FR2879094A1 - Anesthetic gas-inducing device for rodent to allow gradually from a conscious state to a anesthetized state, comprises isolation cell with pin connection sockets, induction cylinder, anesthetic gas generator, mobile and principal bodies - Google Patents

Abstract

The induction of anesthetic gas and the cell are auxiliary equipment of the generator and connected to sockets of coaxial duct which allows independent circulation of the halogenated gases and to a system of extraction of polluted gases. The independent circulation of the gases is prohibited if the sockets are disconnected. The induction of anesthetic gas has mobile parts comprising moving and fixed parts integrated into frame. The cylinder is removed from the moving part by dismantling. The fixed part is provided with central and peripheral channels for allowing free circulation of halogenated and residual halogenated gases. The moving part is assembled on the principal body by pivot with 90[deg] rotation. The induction of gases is operational during the passage of the induction cylinder from the horizontal to vertical position. The mobile body is equipped with a cam and a valve for controlling the opening or the closing of the passage of gases. The isolation cell has moving parts adapted to the principal body, which is equipped with an adjustment wheel supported by fixed frame, which can be removed in order to, be transferred to a unit of acquisition of medical imagery data. The removable parts and principal body are connected with drillings and thermally insulated double circuit. The cell is provided with a cone and a channel equipped with stopper. The maintenance tunnel is equipped with another channel for the passage of gases delivered at the cone outlet and inclined along its longitudinal axis. The wheel adjusts the minimum and maximum extraction of gases by the obstruction of air inlet. The outlets of the drillings are connected to the extraction duct of cold gas and heating duct used for the reintroduction of heated gases into the transparent external chamber double circuit.

Description

TECHNICAL FIELD OF THE INVENTION

  The invention is in the field of medical and biological research activities on small laboratory animals in general and those relating to the acquisition of data in medical imaging in particular. The invention relates to equipment equipment designed to contain in a sterile hermetic isolation cell, a rodent under gas anesthesia, so that it can be transported to a unit of data in medical imaging.

  The acquisition of the images can be spread out over several hours, animals infected or not must be kept calm, insensitive to pain and immobile.

  This physiological state, characterized by good general chemical or volatile anesthesia, good ventilation and good maintenance of body temperature, is obtained in four stages: 1 preparation: it ensures the conditioning of the animal according to the species , his state of health, the experimental protocol.

  2 premedication: it consists in administering pre-anesthetic agents intended to calm the animal.

  3 Anesthesia: It is obtained by administering inhaled / injected substances or a combination of both.

  4 awakening: as fast as possible, it concretizes the good implementation and the successful completion of the 3 previous steps.

  Steps 1-2 and 4, closely related to the species, the type of intervention and associated protocols, are part of a different technical field from that of the invention and have been recalled here for the record. Step 3 is one of the constraints related to the invention and is recalled below.

  Liquid, highly volatile, non-flammable or explosive halogenated anesthetic agents are used in combination with a carrier gas such as air or oxygen alone and / or supplemented with an anesthetic gas such as nitrous oxide (N2O). . These agents are: halothane (CF3-CHBrCL), isoflurane (CF3-CHCI-O-CHF2) -enflurane (CHCIF-CF2-OCHF2), desflurane (CF3-CHF-O-CHF2), sevoflurane (CF3-CH (CF3) -O-CH2F).

  The apparatus consists of a flow meter distributing the carrier gas (flow expressed in liters per minute) which, by passing through an evaporator of anesthetic agent (evaporation expressed in% adjustable), charges said anesthetic agent at the level of the concentration displayed on The anesthetic gases are directed to various accessories that will allow either to fall asleep or to keep the animal to be treated asleep. -Sleep, allowing the animal to progressively move from the vigil state to the pre-anesthesia, is obtained with the help of a hermetic chamber or induction cage. It must be filled with anesthetic gases and then empty of its halogenated vapors before taking the animal to be treated.

  - Maintenance under anesthesia, allowing the animal to pass from the stage of pre-anesthesia to true anesthesia, is obtained with the help of a mask or tunnel or a respirator equipped. The apparatus delivers the anesthetic gases to the muzzle of the animal and simultaneously extracts the excess halogenated vapors.

