MX9305843A - Acidos bencenalcanoicos para enfermedades cardiovasculares. - Google Patents
Acidos bencenalcanoicos para enfermedades cardiovasculares.Info
- Publication number
- MX9305843A MX9305843A MX9305843A MX9305843A MX9305843A MX 9305843 A MX9305843 A MX 9305843A MX 9305843 A MX9305843 A MX 9305843A MX 9305843 A MX9305843 A MX 9305843A MX 9305843 A MX9305843 A MX 9305843A
- Authority
- MX
- Mexico
- Prior art keywords
- carbon atoms
- alkyl
- benzenalcanoic
- acids
- cardiovascular diseases
- Prior art date
Links
- 208000024172 Cardiovascular disease Diseases 0.000 title 1
- 239000002253 acid Substances 0.000 title 1
- 150000007513 acids Chemical class 0.000 title 1
- 125000004432 carbon atom Chemical group C* 0.000 abstract 5
- 125000000217 alkyl group Chemical group 0.000 abstract 3
- 125000003118 aryl group Chemical group 0.000 abstract 2
- UUFQTNFCRMXOAE-UHFFFAOYSA-N 1-methylmethylene Chemical group C[CH] UUFQTNFCRMXOAE-UHFFFAOYSA-N 0.000 abstract 1
- 206010002388 Angina unstable Diseases 0.000 abstract 1
- 201000001320 Atherosclerosis Diseases 0.000 abstract 1
- 101100167062 Caenorhabditis elegans chch-3 gene Chemical group 0.000 abstract 1
- 206010038563 Reocclusion Diseases 0.000 abstract 1
- 108010069102 Thromboxane-A synthase Proteins 0.000 abstract 1
- 208000007814 Unstable Angina Diseases 0.000 abstract 1
- 125000003545 alkoxy group Chemical group 0.000 abstract 1
- 238000002399 angioplasty Methods 0.000 abstract 1
- 239000005557 antagonist Substances 0.000 abstract 1
- 125000003917 carbamoyl group Chemical group [H]N([H])C(*)=O 0.000 abstract 1
- 150000001875 compounds Chemical class 0.000 abstract 1
- 125000000753 cycloalkyl group Chemical group 0.000 abstract 1
- 150000002148 esters Chemical class 0.000 abstract 1
- 229910052736 halogen Inorganic materials 0.000 abstract 1
- 150000002367 halogens Chemical class 0.000 abstract 1
- 125000001072 heteroaryl group Chemical group 0.000 abstract 1
- 239000003112 inhibitor Substances 0.000 abstract 1
- 201000004332 intermediate coronary syndrome Diseases 0.000 abstract 1
- 230000002265 prevention Effects 0.000 abstract 1
- 150000003839 salts Chemical class 0.000 abstract 1
- DSNBHJFQCNUKMA-SCKDECHMSA-N thromboxane A2 Chemical compound OC(=O)CCC\C=C/C[C@@H]1[C@@H](/C=C/[C@@H](O)CCCCC)O[C@@H]2O[C@H]1C2 DSNBHJFQCNUKMA-SCKDECHMSA-N 0.000 abstract 1
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 abstract 1
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/57—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings
- C07C233/63—Carboxylic acid amides having carbon atoms of carboxamide groups bound to carbon atoms of rings other than six-membered aromatic rings having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A61P11/06—Antiasthmatics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P13/00—Drugs for disorders of the urinary system
- A61P13/02—Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/06—Antiarrhythmics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/08—Vasodilators for multiple indications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C233/00—Carboxylic acid amides
- C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
- C07C233/02—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals
- C07C233/11—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having nitrogen atoms of carboxamide groups bound to hydrogen atoms or to carbon atoms of unsubstituted hydrocarbon radicals with carbon atoms of carboxamide groups bound to carbon atoms of an unsaturated carbon skeleton containing six-membered aromatic rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C235/00—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms
- C07C235/02—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton
- C07C235/32—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings
- C07C235/34—Carboxylic acid amides, the carbon skeleton of the acid part being further substituted by oxygen atoms having carbon atoms of carboxamide groups bound to acyclic carbon atoms and singly-bound oxygen atoms bound to the same carbon skeleton the carbon skeleton containing six-membered aromatic rings having the nitrogen atoms of the carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
