SA98190747B1 - توليفة من عوامل فعالة وبصفة خاصة tetrahydropyridine وعوامل مثبطة لانزيم acetylcholinesterase لعلاج عته الشيخويخة مثل عته الزهايمر alzheimer - Google Patents

توليفة من عوامل فعالة وبصفة خاصة tetrahydropyridine وعوامل مثبطة لانزيم acetylcholinesterase لعلاج عته الشيخويخة مثل عته الزهايمر alzheimer Download PDF

Info

Publication number: SA98190747B1
Authority: SA; Saudi Arabia
Prior art keywords: tetrahydropyridine; trifluoromethylphenyl; ethyl; biphenylyl; alkyl
Prior art date: 1997-11-14

Application number

SA98190747A

Other languages

Arabic (ar)

English (en)

Inventor

جان بيري مافراند

جان بول تيرانوفا

فيليب سوبري

Original Assignee

سانوفي

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1997-11-14

Filing date

1998-11-14

Publication date

2006-11-04

1997-11-14 Priority claimed from FR9714324A external-priority patent/FR2771006B1/fr

1997-11-14 Priority claimed from FR9714322A external-priority patent/FR2771007B1/fr

1998-11-14 Application filed by سانوفي filed Critical سانوفي

2006-11-04 Publication of SA98190747B1 publication Critical patent/SA98190747B1/ar