  The present invention addresses the material aspect downstream of the anesthetic gas delivery source. It ensures falling asleep, maintaining under volatile anesthesia of a contaminated animal or not, so that it can be transported, manually or automatically to a data acquisition unit in medical imaging. It takes into account the safety of the users and the regulations in force.

STATE OF THE PRIOR ART

  1) To ensure that the animal falls asleep, the existing cages or induction chambers on the market have in common: - the obligation to fill the available volume of anesthetic gases followed by the obligation to empty the same volume before extracting the animal for the follow-up.

  - They are heavy users of anesthetic agents, carrier gas and other consumables intended to capture the extracted polluting vapors.

  they require a constraining manipulation, a relatively long immobilization of the animal and an overall excessive treatment time (with constant induction parameters, according to the cage model and the manufacturer, according to the physiological characteristics of the animal, between 2 to 4 minutes) - they do not prevent the impregnation of the fur of the animal by the halogenated vapors. Example: For the induction of a 350 gram rat with a cage of about 6 liters, a carrier gas flow rate of 1.5 liters / minute, an anesthetic concentration delivered by the evaporator of 3 to 4.5%, will have: - Induction time: between 3 and 4 minutes Consumption of motor gas: 4.5 to 6 liters - Consumption of anesthetic agents: about 1.5 ml to 2 ml 3 2879094 - Concentration of anesthetics present in the cage: between 30 000 and 45,000 particles per million will have to be reduced to zero particles per million and per hour at best or two particles per million and per hour at worst, in the user's work environment, given the risks associated with exposure to halogens.

  2) In order to maintain the animal under volatile anesthesia, the existing systems are designed according to the principle of double-pipe circuits with induction of anesthetics / simultaneous extraction of polluting gases. In their present form, certain systems providing the function of Sleep and keeping under volatile anesthesia respond to many applications of research centers under appropriate safety conditions. Depending on the model and the manufacturer, they can be simple or allow the warming of the animal to avoid hypothermia. and its consequences.

  However, none exactly fits the needs of equipment for capturing and acquiring medical images. Existing systems are not designed with non-magnetic components and do not allow the transfer or monitoring of a contaminated or immuno-deficient animal in the required physiological state to a medical imaging data acquisition unit.

  DESCRIPTION OF THE INVENTION The invention satisfies the following functions: 1) Ensuring that the animal falls asleep by means of an induction device.

  2) ensure the maintenance of the animal under anesthesia in an isolation cell (sterile or not) hermetically sealed or not.

  3) ensure the establishment of equipment and accessories adapted to the experimental protocol, by means of secure access from the outside to the inside of the isolation cell occupied by the anesthetized animal.

  4) to maintain the body temperature of the animal under anesthesia, by means of a controlled heating system of the ambient gases contained in the isolation cell.

  5) ensure the transfer, manual or robotic, of the isolation cell occupied by the anesthetized and heated animal, to the imaging unit without risk of cross-contamination 6) to ensure optimal safety of the users, by means of secure connection with double shutter on all workstations and accessories.

  4 2879094 It is materialized by two different products which are the induction device and the isolation cell. They are complementary and interdependent of each other in a context integrating a tool for acquiring medical image data (imaging by R.M.N). The induction device can, however, be dissociated from the field of medical image data acquisition since it can be substituted purely and simply for the induction chamber or cage in most of the fields of application where it is in use. Regarding the induction device.

  The induction device is an accessory to the anesthetic gas generator allowing sleep of the animal to be treated. It is connected by means of a coaxial circuit for the circulation of two gas streams simultaneously. One from the generator to the device, the other vice versa from the device to a suction unit residual gaseous pollutants. This circuit is provided at both ends with a male plug with double shutter system. These sockets are designed to connect to a socket, itself equipped with the double-shutter system.If the male / female plugs are separated from each other, the flow of halogenated and extraction of residual polluted gases will be closed. This equipment makes it possible to isolate with respect to the environment the coaxial circuit itself but also all the devices connected to it. In addition, there will be no emission of halogenated gases into the environment if the coaxial circuit, - connected to the anesthetic gas generator - is not to the induction device or the isolation cell.

