SE460948B - Med zinkjoner stabiliserad insulinloesning samt foerfarande foer dess framstaellning - Google Patents

Med zinkjoner stabiliserad insulinloesning samt foerfarande foer dess framstaellning

Info

Publication number: SE460948B
Authority: SE; Sweden
Prior art keywords: insulin; zinc; content; solution according; solution
Prior art date: 1982-02-05

Application number

SE8300598A

Other languages

English (en)

Swedish (sv)

Other versions

SE8300598L (sv

SE8300598D0 (sv

Inventor

J J V Brange

S Havelund

Original Assignee

Novo Industri As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1982-02-05

Filing date

1983-02-04

Publication date

1989-12-11

1983-02-04 Application filed by Novo Industri As filed Critical Novo Industri As

1983-02-04 Publication of SE8300598D0 publication Critical patent/SE8300598D0/xx

1983-08-06 Publication of SE8300598L publication Critical patent/SE8300598L/

1989-12-11 Publication of SE460948B publication Critical patent/SE460948B/sv

Links

NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title claims description 286
229940125396 insulin Drugs 0.000 title claims description 135
108090001061 Insulin Proteins 0.000 title claims description 132
102000004877 Insulin Human genes 0.000 title claims description 132
PTFCDOFLOPIGGS-UHFFFAOYSA-N Zinc dication Chemical compound [Zn+2] PTFCDOFLOPIGGS-UHFFFAOYSA-N 0.000 title claims description 39
238000000034 method Methods 0.000 title claims description 5
238000002360 preparation method Methods 0.000 title description 14
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HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 claims description 66
239000008139 complexing agent Substances 0.000 claims description 32
PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims description 30
DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Chemical compound NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims description 20
ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 claims description 19
KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims description 18
238000001556 precipitation Methods 0.000 claims description 14
ZOIORXHNWRGPMV-UHFFFAOYSA-N acetic acid;zinc Chemical group [Zn].CC(O)=O.CC(O)=O ZOIORXHNWRGPMV-UHFFFAOYSA-N 0.000 claims description 13
239000004246 zinc acetate Substances 0.000 claims description 13
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JIAARYAFYJHUJI-UHFFFAOYSA-L zinc dichloride Chemical compound [Cl-].[Cl-].[Zn+2] JIAARYAFYJHUJI-UHFFFAOYSA-L 0.000 claims description 4
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HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 24
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VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 16
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230000000694 effects Effects 0.000 description 8
KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 7
PBGKTOXHQIOBKM-FHFVDXKLSA-N insulin (human) Chemical compound C([C@@H](C(=O)N[C@@H](CC(C)C)C(=O)N[C@H]1CSSC[C@H]2C(=O)N[C@H](C(=O)N[C@@H](CO)C(=O)N[C@H](C(=O)N[C@H](C(N[C@@H](CO)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CCC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H](CC=3C=CC(O)=CC=3)C(=O)N[C@@H](CSSC[C@H](NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3C=CC(O)=CC=3)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](C)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CC=3NC=NC=3)NC(=O)[C@H](CO)NC(=O)CNC1=O)C(=O)NCC(=O)N[C@@H](CCC(O)=O)C(=O)N[C@@H](CCCNC(N)=N)C(=O)NCC(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC=CC=1)C(=O)N[C@@H](CC=1C=CC(O)=CC=1)C(=O)N[C@@H]([C@@H](C)O)C(=O)N1[C@@H](CCC1)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H]([C@@H](C)O)C(O)=O)C(=O)N[C@@H](CC(N)=O)C(O)=O)=O)CSSC[C@@H](C(N2)=O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](C(C)C)NC(=O)[C@@H](NC(=O)CN)[C@@H](C)CC)[C@@H](C)CC)[C@@H](C)O)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CC(N)=O)NC(=O)[C@@H](NC(=O)[C@@H](N)CC=1C=CC=CC=1)C(C)C)C1=CN=CN1 PBGKTOXHQIOBKM-FHFVDXKLSA-N 0.000 description 7
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WHBMMWSBFZVSSR-UHFFFAOYSA-N 3-hydroxybutyric acid Chemical compound CC(O)CC(O)=O WHBMMWSBFZVSSR-UHFFFAOYSA-N 0.000 description 2
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Classifications

- H—ELECTRICITY
- H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
- H05K—PRINTED CIRCUITS; CASINGS OR CONSTRUCTIONAL DETAILS OF ELECTRIC APPARATUS; MANUFACTURE OF ASSEMBLAGES OF ELECTRICAL COMPONENTS
- H05K13/00—Apparatus or processes specially adapted for manufacturing or adjusting assemblages of electric components
- H05K13/06—Wiring by machine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins

