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RU94046057A - Ингибиторы активности тестостерон 5 альфа -редуктазы, фармкомпозиция, способ подавления активности, тестостерон 5 альфа -редуктазы - Google Patents

Ингибиторы активности тестостерон 5 альфа -редуктазы, фармкомпозиция, способ подавления активности, тестостерон 5 альфа -редуктазы

Info

Publication number
RU94046057A
RU94046057A RU94046057/04A RU94046057A RU94046057A RU 94046057 A RU94046057 A RU 94046057A RU 94046057/04 A RU94046057/04 A RU 94046057/04A RU 94046057 A RU94046057 A RU 94046057A RU 94046057 A RU94046057 A RU 94046057A
Authority
RU
Russia
Prior art keywords
testosterone
activity
reductase
pharmcomposition
inhibitors
Prior art date
Application number
RU94046057/04A
Other languages
English (en)
Other versions
RU2141967C1 (ru
Inventor
Лабри Фернан
Ca]
Меран Ив
М.Сингх Шанкар
Original Assignee
Андорешерш Инк. (CA)
Андорешерш Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Андорешерш Инк. (CA), Андорешерш Инк. filed Critical Андорешерш Инк. (CA)
Publication of RU94046057A publication Critical patent/RU94046057A/ru
Application granted granted Critical
Publication of RU2141967C1 publication Critical patent/RU2141967C1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07J—STEROIDS
    • C07J73/00—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms
    • C07J73/001—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom
    • C07J73/005—Steroids in which the cyclopenta[a]hydrophenanthrene skeleton has been modified by substitution of one or two carbon atoms by hetero atoms by one hetero atom by nitrogen as hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/56—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids
    • A61K31/58—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids containing heterocyclic rings, e.g. danazol, stanozolol, pancuronium or digitogenin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system
    • A61P5/24—Drugs for disorders of the endocrine system of the sex hormones

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Diabetes (AREA)
  • Endocrinology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

Ингибитор активности тестостерон 5альфа редуктазы, например формулы (I), где новыми заместителями являются R, R, R, Rи/иликоторые полезны при лечении заболеваний, развитию которых способствует активация андрогенных рецепторов, например, рак простаты, доброкачественная гиперплазия простаты, воспаление сальной железы, себорея, ненормальная волосатость, андрогенное облысение и тому подобное.

Claims (1)

  1. Ингибитор активности тестостерон 5альфа редуктазы, например формулы (I), где новыми заместителями являются R4, R4, R7, R17альфа и/или 17бета которые полезны при лечении заболеваний, развитию которых способствует активация андрогенных рецепторов, например, рак простаты, доброкачественная гиперплазия простаты, воспаление сальной железы, себорея, ненормальная волосатость, андрогенное облысение и тому подобное.
RU94046057A 1992-05-21 1993-05-06 ИНГИБИТОРЫ ТЕСТОСТЕРОН 5α-РЕДУКТАЗЫ, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ И СПОСОБ ИНГИБИРОВАНИЯ АКТИВНОСТИ ТЕСТОСТЕРОН 5α-РЕДУКТАЗЫ RU2141967C1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US88696192A 1992-05-21 1992-05-21
US886,961 1992-05-21
PCT/CA1993/000192 WO1993023053A1 (en) 1992-05-21 1993-05-06 INHIBITORS OF TESTOSTERONE 5α-REDUCTASE ACTIVITY

Publications (2)

Publication Number Publication Date
RU94046057A true RU94046057A (ru) 1996-10-10
RU2141967C1 RU2141967C1 (ru) 1999-11-27

Family

ID=25390152

Family Applications (1)

Application Number Title Priority Date Filing Date
RU94046057A RU2141967C1 (ru) 1992-05-21 1993-05-06 ИНГИБИТОРЫ ТЕСТОСТЕРОН 5α-РЕДУКТАЗЫ, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ И СПОСОБ ИНГИБИРОВАНИЯ АКТИВНОСТИ ТЕСТОСТЕРОН 5α-РЕДУКТАЗЫ

Country Status (20)

Country Link
US (1) US5494914A (ru)
EP (1) EP0641211A1 (ru)
JP (1) JPH07506575A (ru)
KR (1) KR950701527A (ru)
AU (1) AU4258493A (ru)
CA (1) CA2136304A1 (ru)
CZ (1) CZ286894A3 (ru)
FI (1) FI945457A (ru)
HU (1) HUT71514A (ru)
IL (1) IL105721A0 (ru)
NO (1) NO306619B1 (ru)
NZ (1) NZ247598A (ru)
PH (1) PH30247A (ru)
PL (1) PL175591B1 (ru)
RU (1) RU2141967C1 (ru)
SK (1) SK140494A3 (ru)
TW (1) TW239145B (ru)
UA (1) UA35589C2 (ru)
WO (1) WO1993023053A1 (ru)
ZA (2) ZA933441B (ru)

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CA2136304A1 (en) 1993-11-25
AU4258493A (en) 1993-12-13
TW239145B (ru) 1995-01-21
NO306619B1 (no) 1999-11-29
HUT71514A (en) 1995-12-28
NO944458L (no) 1995-01-09
ZA933441B (en) 1994-11-18
US5494914A (en) 1996-02-27
FI945457A0 (fi) 1994-11-21
EP0641211A1 (en) 1995-03-08
NO944458D0 (no) 1994-11-21
FI945457A (fi) 1995-01-16
KR950701527A (ko) 1995-04-28
PL175591B1 (pl) 1999-01-29
CZ286894A3 (en) 1995-09-13
NZ247598A (en) 1995-12-21
ZA933545B (en) 1994-11-21
SK140494A3 (en) 1995-07-11
IL105721A0 (en) 1993-09-22
PH30247A (en) 1997-02-05
UA35589C2 (ru) 2001-04-16

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