  The double-ended male / female plugs are designed to activate, at the time of coupling, the extraction of the residual gases at first and then the induction of the anesthetics in a second step so that any leakage of halogens, at moment of connection, would be captured. They constitute a security of connection of peripheral equipment to the anesthesia station. This system of secured male / female plugs equip the anesthetic gas generator, the induction device and the isolation cell and is an integral part of the invention.

  The induction device consists of a main body fixed on a frame ensuring the mechanical stability of the assembly, and two movable parts solidarisables constituted by the induction cylinder and the movable body. The induction cylinder is equipped, at its rear end with a conical portion of dimensions adapted to the animal species to contain and to induce. The front end is mounted in pivot connection relative to the frame. The angular displacement of this pivot connection is limited to 90 so that the induction cylinder can debate from a vertical position to a horizontal position.

  In horizontal position, the induction cylinder allows the establishment, head first, of the live animal. The transition from the horizontal position to the vertical position is performed manually by the user of the device. This maneuver operates the mechanical opening of a valve located in the body of the frame. It allows the passage of halogenated gases via a channel that opens into the front of the cylinder and ends precisely at the muzzle of the animal. The effects of induction are almost immediate due to the absence of dead volume to saturate. The distribution of anesthetic gases may remain very low, ie about a volume equal to the product of the tidal volume by the respiratory rate of the animal species concerned (V = VC x Freq). The induction cylinder is equipped with a permanent suction located upstream of the anesthetic gas distribution source. This suction is in use regardless of the position of the cylinder, (vertical or horizontal) so as to capture as close as possible to the source of emission excess halogenated gases. The central part of the cylinder, equipped with a transparent window, allows the user to visualize the behavior of the animal to be induced.

  At the end of the induction time required, ie approximately 20 to 30 seconds of exposure, the user interrupts the sending of the anesthetic gases by tilting the cylinder from the vertical position to the horizontal position. The sleeping animal, whose coat is preserved from halogenated vapors, can be extracted from the induction cylinder. To do this, the operator disengages the cylinder from its frame and thus accesses the anterior part of the animal. It can be easily disengaged and positioned on a standard support accessory under anesthesia or in the isolation cell in the open position. During this period of handling, the suction is always active and evacuates residual halogenated particles.

  This device offers a significant time saving (of the order of 5 to 6 times faster than the induction cage), an increased safety of users (the animals' peel handled is preserved from halogenated vapors). The cost of experimentation is therefore reduced at the level of consumption of anesthetic agent, carrier gas, filter elements.

  Regarding the isolation cell.

  In advance, it is indicated that the use of magnetic resonance imaging system prohibits the proximity of magnetic materials. In studies of certain diseases, animals undergoing medical and / or surgical treatment are weakened and / or contaminated. It may be necessary to isolate them from the personnel who handle them, but also from other animals. The monitoring of their anesthesia, their heart rate, their breathing rate, their temperature, is made necessary during the entire treatment period in imaging unit.

  The isolation cell, is also an accessory to the anesthetic gas generator. It makes it possible to maintain under anesthesia gas an animal for transfer and / or transit in a data acquisition unit in medical imaging. It is connected to the generator by means of a coaxial circuit for the circulation of two gas flows. simultaneously. One from the anesthetic gas generator to the device, the other, conversely, from the device to a suction unit of residual polluted gases. This is the same type of circuit as used with the induction device.

