RU2388225C2 - Композиции и способы борьбы с насекомыми - Google Patents
Композиции и способы борьбы с насекомыми Download PDFInfo
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- RU2388225C2 RU2388225C2 RU2005133393/15A RU2005133393A RU2388225C2 RU 2388225 C2 RU2388225 C2 RU 2388225C2 RU 2005133393/15 A RU2005133393/15 A RU 2005133393/15A RU 2005133393 A RU2005133393 A RU 2005133393A RU 2388225 C2 RU2388225 C2 RU 2388225C2
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- 108020003175 receptors Proteins 0.000 claims abstract 7
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Classifications
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/44—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing at least one carboxylic group or a thio analogue, or a derivative thereof, and a nitrogen atom attached to the same carbon skeleton by a single or double bond, this nitrogen atom not being a member of a derivative or of a thio analogue of a carboxylic group, e.g. amino-carboxylic acids
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- A—HUMAN NECESSITIES
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- A—HUMAN NECESSITIES
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- A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
- A01N31/04—Oxygen or sulfur attached to an aliphatic side-chain of a carbocyclic ring system
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- A—HUMAN NECESSITIES
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- A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
- A01N31/08—Oxygen or sulfur directly attached to an aromatic ring system
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N31/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic oxygen or sulfur compounds
- A01N31/08—Oxygen or sulfur directly attached to an aromatic ring system
- A01N31/16—Oxygen or sulfur directly attached to an aromatic ring system with two or more oxygen or sulfur atoms directly attached to the same aromatic ring system
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- A—HUMAN NECESSITIES
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- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N35/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical
- A01N35/02—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical containing aliphatically bound aldehyde or keto groups, or thio analogues thereof; Derivatives thereof, e.g. acetals
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- A—HUMAN NECESSITIES
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- A01N35/06—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having two bonds to hetero atoms with at the most one bond to halogen, e.g. aldehyde radical containing keto or thioketo groups as part of a ring, e.g. cyclohexanone, quinone; Derivatives thereof, e.g. ketals
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- A—HUMAN NECESSITIES
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- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N37/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids
- A01N37/18—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom having three bonds to hetero atoms with at the most two bonds to halogen, e.g. carboxylic acids containing the group —CO—N<, e.g. carboxylic acid amides or imides; Thio analogues thereof
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- A—HUMAN NECESSITIES
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- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
- A01N43/24—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with two or more hetero atoms
- A01N43/26—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with two or more hetero atoms five-membered rings
- A01N43/28—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with two or more hetero atoms five-membered rings with two hetero atoms in positions 1,3
- A01N43/30—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with two or more hetero atoms five-membered rings with two hetero atoms in positions 1,3 with two oxygen atoms in positions 1,3, condensed with a carbocyclic ring
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N49/00—Biocides, pest repellants or attractants, or plant growth regulators, containing compounds containing the group, wherein m+n>=1, both X together may also mean —Y— or a direct carbon-to-carbon bond, and the carbon atoms marked with an asterisk are not part of any ring system other than that which may be formed by the atoms X, the carbon atoms in square brackets being part of any acyclic or cyclic structure, or the group, wherein A means a carbon atom or Y, n>=0, and not more than one of these carbon atoms being a member of the same ring system, e.g. juvenile insect hormones or mimics thereof
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- A—HUMAN NECESSITIES
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Abstract
Изобретение включает композиции, способы и клеточные линии, имеющие отношение к борьбе с насекомыми. Сущность изобретения включает композиции, содержащие растительные эфирные масла, целенаправленно воздействующие, по крайней мере, на один рецептор насекомых, выбранный из числа рецептора тирамина, обонятельного рецептора Or83b или обонятельного рецептора Or43a, следствием чего является изменение у насекомых внутриклеточных уровней цАМФ, Са2+ или обоих. Также изобретение включает способ борьбы с насекомыми, линию клеток насекомых, включающую последовательность нуклеиновой кислоты вышеуказанных рецепторов и способы отбора композиции по активности в отношении насекомых с использованием указанной линии клеток насекомых. Преимущество изобретения заключается в разработке более мягких, щадящих композиций, не являющихся токсичными для млекопитающих и других видов. 5 н. и 15 з.п. ф-лы, 35 табл., 33 ил.
