ES519533A0 - Un metodo de producir una solucion de insulina. - Google Patents

Un metodo de producir una solucion de insulina.

Info

Publication number: ES519533A0
Authority: ES; Spain
Prior art keywords: producing; insulin solution; insulin; solution
Prior art date: 1982-02-05
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.): Granted

Application number

ES519533A

Other languages

English (en)

Other versions

ES8500060A1 (es

Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)

Novo Nordisk AS

Original Assignee

Novo Industri AS

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1982-02-05

Filing date

1983-02-04

Publication date

1984-10-16

1983-02-04 Application filed by Novo Industri AS filed Critical Novo Industri AS

1984-10-16 Publication of ES8500060A1 publication Critical patent/ES8500060A1/es

1984-10-16 Publication of ES519533A0 publication Critical patent/ES519533A0/es

Status Granted legal-status Critical Current

Links

NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title 2
102000004877 Insulin Human genes 0.000 title 1
108090001061 Insulin Proteins 0.000 title 1
229940125396 insulin Drugs 0.000 title 1

Classifications

- H—ELECTRICITY
- H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
- H05K—PRINTED CIRCUITS; CASINGS OR CONSTRUCTIONAL DETAILS OF ELECTRIC APPARATUS; MANUFACTURE OF ASSEMBLAGES OF ELECTRICAL COMPONENTS
- H05K13/00—Apparatus or processes specially adapted for manufacturing or adjusting assemblages of electric components
- H05K13/06—Wiring by machine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins

Landscapes

Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Medicinal Chemistry (AREA)
Endocrinology (AREA)
Microelectronics & Electronic Packaging (AREA)
Zoology (AREA)
Gastroenterology & Hepatology (AREA)
Chemical & Material Sciences (AREA)
Manufacturing & Machinery (AREA)
Immunology (AREA)
Diabetes (AREA)
Pharmacology & Pharmacy (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Epidemiology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)

ES519533A 1982-02-05 1983-02-04 Un metodo de producir una solucion de insulina. Granted ES519533A0 (es)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DK49182		1982-02-05

Publications (2)

Publication Number	Publication Date
ES8500060A1 ES8500060A1 (es)	1984-10-16
ES519533A0 true ES519533A0 (es)	1984-10-16

Family

ID=8094159

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
ES519533A Granted ES519533A0 (es)	1982-02-05	1983-02-04	Un metodo de producir una solucion de insulina.

Country Status (22)

Country	Link
US (1)	US4476118A (es)
JP (1)	JPS58192818A (es)
AT (1)	AT382780B (es)
AU (1)	AU549981B2 (es)
BE (1)	BE895832A (es)
CA (1)	CA1203476A (es)
CH (1)	CH657530A5 (es)
DE (1)	DE3303860A1 (es)
ES (1)	ES519533A0 (es)
FI (1)	FI78616C (es)
FR (1)	FR2521009B1 (es)
GB (1)	GB2114573B (es)
GR (1)	GR77388B (es)
IE (1)	IE54548B1 (es)
IT (1)	IT1178455B (es)
LU (1)	LU84632A1 (es)
NL (1)	NL187269C (es)
NO (1)	NO161204C (es)
NZ (1)	NZ203189A (es)
PT (1)	PT76195B (es)
SE (1)	SE460948B (es)
ZA (1)	ZA83742B (es)

