PT97602A - Processo para a preparacao de indolonas neuroprotectoras e de derivados relacionados com as mesmas - Google Patents

Processo para a preparacao de indolonas neuroprotectoras e de derivados relacionados com as mesmas

Info

Publication number: PT97602A
Authority: PT; Portugal
Prior art keywords: pct; preparation; neuroprotectal; indolones; same
Prior art date: 1990-05-10

Application number

PT97602A

Other languages

English (en)

Other versions

PT97602B (pt

Inventor

Bertrand Leo Chenard

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-05-10

Filing date

1991-05-08

Publication date

1992-02-28

1991-05-08 Application filed by Pfizer filed Critical Pfizer

1992-02-28 Publication of PT97602A publication Critical patent/PT97602A/pt

1998-08-31 Publication of PT97602B publication Critical patent/PT97602B/pt

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Hydrogenated Pyridines (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)

PT97602A 1990-05-10 1991-05-08 Processo para a preparacao de indolonas neuroprotectoras e de derivados relacionados com as mesmas PT97602B (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US52233290A	1990-05-10	1990-05-10

Publications (2)

Publication Number	Publication Date
PT97602A true PT97602A (pt)	1992-02-28
PT97602B PT97602B (pt)	1998-08-31

Family

ID=24080448

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT97602A PT97602B (pt)	1990-05-10	1991-05-08	Processo para a preparacao de indolonas neuroprotectoras e de derivados relacionados com as mesmas

Country Status (30)

Country	Link
US (1)	US5306723A (pt)
EP (1)	EP0554247B1 (pt)
JP (1)	JPH0699423B2 (pt)
KR (1)	KR0163355B1 (pt)
CN (1)	CN1037439C (pt)
AT (1)	ATE192149T1 (pt)
AU (1)	AU642994B2 (pt)
BR (1)	BR9106432A (pt)
CA (1)	CA2080475C (pt)
CZ (1)	CZ280560B6 (pt)
DE (1)	DE69132141T2 (pt)
DK (1)	DK0554247T3 (pt)
EG (1)	EG19647A (pt)
ES (1)	ES2146578T3 (pt)
FI (1)	FI109121B (pt)
GR (1)	GR3034005T3 (pt)
HU (1)	HU221193B1 (pt)
IE (1)	IE911569A1 (pt)
IL (1)	IL98056A (pt)
MY (1)	MY107799A (pt)
NO (1)	NO301979B1 (pt)
PH (1)	PH29902A (pt)
PL (1)	PL169267B1 (pt)
PT (1)	PT97602B (pt)
RU (1)	RU2068414C1 (pt)
SK (1)	SK280833B6 (pt)
TW (1)	TW198720B (pt)
WO (1)	WO1991017156A1 (pt)
YU (1)	YU48528B (pt)
ZA (1)	ZA913494B (pt)