  The isolation cell consists of a main body and a movable part called insulating bubble. The assembly rests on a fixed frame intended to ensure the mechanical stability of the product. This set is designed to allow manual or automated transfer to the core of a R.M.N. The main body is provided with two specific channels ensuring, for one, the removal of the gas contained in the cell, for the other, the simultaneous and complete return of this gas after having controlled and / or modified the temperature. In this main body is fitted a holding tunnel with a perforable membrane technical channel which allows the passage of catheters, probes, electrodes, breathing circuits, pneumatic control circuits of nonmagnetic respiratory valve or other. The insulating bubble, consisting of a bed, a holding tunnel and a transparent outer container, isolates the animal contained in the bubble of the environment, when the outer container is screwed on the control wheel . Some parts of this cell may consist of sterile single-use items for applications that prohibit the risk of cross-contamination. The isolation cell can be used in a dedicated isolator, in the open position (no isolation of the surrounding environment) or in the closed position (isolation with respect to the ambient environment). The open position is obtained by turning the control wheel to the induction + extraction position. It allows the user to position / contain / prepare the animal that has just been extracted from the induction device and keep it asleep. It will be placed on a bed of shapes and dimensions adapted to its morphology. This bed can be equipped with earrings for the restraint of the animal. It can be made of transparent materials and thin. It is adjustable in inclination along the longitudinal axis of the animal to facilitate the taking of certain images. The muzzle of animal 7 2879094 is directed towards a cone allowing its immobilization and the direct admission of halogens. On the periphery of this cone and downstream of its muzzle, extraction channels are arranged allowing the maximum aspiration of the polluted gases in surplus. After the installation of the animal under anesthesia, its connection to the materials adapted to the experimental protocol via the specific secure access from the outside to the inside of the isolation cell, the connection of the gas heating system In the cold cell contained in the isolation cell, the user screws the outer transparent container of the cell on the control wheel so that it will be in the closed position.

  The closed position is obtained by completely turning the control knob towards the induction + overpressure position. This wheel will be operated after closing the transparent cover. The commissioning of this function has the effect of allowing the passage of halogenated to the animal while the extraction will be mechanically deviated so that the interior of the cell will be only partially sucked. The mechanical deviation of the extraction thus avoids a depression inside the cell.

  The animal, maintained under anesthesia, heated, isolated from the environment, treated according to the needs of the application, is ready to be transferred manually or automatically, from the preparation zone to the treatment area such as the unit of acquisition of medical images, or to be put on hold for further processing.

  In the final phase of experimentation, the animal will be removed from the cell which can be reused after decontamination and / or re-equipped with new sterile elements.

  SYNTHETIC PRESENTATION OF THE 6 DIAGRAMS constituting the induction device (FIGS. 1 and 2), the secure system of male / female plugs with double shutter (FIGS. 3 and 4) and the isolation cell (FIGS. 5 and 6) 1/6 Diagram of the induction device HORIZONTAL CYLINDER POSITION (Fig. 1) - AA section closed valve view - BB section cylinder rotation stop display -2 / 6 Principle diagram of the induction device VERTICAL CYLINDER POSITION (Fig. 2) - Section AA open valve display - BB section cylinder rotation stop display - 3/6 Schematic diagram of male / female plug connectors CONNECTED (Fig 3) 8 2879094 - 4/6 Schematic diagram of male / female plugs DISCONNECTED (Fig 4) - 5/6 Block diagram of the uninsulated cell OPEN POSITION (Fig 5) - Section AA visualization of the rotation stop of the knob - BB section visualization of the plugged air intake - 6/6 Diagram principle of the isolation cell POSITION CLOSED (Fig 6) - Section AA visualization of the rotational stop of the wheel Cup BB visualization of the open air intake DETAILED DESCRIPTION OF AN EMBODIMENT Referring to Figures 1 to 6 (Fig. 10 1 to 6) - Figures 1 and 2: The induction device is permanently linked to a fixed frame (1) placed on a bench or worktop. This frame ensuring the stability of the mechanical assembly is of size, shape, weight such that it remains stable during the induction phase. The induction device comprises a main body (7) fixed on the frame, with a female coaxial plug with double shutter (4) integrated and two movable parts solidarisables. The first consists of the induction cylinder and contention (2) the second of the movable body (3). The female coaxial plug (4) fitted to the main body (7) must be connected (FIG. 3) and screwed to the coaxial male double-shutter plug (5) of the coaxial circuit connecting the anesthetic gas generator to the induction device in order to allow two free and independent gas flows. The first vehicle halogenated gases from the anesthetic gas generator to the induction device. The second extracts the residual halogenated gases from the induction device to the downstream polluted gas suction unit.