Families Citing this family (49)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ATE50502T1 (de) *	1984-06-09	1990-03-15	Hoechst Ag	Insulinzubereitungen, verfahren zu deren herstellung und deren verwendung.
JP2520262B2 (ja) *	1987-08-21	1996-07-31	春幸川原	パツチテスト材料
US4789660A (en) *	1987-09-10	1988-12-06	American Home Products Corporation	Insulin administration using methyl and propyl paraben
US5130298A (en) *	1989-05-16	1992-07-14	Ethicon, Inc.	Stabilized compositions containing epidermal growth factor
US5534488A (en) *	1993-08-13	1996-07-09	Eli Lilly And Company	Insulin formulation
US5474978A (en) *	1994-06-16	1995-12-12	Eli Lilly And Company	Insulin analog formulations
AR002976A1 (es) *	1995-03-31	1998-05-27	Lilly Co Eli	Formulaciones farmaceuticas parenterales de efecto prolongado de insulina; cristales de dichos analogos aplicables en dichas formulaciones yprocedimiento de las formulaciones mencionadas
JP4307550B2 (ja) *	1995-11-13	2009-08-05	メドトロニックミニメッド、インコーポレイティド	単量体状タンパク質の送達のための方法及び組成物
US6733746B2 (en) *	1996-03-12	2004-05-11	Invitrogen Corporation	Hematopoietic cell culture nutrient supplement
ATE264871T1 (de) *	1996-07-26	2004-05-15	Aventis Pharma Gmbh	Insulinderivate mit erhöhter zinkbindung
EP1283051B1 (en) *	1997-06-13	2006-06-14	Eli Lilly And Company	Stable insulin formulations
CO4750643A1 (es) *	1997-06-13	1999-03-31	Lilly Co Eli	Formulacion estable de la insulina que contiene l-arginina y protamina
WO1999024071A1 (en) *	1997-11-12	1999-05-20	Alza Corporation	Method for decreasing self-association of polypeptides
DE19825447A1 (de)	1998-06-06	1999-12-09	Hoechst Marion Roussel De Gmbh	Neue Insulinanaloga mit erhöhter Zinkbildung
ATE277630T1 (de) *	1998-10-16	2004-10-15	Novo Nordisk As	Stabile konzentrierte insulin präparationen zur pulmonaren verabreichung
DE19930676B4 (de) *	1999-07-02	2006-01-19	Sanofi-Aventis Deutschland Gmbh	Verfahren zur Stabilisierung von Insulin, Insulinderivaten und/oder deren Vorläufer in komplexen Mischungen bei deren Lagerung in wäßrigen Lösungsmitteln
DK1265630T3 (da) *	2000-03-24	2006-10-09	Genentech Inc	Anvendelse af insulin til behandling af brusksygdomme
JP4147234B2 (ja) *	2004-09-27	2008-09-10	キヤノン株式会社	吐出用液体、吐出方法、カートリッジ及び吐出装置
EP1506230B1 (en)	2002-05-07	2011-01-19	Novo Nordisk A/S	Soluble formulations comprising monomeric insulin and acylated insulin
US20050065066A1 (en) *	2002-12-20	2005-03-24	Kaarsholm Niels Christian	Stabilised insulin compositions
DE60317565T2 (de) *	2002-12-20	2008-09-11	Novo Nordisk A/S	Pharmazeutische zusammensetzungen mit insulin und insulin-hexamer-liganden
WO2004096266A1 (en) *	2003-05-02	2004-11-11	Novo Nordisk A/S	Improved physical stability of insulin formulations
BRPI0413276B8 (pt) *	2003-08-05	2021-05-25	Novo Nordisk As	derivado de insulina, complexo de zinco do mesmo, e, composição farmacêutica
KR101276754B1 (ko) *	2004-07-19	2013-06-19	바이오콘 리미티드	인슐린―올리고머 접합체，제형 및 이들의 용도
ATE519780T1 (de) *	2005-12-28	2011-08-15	Novo Nordisk As	Ein acyliertes insulin und zink enthaltende zusammensetzungen und verfahren zur herstellung dieser zusammensetzungen
US20090136538A1 (en) *	2006-05-22	2009-05-28	Jan Jezek	Stable vaccine formulation
GB0700523D0 (en) *	2007-01-11	2007-02-21	Insense Ltd	The Stabilisation Of Proteins
CA2681158C (en)	2007-03-13	2018-09-18	Nutrition 21, Inc.	Methods and compositions for the sustained release of chromium
JP5552046B2 (ja) *	2007-06-13	2014-07-16	ノボ・ノルデイスク・エー／エス	インスリン誘導体を含有する薬学的製剤
WO2009002867A2 (en)	2007-06-26	2008-12-31	Nutrition 21, Inc.	Multiple unit dosage form having a therapeutic agents in combination with a nutritional supplement
PT2597103T (pt) *	2007-11-16	2017-02-08	Novo Nordisk As	Composições farmacêuticas contendo insulina e um péptido insulinotrófico
EP2341940A1 (en) *	2008-07-16	2011-07-13	Arecor Limited	The stabilisation of proteins
EP2328607A1 (en) *	2008-07-16	2011-06-08	Arecor Limited	Stable formulation of a therapeutic protein
RU2540922C2 (ru) *	2008-10-30	2015-02-10	Ново Нордиск А/С	Лечение сахарного диабета с использованием инъекций инсулина с частотой менее одного раза в день
US9060927B2 (en)	2009-03-03	2015-06-23	Biodel Inc.	Insulin formulations for rapid uptake
JP6049625B2 (ja)	2010-10-27	2016-12-21	ノヴォノルディスクアー／エス	様々な注射間隔を用いて施されるインスリン注射を使用する、真性糖尿病の治療
ES2927800T3 (es)	2011-03-01	2022-11-11	Nutrition 21 Llc	Composición de insulina y cromo para el tratamiento y la prevención de diabetes, hipoglicemia y trastornos relacionados
JP6322642B2 (ja)	2012-11-13	2018-05-09	アドシア	置換されたアニオン性化合物を含有する速効型インスリン製剤
RU2015129087A (ru) *	2012-12-19	2017-02-02	Вокхардт Лимитед	Стабильная водная композиция, содержащая инсулин человека или его аналог или производное
AU2013368990B2 (en)	2012-12-26	2017-05-18	Wockhardt Limited	Pharmaceutical composition
TWI641381B (zh) *	2013-02-04	2018-11-21	法商賽諾菲公司	胰島素類似物及／或胰島素衍生物之穩定化醫藥調配物
US10137172B2 (en)	2013-04-30	2018-11-27	Novo Nordisk A/S	Administration regime
WO2015084694A2 (en) *	2013-12-04	2015-06-11	Merck Sharp & Dohme Corp.	Method for preparing crystalline insulin
TW201630622A (zh)	2014-12-16	2016-09-01	美國禮來大藥廠	速效胰島素組合物
JO3749B1 (ar)	2015-08-27	2021-01-31	Lilly Co Eli	تركيبات إنسولين سريعة المفعول
WO2017139337A1 (en)	2016-02-11	2017-08-17	Nutrition 21, Llc	Chromium containing compositions for improving health and fitness
EP3518893A1 (en) *	2016-09-29	2019-08-07	Arecor Limited	Novel formulations
PE20200017A1 (es)	2017-06-01	2020-01-06	Lilly Co Eli	Composiciones de insulina de rapida accion
US10335464B1 (en)	2018-06-26	2019-07-02	Novo Nordisk A/S	Device for titrating basal insulin