Description
Claims (20)
1. Композиция для борьбы с насекомыми, включающая, по крайней мере, два масла, при этом упомянутые два масла, по крайней мере, являются маслами, выбранными из группы, включающей t-анетол, масло из семян спороболуса вытянутого, камфен, карвакрол, d-карвон, l-карвон, 1,8-цинеол, р-цимен, диэтилфталат, эвгенол, гераниол, изопропилцитрат, масло сорго лимонного, масло из цветков сирени, лаймовое масло, d-лимонен, линалилантранилат, линалоол, линденол, метилцитрат, метилдигидрожасмонат, мирцен, периллиловый спирт, фенилацеталь-дегид, α-пинен, β-пинен, пиперональ, пиперонил, пиперонилацетат, пиперониловый спирт, пиперониламин, хинин, сабинен, α-терпинен, терпинен 900, α-терпинеол, гамма-терпинеол, 2-tret-бутил-р-хинон, α-туйон, тимьяновое масло и тимол, причем композиция целенаправленно воздействует на, по крайней мере, один рецептор насекомых, выбранный из числа рецептора тирамина, обонятельного рецептора Or83b или обонятельного рецептора Or43a, следствием чего является изменение у упомянутых насекомых внутриклеточных уровней цАМФ, Ca2+ или того и другого и, по крайней мере, упомянутые два масла характеризуются синергетическим эффектом активности.
2. Композиция по п.1, отличающаяся тем, что обработка упомянутой композицией оказывает репеллентное действие.
3. Композиция по п.1, отличающаяся тем, что обработка упомянутой композицией оказывает пестицидное действие.
4. Композиция по п.1, дополнительно включающая, по крайней мере, одно нелетучее масло.
5. Композиция по п.1, в которой масла предпочтительно выбирают из: около 44% по весу масла цветков сирени, около 10% по весу гераниола, около 2% по весу масла тимьяна, и около 44% по весу масла тмина.
6. Композиция по п.1, в которой масла предпочтительно выбирают из: около 20% до 50% по весу d-лимонена, около 20% по весу масла тимьяна, около 20% по весу гераниола, около 20% по весу α-пинена, и около 20% по весу p-цимена.
7. Композиция по п.1, далее включающая фенилацетальдегид, в которой масла предпочтительно выбирают из: около 10% по весу d-лимонена, около 30% по весу масла тимьяна, около 35% по весу гераниола, около 10% по весу α-пинена, и около 5% по весу фенилацетальдегида.
8. Композиция по п.1, в которой масла предпочтительно выбирают из: около 50% по весу гераниола, около 40% по весу масла тимьяна, около 10% по весу масло из семян спороболуса вытянутого.
9. Композиция по п.1, в которой масла предпочтительно выбирают из: около 20% по весу d-лимонена, около 10% по весу линденола, около 10% по весу евгенола, около 10% по весу фенилацетальдегида, и около 50% по весу гераниола.
10. Композиция по п.1, в которой масла предпочтительно выбирают из: около 15% по весу d-лимонена, около 50% по весу гераниола, около 15% по весу α-пинена, около 15% по весу р-цимена, и около 5% по весу фенилацетальдегида.
11. Композиция по п.1, в которой масла предпочтительно выбирают из: α-туйона, α-пинена, сабинена, β-пинена, p-цимена и лимонена.
12. Композиция по п.1, в которой масла предпочтительно выбирают из: диэтилфталата, α-терпениола, пиперонала, линалоола, гамма-терпениола, метилдигидрожасмоната, метилцитрата, изопропилцитрата.
13. Композиция по п.1 для борьбы с насекомыми, содержащая: около 10% по весу DEET, около 18% по весу d-лимонена, около 18% по весу масла тимьяна, около 20% по весу гераниола, около 20% по весу α-пинена, и около 18% по весу p-цимена.
14. Композиция по п.1, в которой, по крайней мере, два растительных эфирных масла являются маслом из цветков сирени и маслом из семян спороболуса.
15. Композиция по п.1, в которой, по крайней мере, два растительных эфирных масла являются тимьяновым маслом, маслом из цветков сирени, и d-лимоненом.
16. Композиция по п.1, в которой, по крайней мере, одно растительное эфирное масло содержится в количестве от 18 до 50%, при этом, по крайней мере, этим растительным эфирным маслом является d-лимонен; другим, по крайней мере, растительным эфирным маслом является тимьяновое масло в количестве от 2 до 50%; другим, по крайней мере, растительным эфирным маслом является гераниол в количестве от 18 до 70%; другим, по крайней мере, растительным эфирным маслом является масло из цветков сирени в количестве от 40 до 50%; другим, по крайней мере, растительным эфирным маслом является масло из семян спороболуса в количестве от 50 до 75%.