- C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
- C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
- C07C311/19—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by carboxyl groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C317/00—Sulfones; Sulfoxides
- C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
- C07C317/48—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton the carbon skeleton being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C2601/00—Systems containing only non-condensed rings
- C07C2601/02—Systems containing only non-condensed rings with a three-membered ring
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Veterinary Medicine (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pharmacology & Pharmacy (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Engineering & Computer Science (AREA)
- Cardiology (AREA)
- Heart & Thoracic Surgery (AREA)
- Pulmonology (AREA)
- Urology & Nephrology (AREA)
- Hematology (AREA)
- Vascular Medicine (AREA)
- Diabetes (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Steroid Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Los compuestos de la fórmula: (Ver Fórmula I); en donde R1, R2, R3 y R4son cada H o alquilo de 1 a 4 átomos de carbono; R5 es (CH2)mNHSO2R6 o(CH)mNHCOR6; R6 es alquilo de 1 a 6 átomos de carbono, cicloalquilo de 3 a6 átomos de carbono, opcionalmente sustituido con arilo, arilo oheteroarilo R7 es H, alquilo de 1 a 4 átomos de carbono, alcoxi de 1 a 4átomos de carbono, halógeno, CF3, OCF3, CN, CONH2 o S(O)n (alquilo de 1 a4 átomos de carbono; X es CH2, CHCH3, CH(OH), C(OH)CH3, C=CH2, CO u O; mes O o 1 y n es O, 1 o 2; y sus sales farmacéuticamente aceptables y susésteres biclábiles, son antagonistas del tromboxano A2, y tienen utilidad,particularmente en combinación con un inhibidor de tromboxano-sintetasa,en el tratamiento de la ateroesclerosis y angina inestable, y para laprevención de la reoclusión después de una angioplastia transluminalpercutánea.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB929220137A GB9220137D0 (en) | 1992-09-23 | 1992-09-23 | Therapeutic agents |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| MX9305843A true MX9305843A (es) | 1995-01-31 |
Family
ID=10722399
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX9305843A MX9305843A (es) | 1992-09-23 | 1993-09-22 | Acidos bencenalcanoicos para enfermedades cardiovasculares. |
Country Status (29)
| Country | Link |
|---|---|
| US (1) | US5618941A (es) |
| EP (1) | EP0662950B1 (es) |
| JP (1) | JP2625262B2 (es) |
| KR (1) | KR0169182B1 (es) |
| CN (1) | CN1037176C (es) |
| AT (1) | ATE162184T1 (es) |
| AU (1) | AU666976B2 (es) |
| BR (1) | BR9307091A (es) |
| CA (1) | CA2145296C (es) |
| CZ (1) | CZ72095A3 (es) |
| DE (1) | DE69316380T2 (es) |
| DK (1) | DK0662950T3 (es) |
| EG (1) | EG20285A (es) |
| ES (1) | ES2111176T3 (es) |
| FI (1) | FI114862B (es) |
| GB (1) | GB9220137D0 (es) |
| GR (1) | GR3025909T3 (es) |
| HU (1) | HUT70512A (es) |
| IL (1) | IL106993A (es) |
| MX (1) | MX9305843A (es) |
| MY (1) | MY109576A (es) |
| NO (1) | NO302698B1 (es) |
| NZ (1) | NZ255412A (es) |
| PL (1) | PL174431B1 (es) |
| RU (1) | RU2110512C1 (es) |
| TW (1) | TW283704B (es) |
| WO (1) | WO1994006761A1 (es) |
| YU (1) | YU60993A (es) |
| ZA (1) | ZA936961B (es) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0942903A1 (en) | 1996-09-26 | 1999-09-22 | Novartis AG | Aryl-substituted acrylamides with leukotriene b4 (ltb-4) receptor antagonist activity |
| US5986136A (en) * | 1997-04-15 | 1999-11-16 | President And Fellows Of Harvard College | Photolabeling reagent |
| DE10059418A1 (de) * | 2000-11-30 | 2002-06-20 | Aventis Pharma Gmbh | Ortho, meta-substituierte Bisarylverbindungen, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament sowie sie enthaltende pharmazeutische Zubereitungen |
| FR2827280B1 (fr) * | 2001-07-13 | 2003-10-31 | Servier Lab | Nouveaux derives de benzene sulfonamide, leur procede de preparation et les compositions pharmaceutiques qui les contiennent |
