RU212642U1 - Device for inhalation treatment of endobronchitis in experiment - Google Patents

Abstract

The device relates to medicine, namely to experimental surgery, and is designed to perform inhalation treatment of endobronchitis in an experiment on small laboratory animals. The device consists of a compressor, a container with a medicinal substance, connecting tubes. The cap allows the animal to move freely under it, in the upper part of the cap there is a pressure compensator valve, perpendicular to the walls of the cap, on its lower surface there are at least two protrusion locks at an angle of 90° with an area of at least five square centimeters each. The device is compact, mobile, does not interfere with the natural movements of the animal, allows you to perform an inhalation treatment session in any laboratory, even with minimal equipment. The device is simple and cheap to manufacture.

Description

The device relates to medicine, namely to experimental surgery, and is designed to perform inhalation treatment of endobronchitis in an experiment on small laboratory animals.

A known method of inhalation administration of drugs using a nebulizer in humans [Guide for physicians: In 4 v. Edited by N.R. Paleev. General pulmonology N.I. Alexandrova, A.G. Bobkov, N.A. Bogdanov and others, ed. N.V. Putov. M. Medicine, 1989. P. 541], but the use of this device when working with small laboratory animals in the experiment is impossible, since the size of the mask and its shape do not allow creating a closed space for inhaling medicinal substances, preventing their dispersion and a sharp decrease in concentration. Behavioral stress reactions in animals do not allow to keep them in place, rigid fixation exacerbates stress and makes breathing difficult due to the unnatural position of the animal.

A device for conducting inhalation anesthesia in rats is known [patent for PM RU No. 148362]. The model consists of a latex balloon, a device for precise dosing of infusion and a system for intravenous blood transfusion. The latex balloon is filled with a gas mixture for inhalation anesthesia up to a volume of 4000 ml. One end of the precision dosing device is tightly fixed to the ball. The roller regulator of the precision dosing device is pre-tested to determine the position that allows the passage of 100-120 ml of a gas mixture. An intravenous blood transfusion system is connected to the Luer end of the precision dosing device. The drop chamber on the system is partially cut off and serves as a mask for the animal.

In a device for the introduction of inhalation anesthesia to small laboratory animals [PM RU No. 103726], including an inlet tube, a latch clamp, needles, a cylindrical anesthesia mask made of transparent material, and its diameter must be at least 14 mm and a depth of at least 40 mm The main element of the delivery of medicinal substances to the respiratory system is also a mask.

The disadvantage of using such devices for performing therapeutic inhalations is the need to fix the animal to eliminate the sliding of the mask from its muzzle and the inappropriate direction past the respiratory tract of the flow of medicinal substances suspended in the air mixture.

The technical result of the proposed utility model is the possibility of non-contact inhalation administration of medicines to small laboratory animals, without performing their rigid fixation.

The device includes a cord (1) for connection to the mains; compressor nebulizer - inhaler MED 2000 p5 (2); tube (3) for air supply; container (4) with medicinal substance; a tube (5) for supplying an inhalation mixture; cap (6), creating a closed space above the experimental field, which is placed on the animal; hole (7) for the inlet of the tube for supplying inhalation steam; pressure compensator valve (8); cap retainers (9).

The principle of operation is the following. Connect the compressor nebulizer (2) to the network by means of a cord (1). A solution of the medicinal substance is added to the container (4), the animal with simulated endobronchitis is placed under the cap (6), on a flat surface, which can be designated as an experimental field. The working mixture, including air and vapors of the medicinal substance, is fed through the tube (5) and the hole (7) under the cap (6). At the exit from the hole (7), the pressure drops, and the speed of the jet of the working mixture increases significantly, which leads to the creation of a reduced pressure under the cap (6) and the free flow of the working mixture from the nebulizer (2) through the container (4) with the medicinal substance. To avoid oversaturation with liquid vapor and fogging of the space under the cap (6), it is equipped with a pressure compensator valve (8) located in the center of the cap (6). The animal has the ability to move freely inside the cap (6), but cannot go beyond it, since the cap (6) is equipped with clamps (9) that allow it to be pressed tightly against the surface of the conditional experimental field - any flat surface, for example, a table, bedside table. As a basis for creating a cap (6), you can use a cover for dishes in a microwave oven or any other product made of transparent plastic. The retainers (9) are protrusions located at an angle of 90° with respect to the walls of the cap (6), the area of which is at least five cm ² . Any methods of fixing the cap (6) on a flat surface using clamps (9) are acceptable, for example, placing an object weighing more than a kilogram on the clamps - a weight, a book that cannot be moved by a small laboratory animal. There must be at least two latches; the latches are located on diametrically opposite stacks of the cap (6).

Thus, the proposed device is compact, mobile, does not interfere with the natural movements of the animal, allows you to perform an inhalation treatment session in any laboratory, even with minimal equipment. The device is simple and cheap to manufacture.

Description for the figures

Fig. 1. General view of the device:

1) cord for connecting to the mains;

2) compressor nebulizer - inhaler MED 2000 P5;

3) tube for air supply;

4) a container with a medicinal substance;

5) a tube for supplying an inhalation mixture;

6) a cap that creates a closed space above the experimental field, on which the animal is placed;

7) an opening for the inlet of a tube for supplying inhalation steam;

8) pressure compensator valve;

9) hood clamps.

Claims (1)

A device for the treatment of endobronchitis in small laboratory animals in the experiment, consisting of a compressor nebulizer, a container with a medicinal substance, connecting tubes, characterized in that it has a cap for free movement of the animal under it, in the upper part of the cap there is a pressure compensator valve, perpendicular to the walls of the cap, at least two retainers are located on its lower surface, which are protrusions at an angle of 90° with respect to the walls of the cap with an area of at least five square centimeters each, made with the possibility of pressing the cap to a flat surface.

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