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JPH0788355B2 (ja) *	1991-04-18	1995-09-27	フアイザー・インコーポレイテツド	フェノール性２―ピペリジノ―１―アルカノールのプロドラグエステル
US5594007A (en) *	1991-04-18	1997-01-14	Pfizer Inc.	Method for treating spinal cord trauma with phenolic 2-piperidino-1-alkanols
EP0594729A1 (en) *	1991-07-17	1994-05-04	Pfizer Inc.	2-(4-hydroxypiperidino)-1-alkanol derivatives as antiischemic agents
FR2688504B1 (fr) *	1992-03-13	1995-05-05	Synthelabo	Derives de 2-(piperidin-1-yl)ethanol, leur preparation et leur application en therapeutique.
US5319096A (en) *	1992-04-03	1994-06-07	Hoechst-Roussel Pharmaceuticals Inc.	(1H-indol-1-yl)-2-(amino) acetamides and related (1H-indol-1-yl)-(aminoalkyl)amides, pharmaceutical composition and use
US6255322B1 (en)	1992-06-19	2001-07-03	Pfizer Inc.	2-(4-hydroxypiperidino)-1-alkanol derivatives as antiischemic agents
US5436255A (en) *	1992-07-23	1995-07-25	Pfizer Inc.	Method of treating diseases susceptable to treatment by blocking NMDA-receptors
CA2146260C (en) *	1992-10-30	1998-04-07	Bertrand L. Chenard	Neuroprotective 3,4-dihydro-2(1h)-quinolone compounds
US5498610A (en) *	1992-11-06	1996-03-12	Pfizer Inc.	Neuroprotective indolone and related derivatives
PL318658A1 (en) *	1994-08-18	1997-07-07	Pfizer	Neuroprotective derivatives of 3-(piperidinyl-1)-chromanodiole-4,7 and 1-(4-hydrophenyl)-2-(piperidinyl-1)-alkanol
GB9510459D0 (en)	1995-05-24	1995-07-19	Zeneca Ltd	Bicyclic amines
ZA9610738B (en)	1995-12-22	1997-06-24	Warner Lambert Co	Subtype selective nmda receptor ligands and the use thereof
ZA9610745B (en) *	1995-12-22	1997-06-24	Warner Lambert Co	4-Subsituted piperidine analogs and their use as subtype selective nmda receptor antagonists
ZA9610736B (en) *	1995-12-22	1997-06-27	Warner Lambert Co	2-Substituted piperidine analogs and their use as subtypeselective nmda receptor antagonists
ZA9610741B (en)	1995-12-22	1997-06-24	Warner Lambert Co	4-Substituted piperidine analogs and their use as subtype selective nmda receptor antagonists
TW427978B (en) *	1996-02-03	2001-04-01	Hoffmann La Roche	Tetrahydroisoquinoline derivatives
ATE263765T1 (de) *	1996-05-13	2004-04-15	Syngenta Ltd	Bicyclische amine als insektizide
GB9623944D0 (en) *	1996-11-15	1997-01-08	Zeneca Ltd	Bicyclic amine derivatives
GB9624114D0 (en) *	1996-11-20	1997-01-08	Zeneca Ltd	Pesticidal bicyclic amine derivatives
GB9624611D0 (en) *	1996-11-26	1997-01-15	Zeneca Ltd	Bicyclic amine compounds
NZ335422A (en)	1996-11-26	2000-10-27	Zeneca Ltd	8-azabicyclo[3.2.1]octane-, 8-azabicyclo [3.2.1] oct-6-ene-, 9-azabicyclo[3.3.1]nonane-, 9-aza-3-oxabicyclo[3.3.1]nonane- and 9-aza-3-thiabicyclo[3.3.1]nonane derivatives for use in insecticides
CA2220649C (en)	1996-12-03	2007-02-13	F. Hoffmann-La Roche Ag	4-hydroxy-piperidine derivatives
EP0846683B1 (en) *	1996-12-03	2001-09-19	F. Hoffmann-La Roche Ag	4-Hydroxy-piperidine derivatives
JP2002542280A (ja) *	1999-04-27	2002-12-10	スミスクライン・ビーチャム・パブリック・リミテッド・カンパニー	新規な治療
EP1235572A2 (en)	1999-10-29	2002-09-04	MERCK SHARP & DOHME LTD.	Method to treat pain utilizing benzimidazole nmda/nr2b antagonists
US6489477B1 (en)	1999-10-29	2002-12-03	Merck & Co., Inc.	2-aza-bicyclo[2.2.2]octane NMDA/NR2B antigonists
US6369076B1 (en)	1999-10-29	2002-04-09	Merck & Co. Inc.	5-benzyl-octahydroindole and 6-benzyl-decahydroquinoline NMDA/NR2B antagonists
US6316474B1 (en)	1999-10-29	2001-11-13	Merck & Co., Inc.	2-benzyl and 2-heteroaryl benzimidazole NMDA/NR2B antagonists
US6432976B1 (en)	1999-10-29	2002-08-13	Merck & Co., Inc.	8-aza-bicyclo[3.2.1]octane NMDA/NR2B antagonists
US6495561B2 (en)	1999-10-29	2002-12-17	Merck & Co., Inc.	2-cyclohexyl imidazopyridine NMDA/NR2B antagonists
US6291499B1 (en)	1999-10-29	2001-09-18	Merck & Co., Inc.	2-cyclohexyl benzimidazole NMDA/NR2B antagonists
US6380205B1 (en)	1999-10-29	2002-04-30	Merck & Co., Inc.	2-cyclohexyl quinazoline NMDA/NR2B antagonists
US6476041B1 (en)	1999-10-29	2002-11-05	Merck & Co., Inc.	1,4 substituted piperidinyl NMDA/NR2B antagonists
CN100567293C (zh)	2001-02-23	2009-12-09	麦克公司	N-取代的非芳基-杂环nmda/nr2b拮抗剂
JP2005511478A (ja)	2001-04-03	2005-04-28	メルク　エンド　カムパニー　インコーポレーテッド	Ｎ−置換非アリール複素環アミジル系ｎｍｄａ／ｎｒ２ｂ拮抗薬
WO2003062235A1 (en) *	2002-01-17	2003-07-31	Eli Lilly And Company	Modulators of acetylcholine receptors
US6713490B2 (en) *	2002-04-26	2004-03-30	Pfizer, Inc.	3,4-dihydroquinolin-2(1H)-one compounds as NR2B receptor antagonists
EP1673367A1 (en) *	2003-10-08	2006-06-28	Pfizer, Inc.	Fused lactam compounds
US7713990B2 (en) *	2005-01-13	2010-05-11	Neurosearch A/S	3,8-substituted 8-AZA-bicyclo[3.2.1]octane derivatives and their use as monomine neurotransmitter re-uptake inhibitors
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US4358456A (en) *	1980-05-03	1982-11-09	John Wyeth & Brother Limited	Antipsychotic piperidinomethyl-indole derivatives
DE3045688A1 (de) *	1980-12-04	1982-07-08	C.H. Boehringer Sohn, 6507 Ingelheim	Neue 8-arylalkyl-3-phenyl-3-nortropanole, deren saeureadditionssalze, diese enthaltende arzneimittel und verfahren zu ihrer herstellung
JPS57142972A (en) *	1981-02-27	1982-09-03	Otsuka Pharmaceut Co Ltd	Carbostyril derivative
FR2534580A1 (fr) *	1982-10-13	1984-04-20	Synthelabo	Derives de phenyl-1 piperidino-2 propanol, leur preparation, et medicaments qui les contiennent
FR2546166B1 (fr) *	1983-05-19	1985-10-25	Synthelabo	Enantiomeres du erythro (benzyl-4 piperidino)-2 (hydroxy-4 ou benzyloxy-4 phenyl)-1 propanol, leur preparation et leur application en therapeutique
FR2581993B1 (fr) *	1985-05-14	1988-03-18	Synthelabo	Derives de (benzoyl-4 piperidino)-2 phenyl-1 alcanols, leur preparation et leur application en therapeutique
KR910006138B1 (ko) *	1986-09-30	1991-08-16	에자이 가부시끼가이샤	환상아민 유도체
EP0322361A3 (de) *	1987-12-23	1990-01-24	Ciba-Geigy Ag	Weitere hydrierte 1-Benzooxacycloalkylpyridincarbonsäureverbindungen
FR2640266B2 (fr) *	1988-07-12	1992-07-10	Synthelabo	Derives de (hydroxy-1 piperidinyl-2 alkyl) indolones-2, quinoleinones-2, benzo(b)azepinones-2 et benzimidazolones-2, leur preparation et leur application en therapeutique
EP0398578B1 (en) *	1989-05-17	1997-03-12	Pfizer Inc.	2-piperidino-1-alkanol derivatives as antiischemic agents