  If the female coaxial plug (4) is disconnected (Fig 4) from the plug (5), the two gas flows will be closed so that there will be no emission of halogenated gases or aspiration of the ambient air of the work environment. In addition, the systems located upstream and downstream of the female / male receptacles will be completely isolated.

  The mobile part called the induction and compression cylinder (2) is of shape and size adapted to the morphology of the animal to be induced. This induction cylinder, provided with a monitoring window, is provided with a central bore allowing the free passage of halogenated to the muzzle of the animal to induce and peripheral channels (31) allowing the free extraction of halogens Residuals The induction cylinder (2) can be rapidly detached from the moving body (3) during operations of cylinder change of larger or smaller size by disengagement.

  The movable body (3) is mounted in pivot connection on the main body (7) with a rotation limited to 90 so that the induction cylinder (2) can discuss the horizontal position (Fig 1) to the position vertical (Fig 2). Its stop in rotation and translation relative to the main body (7) is provided by a stop pin (8). The movable body (3) is provided with a bore (32) making it possible to communicate the suction channels (31) of the induction cylinder (2) to the dedicated bore of the main body (7) whatever the position ( horizontal Fig 1 or vertical Fig 2) of the induction cylinder (2) so that the extraction of residual halogens is still active.

  The end of the movable body (3) is provided with a cam (33) for opening or closing the halogenated gases. The valve (6) as it is actuated (Fig 2 - AA cut) or 'not (Fig 1 - AA cut) is peeled from the main body (7) or not. It therefore has the function of opening or closing the arrival of halogenated gases. When the induction cylinder (2) is in a horizontal position (FIG. 1), the halogenated gases are stopped at the valve (6) which is kept closed and in contact with the main body (7) by means of the spring (FIG. 34). This position allows the establishment of the live animal. When the induction cylinder (2) is in a vertical position (FIG. 2), the halogenated gases can pass through the open and peeled valve (6) of the main body (7), pass through the mobile body (3) and the central channel and lead into the center of the induction cylinder. This position allows the live animal to go to sleep. The operating state of the equipment is marked on the movable body (3): Vertical position of the induction cone: Extraction + induction (animal during induction), horizontal position of the induction cone: Extraction (in animal wait to induce or stop) -Figures 5 and 6: The isolation cell is supported by a fixed frame (1) itself placed on a bench or a worktop. This fixed frame (1) ensuring the stability of the mechanical assembly is of size, shape, weight such that it remains stable throughout the preparation phase of the animal previously induced. The isolation cell comprises a main body (7) with a double shutter female coaxial plug (4), an adjusting wheel (13), and three removable parts constituting the insulating bubble. The first one; the bed (10) on which the induced animal is placed, the second; the holding tunnel (11) the third; the transparent outer container (Fig 6 - 16) .The mounted assembly can be detached from the frame (1) to ensure its transfer.

  The female coaxial plug (4) fitted to the main body (7) must be connected 2879094 (FIG. 3) and screwed to the coaxial male double-shutter plug (5) of the coaxial circuit connecting the anesthetic gas generator to the cell in order to allow two free and independent gas flows. The first vehicle halogenated gases from the anesthetic gas generator to the isolation cell, the second extract the residual polluted gases from the isolation cell to the downstream polluted gas suction unit. If this female coaxial plug (4) is disconnected (Fig 4) from the plug (5), the two gas flows will be closed so that there will be no emission of halogenated gases or aspiration of the ambient air of the work environment. In addition, the systems located upstream and downstream of the female / male sockets (4 - 5) will be completely isolated.

  The main body (7) is equipped with two channels (22 - 23) and a bore (40) reserved for the passage of the holding tunnel (11) and its interlocking. The two channels (22 - 23) have outputs to connect to the heating system of the animal under anesthesia (17). This system, operating in a closed circuit, comprises a pump (14) for extracting the cold gases contained in the insulation bubble (11 + 10 + 16) via a double thermally insulated circuit, reheating them, regulating them, and then reintroduce into the isolation bubble. One of the pipes of the circuit is connected to the channel (23) dedicated to the extraction of the cold gases contained in the isolation bubble, the other channel, equipped with a heating and regulation system, is connected to the channel (22). ) dedicated to the reintroduction of the gases reheated in the isolation bubble. The channel (41) of the main body (7) makes it possible to make the suction / cone (19) communicate outwards. The first removable part called bed (10) is of shape and dimension adapted to the morphology of the animal to be treated. This bed (10), transparent and thin, is secured to the holding tunnel (11) and can be quickly detached in case of use prohibiting any risk of cross-contamination (disposable bed) by simple pulling.