Links

239000013543 active substance Substances 0.000 title claims abstract description 26
VSWICNJIUPRZIK-UHFFFAOYSA-N 2-piperideine Chemical compound C1CNC=CC1 VSWICNJIUPRZIK-UHFFFAOYSA-N 0.000 title claims description 38
238000011282 treatment Methods 0.000 title claims description 14
239000000544 cholinesterase inhibitor Substances 0.000 title claims description 11
208000024827 Alzheimer disease Diseases 0.000 title claims description 6
206010039966 Senile dementia Diseases 0.000 title 1
150000001875 compounds Chemical class 0.000 claims abstract description 42
150000003839 salts Chemical class 0.000 claims abstract description 35
125000000217 alkyl group Chemical group 0.000 claims abstract description 28
125000003545 alkoxy group Chemical group 0.000 claims abstract description 17
-1 phenylthio, phenylsulphonyl Chemical group 0.000 claims abstract description 15
125000004453 alkoxycarbonyl group Chemical group 0.000 claims abstract description 14
229910052736 halogen Inorganic materials 0.000 claims abstract description 14
150000002367 halogens Chemical class 0.000 claims abstract description 13
125000002887 hydroxy group Chemical group [H]O* 0.000 claims abstract description 12
125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims abstract description 12
102000012440 Acetylcholinesterase Human genes 0.000 claims abstract description 11
108010022752 Acetylcholinesterase Proteins 0.000 claims abstract description 11
229910052739 hydrogen Inorganic materials 0.000 claims abstract description 11
239000001257 hydrogen Substances 0.000 claims abstract description 11
229940022698 acetylcholinesterase Drugs 0.000 claims abstract description 10
125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims abstract description 10
UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims abstract description 8
125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims abstract description 8
239000008194 pharmaceutical composition Substances 0.000 claims abstract description 8
238000006467 substitution reaction Methods 0.000 claims abstract description 6
239000004615 ingredient Substances 0.000 claims abstract description 5
125000004442 acylamino group Chemical group 0.000 claims abstract description 4
125000004457 alkyl amino carbonyl group Chemical group 0.000 claims abstract description 4
125000004181 carboxyalkyl group Chemical group 0.000 claims abstract description 4
125000006310 cycloalkyl amino group Chemical group 0.000 claims abstract description 4
125000000596 cyclohexenyl group Chemical group C1(=CCCCC1)* 0.000 claims abstract description 4
125000000951 phenoxy group Chemical group [H]C1=C([H])C([H])=C(O*)C([H])=C1[H] 0.000 claims abstract description 4
125000000286 phenylethyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])C([H])([H])* 0.000 claims abstract description 4
125000005504 styryl group Chemical group 0.000 claims abstract description 4
125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 claims abstract description 3
125000005843 halogen group Chemical group 0.000 claims abstract description 3
125000000000 cycloalkoxy group Chemical group 0.000 claims abstract 9
125000004178 (C1-C4) alkyl group Chemical group 0.000 claims abstract 3
125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 claims abstract 3
125000004093 cyano group Chemical group *C#N 0.000 claims abstract 3
230000002401 inhibitory effect Effects 0.000 claims abstract 2
125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims description 39
239000000203 mixture Substances 0.000 claims description 27
ADEBPBSSDYVVLD-UHFFFAOYSA-N donepezil Chemical compound O=C1C=2C=C(OC)C(OC)=CC=2CC1CC(CC1)CCN1CC1=CC=CC=C1 ADEBPBSSDYVVLD-UHFFFAOYSA-N 0.000 claims description 18
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YLJREFDVOIBQDA-UHFFFAOYSA-N tacrine Chemical compound C1=CC=C2C(N)=C(CCCC3)C3=NC2=C1 YLJREFDVOIBQDA-UHFFFAOYSA-N 0.000 claims description 7
239000003112 inhibitor Substances 0.000 claims description 6
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FTAHXMZRJCZXDL-UHFFFAOYSA-N 3-piperideine Chemical compound C1CC=CCN1 FTAHXMZRJCZXDL-UHFFFAOYSA-N 0.000 claims description 5
125000003282 alkyl amino group Chemical group 0.000 claims description 5
229940079593 drug Drugs 0.000 claims description 5
239000003814 drug Substances 0.000 claims description 5
ASUTZQLVASHGKV-JDFRZJQESA-N galanthamine Chemical compound O1C(=C23)C(OC)=CC=C2CN(C)CC[C@]23[C@@H]1C[C@@H](O)C=C2 ASUTZQLVASHGKV-JDFRZJQESA-N 0.000 claims description 4
