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RU95100773A - Новые сложные эфиры серной кислоты сахарных спиртов - Google Patents

Новые сложные эфиры серной кислоты сахарных спиртов

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Publication number
RU95100773A
RU95100773A RU95100773/04A RU95100773A RU95100773A RU 95100773 A RU95100773 A RU 95100773A RU 95100773/04 A RU95100773/04 A RU 95100773/04A RU 95100773 A RU95100773 A RU 95100773A RU 95100773 A RU95100773 A RU 95100773A
Authority
RU
Russia
Prior art keywords
general formula
salts
compounds
sulfuric acid
sugar alcohols
Prior art date
Application number
RU95100773/04A
Other languages
English (en)
Other versions
RU2139854C1 (ru
Inventor
Куколовски Александр
De]
Фингерле Юрген
Иберг Нигги
Петер Мэрки Ганс
Мюллер Рита
Ch]
Пех Михаель
Руж Марианн
Шмид Жерар
Чепп Томас
Петер Вессель Ганс
Original Assignee
Ф.Хоффманн-Ля Рош Аг (Ch)
Ф.Хоффманн-Ля Рош Аг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Ф.Хоффманн-Ля Рош Аг (Ch), Ф.Хоффманн-Ля Рош Аг filed Critical Ф.Хоффманн-Ля Рош Аг (Ch)
Publication of RU95100773A publication Critical patent/RU95100773A/ru
Application granted granted Critical
Publication of RU2139854C1 publication Critical patent/RU2139854C1/ru

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C323/00—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups
    • C07C323/50—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton
    • C07C323/51—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton
    • C07C323/57—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C323/58—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton
    • C07C323/59—Thiols, sulfides, hydropolysulfides or polysulfides substituted by halogen, oxygen or nitrogen atoms, or by sulfur atoms not being part of thio groups containing thio groups and carboxyl groups bound to the same carbon skeleton having the sulfur atoms of the thio groups bound to acyclic carbon atoms of the carbon skeleton the carbon skeleton being further substituted by nitrogen atoms, not being part of nitro or nitroso groups with amino groups bound to the carbon skeleton with acylated amino groups bound to the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C305/00—Esters of sulfuric acids
    • C07C305/02—Esters of sulfuric acids having oxygen atoms of sulfate groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C305/04—Esters of sulfuric acids having oxygen atoms of sulfate groups bound to acyclic carbon atoms of a carbon skeleton being acyclic and saturated
    • C07C305/10—Esters of sulfuric acids having oxygen atoms of sulfate groups bound to acyclic carbon atoms of a carbon skeleton being acyclic and saturated being further substituted by singly-bound oxygen atoms
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C305/00—Esters of sulfuric acids
    • C07C305/02—Esters of sulfuric acids having oxygen atoms of sulfate groups bound to acyclic carbon atoms of a carbon skeleton
    • C07C305/04—Esters of sulfuric acids having oxygen atoms of sulfate groups bound to acyclic carbon atoms of a carbon skeleton being acyclic and saturated
    • C07C305/06—Hydrogenosulfates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/16—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
    • C07C311/17—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by singly-bound oxygen atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/16—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton
    • C07C317/22—Sulfones; Sulfoxides having sulfone or sulfoxide groups and singly-bound oxygen atoms bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/26—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton
    • C07C317/32—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton
    • C07C317/34—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having sulfone or sulfoxide groups and amino groups bound to carbon atoms of six-membered aromatic rings being part of the same non-condensed ring or of a condensed ring system containing that ring
    • C07C317/36—Sulfones; Sulfoxides having sulfone or sulfoxide groups and nitrogen atoms, not being part of nitro or nitroso groups, bound to the same carbon skeleton with sulfone or sulfoxide groups bound to carbon atoms of six-membered aromatic rings of the carbon skeleton having sulfone or sulfoxide groups and amino groups bound to carbon atoms of six-membered aromatic rings being part of the same non-condensed ring or of a condensed ring system containing that ring with the nitrogen atoms of the amino groups bound to hydrogen atoms or to carbon atoms
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C317/00—Sulfones; Sulfoxides
    • C07C317/44—Sulfones; Sulfoxides having sulfone or sulfoxide groups and carboxyl groups bound to the same carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/04—Derivatives of thiourea
    • C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D307/00—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom
    • C07D307/02—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings
    • C07D307/34—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
    • C07D307/56—Heterocyclic compounds containing five-membered rings having one oxygen atom as the only ring hetero atom not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D307/68—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D311/00—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings
    • C07D311/02—Heterocyclic compounds containing six-membered rings having one oxygen atom as the only hetero atom, condensed with other rings ortho- or peri-condensed with carbocyclic rings or ring systems
    • C07D311/78—Ring systems having three or more relevant rings
    • C07D311/80—Dibenzopyrans; Hydrogenated dibenzopyrans
    • C07D311/82—Xanthenes