  The second removable part called holding tunnel (11) is provided with a cone (19) in which is positioned the muzzle of the animal to be treated. In the extension of the holding tunnel (11) there is a technical channel (18) closed by a plug (12). This pierceable stopper (12) provides secure access from the outside to the inside of the cell.

  The passage thus cleared allows the installation of catheter, probe, electrode ... directly abutting the muzzle of the animal. These various equipment will be put in place during the preparation phase of the animal. The holding tunnel (11) is also provided with a channel (20) dedicated to the passage of halogenated gases directly delivered to the level of the muzzle of the animal and peripheral channels (21) allowing the suction of residual halogenated gases. . When the retaining tunnel (11) is completely fitted into the main body (7), it actuates the valve (6) and allows the passage of the halogenated gases. When the holding tunnel (II) is removed from the main body (7), the valve (6) blocks the passage of halogenated gases. The holding tunnel (11) is steerably inclined along its longitudinal axis. The holding tunnel (11) is provided with markers making it possible to know the angle of inclination described between the main body (7) and the tunnel (11). This feature allows you to orient the whole bed (10) + animal + tunnel (11) so that taking some images will be facilitated. The holding tunnel (11) can be quickly detached and changed in case of use prohibiting any risk of cross-contamination by simple pulling.

  The third removable part called outer container (16), of shape and size adapted to the morphology of the animal, transparent and thin, is referred to the adjusting wheel (13) with a thread for quick closing. Its placement completely isolates the animal to treat ambient air.

  An adjusting wheel (13) is mounted in pivot connection (Fig. 6, section AA) on the main body (7) with a rotation limited to 90 relative to the longitudinal axis of the cell. Its stop in rotation and translation relative to the main body (7) is provided by a stop pin (8). The knob (13) is set in two different positions: 1) open cell position (Fig 5): maximum extraction since the suction channel is completely free 2) closed cell position (Fig 6): minimal extraction since taking Air (41) located outside the cell accentuates the effects of suction reduction. When the. cell is closed, the extraction is used as a device for collecting residual halogenated gases.

  The operating state of the equipment is marked on the control wheel (13) - open cell: induction + extraction (anesthetic animal not isolated from the ambient air) - closed cell: induction + overpressure (anesthetized animal, isolated from ambient air, effects related to overpressure curbed)

  POSSIBLE INDUSTRIAL APPLICATIONS

  The induction device: it can be part of any field of activity requiring the admission of a gas with simultaneous extraction of the same gas or another gas to another container.

  - use in a medium itself isolated from the ambient air.

  The isolation cell: it can be part of the same areas of activity as those of the induction device. In addition, it is part of any field of activity 5 requiring - the admission of a gas to a container, itself contained in a hermetically sealed container and where all the effects of internal overpressure will be curbed.

  - the closed circuit treatment of the gas contained in the hermetically sealed outer container - a secure access to the inside of the hermetically sealed outer container for the passage of various instruments / equipment - the secure transfer of the hermetically sealed outer container from one zone to another The double-shutter male / female plug system can be used in any field of activity requiring the circulation of two gas flows in the opposite direction and simultaneously with obstruction of the circulation of the two gas flows. and in both directions when said male / female plugs are disconnected.

