RU95108547A - Бензолалкановые кислоты, промежуточные соединения, способ получения, фармацевтическая композиция - Google Patents
Бензолалкановые кислоты, промежуточные соединения, способ получения, фармацевтическая композицияInfo
- Publication number
- RU95108547A RU95108547A RU95108547/04A RU95108547A RU95108547A RU 95108547 A RU95108547 A RU 95108547A RU 95108547/04 A RU95108547/04 A RU 95108547/04A RU 95108547 A RU95108547 A RU 95108547A RU 95108547 A RU95108547 A RU 95108547A
- Authority
- RU
- Russia
- Prior art keywords
- alkyl
- ris
- production
- pharmaceutical composition
- intermediate compounds
- Prior art date
Links
- 150000001875 compounds Chemical class 0.000 title claims abstract 4
- UHOVQNZJYSORNB-UHFFFAOYSA-N monobenzene Natural products C1=CC=CC=C1 UHOVQNZJYSORNB-UHFFFAOYSA-N 0.000 title 2
- -1 Benzene alkane acids Chemical class 0.000 title 1
- 239000002253 acid Substances 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 201000001320 Atherosclerosis Diseases 0.000 claims abstract 2
- 239000005557 antagonist Substances 0.000 claims abstract 2
- 150000002148 esters Chemical class 0.000 claims abstract 2
- 150000003839 salts Chemical class 0.000 claims abstract 2
- 206010002388 Angina unstable Diseases 0.000 claims 1
- 206010038563 Reocclusion Diseases 0.000 claims 1
- 108010069102 Thromboxane-A synthase Proteins 0.000 claims 1
- 208000007814 Unstable Angina Diseases 0.000 claims 1
- 238000002399 angioplasty Methods 0.000 claims 1
- 239000003112 inhibitor Substances 0.000 claims 1
- 201000004332 intermediate coronary syndrome Diseases 0.000 claims 1
- DSNBHJFQCNUKMA-SCKDECHMSA-N thromboxane A2 Chemical compound OC(=O)CCC\C=C/C[C@@H]1[C@@H](/C=C/[C@@H](O)CCCCC)O[C@@H]2O[C@H]1C2 DSNBHJFQCNUKMA-SCKDECHMSA-N 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 abstract 2
- GVNVAWHJIKLAGL-UHFFFAOYSA-N 2-(cyclohexen-1-yl)cyclohexan-1-one Chemical compound O=C1CCCCC1C1=CCCCC1 GVNVAWHJIKLAGL-UHFFFAOYSA-N 0.000 abstract 1
- 206010002383 Angina Pectoris Diseases 0.000 abstract 1
- 101150065749 Churc1 gene Proteins 0.000 abstract 1
- 102100038239 Protein Churchill Human genes 0.000 abstract 1
- 239000003814 drug Substances 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 239000000126 substance Substances 0.000 abstract 1
- RZWIIPASKMUIAC-VQTJNVASSA-N thromboxane Chemical compound CCCCCCCC[C@H]1OCCC[C@@H]1CCCCCCC RZWIIPASKMUIAC-VQTJNVASSA-N 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/57—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C233/63—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
- C07C233/11—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to carbon atoms of an unsaturated carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
- C07C235/34—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
- C07C311/19—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
- C07C317/48—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pulmonology (AREA)
- Urology & Nephrology (AREA)
- Endocrinology (AREA)
- Vascular Medicine (AREA)
- Diabetes (AREA)
- Reproductive Health (AREA)
- Hematology (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
- Steroid Compounds (AREA)
Abstract
Соединения общей формулы, приведенной в описании, и их фармацевтически приемлемые соли и биолабильные эфиры являются антагонистами тромбоксана A, их применяют, в частности, в комбинации с ингибитором тромбоксансинтетазы для лечения атеросклероза и нестабильной стенокардии и для предотвращения реокклюзии после чрескожной пластической операции на сосудах.
