SE8300598L - Stabiliserade insulinlosningar och forfarande for deras framstellning - Google Patents

Stabiliserade insulinlosningar och forfarande for deras framstellning

Info

Publication number: SE8300598L
Authority: SE; Sweden
Prior art keywords: insulin; solutions; procedures; preparation; insulin solutions
Prior art date: 1982-02-05

Application number

SE8300598A

Other languages

Unknown language ( )

English (en)

Other versions

SE8300598D0 (sv

SE460948B (sv

Inventor

J J V Brange

S Havelund

Original Assignee

Novo Industri As

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1982-02-05

Filing date

1983-02-04

Publication date

1983-08-06

1983-02-04 Application filed by Novo Industri As filed Critical Novo Industri As

1983-02-04 Publication of SE8300598D0 publication Critical patent/SE8300598D0/sv

1983-08-06 Publication of SE8300598L publication Critical patent/SE8300598L/sv

1989-12-11 Publication of SE460948B publication Critical patent/SE460948B/sv

Links

NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 title abstract 14
102000004877 Insulin Human genes 0.000 title abstract 7
108090001061 Insulin Proteins 0.000 title abstract 7
229940125396 insulin Drugs 0.000 title abstract 7
238000000034 method Methods 0.000 title 1
PTFCDOFLOPIGGS-UHFFFAOYSA-N Zinc dication Chemical compound [Zn+2] PTFCDOFLOPIGGS-UHFFFAOYSA-N 0.000 abstract 3
239000000243 solution Substances 0.000 abstract 2
239000003186 pharmaceutical solution Substances 0.000 abstract 1
150000003751 zinc Chemical class 0.000 abstract 1

Classifications

- H—ELECTRICITY
- H05—ELECTRIC TECHNIQUES NOT OTHERWISE PROVIDED FOR
- H05K—PRINTED CIRCUITS; CASINGS OR CONSTRUCTIONAL DETAILS OF ELECTRIC APPARATUS; MANUFACTURE OF ASSEMBLAGES OF ELECTRICAL COMPONENTS
- H05K13/00—Apparatus or processes specially adapted for manufacturing or adjusting assemblages of electric components
- H05K13/06—Wiring by machine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
- A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- A61K38/22—Hormones
- A61K38/28—Insulins

Landscapes

Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Life Sciences & Earth Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Medicinal Chemistry (AREA)
Endocrinology (AREA)
Microelectronics & Electronic Packaging (AREA)
Zoology (AREA)
Gastroenterology & Hepatology (AREA)
Chemical & Material Sciences (AREA)
Manufacturing & Machinery (AREA)
Immunology (AREA)
Diabetes (AREA)
Pharmacology & Pharmacy (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Epidemiology (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Medicinal Preparation (AREA)

SE8300598A 1982-02-05 1983-02-04 Med zinkjoner stabiliserad insulinloesning samt foerfarande foer dess framstaellning SE460948B (sv)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
DK49182		1982-02-05

Publications (3)

Publication Number	Publication Date
SE8300598D0 SE8300598D0 (sv)	1983-02-04
SE8300598L true SE8300598L (sv)	1983-08-06
SE460948B SE460948B (sv)	1989-12-11

Family

ID=8094159

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SE8300598A SE460948B (sv)	1982-02-05	1983-02-04	Med zinkjoner stabiliserad insulinloesning samt foerfarande foer dess framstaellning

Country Status (22)

Country	Link
US (1)	US4476118A (sv)
JP (1)	JPS58192818A (sv)
AT (1)	AT382780B (sv)
AU (1)	AU549981B2 (sv)
BE (1)	BE895832A (sv)
CA (1)	CA1203476A (sv)
CH (1)	CH657530A5 (sv)
DE (1)	DE3303860A1 (sv)
ES (1)	ES519533A0 (sv)
FI (1)	FI78616C (sv)
FR (1)	FR2521009B1 (sv)
GB (1)	GB2114573B (sv)
GR (1)	GR77388B (sv)
IE (1)	IE54548B1 (sv)
IT (1)	IT1178455B (sv)
LU (1)	LU84632A1 (sv)
NL (1)	NL187269C (sv)
NO (1)	NO161204C (sv)
NZ (1)	NZ203189A (sv)
PT (1)	PT76195B (sv)
SE (1)	SE460948B (sv)
ZA (1)	ZA83742B (sv)