Family Cites Families (15)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2882202A (en) *	1950-04-05	1959-04-14	Novo Terapeutisk Labor As	Insulin crystal preparations and methods of producing them
US2787575A (en) *	1950-11-22	1957-04-02	Organon	Zinc-glycine-insulin composition and production thereof
US2882203A (en) *	1951-06-26	1959-04-14	Novo Terapeutisk Labor As	Injectable insulin preparation with protracted effect
DE1044360B (de) *	1953-08-19	1958-11-20	Roskilde Medical Company Ltd R	Verfahren zur Herstellung von Zinkinsulin mit erhoehtem Zinkgehalt
DE956098C (de) *	1954-02-18	1957-01-10	Dr Dr Guenther Weitzel	Verfahren zur Herstellung zinkreicher Insulin-Komplexverbindungen
US3058885A (en) *	1957-06-08	1962-10-16	Novo Terapeutisk Labor As	Process for treatment of insulin crystals and for production of insulin preparationstherefrom
US3014842A (en) *	1957-08-10	1961-12-26	Novo Terapeutish Lab A S	Injectable bovine insulin crystal suspensions and process of producing same
US3091573A (en) *	1958-05-12	1963-05-28	Novo Terapeutisk Labor As	Quick acting insulin preparation
FR1263220A (fr) *	1958-08-01	1961-06-09	Novo Terapeutisk Labor As	Procédé de production d'une préparation d'insuline à action rapide
DK116527B (da) *	1967-03-01	1970-01-19	Nordisk Insulinlab	Fremgangsmåde til fremstilling af en hurtigtvirkende, holdbar, neutral opløsning af rent krystallinsk okseinsulin eller okseinsulin, der ved tilsætning af Zn er krystalliserbart i vand, eller blandinger af okseinsulin og insulin af anden oprindelse.
GB1285023A (en) *	1968-08-09	1972-08-09	Novo Terapeutisk Labor As	Improvements in or relating to injectable insulin preparations
US3657425A (en) *	1969-03-12	1972-04-18	Burroughs Wellcome Co	Beef insulin preparations
EP0018609B1 (de) *	1979-04-30	1983-09-21	Hoechst Aktiengesellschaft	Gegen Denaturierung beständige, wässrige Protein-Lösungen, Verfahren zu ihrer Herstellung und ihre Verwendung
DK80781A (da) *	1980-02-29	1981-08-30	Hospital For Sick Children	Oploesninger af polypeptider
ES8403723A1 (es) *	1982-03-03	1984-04-16	Nordisk Insulinlab	Procedimiento de producir preparaciones de insulina.