Claims (14)

13 2879094 Claims   1 Device for inducing a rodent gas to progressively transition from the vigil state to the state of anesthesia and then transfer, manually or by robotic system, under good physiological conditions, to a unit of acquisition of data in medical imaging characterized by a device for direct induction of anesthetic gas (FIG. 1 - 2) providing pre-anesthesia, and a transferable isolation cell (FIG. 5 - 6) ensuring maintenance under monitored and heated volatile anesthesia.   2 Device according to claim 1 characterized in that the device for direct induction of anesthetic gas (Fig 1-2) and the isolation cell (Fig 5-6) are accessories of the anesthetic gas generator and are connected thereto. by means of a coaxial circuit which allows the free and independent circulation of two gases, one of which is dedicated to the induction of anesthetic gases.   3 Device according to any one of claims 1 and 2 characterized in that the device for direct induction of anesthetic gas (Fig 12) and the isolation cell (Fig 5 - 6) are connected to an extraction system of polluted gases and are connected via the c oaxial circuit permitting the circulation 1 ibre and independent of two gases, the other is dedicated to the extraction of polluted gases.   4 Device according to any one of claims 1, 2 and 3 characterized in that the device for direct induction of anesthetic gas (Fig 1-2) and the isolation cell (Fig 5 - 6) have a plug female connection socket (Fig 3 - 4) with double shutter to be connected to the male connection socket (Fig 3 - 5) with double closing of the coaxial circuit so that the free and independent circulation of two gases is effected if the two plugs are connected (Fig 3).   Device according to any one of Claims 1 to 4, characterized in that the device for direct induction of anesthetic gas (Fig. 1-2) and the isolation cell (Fig. 5 - 6) are completely isolated if their connection socket female (Fig 4 - 4) with double shut-off is disconnected from the male plug connection (Fig 4 - 5) with double closing of the coaxial circuit (Fig 4) so that free and independent circulation of two gases is prohibited if both The device according to any one of claims 1 to 5 characterized in that the device for direct induction of anesthetic gas (Fig 1-2) comprises two movable parts (2 and 3) and a fixed part (7) secured to the frame (1)  Device according to any one of Claims 1 to 6, characterized in that the device for direct induction of anesthetic gas (FIG. 1 to 2) comprises two moving parts (2 and 3), one of which, called a cylinder. induction, is detachable from the second movable part (3) by disengagement.   8 Device according to claim 7 characterized in that the first movable part (2) is provided with a central channel (30) allowing the free circulation of halogenated gases and is provided with peripheral channels allowing the free extraction of residual halogenated gases.   9 Device according to any one of claims 1 to 6 characterized in that the device for direct induction of anesthetic gas (Fig 1-2) comprises a second movable part (3), called movable body mounted in pivot connection on the main body ( 7), so that the induction cylinder as claimed in 7 and 8 can discuss the horizontal position (Fig 1) to the vertical position (Fig 2). Device according to claim 9 characterized in that the movable body (3) is provided with a free passage for extraction (32) for communicating the extraction of the main body (7) to the suction channels (31). ) of the induction cylinder (2) so that the extraction of the residual halogenated gases is always active regardless of the position of the induction cylinder (2) 11Device according to any one of claims 9 and 10, characterized in that the movable body (3) is provided with a passageway controlled and reserved for the induction of anesthetic gas making it possible to communicate the induction of anesthetics of the main body (7) to the central channel (30) of the cylinder of induction (2) so that the induction of the anesthetic gases is activated during the passage of the induction cylinder (2) from the horizontal position (Fig 1) to the vertical position (Fig 2) 12 Device according to any one of claims 9 to 11 characterized in that the end the movable body (3) is provided with a cam (33) allowing the opening control (FIG. 2 or AA) or closing (FIG. 1) of the delivery of halogenated gases depending on whether the cylinder induction device (2) is in a vertical position (FIG. 2) or in a horizontal position (FIG. 13). Device according to any one of claims 9 to 12 characterized in that the movable body (3) is provided with a valve ( 6) which, held in contact with the main body (7) by means of a spring (34), deactivates the passage of the halogenated gases from the main body 2879094 (7) to the induction cylinder (2) lying brought back to the horizontal position (Fig 1) 14 Device according to any one of claims 9 to 13 characterized