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ATE50502T1 (de) *	1984-06-09	1990-03-15	Hoechst Ag	Insulinzubereitungen, verfahren zu deren herstellung und deren verwendung.
JP2520262B2 (ja) *	1987-08-21	1996-07-31	春幸川原	パツチテスト材料
US4789660A (en) *	1987-09-10	1988-12-06	American Home Products Corporation	Insulin administration using methyl and propyl paraben
US5130298A (en) *	1989-05-16	1992-07-14	Ethicon, Inc.	Stabilized compositions containing epidermal growth factor
US5534488A (en) *	1993-08-13	1996-07-09	Eli Lilly And Company	Insulin formulation
US5474978A (en) *	1994-06-16	1995-12-12	Eli Lilly And Company	Insulin analog formulations
AR002976A1 (es) *	1995-03-31	1998-05-27	Lilly Co Eli	Formulaciones farmaceuticas parenterales de efecto prolongado de insulina; cristales de dichos analogos aplicables en dichas formulaciones yprocedimiento de las formulaciones mencionadas
JP4307550B2 (ja) *	1995-11-13	2009-08-05	メドトロニックミニメッド、インコーポレイティド	単量体状タンパク質の送達のための方法及び組成物
US6733746B2 (en) *	1996-03-12	2004-05-11	Invitrogen Corporation	Hematopoietic cell culture nutrient supplement
ATE264871T1 (de) *	1996-07-26	2004-05-15	Aventis Pharma Gmbh	Insulinderivate mit erhöhter zinkbindung
EP1283051B1 (en) *	1997-06-13	2006-06-14	Eli Lilly And Company	Stable insulin formulations
CO4750643A1 (es) *	1997-06-13	1999-03-31	Lilly Co Eli	Formulacion estable de la insulina que contiene l-arginina y protamina
WO1999024071A1 (en) *	1997-11-12	1999-05-20	Alza Corporation	Method for decreasing self-association of polypeptides
DE19825447A1 (de)	1998-06-06	1999-12-09	Hoechst Marion Roussel De Gmbh	Neue Insulinanaloga mit erhöhter Zinkbildung
ATE277630T1 (de) *	1998-10-16	2004-10-15	Novo Nordisk As	Stabile konzentrierte insulin präparationen zur pulmonaren verabreichung
DE19930676B4 (de) *	1999-07-02	2006-01-19	Sanofi-Aventis Deutschland Gmbh	Verfahren zur Stabilisierung von Insulin, Insulinderivaten und/oder deren Vorläufer in komplexen Mischungen bei deren Lagerung in wäßrigen Lösungsmitteln
DK1265630T3 (da) *	2000-03-24	2006-10-09	Genentech Inc	Anvendelse af insulin til behandling af brusksygdomme
JP4147234B2 (ja) *	2004-09-27	2008-09-10	キヤノン株式会社	吐出用液体、吐出方法、カートリッジ及び吐出装置
EP1506230B1 (en)	2002-05-07	2011-01-19	Novo Nordisk A/S	Soluble formulations comprising monomeric insulin and acylated insulin
US20050065066A1 (en) *	2002-12-20	2005-03-24	Kaarsholm Niels Christian	Stabilised insulin compositions
DE60317565T2 (de) *	2002-12-20	2008-09-11	Novo Nordisk A/S	Pharmazeutische zusammensetzungen mit insulin und insulin-hexamer-liganden
WO2004096266A1 (en) *	2003-05-02	2004-11-11	Novo Nordisk A/S	Improved physical stability of insulin formulations
BRPI0413276B8 (pt) *	2003-08-05	2021-05-25	Novo Nordisk As	derivado de insulina, complexo de zinco do mesmo, e, composição farmacêutica
KR101276754B1 (ko) *	2004-07-19	2013-06-19	바이오콘 리미티드	인슐린―올리고머 접합체，제형 및 이들의 용도
ATE519780T1 (de) *	2005-12-28	2011-08-15	Novo Nordisk As	Ein acyliertes insulin und zink enthaltende zusammensetzungen und verfahren zur herstellung dieser zusammensetzungen
US20090136538A1 (en) *	2006-05-22	2009-05-28	Jan Jezek	Stable vaccine formulation
GB0700523D0 (en) *	2007-01-11	2007-02-21	Insense Ltd	The Stabilisation Of Proteins
CA2681158C (en)	2007-03-13	2018-09-18	Nutrition 21, Inc.	Methods and compositions for the sustained release of chromium
JP5552046B2 (ja) *	2007-06-13	2014-07-16	ノボ・ノルデイスク・エー／エス	インスリン誘導体を含有する薬学的製剤
WO2009002867A2 (en)	2007-06-26	2008-12-31	Nutrition 21, Inc.	Multiple unit dosage form having a therapeutic agents in combination with a nutritional supplement
PT2597103T (pt) *	2007-11-16	2017-02-08	Novo Nordisk As	Composições farmacêuticas contendo insulina e um péptido insulinotrófico
EP2341940A1 (en) *	2008-07-16	2011-07-13	Arecor Limited	The stabilisation of proteins
EP2328607A1 (en) *	2008-07-16	2011-06-08	Arecor Limited	Stable formulation of a therapeutic protein
RU2540922C2 (ru) *	2008-10-30	2015-02-10	Ново Нордиск А/С	Лечение сахарного диабета с использованием инъекций инсулина с частотой менее одного раза в день
US9060927B2 (en)	2009-03-03	2015-06-23	Biodel Inc.	Insulin formulations for rapid uptake
JP6049625B2 (ja)	2010-10-27	2016-12-21	ノヴォノルディスクアー／エス	様々な注射間隔を用いて施されるインスリン注射を使用する、真性糖尿病の治療
ES2927800T3 (es)	2011-03-01	2022-11-11	Nutrition 21 Llc	Composición de insulina y cromo para el tratamiento y la prevención de diabetes, hipoglicemia y trastornos relacionados
JP6322642B2 (ja)	2012-11-13	2018-05-09	アドシア	置換されたアニオン性化合物を含有する速効型インスリン製剤
RU2015129087A (ru) *	2012-12-19	2017-02-02	Вокхардт Лимитед	Стабильная водная композиция, содержащая инсулин человека или его аналог или производное
AU2013368990B2 (en)	2012-12-26	2017-05-18	Wockhardt Limited	Pharmaceutical composition
TWI641381B (zh) *	2013-02-04	2018-11-21	法商賽諾菲公司	胰島素類似物及／或胰島素衍生物之穩定化醫藥調配物
US10137172B2 (en)	2013-04-30	2018-11-27	Novo Nordisk A/S	Administration regime
WO2015084694A2 (en) *	2013-12-04	2015-06-11	Merck Sharp & Dohme Corp.	Method for preparing crystalline insulin
TW201630622A (zh)	2014-12-16	2016-09-01	美國禮來大藥廠	速效胰島素組合物
JO3749B1 (ar)	2015-08-27	2021-01-31	Lilly Co Eli	تركيبات إنسولين سريعة المفعول
WO2017139337A1 (en)	2016-02-11	2017-08-17	Nutrition 21, Llc	Chromium containing compositions for improving health and fitness
EP3518893A1 (en) *	2016-09-29	2019-08-07	Arecor Limited	Novel formulations
PE20200017A1 (es)	2017-06-01	2020-01-06	Lilly Co Eli	Composiciones de insulina de rapida accion
US10335464B1 (en)	2018-06-26	2019-07-02	Novo Nordisk A/S	Device for titrating basal insulin

