33 Chimeric antigen receptor, encoding gene, recombinant expression carrier and its construction method and application
CA3021027A1 (en) 2016-04-15 2017-10-19 Novartis Ag Compositions and methods for selective expression of chimeric antigen receptors
WO2017190100A1 (en) 2016-04-28 2017-11-02 The Trustees Of Dartmouth College Nucleic acid constructs for co-expression of chimeric antigen receptor and transcription factor, cells containing and therapeutic use thereof
WO2017193059A1 (en) 2016-05-06 2017-11-09 The Regents Of The University Of California Systems and methods for targeting cancer cells
CA3025516A1 (en) * 2016-05-27 2017-11-30 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Flt3-specific chimeric antigen receptors and methods using same
IL321834A (en) * 2016-06-08 2025-08-01 Precigen Inc Chimeric receptors for the CD33 antigen
JP7114490B2 (en) * 2016-06-24 2022-08-08 アイセル・ジーン・セラピューティクス・エルエルシー Construction of chimeric antibody receptors (CARs) and methods of their use
WO2018027197A1 (en) 2016-08-04 2018-02-08 Memorial Sloan-Kettering Cancer Center Cancer antigen targets and uses thereof
JP7160482B2 (en) 2016-09-02 2022-10-25 レンティジェン・テクノロジー・インコーポレイテッド Compositions and methods for treating cancer with DUOCAR
AU2017333446A1 (en) 2016-09-28 2019-04-18 Gavish-Galilee Bio Applications Ltd. A universal platform for CAR therapy targeting a novel antigenic signature of cancer
US11421010B2 (en) 2016-10-07 2022-08-23 Board Of Regents, The University Of Texas System T cells expressing membrane-anchored IL-12 for the treatment of cancer
WO2018073394A1 (en) 2016-10-19 2018-04-26 Cellectis Cell death inducing chimeric antigen receptors
KR20250072712A (en) 2016-12-02 2025-05-26 앤젤레스 테라퓨틱스, 인코포레이티드 Synthetic immune receptors and methods of use thereof
AU2017382883B2 (en) 2016-12-21 2024-07-04 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Human monoclonal antibodies specific for FLT3 and uses thereof
US20180100016A1 (en) 2016-12-22 2018-04-12 Xiaotong Song Use of car-modified human natural killer cells to treat cancer
CN106749675B (en) 2016-12-27 2022-05-27 深圳市体内生物医药科技有限公司 Recombinant lentivirus and application thereof
US20190336533A1 (en) 2016-12-28 2019-11-07 Green Cross Lab Cell Corporation Chimeric antigen receptor and natural killer cells expressing same
WO2018132427A1 (en) 2017-01-10 2018-07-19 The General Hospital Corporation Targeted t cells with cytotoxicity toward immunosuppressive cells
CA3057838A1 (en) 2017-03-24 2018-09-27 Lentigen Technology, Inc. Compositions and methods for treating cancer with anti-cd33 immunotherapy
EP3601531B1 (en) 2017-03-30 2023-06-07 Biora Therapeutics, Inc. Treatment of a disease of the gastrointestinal tract with live biotherapeutics
CA3059444A1 (en) 2017-04-14 2018-10-18 The General Hospital Corporation Chimeric antigen receptor t cells targeting the tumor microenvironment
US11344578B2 (en) 2017-04-19 2022-05-31 Board Of Regents, The University Of Texas System Immune cells expressing engineered antigen receptors
CA3062433A1 (en) 2017-05-15 2018-11-22 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Bicistronic chimeric antigen receptors and their uses
US12116406B2 (en) 2017-05-26 2024-10-15 Fred Hutchinson Cancer Center Anti-CD33 antibodies and uses thereof
WO2018222935A1 (en) 2017-06-02 2018-12-06 Pfizer Inc. Chimeric antigen receptors targeting flt3
CN107337736B (en) 2017-06-06 2019-07-26 上海优卡迪生物医药科技有限公司 OCTS-CAR dual-targeting chimeric antigen receptor, encoding gene, recombinant expression vector and its construction and application
US11434290B2 (en) 2017-06-08 2022-09-06 H. Lee Moffitt Cancer Center And Research Institute, Inc. Chimeric antigen receptors with enhanced NFκB signaling
WO2019060174A1 (en) 2017-09-22 2019-03-28 H. Lee Moffitt Cancer Center And Research Institute, Inc. Chimeric antigen receptors with enhanced nfkb signaling
CN118853581A (en) * 2017-06-21 2024-10-29 美商生物细胞基因治疗有限公司 Chimeric antigen receptors (CARs), compositions and methods of use thereof
CN107353343A (en) 2017-07-04 2017-11-17 武汉波睿达生物科技有限公司 A kind of Chimeric antigen receptor of the cell of targeted expression CD33 surface antigens
SG11201911838UA (en) 2017-07-07 2020-01-30 H Lee Moffitt Cancer Center And Research Institute Inc Chimeric antigen receptors with mutated cd28 costimulatory domains
MX2020000686A (en) 2017-07-20 2020-07-29 H Lee Moffitt Cancer Ct & Res Compositions and methods for targeting cd33-expressing cancers.