GAPOASFZXBWUGS-UHFFFAOYSA-N 2,2,2-trifluoro-1-(3-trimethylsilylphenyl)ethanone Chemical compound C[Si](C)(C)C1=CC=CC(C(=O)C(F)(F)F)=C1 GAPOASFZXBWUGS-UHFFFAOYSA-N 0.000 claims description 3
229940100578 Acetylcholinesterase inhibitor Drugs 0.000 claims description 3
VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims description 3
HOKKHZGPKSLGJE-GSVOUGTGSA-N N-Methyl-D-aspartic acid Chemical compound CN[C@@H](C(O)=O)CC(O)=O HOKKHZGPKSLGJE-GSVOUGTGSA-N 0.000 claims description 3
125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 3
125000004981 cycloalkylmethyl group Chemical group 0.000 claims description 3
125000003356 phenylsulfanyl group Chemical group [*]SC1=C([H])C([H])=C([H])C([H])=C1[H] 0.000 claims description 3
239000011885 synergistic combination Substances 0.000 claims description 3
WALYRZRLDDOTJG-UHFFFAOYSA-N 2-chloro-6-[1-[2-(4-phenylphenyl)ethyl]-3,6-dihydro-2h-pyridin-4-yl]pyridine Chemical compound ClC1=CC=CC(C=2CCN(CCC=3C=CC(=CC=3)C=3C=CC=CC=3)CC=2)=N1 WALYRZRLDDOTJG-UHFFFAOYSA-N 0.000 claims description 2
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HLVVITIHAZBPKB-UHFFFAOYSA-N 9-amino-1,2,3,4-tetrahydroacridin-1-ol Chemical compound C1=CC=C2C(N)=C(C(O)CCC3)C3=NC2=C1 HLVVITIHAZBPKB-UHFFFAOYSA-N 0.000 claims description 2
LPCKPBWOSNVCEL-UHFFFAOYSA-N Chlidanthine Natural products O1C(C(=CC=2)O)=C3C=2CN(C)CCC23C1CC(OC)C=C2 LPCKPBWOSNVCEL-UHFFFAOYSA-N 0.000 claims description 2
PIJVFDBKTWXHHD-UHFFFAOYSA-N Physostigmine Natural products C12=CC(OC(=O)NC)=CC=C2N(C)C2C1(C)CCN2C PIJVFDBKTWXHHD-UHFFFAOYSA-N 0.000 claims description 2
XSVMFMHYUFZWBK-NSHDSACASA-N Rivastigmine Chemical compound CCN(C)C(=O)OC1=CC=CC([C@H](C)N(C)C)=C1 XSVMFMHYUFZWBK-NSHDSACASA-N 0.000 claims description 2
RRGMXBQMCUKRLH-CTNGQTDRSA-N [(3ar,8bs)-3,4,8b-trimethyl-2,3a-dihydro-1h-pyrrolo[2,3-b]indol-7-yl] n-heptylcarbamate Chemical compound C12=CC(OC(=O)NCCCCCCC)=CC=C2N(C)[C@@H]2[C@@]1(C)CCN2C RRGMXBQMCUKRLH-CTNGQTDRSA-N 0.000 claims description 2
125000000753 cycloalkyl group Chemical group 0.000 claims description 2
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229960003980 galantamine Drugs 0.000 claims description 2
BGLNUNCBNALFOZ-WMLDXEAASA-N galanthamine Natural products COc1ccc2CCCC[C@@]34C=CCC[C@@H]3Oc1c24 BGLNUNCBNALFOZ-WMLDXEAASA-N 0.000 claims description 2
ASUTZQLVASHGKV-UHFFFAOYSA-N galanthamine hydrochloride Natural products O1C(=C23)C(OC)=CC=C2CN(C)CCC23C1CC(O)C=C2 ASUTZQLVASHGKV-UHFFFAOYSA-N 0.000 claims description 2
IYVSXSLYJLAZAT-NOLJZWGESA-N lycoramine Natural products CN1CC[C@@]23CC[C@H](O)C[C@@H]2Oc4cccc(C1)c34 IYVSXSLYJLAZAT-NOLJZWGESA-N 0.000 claims description 2
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230000003551 muscarinic effect Effects 0.000 claims description 2
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PIJVFDBKTWXHHD-HIFRSBDPSA-N physostigmine Chemical compound C12=CC(OC(=O)NC)=CC=C2N(C)[C@@H]2[C@@]1(C)CCN2C PIJVFDBKTWXHHD-HIFRSBDPSA-N 0.000 claims description 2
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NFACJZMKEDPNKN-UHFFFAOYSA-N trichlorfon Chemical compound COP(=O)(OC)C(O)C(Cl)(Cl)Cl NFACJZMKEDPNKN-UHFFFAOYSA-N 0.000 claims description 2
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229950004402 zifrosilone Drugs 0.000 claims description 2
125000006273 (C1-C3) alkyl group Chemical group 0.000 claims 2
125000000229 (C1-C4)alkoxy group Chemical group 0.000 claims 2
JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical compound C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 2
125000005111 carboxyalkoxy group Chemical group 0.000 claims 2
125000001436 propyl group Chemical group [H]C([*])([H])C([H])([H])C([H])([H])[H] 0.000 claims 2
230000001681 protective effect Effects 0.000 claims 2
125000006272 (C3-C7) cycloalkyl group Chemical group 0.000 claims 1
HAKSOKWVNPZVNM-UHFFFAOYSA-N 1,2,3,4-tetrahydropyridine;hydrochloride Chemical compound Cl.C1CNC=CC1 HAKSOKWVNPZVNM-UHFFFAOYSA-N 0.000 claims 1
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230000032683 aging Effects 0.000 claims 1
239000005515 coenzyme Substances 0.000 claims 1
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NQRYJNQNLNOLGT-UHFFFAOYSA-N tetrahydropyridine hydrochloride Natural products C1CCNCC1 NQRYJNQNLNOLGT-UHFFFAOYSA-N 0.000 claims 1
230000001228 trophic effect Effects 0.000 claims 1
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/64—Sulfonylureas, e.g. glibenclamide, tolbutamide, chlorpropamide
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
- A61K31/445—Non condensed piperidines, e.g. piperocaine
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia