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Publication number	Priority date	Publication date	Assignee	Title
US2882202A (en) *	1950-04-05	1959-04-14	Novo Terapeutisk Labor As	Insulin crystal preparations and methods of producing them
US2787575A (en) *	1950-11-22	1957-04-02	Organon	Zinc-glycine-insulin composition and production thereof
US2882203A (en) *	1951-06-26	1959-04-14	Novo Terapeutisk Labor As	Injectable insulin preparation with protracted effect
DE1044360B (de) *	1953-08-19	1958-11-20	Roskilde Medical Company Ltd R	Verfahren zur Herstellung von Zinkinsulin mit erhoehtem Zinkgehalt
DE956098C (de) *	1954-02-18	1957-01-10	Dr Dr Guenther Weitzel	Verfahren zur Herstellung zinkreicher Insulin-Komplexverbindungen
US3058885A (en) *	1957-06-08	1962-10-16	Novo Terapeutisk Labor As	Process for treatment of insulin crystals and for production of insulin preparationstherefrom
US3014842A (en) *	1957-08-10	1961-12-26	Novo Terapeutish Lab A S	Injectable bovine insulin crystal suspensions and process of producing same
US3091573A (en) *	1958-05-12	1963-05-28	Novo Terapeutisk Labor As	Quick acting insulin preparation
FR1263220A (fr) *	1958-08-01	1961-06-09	Novo Terapeutisk Labor As	Procédé de production d'une préparation d'insuline à action rapide
DK116527B (da) *	1967-03-01	1970-01-19	Nordisk Insulinlab	Fremgangsmåde til fremstilling af en hurtigtvirkende, holdbar, neutral opløsning af rent krystallinsk okseinsulin eller okseinsulin, der ved tilsætning af Zn er krystalliserbart i vand, eller blandinger af okseinsulin og insulin af anden oprindelse.
GB1285023A (en) *	1968-08-09	1972-08-09	Novo Terapeutisk Labor As	Improvements in or relating to injectable insulin preparations
US3657425A (en) *	1969-03-12	1972-04-18	Burroughs Wellcome Co	Beef insulin preparations
EP0018609B1 (de) *	1979-04-30	1983-09-21	Hoechst Aktiengesellschaft	Gegen Denaturierung beständige, wässrige Protein-Lösungen, Verfahren zu ihrer Herstellung und ihre Verwendung
DK80781A (da) *	1980-02-29	1981-08-30	Hospital For Sick Children	Oploesninger af polypeptider
ES8403723A1 (es) *	1982-03-03	1984-04-16	Nordisk Insulinlab	Procedimiento de producir preparaciones de insulina.