in that the movable body (3) is provided with a valve (6) which, taken off the main body (7) by the cam (33), activates the passage of halogenated gases from the main body (7) to the induction cylinder (2) being returned to the vertical position (Fig 2) Dis positive device according to any one of claims 6 to 14 characterized in that the fixed part called main body (7) of the device for direct induction of anesthetic gas (Fig 1-2) has two holes, one of which is connected to the extraction circuits of the two moving parts (2-3) and then to the coaxial circuit going to the residual gas suction unit via the system of the male / female plugs with double connected connection (Fig 3) 16 Device according to the any one of claims 6 to 14 characterized in that the fixed part called main body (7) of the device for direct induction of anesthetic gas (Fig 1-2) has another hole connecting the gas induction circuits. anaesthetizing the two moving parts (2 - 3) to the coaxial circuit from the anesthetic gas generator via the male / female plug-in connection system with double shutter connected (Fig 3) 17 Device according to any one of the claims 1 to 5 characterized in that the isolation cell (FIG. 5 - 6) comprises three removable parts (10-11-16) fitting to the main body (7) itself equipped with a thumbwheel (FIG. adjustment (13) The assembly is supported by a fixed frame (1) from which it can be removed for transfer to a data acquisition unit in medical imaging.   18 Apparatus according to any one of claims 1 to 5 and 17 characterized in that the first removable part called bed (10) of the isolation cell (Fig 5-6) fits or disengages the holding tunnel ( 11), and is intended to support the anesthetized animal. 19 Apparatus according to any one of claims 1 to 5 and 17 and 18 characterized in that the second removable portion called holding tunnel (11) fitting or disengaging the main body (7) of the isolation cell ( Fig 5 -6), is provided with a cone (19) and in the extension of which there is a technical channel (18) equipped with a perforable plug (12) allowing access from the outside to the inside of the cell.   Device according to Claim 19, characterized in that the holding tunnel (11) is provided with another channel (20) dedicated to the passage of the anesthetic gases delivered at the outlet of the cone (19). 21 Device according to any one of the Claims 19 and 20, characterized in that the holding tunnel (11) is provided with peripheral extraction channels (21) for the suction of the residual anesthetic gases. 22 A device according to any one of Claims 19 to 21, characterized in that that the holding tunnel (11) is steerable in inclination along its longitudinal axis.   23 Device according to any one of claims 1 to 5 and 17 and 22 characterized in that the isolation cell (Fig 5 -6) has a third removable portion called external transparent container (16) which completely isolates its contents ambient air when screwed to the adjustment knob (13). 24 Device according to any one of claims 1 to 5 and 17 to 23 characterized in that the isolation cell (Fig 5 - 6) has a control wheel (13) mounted in pivot connection (Fig 6 AA cut ) on the main body (7) with rotation limited to 90 relative to the longitudinal axis of the cell.   Device according to Claim 24, characterized in that the adjusting wheel (13) has two adjustment positions, namely an open position (FIG. 5) which allows maximum extraction from the obstruction of the air intake (41). and a closed position (FIG. 6) which allows a minimum extraction by the opening of the air intake (41) of the halogenated overpressure gases so that the internal pressure in the cell will be very slightly positive.   26 Apparatus according to any one of claims 1 to 5 and 17 to 25 characterized in that the isolation cell (Fig 5 - 6) comprises, in addition to its three removable parts, a main body (7) with the two bores ( 22-23) connected to the thermally insulated dual circuit (22-23).   27 Apparatus according to claim 26 characterized in that the outlet of the first bore (23) is connected to the cold gas extraction pipe contained in the transparent outer container (16) and the outlet of the second bore (22) is connected to the heating pipe reserved for the reintroduction of the heated gases into the transparent outer container (16) of the thermally insulated double circuit (22 + 23).   28 Apparatus according to claim 26 characterized in that the double thermally insulated circuit (22 + 23) is connected to a pump (14) allowing, in a closed circuit, the extraction of the cold gases contained in the transparent outer container (Fig. 6) and their reintroduction after heating in the outer transparent container (16) 29 Device according to any one of claims 1 to 5 and 20 to 22 characterized in that the holding tunnel (11) completely fitted into the main body (7). ) is arranged to actuate the valve (6) which allows the passage of anesthetic gases.