1991
- 1991-03-04 JP JP3505475A patent/JPH0699423B2/ja not_active Expired - Fee Related
- 1991-03-04 PL PL91296711A patent/PL169267B1/pl not_active IP Right Cessation
- 1991-03-04 CA CA002080475A patent/CA2080475C/en not_active Expired - Fee Related
- 1991-03-04 DK DK91905608T patent/DK0554247T3/da active
- 1991-03-04 HU HU9203515A patent/HU221193B1/hu not_active IP Right Cessation
- 1991-03-04 DE DE69132141T patent/DE69132141T2/de not_active Expired - Fee Related
- 1991-03-04 US US07/941,118 patent/US5306723A/en not_active Expired - Fee Related
- 1991-03-04 AU AU74565/91A patent/AU642994B2/en not_active Ceased
- 1991-03-04 BR BR919106432A patent/BR9106432A/pt not_active Application Discontinuation
- 1991-03-04 RU RU9192016415A patent/RU2068414C1/ru not_active IP Right Cessation
- 1991-03-04 WO PCT/US1991/001470 patent/WO1991017156A1/en active IP Right Grant
- 1991-03-04 ES ES91905608T patent/ES2146578T3/es not_active Expired - Lifetime
- 1991-03-04 EP EP91905608A patent/EP0554247B1/en not_active Expired - Lifetime
- 1991-03-04 KR KR1019920702794A patent/KR0163355B1/ko not_active IP Right Cessation
- 1991-03-04 AT AT91905608T patent/ATE192149T1/de not_active IP Right Cessation
- 1991-04-02 TW TW080102540A patent/TW198720B/zh active
- 1991-04-24 PH PH42344A patent/PH29902A/en unknown
- 1991-05-03 IL IL9805691A patent/IL98056A/en not_active IP Right Cessation
- 1991-05-08 SK SK1354-91A patent/SK280833B6/sk unknown
- 1991-05-08 ZA ZA913494A patent/ZA913494B/xx unknown
- 1991-05-08 CZ CS911354A patent/CZ280560B6/cs not_active IP Right Cessation
- 1991-05-08 EG EG27191A patent/EG19647A/xx active
- 1991-05-08 MY MYPI91000778A patent/MY107799A/en unknown
- 1991-05-08 PT PT97602A patent/PT97602B/pt active IP Right Grant
- 1991-05-09 YU YU81091A patent/YU48528B/sh unknown
- 1991-05-09 IE IE156991A patent/IE911569A1/en not_active IP Right Cessation
- 1991-05-09 CN CN91103022A patent/CN1037439C/zh not_active Expired - Fee Related
1992
- 1992-11-09 NO NO924310A patent/NO301979B1/no not_active IP Right Cessation
- 1992-11-09 FI FI925069A patent/FI109121B/fi not_active IP Right Cessation
2000
- 2000-07-24 GR GR20000401691T patent/GR3034005T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
DK0554247T3 (da)	2000-08-07
IL98056A0 (en)	1992-06-21
KR0163355B1 (ko)	1998-12-01
RU2068414C1 (ru)	1996-10-27
CA2080475A1 (en)	1991-11-11
ZA913494B (en)	1992-12-30
FI925069A0 (fi)	1992-11-09
KR930700482A (ko)	1993-03-15
ES2146578T3 (es)	2000-08-16
BR9106432A (pt)	1993-05-04
DE69132141T2 (de)	2000-09-21
YU81091A (sh)	1993-11-16
PL169267B1 (pl)	1996-06-28
TW198720B (pt)	1993-01-21
NO301979B1 (no)	1998-01-05
CS135491A3 (en)	1992-05-13
CN1037439C (zh)	1998-02-18
EP0554247A1 (en)	1993-08-11
IE911569A1 (en)	1991-11-20
WO1991017156A1 (en)	1991-11-14
HUT62879A (en)	1993-06-28
CZ280560B6 (cs)	1996-02-14
GR3034005T3 (en)	2000-11-30
EP0554247B1 (en)	2000-04-26
AU642994B2 (en)	1993-11-04
DE69132141D1 (de)	2000-05-31
CN1056497A (zh)	1991-11-27
EG19647A (en)	1995-08-30
JPH05506433A (ja)	1993-09-22
FI925069A (fi)	1992-11-09
AU7456591A (en)	1991-11-27
PH29902A (en)	1996-09-16
SK280833B6 (sk)	2000-08-14
IL98056A (en)	1995-11-27
FI109121B (fi)	2002-05-31
HU9203515D0 (en)	1993-01-28
US5306723A (en)	1994-04-26
CA2080475C (en)	2001-04-17
NO924310D0 (no)	1992-11-09
NO924310L (no)	1992-11-09
ATE192149T1 (de)	2000-05-15
JPH0699423B2 (ja)	1994-12-07
MY107799A (en)	1996-06-29
YU48528B (sh)	1998-11-05
HU221193B1 (en)	2002-08-28
PT97602B (pt)	1998-08-31