Claims (1)
- Соединения общей формулы, приведенной в описании, и их фармацевтически приемлемые соли и биолабильные эфиры являются антагонистами тромбоксана A2, их применяют, в частности, в комбинации с ингибитором тромбоксансинтетазы для лечения атеросклероза и нестабильной стенокардии и для предотвращения реокклюзии после чрескожной пластической операции на сосудах.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB929220137A GB9220137D0 (en) | 1992-09-23 | 1992-09-23 | Therapeutic agents |
| GB9220137.5 | 1992-09-23 | ||
| PCT/EP1993/002488 WO1994006761A1 (en) | 1992-09-23 | 1993-09-14 | Benzenealkanoic acids for cardiovascular diseases |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| RU95108547A true RU95108547A (ru) | 1997-02-10 |
| RU2110512C1 RU2110512C1 (ru) | 1998-05-10 |
Family
ID=10722399
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| RU95108547A RU2110512C1 (ru) | 1992-09-23 | 1993-09-14 | Производные бензолалкановой кислоты и фармацевтическая композиция |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US5618941A (ru) |
| EP (1) | EP0662950B1 (ru) |
| JP (1) | JP2625262B2 (ru) |
| KR (1) | KR0169182B1 (ru) |
| CN (1) | CN1037176C (ru) |
| AT (1) | ATE162184T1 (ru) |
| AU (1) | AU666976B2 (ru) |
| BR (1) | BR9307091A (ru) |
| CA (1) | CA2145296C (ru) |
| CZ (1) | CZ72095A3 (ru) |
| DE (1) | DE69316380T2 (ru) |
| DK (1) | DK0662950T3 (ru) |
| EG (1) | EG20285A (ru) |
| ES (1) | ES2111176T3 (ru) |
| FI (1) | FI114862B (ru) |
| GB (1) | GB9220137D0 (ru) |
| GR (1) | GR3025909T3 (ru) |
| HU (1) | HUT70512A (ru) |
| IL (1) | IL106993A (ru) |
| MX (1) | MX9305843A (ru) |
| MY (1) | MY109576A (ru) |
| NO (1) | NO302698B1 (ru) |
| NZ (1) | NZ255412A (ru) |
| PL (1) | PL174431B1 (ru) |
| RU (1) | RU2110512C1 (ru) |
| TW (1) | TW283704B (ru) |
| WO (1) | WO1994006761A1 (ru) |
| YU (1) | YU60993A (ru) |
| ZA (1) | ZA936961B (ru) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO1998013347A1 (en) | 1996-09-26 | 1998-04-02 | Novartis Ag | Aryl-substituted acrylamides with leukotriene b4 (ltb-4) receptor antagonist activity |
| US5986136A (en) * | 1997-04-15 | 1999-11-16 | President And Fellows Of Harvard College | Photolabeling reagent |
| DE19848260C2 (de) * | 1998-10-20 | 2002-01-17 | Fumapharm Ag Muri | Fumarsäure-Mikrotabletten |
| DE10059418A1 (de) * | 2000-11-30 | 2002-06-20 | Aventis Pharma Gmbh | Ortho, meta-substituierte Bisarylverbindungen, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament sowie sie enthaltende pharmazeutische Zubereitungen |
| FR2827280B1 (fr) * | 2001-07-13 | 2003-10-31 | Servier Lab | Nouveaux derives de benzene sulfonamide, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| AU2003244913A1 (en) * | 2002-07-09 | 2004-01-23 | B.M.R.A. Corporation B.V. | Pharmaceutical combination of a thromboxane A2 receptor antagonist and a COX-2 inhibitor |
| CN1318507C (zh) * | 2003-03-04 | 2007-05-30 | 陈少岳 | 一种水晶树脂及其生产方法 |
| WO2005016334A1 (en) * | 2003-08-07 | 2005-02-24 | B.M.R.A. Corporation B.V. | Compositions and methods involving the combination of a thromboxane a2 receptor antagonist and an inhibitor of cyclooxigenase-1 |
| DE102004007358B4 (de) * | 2004-02-16 | 2017-10-12 | Chiron As | Kongenere, chlorierte, bromierte und/oder iodierte, fluorierte aromatische Verbindungen mit zwei Benzolringen in ihrer Grundstruktur, Verfahren zu ihrer Herstellung und ihre Verwendung |
| CN101160285A (zh) * | 2005-03-17 | 2008-04-09 | 辉瑞大药厂 | 适用于治疗疼痛的n-(n-磺酰氨基甲基)环丙烷甲酰胺衍生物 |