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Cardiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Vascular Medicine (AREA)
  • General Health & Medical Sciences (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Veterinary Medicine (AREA)
  • Urology & Nephrology (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Saccharide Compounds (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Furan Compounds (AREA)
  • Epoxy Compounds (AREA)
  • Pyrane Compounds (AREA)
  • Seasonings (AREA)
  • Steroid Compounds (AREA)
  • Laser Surgery Devices (AREA)

Abstract

Изобретение относится к новым сложным эфирам серной кислоты сахарных спиртов и соединениям, подобным сахарным спиртам, общей формулы I и к их солям. Кроме того, изобретение относится к фармацевтическим препаратам, содержащим соединения общей формулы I или его соль; к применению соединений общей формулы I и их солей в качестве лекарственных средств, в частности для лечения и/или профилактики артериосклеротических изменений стенок сосудов, например для предотвращения рестеноза после коронарных или периферических операций, связанных с обходным анастомозом; для получения лекарственных средств для указанных показаний; а также к способу получения соединений общей формулы I и их солей.

Claims (1)

  1. Изобретение относится к новым сложным эфирам серной кислоты сахарных спиртов и соединениям, подобным сахарным спиртам, общей формулы I и к их солям. Кроме того, изобретение относится к фармацевтическим препаратам, содержащим соединения общей формулы I или его соль; к применению соединений общей формулы I и их солей в качестве лекарственных средств, в частности для лечения и/или профилактики артериосклеротических изменений стенок сосудов, например для предотвращения рестеноза после коронарных или периферических операций, связанных с обходным анастомозом; для получения лекарственных средств для указанных показаний; а также к способу получения соединений общей формулы I и их солей.
RU95100773A 1994-01-14 1995-01-11 Сложные эфиры серной кислоты сахарных спиртов или их соли, лекарственные средства и способ получения соединений RU2139854C1 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
CH11494 1994-01-14
CH114/94 1994-01-14
CH331594 1994-11-07
CH3315/94 1994-11-07

Publications (2)

Publication Number Publication Date
RU95100773A true RU95100773A (ru) 1996-10-27
RU2139854C1 RU2139854C1 (ru) 1999-10-20

Family

ID=25683559

Family Applications (1)

Application Number Title Priority Date Filing Date
RU95100773A RU2139854C1 (ru) 1994-01-14 1995-01-11 Сложные эфиры серной кислоты сахарных спиртов или их соли, лекарственные средства и способ получения соединений

Country Status (21)