Landscapes

Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Medicinal Chemistry (AREA)
Endocrinology (AREA)
Microelectronics & Electronic Packaging (AREA)
Zoology (AREA)
Gastroenterology & Hepatology (AREA)
Chemical & Material Sciences (AREA)
Manufacturing & Machinery (AREA)
Immunology (AREA)
Diabetes (AREA)
Pharmacology & Pharmacy (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Epidemiology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)

SE8300598A 1982-02-05 1983-02-04 Med zinkjoner stabiliserad insulinloesning samt foerfarande foer dess framstaellning SE460948B (sv)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DK49182		1982-02-05

Publications (3)

Publication Number	Publication Date
SE8300598D0 SE8300598D0 (sv)	1983-02-04
SE8300598L SE8300598L (sv)	1983-08-06
SE460948B true SE460948B (sv)	1989-12-11

Family

ID=8094159

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SE8300598A SE460948B (sv)	1982-02-05	1983-02-04	Med zinkjoner stabiliserad insulinloesning samt foerfarande foer dess framstaellning

Country Status (22)

Country	Link
US (1)	US4476118A (de)
JP (1)	JPS58192818A (de)
AT (1)	AT382780B (de)
AU (1)	AU549981B2 (de)
BE (1)	BE895832A (de)
CA (1)	CA1203476A (de)
CH (1)	CH657530A5 (de)
DE (1)	DE3303860A1 (de)
ES (1)	ES519533A0 (de)
FI (1)	FI78616C (de)
FR (1)	FR2521009B1 (de)
GB (1)	GB2114573B (de)
GR (1)	GR77388B (de)
IE (1)	IE54548B1 (de)
IT (1)	IT1178455B (de)
LU (1)	LU84632A1 (de)
NL (1)	NL187269C (de)
NO (1)	NO161204C (de)
NZ (1)	NZ203189A (de)
PT (1)	PT76195B (de)
SE (1)	SE460948B (de)
ZA (1)	ZA83742B (de)

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ATE50502T1 (de) *	1984-06-09	1990-03-15	Hoechst Ag	Insulinzubereitungen, verfahren zu deren herstellung und deren verwendung.
JP2520262B2 (ja) *	1987-08-21	1996-07-31	春幸川原	パツチテスト材料
US4789660A (en) *	1987-09-10	1988-12-06	American Home Products Corporation	Insulin administration using methyl and propyl paraben
US5130298A (en) *	1989-05-16	1992-07-14	Ethicon, Inc.	Stabilized compositions containing epidermal growth factor
US5534488A (en) *	1993-08-13	1996-07-09	Eli Lilly And Company	Insulin formulation
US5474978A (en) *	1994-06-16	1995-12-12	Eli Lilly And Company	Insulin analog formulations
AR002976A1 (es) *	1995-03-31	1998-05-27	Lilly Co Eli	Formulaciones farmaceuticas parenterales de efecto prolongado de insulina; cristales de dichos analogos aplicables en dichas formulaciones yprocedimiento de las formulaciones mencionadas
JP4307550B2 (ja) *	1995-11-13	2009-08-05	メドトロニックミニメッド、インコーポレイティド	単量体状タンパク質の送達のための方法及び組成物
US6733746B2 (en) *	1996-03-12	2004-05-11	Invitrogen Corporation	Hematopoietic cell culture nutrient supplement
ATE264871T1 (de) *	1996-07-26	2004-05-15	Aventis Pharma Gmbh	Insulinderivate mit erhöhter zinkbindung
EP1283051B1 (de) *	1997-06-13	2006-06-14	Eli Lilly And Company	Stabile Insulinformulierungen
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1983
- 1983-02-03 FI FI830375A patent/FI78616C/fi not_active IP Right Cessation
- 1983-02-04 IE IE220/83A patent/IE54548B1/en not_active IP Right Cessation
- 1983-02-04 GR GR70416A patent/GR77388B/el unknown
- 1983-02-04 ZA ZA83742A patent/ZA83742B/xx unknown
- 1983-02-04 PT PT76195A patent/PT76195B/pt unknown
- 1983-02-04 AU AU11136/83A patent/AU549981B2/en not_active Expired
- 1983-02-04 US US06/463,730 patent/US4476118A/en not_active Expired - Lifetime
- 1983-02-04 NO NO830385A patent/NO161204C/no not_active IP Right Cessation
- 1983-02-04 DE DE19833303860 patent/DE3303860A1/de active Granted
- 1983-02-04 AT AT0038983A patent/AT382780B/de not_active IP Right Cessation
- 1983-02-04 FR FR8301790A patent/FR2521009B1/fr not_active Expired
- 1983-02-04 IT IT19420/83A patent/IT1178455B/it active
- 1983-02-04 LU LU84632A patent/LU84632A1/de unknown
- 1983-02-04 CA CA000420907A patent/CA1203476A/en not_active Expired
- 1983-02-04 GB GB08303133A patent/GB2114573B/en not_active Expired
- 1983-02-04 NZ NZ203189A patent/NZ203189A/en unknown
- 1983-02-04 ES ES519533A patent/ES519533A0/es active Granted
- 1983-02-04 SE SE8300598A patent/SE460948B/sv not_active IP Right Cessation
- 1983-02-04 BE BE6/47775A patent/BE895832A/fr not_active IP Right Cessation
- 1983-02-04 JP JP58016303A patent/JPS58192818A/ja active Granted
- 1983-02-04 CH CH657/83A patent/CH657530A5/de not_active IP Right Cessation
- 1983-02-04 NL NLAANVRAGE8300440,A patent/NL187269C/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
AT382780B (de)	1987-04-10
DE3303860C2 (de)	1989-12-28
FI830375L (fi)	1983-08-06
IE54548B1 (en)	1989-11-08
AU1113683A (en)	1983-08-11
PT76195A (en)	1983-03-01
CH657530A5 (de)	1986-09-15
NZ203189A (en)	1985-07-31
ES8500060A1 (es)	1984-10-16
ATA38983A (de)	1986-09-15
PT76195B (en)	1986-01-27
NO161204B (no)	1989-04-10
FI830375A0 (fi)	1983-02-03
LU84632A1 (fr)	1983-09-08
BE895832A (fr)	1983-08-04
NL187269C (nl)	1991-08-01
IT1178455B (it)	1987-09-09
FR2521009B1 (fr)	1987-07-17
GB2114573A (en)	1983-08-24
GB2114573B (en)	1985-05-01
SE8300598L (sv)	1983-08-06
AU549981B2 (en)	1986-02-20
ES519533A0 (es)	1984-10-16
ZA83742B (en)	1983-11-30
NL187269B (nl)	1991-03-01
JPH0367056B2 (de)	1991-10-21
GB8303133D0 (en)	1983-03-09
DE3303860A1 (de)	1983-08-18
IT8319420A0 (it)	1983-02-04
NO161204C (no)	1989-07-19
CA1203476A (en)	1986-04-22
NO830385L (no)	1983-08-08
SE8300598D0 (sv)	1983-02-04
FI78616B (fi)	1989-05-31
JPS58192818A (ja)	1983-11-10
NL8300440A (nl)	1983-09-01
FR2521009A1 (fr)	1983-08-12
US4476118A (en)	1984-10-09
GR77388B (de)	1984-09-11
IE830220L (en)	1983-08-05
FI78616C (fi)	1989-09-11