1983
- 1983-02-03 FI FI830375A patent/FI78616C/sv not_active IP Right Cessation
- 1983-02-04 IE IE220/83A patent/IE54548B1/en not_active IP Right Cessation
- 1983-02-04 GR GR70416A patent/GR77388B/el unknown
- 1983-02-04 ZA ZA83742A patent/ZA83742B/xx unknown
- 1983-02-04 PT PT76195A patent/PT76195B/pt unknown
- 1983-02-04 AU AU11136/83A patent/AU549981B2/en not_active Expired
- 1983-02-04 US US06/463,730 patent/US4476118A/en not_active Expired - Lifetime
- 1983-02-04 NO NO830385A patent/NO161204C/no not_active IP Right Cessation
- 1983-02-04 DE DE19833303860 patent/DE3303860A1/de active Granted
- 1983-02-04 AT AT0038983A patent/AT382780B/de not_active IP Right Cessation
- 1983-02-04 FR FR8301790A patent/FR2521009B1/fr not_active Expired
- 1983-02-04 IT IT19420/83A patent/IT1178455B/it active
- 1983-02-04 LU LU84632A patent/LU84632A1/de unknown
- 1983-02-04 CA CA000420907A patent/CA1203476A/en not_active Expired
- 1983-02-04 GB GB08303133A patent/GB2114573B/en not_active Expired
- 1983-02-04 NZ NZ203189A patent/NZ203189A/en unknown
- 1983-02-04 ES ES519533A patent/ES519533A0/es active Granted
- 1983-02-04 SE SE8300598A patent/SE460948B/sv not_active IP Right Cessation
- 1983-02-04 BE BE6/47775A patent/BE895832A/fr not_active IP Right Cessation
- 1983-02-04 JP JP58016303A patent/JPS58192818A/ja active Granted
- 1983-02-04 CH CH657/83A patent/CH657530A5/de not_active IP Right Cessation
- 1983-02-04 NL NLAANVRAGE8300440,A patent/NL187269C/xx not_active IP Right Cessation

Also Published As

Publication number	Publication date
AT382780B (de)	1987-04-10
DE3303860C2 (sv)	1989-12-28
FI830375L (fi)	1983-08-06
IE54548B1 (en)	1989-11-08
AU1113683A (en)	1983-08-11
PT76195A (en)	1983-03-01
CH657530A5 (de)	1986-09-15
NZ203189A (en)	1985-07-31
ES8500060A1 (es)	1984-10-16
ATA38983A (de)	1986-09-15
PT76195B (en)	1986-01-27
NO161204B (no)	1989-04-10
FI830375A0 (fi)	1983-02-03
LU84632A1 (fr)	1983-09-08
BE895832A (fr)	1983-08-04
NL187269C (nl)	1991-08-01
IT1178455B (it)	1987-09-09
FR2521009B1 (fr)	1987-07-17
GB2114573A (en)	1983-08-24
GB2114573B (en)	1985-05-01
AU549981B2 (en)	1986-02-20
ES519533A0 (es)	1984-10-16
ZA83742B (en)	1983-11-30
NL187269B (nl)	1991-03-01
JPH0367056B2 (sv)	1991-10-21
GB8303133D0 (en)	1983-03-09
DE3303860A1 (de)	1983-08-18
IT8319420A0 (it)	1983-02-04
NO161204C (no)	1989-07-19
CA1203476A (en)	1986-04-22
NO830385L (no)	1983-08-08
SE8300598D0 (sv)	1983-02-04
SE460948B (sv)	1989-12-11
FI78616B (fi)	1989-05-31
JPS58192818A (ja)	1983-11-10
NL8300440A (nl)	1983-09-01
FR2521009A1 (fr)	1983-08-12
US4476118A (en)	1984-10-09
GR77388B (sv)	1984-09-11
IE830220L (en)	1983-08-05
FI78616C (sv)	1989-09-11