US20200206266A1 (en) * 2017-08-01 2020-07-02 Julius-Maximilians-Universität Würzburg Use of flt3 car-t cells and flt3 inhibitors to treat acute myeloid leukemia
CA3072777A1 (en) 2017-09-08 2019-03-14 Poseida Therapeutics, Inc. Compositions and methods for chimeric ligand receptor (clr)-mediated conditional gene expression
US20190091310A1 (en) 2017-09-26 2019-03-28 Stephen E. Wright Nonreleased il-12 for therapy of cancer
US11660315B2 (en) * 2017-09-28 2023-05-30 Immpact-Bio Ltd. Universal platform for preparing an inhibitory chimeric antigen receptor (iCAR)
CN111247168B (en) * 2017-10-12 2023-12-29 美商生物细胞基因治疗有限公司 Composite chimeric antigen receptors (cCAR) targeting multiple antigens and their composition and methods of use
KR102742741B1 (en) 2017-10-18 2024-12-16 프레시전 인코포레이티드 Polypeptide composition comprising a spacer
WO2019084234A1 (en) 2017-10-26 2019-05-02 St. Jude Childen's Research Hospital, Inc. Methods and compositions for treating cd33+ cancers and improving in vivo persistence of chimeric antigen receptor t cells
WO2019089813A1 (en) 2017-11-01 2019-05-09 Nantkwest, Inc. Nk-92 cells to stimulate anti-cancer vaccine
US11390655B2 (en) 2017-11-16 2022-07-19 Kite Pharma, Inc. Modified chimeric antigen receptors and methods of use
AU2018392080A1 (en) 2017-12-22 2020-07-02 2Seventy Bio, Inc. Multivalent chimeric antigen receptor
CN108060136A (en) 2017-12-26 2018-05-22 东莞赛尔生物科技有限公司 A kind of Chimeric antigen receptor T cell, preparation method and application for being used to treat AML
KR102865130B1 (en) 2017-12-29 2025-09-29 메모리얼 슬로안 케터링 캔서 센터 Improved chimeric antigen receptor and uses thereof
CN108047333B (en) 2018-01-15 2021-05-25 浙江阿思科力生物科技有限公司 Specific antibodies targeting CD33, CAR-NK cells and their preparation and application
CN108251442B (en) 2018-02-07 2022-04-19 中国医学科学院血液病医院(中国医学科学院血液学研究所) FLT3 chimeric antigen receptor and application thereof
PE20211224A1 (en) 2018-02-20 2021-07-06 Dragonfly Therapeutics Inc VARIABLE ANTIBODY DOMAINS TARGETING CD33 AND ITS USES
TW201942134A (en) 2018-02-20 2019-11-01 美商蜻蜓醫療公司 Multi-specific binding proteins that bind CD33, NKG2D, and CD16, and methods of use
US20210079061A1 (en) 2018-02-26 2021-03-18 Fred Hutchinson Cancer Research Center Compositions and methods for cellular immunotherapy
CA3091224A1 (en) 2018-03-12 2019-09-19 Nantkwest, Inc. Use of cd33car modified high affinity nk cells (t-hank) to reduce myeloid-derived suppressor cells suppressor activity (or reduce negative impact on nk cell activity)
WO2019178382A1 (en) 2018-03-14 2019-09-19 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Anti-cd33 chimeric antigen receptors and their uses
WO2019178518A1 (en) 2018-03-16 2019-09-19 The Regents Of The University Of California Cellular signaling domain engineering in chimeric antigen receptor-modified regulatory t cells