| US8551489B2 (en) | 2008-01-03 | 2013-10-08 | Musc Foundation For Research Development | Methods for the treatment of cancers |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2809377A1 (de) * | 1978-03-04 | 1979-09-13 | Boehringer Mannheim Gmbh | Phenoxyalkylcarbonsaeure-derivate, verfahren zu deren herstellung sowie diese verbindungen enthaltende arzneimittel |
| DE3000377A1 (de) * | 1980-01-07 | 1981-07-09 | Boehringer Mannheim Gmbh, 6800 Mannheim | Neue sulfonamide, verfahren zu deren herstellung sowie diese verbindungen enthaltende arzneimittel |
| DE3623944A1 (de) * | 1986-07-16 | 1988-02-11 | Thomae Gmbh Dr K | Neue benzolsulfonamido-indanylverbindungen, diese verbindungen enthaltende arzneimittel und verfahren zu ihrer herstellung |
| IL83230A (en) * | 1986-08-06 | 1992-06-21 | Tanabe Seiyaku Co | Phenoxyacetic acid derivatives,their preparation and pharmaceutical compositions containing them |
| DE68909958D1 (de) * | 1988-01-19 | 1993-11-25 | Tanabe Seiyaku Co | Phenoxyessigsäure-Derivate, ihre Herstellung, pharmazeutische Zusammensetzungen, die sie enthalten, und deren Verwendung. |
| DE3819052A1 (de) * | 1988-06-04 | 1989-12-07 | Basf Ag | Neue sulfonamid-derivate, ihre herstellung und verwendung |
| GB9107043D0 (en) * | 1991-04-04 | 1991-05-22 | Pfizer Ltd | Therapeutic agents |
| TW219358B (ru) * | 1991-12-20 | 1994-01-21 | Hokuriku Pharmaceutical |
-
1992
- 1992-09-23 GB GB929220137A patent/GB9220137D0/en active Pending
-
1993
- 1993-08-23 TW TW082106790A patent/TW283704B/zh active
- 1993-09-13 IL IL106993A patent/IL106993A/xx not_active IP Right Cessation
- 1993-09-14 DE DE69316380T patent/DE69316380T2/de not_active Expired - Fee Related
- 1993-09-14 DK DK93919328.0T patent/DK0662950T3/da active
- 1993-09-14 AT AT93919328T patent/ATE162184T1/de not_active IP Right Cessation
- 1993-09-14 ES ES93919328T patent/ES2111176T3/es not_active Expired - Lifetime
- 1993-09-14 CA CA002145296A patent/CA2145296C/en not_active Expired - Fee Related
- 1993-09-14 CZ CZ95720A patent/CZ72095A3/cs unknown
- 1993-09-14 JP JP6507788A patent/JP2625262B2/ja not_active Expired - Fee Related
- 1993-09-14 PL PL93308144A patent/PL174431B1/pl unknown
- 1993-09-14 KR KR1019950701124A patent/KR0169182B1/ko not_active Expired - Fee Related
- 1993-09-14 EP EP93919328A patent/EP0662950B1/en not_active Expired - Lifetime
- 1993-09-14 RU RU95108547A patent/RU2110512C1/ru active
- 1993-09-14 HU HU9500838A patent/HUT70512A/hu unknown
- 1993-09-14 WO PCT/EP1993/002488 patent/WO1994006761A1/en active IP Right Grant
- 1993-09-14 BR BR9307091A patent/BR9307091A/pt not_active Application Discontinuation
- 1993-09-14 NZ NZ255412A patent/NZ255412A/en unknown
- 1993-09-14 AU AU49600/93A patent/AU666976B2/en not_active Ceased
- 1993-09-14 US US08/397,063 patent/US5618941A/en not_active Expired - Fee Related
- 1993-09-21 ZA ZA936961A patent/ZA936961B/xx unknown
- 1993-09-21 MY MYPI93001915A patent/MY109576A/en unknown
- 1993-09-22 YU YU60993A patent/YU60993A/sh unknown
- 1993-09-22 EG EG61493A patent/EG20285A/xx active
- 1993-09-22 MX MX9305843A patent/MX9305843A/es unknown
- 1993-09-23 CN CN93117896A patent/CN1037176C/zh not_active Expired - Fee Related
-
1995
- 1995-03-21 NO NO951080A patent/NO302698B1/no not_active IP Right Cessation
- 1995-03-22 FI FI951341A patent/FI114862B/fi active IP Right Grant
-
1998
- 1998-01-15 GR GR980400028T patent/GR3025909T3/el unknown
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