Landscapes

Health & Medical Sciences (AREA)
Veterinary Medicine (AREA)
Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Biomedical Technology (AREA)
Bioinformatics & Cheminformatics (AREA)
Epidemiology (AREA)
Engineering & Computer Science (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Organic Chemistry (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Hospice & Palliative Care (AREA)
Psychiatry (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)

SA98190747A 1997-11-14 1998-11-14 توليفة من عوامل فعالة وبصفة خاصة tetrahydropyridine وعوامل مثبطة لانزيم acetylcholinesterase لعلاج عته الشيخويخة مثل عته الزهايمر alzheimer SA98190747B1 (ar)

Applications Claiming Priority (2)

Application Number	Priority Date	Filing Date	Title
FR9714324A FR2771006B1 (fr)	1997-11-14	1997-11-14	Association de principes actifs pour le traitement de la demence senile du type alzheimer
FR9714322A FR2771007B1 (fr)	1997-11-14	1997-11-14	Association de principes actifs pour le traitement de la demence senile du type alzheimer

Publications (1)

Publication Number	Publication Date
SA98190747B1 true SA98190747B1 (ar)	2006-11-04

Family

ID=26233932

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
SA98190747A SA98190747B1 (ar)	1997-11-14	1998-11-14	توليفة من عوامل فعالة وبصفة خاصة tetrahydropyridine وعوامل مثبطة لانزيم acetylcholinesterase لعلاج عته الشيخويخة مثل عته الزهايمر alzheimer

Country Status (27)

Country	Link
EP (1)	EP1030671A1 (et)
JP (1)	JP2001523642A (et)
KR (1)	KR100599350B1 (et)
CN (1)	CN1243540C (et)
AU (1)	AU743228B2 (et)
BG (1)	BG64819B1 (et)
BR (1)	BR9814035A (et)
CA (1)	CA2309966A1 (et)
CO (1)	CO4980891A1 (et)
DZ (1)	DZ2649A1 (et)
EA (1)	EA003255B1 (et)
EE (1)	EE04235B1 (et)
HU (1)	HUP0100098A3 (et)
ID (1)	ID24933A (et)
IL (2)	IL136122A0 (et)
IS (1)	IS5482A (et)
MY (1)	MY120461A (et)
NO (1)	NO20002450L (et)
NZ (1)	NZ504420A (et)
OA (1)	OA11464A (et)
PL (1)	PL194597B1 (et)
SA (1)	SA98190747B1 (et)
SK (1)	SK286040B6 (et)
TR (1)	TR200001262T2 (et)
TW (1)	TW585766B (et)
UY (1)	UY25247A1 (et)
WO (1)	WO1999025363A1 (et)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
PT2389937T (pt)	2002-06-14	2018-10-26	Toyama Chemical Co Ltd	Composição farmacêutica para melhorar as funções cerebrais
ES2327914T3 (es) *	2002-08-07	2009-11-05	Novartis Ag	Metodo para pronosticar la sensibilidad al tratamiento con ravastigmina basado en el genotipo apoe de pacintes con demencia.
CN1520818A (zh) *	2003-02-09	2004-08-18	山东绿叶天然药物研究开发有限公司	治疗老年性痴呆的胆碱酯酶抑制剂药物组合物
RU2401125C2 (ru)	2004-12-27	2010-10-10	Эйсай Ар Энд Ди Менеджмент Ко., Лтд.	Способ стабилизации лекарственного средства против деменции
DK3498692T3 (da)	2014-01-31	2022-05-16	Cognition Therapeutics Inc	Isoindolin-sammensætninger og fremgangsmåder til behandling af neurodegenerativ sygdom og makulær degeneration
KR102614814B1 (ko)	2017-05-15	2023-12-20	카그니션 테라퓨틱스, 인코퍼레이티드	신경변성 질환 치료용 조성물
WO2019182319A1 (ko) *	2018-03-20	2019-09-26	(주)인벤티지랩	인지 장애 관련 질병의 예방 또는 치료용 약학적 조성물의 제조 방법 및 이의 제조 방법으로 제조된 인지 장애 관련 질병의 예방 또는 치료용 약학적 조성물
KR102224918B1 (ko)	2018-03-20	2021-03-09	(주)인벤티지랩	도네페질 및 메만틴을 포함하는 인지 장애 관련 질병의 예방 또는 치료용 약학적 복합 조성물 및 이의 제조 방법
CN109265391B (zh) *	2018-11-13	2021-11-19	枣庄学院	联苯多取代1,2,5,6-四氢吡啶化合物及其合成方法与应用