WO2019178463A1 (en) 2018-03-16 2019-09-19 H. Lee Moffitt Cancer Center And Research Institute Inc. Chimeric antigen receptors with mutated cd28 phosphorylation sites
AU2019253562B2 (en) 2018-04-09 2025-11-27 The Trustees Of The University Of Pennsylvania Methods and compositions comprising a viral vector for expression of a transgene and an effector
US10869888B2 (en) 2018-04-17 2020-12-22 Innovative Cellular Therapeutics CO., LTD. Modified cell expansion and uses thereof
US20210094994A1 (en) 2018-04-27 2021-04-01 Baylor College Of Medicine Car t cells with one or more interleukins
EA202091977A1 (en) 2018-05-28 2021-02-09 Драгонфлай Терапьютикс, Инк. MULTI-SPECIFIC BINDING PROTEINS THAT BIND CD33, NKG2D AND CD16 AND METHODS OF APPLICATION
GB201813178D0 (en) * 2018-08-13 2018-09-26 Autolus Ltd Cell
US11866494B2 (en) 2018-08-31 2024-01-09 Innovative Cellular Therapeutics Holdings, Ltd. CAR T therapy through uses of co-stimulation
EP3856236B1 (en) * 2018-09-28 2023-05-17 ImmPACT-Bio Ltd. Methods for identifying activating antigen receptor (acar)/inhibitory chimeric antigen receptor (icar) pairs for use in cancer therapies
EP3864142A4 (en) 2018-10-12 2023-07-19 iCell Gene Therapeutics LLC Chimeric antigen receptors (cars) compositions and methods of use thereof
AU2019375375B2 (en) 2018-11-06 2022-12-01 Immunitybio, Inc. Chimeric antigen receptor-modified NK-92 cells
US10918667B2 (en) 2018-11-20 2021-02-16 Innovative Cellular Therapeutics CO., LTD. Modified cell expressing therapeutic agent and uses thereof
AU2020206359A1 (en) 2019-01-10 2021-07-29 Innovative Cellular Therapeutics Holdings, Ltd. Modified cell expansion and uses thereof
WO2020146706A2 (en) 2019-01-11 2020-07-16 The University Of North Carolina At Chapel Hill Highly modular biepitopic and bispecific car-t cells for cancer immunotherapy
CA3136618A1 (en) 2019-04-10 2020-10-15 Elevatebio Technologies, Inc. Flt3-specific chimeric antigen receptors and methods of using the same
WO2020219425A1 (en) 2019-04-25 2020-10-29 Seattle Children's Hospital (dba Seattle Children's Research Institute) Combinatorial car t cell and hematopoeitic stem cell genetic engineering for specific immunotherapy of myeloid leukemias
SG11202111130SA (en) 2019-04-30 2021-11-29 Senti Biosciences Inc Chimeric receptors and methods of use thereof
US20220241330A1 (en) 2019-05-16 2022-08-04 Nanjing Legend Biotech Co., Ltd. Immune cell receptors comprising cd4 binding moieties
CA3142159A1 (en) 2019-05-31 2020-12-03 City Of Hope Cd33 targeted chimeric antigen receptor modified t cells for treatment of cd33 positive malignancies
AU2020286471B2 (en) 2019-06-07 2025-07-31 The Trustees Of The University Of Pennsylvania Dual CAR expressing T cells individually linked to CD28 and 4-1BB
MX2021015967A (en) 2019-06-27 2022-04-06 Eutilex Co Ltd CHIMERIC ANTIGEN RECEPTOR WITH CO-STIMULATORY DOMAIN 4-1BB.