1983
- 1983-02-03 FI FI830375A patent/FI78616C/fi not_active IP Right Cessation
- 1983-02-04 IE IE220/83A patent/IE54548B1/en not_active IP Right Cessation
- 1983-02-04 GR GR70416A patent/GR77388B/el unknown
- 1983-02-04 ZA ZA83742A patent/ZA83742B/xx unknown
- 1983-02-04 PT PT76195A patent/PT76195B/pt unknown
- 1983-02-04 AU AU11136/83A patent/AU549981B2/en not_active Expired
- 1983-02-04 US US06/463,730 patent/US4476118A/en not_active Expired - Lifetime
- 1983-02-04 NO NO830385A patent/NO161204C/no not_active IP Right Cessation
- 1983-02-04 DE DE19833303860 patent/DE3303860A1/de active Granted
- 1983-02-04 AT AT0038983A patent/AT382780B/de not_active IP Right Cessation
- 1983-02-04 FR FR8301790A patent/FR2521009B1/fr not_active Expired
- 1983-02-04 IT IT19420/83A patent/IT1178455B/it active
- 1983-02-04 LU LU84632A patent/LU84632A1/de unknown
- 1983-02-04 CA CA000420907A patent/CA1203476A/en not_active Expired
- 1983-02-04 GB GB08303133A patent/GB2114573B/en not_active Expired
- 1983-02-04 NZ NZ203189A patent/NZ203189A/en unknown
- 1983-02-04 ES ES519533A patent/ES519533A0/es active Granted
- 1983-02-04 SE SE8300598A patent/SE460948B/sv not_active IP Right Cessation
- 1983-02-04 BE BE6/47775A patent/BE895832A/fr not_active IP Right Cessation
- 1983-02-04 JP JP58016303A patent/JPS58192818A/ja active Granted
- 1983-02-04 CH CH657/83A patent/CH657530A5/de not_active IP Right Cessation
- 1983-02-04 NL NLAANVRAGE8300440,A patent/NL187269C/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
AT382780B (de)	1987-04-10
DE3303860C2 (es)	1989-12-28
FI830375L (fi)	1983-08-06
IE54548B1 (en)	1989-11-08
AU1113683A (en)	1983-08-11
PT76195A (en)	1983-03-01
CH657530A5 (de)	1986-09-15
NZ203189A (en)	1985-07-31
ES8500060A1 (es)	1984-10-16
ATA38983A (de)	1986-09-15
PT76195B (en)	1986-01-27
NO161204B (no)	1989-04-10
FI830375A0 (fi)	1983-02-03
LU84632A1 (fr)	1983-09-08
BE895832A (fr)	1983-08-04
NL187269C (nl)	1991-08-01
IT1178455B (it)	1987-09-09
FR2521009B1 (fr)	1987-07-17
GB2114573A (en)	1983-08-24
GB2114573B (en)	1985-05-01
SE8300598L (sv)	1983-08-06
AU549981B2 (en)	1986-02-20
ZA83742B (en)	1983-11-30
NL187269B (nl)	1991-03-01
JPH0367056B2 (es)	1991-10-21
GB8303133D0 (en)	1983-03-09
DE3303860A1 (de)	1983-08-18
IT8319420A0 (it)	1983-02-04
NO161204C (no)	1989-07-19
CA1203476A (en)	1986-04-22
NO830385L (no)	1983-08-08
SE8300598D0 (sv)	1983-02-04
SE460948B (sv)	1989-12-11
FI78616B (fi)	1989-05-31
JPS58192818A (ja)	1983-11-10
NL8300440A (nl)	1983-09-01
FR2521009A1 (fr)	1983-08-12
US4476118A (en)	1984-10-09
GR77388B (es)	1984-09-11
IE830220L (en)	1983-08-05
FI78616C (fi)	1989-09-11