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Publication number	Priority date	Publication date	Assignee	Title
FR2662355B1 (fr) *	1990-05-22	1994-11-10	Sanofi Sa	Utilisation de la 1-[2-(2-naphtyl)ethyl]-4-(3-trifluoromethylphenyl)-1,2,3,6-tetrahydropyridine pour la preparation de medicaments destines au traitement de troubles cerebraux et neuronaux.
US5453428A (en) *	1991-02-14	1995-09-26	The Mount Sinai School Of Medicine Of The City Of New York	Method and composition for the treatment of apathy-amotivation syndrome
CA2213000A1 (en) *	1995-03-06	1996-09-12	Interneuron Pharmaceuticals, Inc.	Reduction of infarct volume using citicoline
FR2736053B1 (fr) *	1995-06-28	1997-09-19	Sanofi Sa	Nouvelles 1-phenylalkyl-1,2,3,6-tetrahydropyridines

1998
- 1998-10-26 CO CO98062479A patent/CO4980891A1/es unknown
- 1998-10-28 TW TW087117874A patent/TW585766B/zh not_active IP Right Cessation
- 1998-11-09 JP JP2000520796A patent/JP2001523642A/ja not_active Withdrawn
- 1998-11-09 HU HU0100098A patent/HUP0100098A3/hu unknown
- 1998-11-09 SK SK711-2000A patent/SK286040B6/sk unknown
- 1998-11-09 KR KR1020007005231A patent/KR100599350B1/ko not_active Expired - Fee Related
- 1998-11-09 EP EP98954538A patent/EP1030671A1/fr not_active Withdrawn
- 1998-11-09 CN CNB988130947A patent/CN1243540C/zh not_active Expired - Fee Related
- 1998-11-09 AU AU11609/99A patent/AU743228B2/en not_active Ceased
- 1998-11-09 TR TR2000/01262T patent/TR200001262T2/xx unknown
- 1998-11-09 EA EA200000412A patent/EA003255B1/ru not_active IP Right Cessation
- 1998-11-09 NZ NZ504420A patent/NZ504420A/en unknown
- 1998-11-09 IL IL13612298A patent/IL136122A0/xx not_active IP Right Cessation
- 1998-11-09 PL PL98340500A patent/PL194597B1/pl not_active IP Right Cessation
- 1998-11-09 WO PCT/FR1998/002384 patent/WO1999025363A1/fr not_active Application Discontinuation
- 1998-11-09 EE EEP200000290A patent/EE04235B1/et not_active IP Right Cessation
- 1998-11-09 CA CA002309966A patent/CA2309966A1/en not_active Abandoned
- 1998-11-09 ID IDW20000860A patent/ID24933A/id unknown
- 1998-11-09 BR BR9814035-3A patent/BR9814035A/pt not_active Application Discontinuation
- 1998-11-11 DZ DZ980259A patent/DZ2649A1/xx active
- 1998-11-12 UY UY25247A patent/UY25247A1/es not_active IP Right Cessation
- 1998-11-14 MY MYPI98005180A patent/MY120461A/en unknown
- 1998-11-14 SA SA98190747A patent/SA98190747B1/ar unknown
2000
- 2000-05-09 IS IS5482A patent/IS5482A/is unknown
- 2000-05-11 BG BG104428A patent/BG64819B1/bg unknown
- 2000-05-11 NO NO20002450A patent/NO20002450L/no unknown
- 2000-05-12 OA OA1200000141A patent/OA11464A/en unknown
- 2000-05-14 IL IL136122A patent/IL136122A/en unknown