CN118165120A (en) 2019-07-22 2024-06-11 南京助天中科科技发展有限公司 Chimeric antigen receptor and its application
JP7739261B2 (en) 2019-08-09 2025-09-16 エイ２・バイオセラピューティクス・インコーポレイテッド Cell surface receptors that respond to loss of heterozygosity
CN112390894A (en) 2019-08-12 2021-02-23 广东东阳光药业有限公司 Chimeric antigen receptor and uses thereof
CN112390891B (en) 2019-08-14 2022-06-03 苏州方德门达新药开发有限公司 Chimeric antigen receptor and its construction method and application
CN112500492B (en) 2019-09-13 2023-08-04 中国科学院分子细胞科学卓越创新中心 Chimeric antigen receptor and application thereof
US20210137983A1 (en) 2019-11-08 2021-05-13 Innovative Cellular Therapeutics Holdings, Ltd. Nk cell expansion and uses thereof
US20220389075A1 (en) 2019-11-12 2022-12-08 A2 Biotherapeutics, Inc. Engineered t cell receptors and uses thereof
AU2020401315B2 (en) 2019-12-11 2023-11-09 A2 Biotherapeutics, Inc. LILRB1-based chimeric antigen receptor
CN112501125A (en) 2020-11-30 2021-03-16 上海斯丹赛生物技术有限公司 Coupled chimeric antigen receptor cells and uses thereof

Also Published As

Publication number Publication date
JP2025143407A (en) 2025-10-01
US20240277765A1 (en) 2024-08-22
CA3133333A1 (en) 2020-04-30
CN114007642A (en) 2022-02-01
EP3962527A1 (en) 2022-03-09
WO2020223445A1 (en) 2020-11-05
EP3962527A4 (en) 2023-11-01
IL287407A (en) 2021-12-01
JP2022530542A (en) 2022-06-29
TW202110873A (en) 2021-03-16
JP7711945B2 (en) 2025-07-23
AU2020265679A1 (en) 2021-12-23
US12005081B2 (en) 2024-06-11
KR20220016083A (en) 2022-02-08
US20210299177A1 (en) 2021-09-30

Similar Documents

Publication Publication Date Title
IL287407A (en) Chimeric receptors and methods of use thereof
SG11202106302WA (en) Chimeric antigen receptors and car-t cells and methods of use
SG10201912519VA (en) Chimeric receptors and methods of use thereof
IL277735A (en) Chimeric receptors to dll3 and methods of use thereof
ZA201705720B (en) Anti-dll3 chimeric antigen receptors and methods of use
IL255336A0 (en) Chimeric antigen receptors and methods of their use
IL275512A (en) Multispecific chimeric receptors comprising an nkg2d domain and methods of use thereof
SG11202108734VA (en) Anti-trem2 antibodies and methods of use thereof
IL324856A (en) Chimeric receptors to steap1 and methods of use thereof
SG11202108403UA (en) Anti-clec2d antibodies and methods of use thereof
IL265438A (en) Chimeric antigen receptors and compositions and methods of use thereof
IL288803A (en) Tgf-β receptors and methods of use
IL277212A (en) Anti-klk5 antibodies and methods of use
SG11202109701SA (en) T cell receptors and methods of use thereof
IL290741A (en) Anti-cd96 antibodies and methods of use thereof
IL289952A (en) Anti-ms4a4a antibodies and methods of use thereof
IL291461A (en) Anti-alpha-synuclein antibodies and methods of use thereof
SG11202109589VA (en) T cell receptors and methods of use thereof
IL288886A (en) Antibodies and methods of use
EP4334346A4 (en) Chimeric receptors and methods of use thereof
SG11202109595TA (en) T cell receptors and methods of use thereof
SG11202109593SA (en) T cell receptors and methods of use thereof
SG11202109588RA (en) T cell receptors and methods of use thereof
SG11202109591QA (en) T cell receptors and methods of use thereof
SG11202109590VA (en) T cell receptors and methods of use thereof