| JP2005533830A (ja) * | 2002-07-09 | 2005-11-10 | ビー．エム．アール．エイ． コーポレイション ベスローテン フェンノートシャップ | トロンボキサンａ２受容体アンタゴニストおよびｃｏｘ−２阻害剤の薬剤の組み合わせ |
| CN1318507C (zh) * | 2003-03-04 | 2007-05-30 | 陈少岳 | 一种水晶树脂及其生产方法 |
| CA2534316A1 (en) * | 2003-08-07 | 2005-02-24 | B.M.R.A. Corporation B.V. | Compositions and methods involving the combination of a thromboxane a2 receptor antagonist and an inhibitor of cyclooxygenase-1 |
| DE102004007358B4 (de) * | 2004-02-16 | 2017-10-12 | Chiron As | Kongenere, chlorierte, bromierte und/oder iodierte, fluorierte aromatische Verbindungen mit zwei Benzolringen in ihrer Grundstruktur, Verfahren zu ihrer Herstellung und ihre Verwendung |
| EA200701745A1 (ru) * | 2005-03-17 | 2008-06-30 | Пфайзер, Инк. | Циклопропанкарбоксамидные производные |
| GB0606201D0 (en) * | 2006-03-28 | 2006-05-10 | Karobio Ab | Improved crytalline material |
| US8551489B2 (en) | 2008-01-03 | 2013-10-08 | Musc Foundation For Research Development | Methods for the treatment of cancers |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE2809377A1 (de) * | 1978-03-04 | 1979-09-13 | Boehringer Mannheim Gmbh | Phenoxyalkylcarbonsaeure-derivate, verfahren zu deren herstellung sowie diese verbindungen enthaltende arzneimittel |
| DE3000377A1 (de) * | 1980-01-07 | 1981-07-09 | Boehringer Mannheim Gmbh, 6800 Mannheim | Neue sulfonamide, verfahren zu deren herstellung sowie diese verbindungen enthaltende arzneimittel |
| IL83230A (en) * | 1986-08-06 | 1992-06-21 | Tanabe Seiyaku Co | Phenoxyacetic acid derivatives,their preparation and pharmaceutical compositions containing them |
| DE68909958D1 (de) * | 1988-01-19 | 1993-11-25 | Tanabe Seiyaku Co | Phenoxyessigsäure-Derivate, ihre Herstellung, pharmazeutische Zusammensetzungen, die sie enthalten, und deren Verwendung. |
| DE3819052A1 (de) * | 1988-06-04 | 1989-12-07 | Basf Ag | Neue sulfonamid-derivate, ihre herstellung und verwendung |
| GB9107043D0 (en) * | 1991-04-04 | 1991-05-22 | Pfizer Ltd | Therapeutic agents |
| TW219358B (es) * | 1991-12-20 | 1994-01-21 | Hokuriku Pharmaceutical |
-
1992
- 1992-09-23 GB GB929220137A patent/GB9220137D0/en active Pending
-
1993
- 1993-08-23 TW TW082106790A patent/TW283704B/zh active
- 1993-09-13 IL IL106993A patent/IL106993A/xx not_active IP Right Cessation
- 1993-09-14 BR BR9307091A patent/BR9307091A/pt not_active Application Discontinuation
- 1993-09-14 US US08/397,063 patent/US5618941A/en not_active Expired - Fee Related
- 1993-09-14 JP JP6507788A patent/JP2625262B2/ja not_active Expired - Fee Related
- 1993-09-14 WO PCT/EP1993/002488 patent/WO1994006761A1/en active IP Right Grant
- 1993-09-14 DE DE69316380T patent/DE69316380T2/de not_active Expired - Fee Related
- 1993-09-14 ES ES93919328T patent/ES2111176T3/es not_active Expired - Lifetime
- 1993-09-14 HU HU9500838A patent/HUT70512A/hu unknown
- 1993-09-14 AU AU49600/93A patent/AU666976B2/en not_active Ceased
- 1993-09-14 PL PL93308144A patent/PL174431B1/pl unknown
- 1993-09-14 CA CA002145296A patent/CA2145296C/en not_active Expired - Fee Related
- 1993-09-14 EP EP93919328A patent/EP0662950B1/en not_active Expired - Lifetime
- 1993-09-14 NZ NZ255412A patent/NZ255412A/en unknown
- 1993-09-14 KR KR1019950701124A patent/KR0169182B1/ko not_active Expired - Fee Related
- 1993-09-14 CZ CZ95720A patent/CZ72095A3/cs unknown
- 1993-09-14 AT AT93919328T patent/ATE162184T1/de not_active IP Right Cessation
- 1993-09-14 RU RU95108547A patent/RU2110512C1/ru active
- 1993-09-14 DK DK93919328.0T patent/DK0662950T3/da active
- 1993-09-21 MY MYPI93001915A patent/MY109576A/en unknown
- 1993-09-21 ZA ZA936961A patent/ZA936961B/xx unknown
- 1993-09-22 YU YU60993A patent/YU60993A/sh unknown
- 1993-09-22 EG EG61493A patent/EG20285A/xx active
- 1993-09-22 MX MX9305843A patent/MX9305843A/es unknown
- 1993-09-23 CN CN93117896A patent/CN1037176C/zh not_active Expired - Fee Related
-
1995
- 1995-03-21 NO NO951080A patent/NO302698B1/no not_active IP Right Cessation
- 1995-03-22 FI FI951341A patent/FI114862B/fi active IP Right Grant
-
1998
- 1998-01-15 GR GR980400028T patent/GR3025909T3/el unknown
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