Also Published As

Publication number	Publication date
UY25247A1 (es)	2001-05-31
CN1285742A (zh)	2001-02-28
ID24933A (id)	2000-08-31
HUP0100098A3 (en)	2001-12-28
OA11464A (en)	2003-11-18
EE200000290A (et)	2001-06-15
IL136122A (en)	2006-07-05
CO4980891A1 (es)	2000-11-27
KR100599350B1 (ko)	2006-07-12
IS5482A (is)	2000-05-09
CA2309966A1 (en)	1999-05-27
SK286040B6 (sk)	2008-01-07
TW585766B (en)	2004-05-01
SK7112000A3 (en)	2000-10-09
TR200001262T2 (tr)	2001-01-22
PL194597B1 (pl)	2007-06-29
EP1030671A1 (fr)	2000-08-30
BG64819B1 (bg)	2006-05-31
NO20002450L (no)	2000-07-14
NO20002450D0 (no)	2000-05-11
EA200000412A1 (ru)	2000-12-25
JP2001523642A (ja)	2001-11-27
BG104428A (en)	2001-08-31
AU743228B2 (en)	2002-01-24
EA003255B1 (ru)	2003-02-27
KR20010032099A (ko)	2001-04-16
EE04235B1 (et)	2004-02-16
HUP0100098A2 (hu)	2001-07-30
CN1243540C (zh)	2006-03-01
NZ504420A (en)	2003-08-29
PL340500A1 (en)	2001-02-12
WO1999025363A1 (fr)	1999-05-27
IL136122A0 (en)	2001-05-20
AU1160999A (en)	1999-06-07
MY120461A (en)	2005-10-31
BR9814035A (pt)	2000-09-26
DZ2649A1 (fr)	2004-12-28

Publication	Publication Date	Title
DE69231395T3 (de)	2005-07-21	Neue medizinische Indikation für Tachykinin-Antagonisten
US6455544B1 (en)	2002-09-24	Use of cholinesterase inhibitors to treat disorders of attention
EP0216555B1 (en)	1992-09-02	Use of dioxopiperidine derivatives in the treatment of anxiety, for the reduction of chronic abnormally high brain levels of serotonin or 5-hydroxy-indoleacetic acid, and in the treatment of bacterial or viral infections
AU2004283425B2 (en)	2010-07-08	Pharmaceutical composition comprising a monoamine neurotransmitter re-uptake inhibitor and an acetylcholinesterase inhibitor
WO2008112525A2 (en)	2008-09-18	Treatment of lysosomal storage diseases
AT3185U2 (de)	1999-11-25	Paroxetinmethansulfonat
US20090192142A1 (en)	2009-07-30	Use of carbamazepine derivatives for the treatment of agitation in dementia patients
SA98190747B1 (ar)	2006-11-04	توليفة من عوامل فعالة وبصفة خاصة tetrahydropyridine وعوامل مثبطة لانزيم acetylcholinesterase لعلاج عته الشيخويخة مثل عته الزهايمر alzheimer
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