Publication	Publication Date	Title
PT97602A (pt)	1992-02-28	Processo para a preparacao de indolonas neuroprotectoras e de derivados relacionados com as mesmas
PT98710A (pt)	1992-07-31	Processo de preparacao de compostos de indolilo substituidos e de composicoes farmaceuticas que os contem
ES542321A0 (es)	1985-12-16	Un procedimiento para la preparacion de derivados de la 2 pirimidinil-1-piperazina
ES2124424T3 (es)	1999-02-01	Azadioxacicloalquenos substituidos y su empleo como fungicidas.
DK0641328T3 (da)	2002-05-21	Broforbundne, azabicykliske derivater som substans P-antagonister
ES2132415T3 (es)	1999-08-16	Nuevos derivados de 5-pirrolil-2-piridilmetilsulfinilbencimidazol.
NO962286D0 (no)	1996-06-03	N-substituerte azabicykloalkanderivater som neuroleptika etc.
FI970149A0 (fi)	1997-01-14	Tiatsoli- ja tiadiatsoliyhdisteiden käyttö D3-reseptoriligandeina
BR9508294A (pt)	1997-12-30	Composto de triazol processo para a preparação dos mesmos composição farmacêutica e utilização de pelo menos um composto
YU14893A (sh)	1996-05-20	Derivati indola, intermedijeri za njihovo dobijanje i smeše koje ih sadrže
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