Country Link
US (1) US5521160A (ru)
EP (1) EP0663391B1 (ru)
JP (1) JP2862489B2 (ru)
KR (1) KR950032111A (ru)
CN (1) CN1043349C (ru)
AT (1) ATE151416T1 (ru)
AU (1) AU685196B2 (ru)
CA (1) CA2139720A1 (ru)
CZ (1) CZ8395A3 (ru)
DE (1) DE59500162D1 (ru)
DK (1) DK0663391T3 (ru)
ES (1) ES2101583T3 (ru)
FI (1) FI950127L (ru)
GR (1) GR3024012T3 (ru)
HU (1) HUT72412A (ru)
IL (1) IL112284A (ru)
NO (1) NO302817B1 (ru)
NZ (1) NZ270316A (ru)
RU (1) RU2139854C1 (ru)
TW (1) TW308598B (ru)
UA (1) UA42696C2 (ru)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2174582A1 (en) * 1995-05-05 1996-11-06 Alexander Chucholowski Sulphuric acid esters of amino-sugars
TR199600329A2 (tr) * 1995-05-05 1997-03-21 Hoffmann La Roche Seker alkollerin yeni sülfürik asit esterleri.
US6245814B1 (en) 1998-05-08 2001-06-12 Calyx Therapeutics, Inc. Diphenylethylene compounds
US6624197B1 (en) 1998-05-08 2003-09-23 Calyx Therapeutics, Inc. Diphenylethylene compounds
US7105552B2 (en) * 1998-05-08 2006-09-12 Theracos, Inc. Heterocyclic analogs of diphenylethylene compounds
US6331633B1 (en) 1998-05-08 2001-12-18 Calyx Therapeutics Inc. Heterocyclic analogs of diphenylethylene compounds
WO2000015214A1 (en) * 1998-09-11 2000-03-23 Ilexus Pty Limited Fc RECEPTOR MODULATORS AND USES THEREOF
US7407978B2 (en) * 1999-04-06 2008-08-05 Theracos, Inc. Heterocyclic analogs of diphenylethylene compounds
US20020002200A1 (en) * 2000-02-04 2002-01-03 Bishwagit Nag Novel diphenylethylene compounds
US7323496B2 (en) * 1999-11-08 2008-01-29 Theracos, Inc. Compounds for treatment of inflammation, diabetes and related disorders
US6525093B1 (en) * 1999-11-08 2003-02-25 Calyx Therapeutics Inc. Compounds to treat diabetes and associated conditions
US20080108825A1 (en) * 1999-11-08 2008-05-08 Theracos, Inc. Compounds for treatment of inflammation, diabetes and related disorders
US20080103302A1 (en) * 2000-02-04 2008-05-01 Theracos, Inc. Compounds for treatment of inflammation, diabetes and related disorders
EP1360167A1 (en) * 2001-01-16 2003-11-12 Guilford Pharmaceuticals Inc. Symmetrically disubstituted aromatic compounds and pharmaceutical compositions for inhibiting poly (adp-ribose) glycohydrolase, and methods for their use
GB0228410D0 (en) 2002-12-05 2003-01-08 Glaxo Group Ltd Novel Compounds
WO2004052962A1 (ja) * 2002-12-11 2004-06-24 Nissan Chemical Industries, Ltd. 新規なジアミノベンゼン誘導体、それを用いたポリイミド前駆体およびポリイミド、並びに液晶配向処理剤
JP6051998B2 (ja) * 2012-03-30 2016-12-27 日油株式会社 マルチアーム型ポリエチレングリコール誘導体、その中間体及び製造方法
JP6293127B2 (ja) * 2012-05-22 2018-03-14 イッサム リサーチ ディベロップメント カンパニー オブ ザ ヘブリュー ユニバーシティー オブ エルサレム リミテッド 未分化細胞の選択的阻害剤
CN110092737B (zh) * 2018-01-31 2022-06-17 海思美域(深圳)科技有限公司 一种抗静电化合物、材料的表面处理方法及改性材料

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE3734853A1 (de) * 1987-10-14 1989-04-27 Luitpold Werk Chem Pharm Bis-aldonsaeureamide und verfahren zu ihrer herstellung
DE3734815A1 (de) * 1987-10-14 1989-04-27 Luitpold Werk Chem Pharm Polyschwefelsaeureester von bis-aldonsaeureamiden und deren derivaten, verfahren zu ihrer herstellung und arzneimittel
US5298616A (en) * 1990-10-03 1994-03-29 Hoffmann-La Roche Inc. Sulfated O-polysaccharide-trehaloses
CA2061370A1 (en) * 1991-03-13 1992-09-14 Markus Hosang Pharmaceutical preparations

Also Published As

Publication number Publication date
DK0663391T3 (da) 1997-10-20
CN1043349C (zh) 1999-05-12
EP0663391B1 (de) 1997-04-09
EP0663391A1 (de) 1995-07-19
NO950137D0 (no) 1995-01-13
CN1109889A (zh) 1995-10-11
JPH07206803A (ja) 1995-08-08
GR3024012T3 (en) 1997-10-31
US5521160A (en) 1996-05-28
DE59500162D1 (de) 1997-05-15
NZ270316A (en) 1996-08-27
NO950137L (no) 1995-07-17
ATE151416T1 (de) 1997-04-15
CZ8395A3 (en) 1995-11-15
TW308598B (ru) 1997-06-21
KR950032111A (ko) 1995-12-20
IL112284A (en) 1998-10-30
UA42696C2 (ru) 2001-11-15
CA2139720A1 (en) 1995-07-15
FI950127A0 (fi) 1995-01-11
IL112284A0 (en) 1995-03-30
NO302817B1 (no) 1998-04-27
AU685196B2 (en) 1998-01-15
AU1010695A (en) 1995-07-27
FI950127L (fi) 1995-07-15
JP2862489B2 (ja) 1999-03-03
ES2101583T3 (es) 1997-07-01
HUT72412A (en) 1996-04-29
RU2139854C1 (ru) 1999-10-20

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