Publication	Publication Date	Title
ES519533A0 (es)	1984-10-16	Un metodo de producir una solucion de insulina.
ES524019A0 (es)	1984-11-16	Un metodo para producir una bebida en infusion
ES520464A0 (es)	1984-04-16	Un metodo de activar hidroxietil-celulosa.
ES518800A0 (es)	1984-02-01	Un metodo de producir derivados de tiazolidina.
ES528620A0 (es)	1985-05-01	Un metodo de preparacion de una espuma de poliorganosiloxano.
ES506925A0 (es)	1983-02-01	Un metodo de preparar un champu.
ES521145A0 (es)	1986-03-01	Un metodo de fabricar un catodo suministrador.
ES503602A0 (es)	1983-08-16	Un metodo para la produccion de una composicion de caucho de silicona vulzanizada.
IT1211036B (it)	1989-09-29	Procedimento per una trasmissione di messaggi resistente a disturbi.
ES525971A0 (es)	1985-09-01	Un metodo de preparar una sal de acilo c6-c18-oxibencenosulfonato.
ES527359A0 (es)	1985-02-16	Metodo de fabricacion de un cateter.
ES519771A0 (es)	1984-09-01	Un metodo de producir una preparacion farmaceutica que contiene un derivado de sulfonil urea.
ES520249A0 (es)	1984-04-16	Procedimiento de producir preparaciones de insulina.
ES520029A0 (es)	1983-12-01	Metodo de producir ferrosilicio.
ES504018A0 (es)	1983-08-01	Un metodo de fabricar una disposicion de interconexion elec-trica
ES522416A0 (es)	1984-03-01	Un metodo de producir un catodo termoionico.
ES520245A0 (es)	1984-04-01	Un metodo de fabricacion de un electrodo cargado.
ES517460A0 (es)	1985-11-01	Metodo de fabricar una estructura compuesta coherente.
IT8124331A0 (it)	1981-10-05	Metodo per creare una struttura a metallizzazione dielettrico.
ES548109A0 (es)	1986-05-01	Un metodo de preparacion de n,n-di-n-propil-4-hidroxi-3- metanosulfonamido-fenetilamina
ES520929A0 (es)	1984-05-16	Un metodo de producir un organo-siloxano.
ES513698A0 (es)	1984-10-01	"un metodo de fabricar una unidad de construccion".
AR224933A1 (es)	1982-01-29	Un procedimiento para producir un precursor de insulina
ES515225A0 (es)	1983-08-16	Un metodo de fabricacion de una seccion de entubado.
ES510234A0 (es)	1983-04-01	Metodo de fabricacion de una espuma de poliurietano.