Publication	Publication Date	Title
SE8300598L (sv)	1983-08-06	Stabiliserade insulinlosningar och forfarande for deras framstellning
GR1001503B (el)	1994-02-28	Μέ?οδος δια την παρασκευή φαρμακευτικών ενώσεων αι οποίαι περιέχουν ως δραστική ουσία καρβονικά οξέα τα οποία περιέχουν ?είον κα?ώς και η χρησιμοποίησις αυτών δια την καταπολέμησιν των ρετροιών.
ZA867347B (en)	1987-05-27	Medicaments to combat chronic graft-versus-host diseases and to combat autoimmune diseases,in particular systemic lupus erythematosus
DE3583008D1 (de)	1991-07-04	Pharmazeutische zusammensetzungen von dihydrocodeine/ibuprofen und verfahren.
EG18265A (en)	1992-12-30	New pharmaceutical preparation with extended release
ES510245A0 (es)	1983-01-16	"un metodo para obtener una preparacion de insulina".
DE68909409D1 (de)	1993-10-28	Heilmitteldosierung zur verabreichung an fische.
SE8102456L (sv)	1981-10-19	Farmaceutisk komposition for oral administering och innehallande cytidindifosfokolin
SE8204873L (sv)	1983-02-28	Farmaceutiska preparat, innefattande humant insulin och human c-peptid
IT1195324B (it)	1988-10-12	Derivati encefalinici dotati di attivita' analgesica e composizioni farmaceutiche che li contengono
ATE24111T1 (de)	1986-12-15	Mischung mit gehalt an einem zentral-analgetikum und an vitamine b12 oder einem seiner analoge als wirkstoffe.
DK42483A (da)	1983-08-06	Stabiliserede insulinoploesninger
SE8204872L (sv)	1983-02-28	Farmaceutiska preparat, innefattande humant insulin, human c-peptid och humant proinsulin
JPS56138112A (en)	1981-10-28	Suppository containing ascorbic acid or sodium ascorbate
KR900002779A (ko)	1990-03-23	종양치료용 약학 조성물
FR2496658B1 (fr)	1985-06-07	Derives de l'acide nicotinique, leur preparation et medicament contenant ces substances
FR2589729B1 (fr)	1988-02-05	Moderateur de l'envie de fumer par inhalation de super essence de tabac et de foin absolu decolore
SE8206728D0 (sv)	1982-11-25	Lekemedelspreparat
JPS5758630A (en)	1982-04-08	Interferon inducer
JPS5687504A (en)	1981-07-16	Insecticidal composition
JPS52130926A (en)	1977-11-02	Medicinal composition comprising pentazocine and salicylamide
DK100882A (da)	1982-09-11	Stabiliseret oploesning af insulin samt fremgangsmaade til fremstilling deraf
BG94567A (en)	1995-01-31	Medicaments for the treatment of aids and method for its application
ATE18994T1 (de)	1986-04-15	Neue pharmazeutische zusammensetzung.
KR930700109A (ko)	1993-03-13	신경 질환 치료용 4,4'-[9h-플루오렌-9-일리덴비스(메틸렌)]-비스피리미딘

Legal Events

Date	Code	Title	Description
1995-01-31	NAL	Patent in force	Ref document number: 8300598-3 Format of ref document f/p: F
2003-04-01	NUG	Patent has lapsed

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Title

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1995-01-31

NAL

Patent in force

Ref document number: 8300598-3

Format of ref document f/p: F

2003-04-01

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Patent has lapsed