17. Способ борьбы с насекомыми, включающий:
обеспечение композиции по п.1, и
воздействие на насекомых упомянутой композицией в концентрации, достаточной для оказания репелентного или пестицидного воздействия.
обеспечение композиции по п.1, и
воздействие на насекомых упомянутой композицией в концентрации, достаточной для оказания репелентного или пестицидного воздействия.
18. Линия клеток насекомых Drosophila Schneider, включающая нуклеиновокислотную последовательность, выбираемую из: нуклеиновокислотной последовательности рецептора тирамина, представленной на Фиг.31А и Фиг.31В; нуклеиновокислотной последовательности обонятельного рецептора Ог43а, представленной на Фиг.32А и Фиг.32В; нуклеиновокислотной последовательности обонятельного рецептора Or83b, представленной на Фиг.33А и Фиг.33В.
19. Способ отбора композиций по активности в отношении насекомых, включающий добавление упомянутых композиций к клеткам насекомых линии Drosophila Schneider по п.18;
подготовку клеток насекомых, экспрессирующих рецептор, выбранный из группы, включающей рецептор тирамина, обонятельный рецептор Or83b и обонятельный рецептор Or43a;
добавление упомянутых композиций к клеткам;
определение афинности связывания упомянутых композиций с рецептором; и
отбор композиций, обладающих сродством к рецептору.
подготовку клеток насекомых, экспрессирующих рецептор, выбранный из группы, включающей рецептор тирамина, обонятельный рецептор Or83b и обонятельный рецептор Or43a;
добавление упомянутых композиций к клеткам;
определение афинности связывания упомянутых композиций с рецептором; и
отбор композиций, обладающих сродством к рецептору.
20. Способ отбора композиций по активности в отношении насекомых, включающий добавление упомянутых композиций к клеткам насекомых линии Drosophila Schneider по п.18;
подготовку клеток насекомых, экспрессирующих рецептор, выбранный из группы, включающей рецептор тирамина, обонятельный рецептор Or83b и обонятельный рецептор Or43a;
добавление упомянутых композиций к клеткам;
экстрагирование внутриклеточного цАМФ или Са2+ из клеток;
определение внутриклеточных уровней цАМФ или Са2+;
сравнение внутриклеточных уровней цАМФ или Са2+ в клетках, обработанных упомянутыми композициями, с внутриклеточными уровнями цАМФ или Са2+ в необработанных клетках; и
выбор композиций, обработка которыми вызывает изменение внутриклеточных уровней цАМФ или Са2+ либо обоих.
подготовку клеток насекомых, экспрессирующих рецептор, выбранный из группы, включающей рецептор тирамина, обонятельный рецептор Or83b и обонятельный рецептор Or43a;
добавление упомянутых композиций к клеткам;
экстрагирование внутриклеточного цАМФ или Са2+ из клеток;
определение внутриклеточных уровней цАМФ или Са2+;
сравнение внутриклеточных уровней цАМФ или Са2+ в клетках, обработанных упомянутыми композициями, с внутриклеточными уровнями цАМФ или Са2+ в необработанных клетках; и
выбор композиций, обработка которыми вызывает изменение внутриклеточных уровней цАМФ или Са2+ либо обоих.
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- 2004-04-26 BR BRPI0410491A patent/BRPI0410491A8/pt not_active Application Discontinuation
- 2004-04-26 AU AU2004238220A patent/AU2004238220B2/en not_active Expired
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JP2007502860A (ja) | 2007-02-15 |
BRPI0410491A8 (pt) | 2017-10-24 |
EP2533046A1 (en) | 2012-12-12 |
US20080075796A1 (en) | 2008-03-27 |
EP1624881A1 (en) | 2006-02-15 |
US8507013B2 (en) | 2013-08-13 |
HK1089086A1 (en) | 2006-11-24 |
WO2004100971A1 (en) | 2004-11-25 |
AU2004238220A1 (en) | 2004-11-25 |
RU2005133393A (ru) | 2006-06-10 |
EP1624881A4 (en) | 2010-01-06 |
BRPI0410491A (pt) | 2006-06-13 |
US7541155B2 (en) | 2009-06-02 |
AU2004238220B2 (en) | 2009-05-28 |
US20090232918A1 (en) | 2009-09-17 |
US20050008714A1 (en) | 2005-01-13 |
JP2011201898A (ja) | 2011-10-13 |
US20110217397A1 (en) | 2011-09-08 |
CA2523489A1 (en) | 2004-11-25 |
OA13160A (en) | 2006-12-13 |
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