Publication	Publication Date	Title
SE460948B (sv)	1989-12-11	Med zinkjoner stabiliserad insulinloesning samt foerfarande foer dess framstaellning
US4853218A (en)	1989-08-01	Zinc-protamine-alpha interferon complex
CA1330301C (en)	1994-06-21	Stabilised human protein preparations
FI80595B (fi)	1990-03-30	Foerfarande foer framstaellning av en vattenhaltig insulinloesning som aer fysikaliskt stabiliserad mot graensytepolymerisation.
EP0303746B2 (de)	1998-12-02	Stabilisierung von Wachstumshormonen
AU686567C (en)	2002-08-08	Human growth hormone aqueous formulation
RU2001130142A (ru)	2003-06-20	Фармацевтические композиции эритропоэтина
US5830999A (en)	1998-11-03	Stabilization of insulin through ligand binding interations
CA2477557A1 (en)	2003-09-04	Stabilized albumin preparations
EP0399781B1 (de)	1992-12-23	Stabilisierte Kalcitoninzubereitung
KR900004799B1 (ko)	1990-07-06	안정한 감마 인터페론 제제 및 이의 제조방법
CA2558985C (en)	2012-09-25	Erythropoietin liquid formulation
DK150813B (da)	1987-06-29	Fremgangsmaade til fremstilling af stabiliserede insulinoploesninger
KR830001815B1 (ko)	1983-09-12	변성에 안정한 인슐린 액제의 제조방법
DK149833B (da)	1986-10-13	Fremgangsmaade til fremstilling af et oploest zinkinsulinpraeparat, derer fysisk stabilt
Ono et al.	1998	Tauroursodeoxycholic Acid Protects Cholestasis in Rat Reperfused Livers (Its Roles in Hepatic Calcium Mobilization)
Simpson et al.	1986	Hyperprolactinaemia does not alter specific striatal 3H-spiperone binding in the rat
JPH0366290B2 (de)	1991-10-16
JPH0366291B2 (de)	1991-10-16
JP2002101879A (ja)	2002-04-09	有用タンパク質組成物および有用タンパク質組成物の製造方法
JPH01175995A (ja)	1989-07-12	生理活性物質の農縮・脱塩方法
US20160095904A1 (en)	2016-04-07	Stabilized liquid formulation

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