EG19647A - Neuroprotective indolone and related derivatives - Google Patents

Neuroprotective indolone and related derivatives

Info

Publication number: EG19647A
Authority: EG; Egypt
Prior art keywords: pct; indolone; neuroprotective; date nov; related derivatives
Prior art date: 1990-05-10

Application number

EG27191A

Other languages

English (en)

Inventor

Bertrand L Chemard

Original Assignee

Pfizer

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1990-05-10

Filing date

1991-05-08

Publication date

1995-08-30

1991-05-08 Application filed by Pfizer filed Critical Pfizer

1995-08-30 Application granted granted Critical

1995-08-30 Publication of EG19647A publication Critical patent/EG19647A/xx

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/06—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
- C07D413/06—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing only aliphatic carbon atoms
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D451/00—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof
- C07D451/02—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof
- C07D451/04—Heterocyclic compounds containing 8-azabicyclo [3.2.1] octane, 9-azabicyclo [3.3.1] nonane, or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane or granatane alkaloids, scopolamine; Cyclic acetals thereof containing not further condensed 8-azabicyclo [3.2.1] octane or 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring systems, e.g. tropane; Cyclic acetals thereof with hetero atoms directly attached in position 3 of the 8-azabicyclo [3.2.1] octane or in position 7 of the 3-oxa-9-azatricyclo [3.3.1.0<2,4>] nonane ring system
- C07D451/06—Oxygen atoms

Landscapes

Chemical & Material Sciences (AREA)
Organic Chemistry (AREA)
Health & Medical Sciences (AREA)
Engineering & Computer Science (AREA)
Bioinformatics & Cheminformatics (AREA)
Biomedical Technology (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Veterinary Medicine (AREA)
Chemical Kinetics & Catalysis (AREA)
General Chemical & Material Sciences (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Public Health (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Psychiatry (AREA)
Hospice & Palliative Care (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Indole Compounds (AREA)
Plural Heterocyclic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Hydrogenated Pyridines (AREA)

EG27191A 1990-05-10 1991-05-08 Neuroprotective indolone and related derivatives EG19647A (en)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
US52233290A	1990-05-10	1990-05-10

Publications (1)

Publication Number	Publication Date
EG19647A true EG19647A (en)	1995-08-30

Family

ID=24080448

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
EG27191A EG19647A (en)	1990-05-10	1991-05-08	Neuroprotective indolone and related derivatives

Country Status (30)

Country	Link
US (1)	US5306723A (pt)
EP (1)	EP0554247B1 (pt)
JP (1)	JPH0699423B2 (pt)
KR (1)	KR0163355B1 (pt)
CN (1)	CN1037439C (pt)
AT (1)	ATE192149T1 (pt)
AU (1)	AU642994B2 (pt)
BR (1)	BR9106432A (pt)
CA (1)	CA2080475C (pt)
CZ (1)	CZ280560B6 (pt)
DE (1)	DE69132141T2 (pt)
DK (1)	DK0554247T3 (pt)
EG (1)	EG19647A (pt)
ES (1)	ES2146578T3 (pt)
FI (1)	FI109121B (pt)
GR (1)	GR3034005T3 (pt)
HU (1)	HU221193B1 (pt)
IE (1)	IE911569A1 (pt)
IL (1)	IL98056A (pt)
MY (1)	MY107799A (pt)
NO (1)	NO301979B1 (pt)
PH (1)	PH29902A (pt)
PL (1)	PL169267B1 (pt)
PT (1)	PT97602B (pt)
RU (1)	RU2068414C1 (pt)
SK (1)	SK280833B6 (pt)
TW (1)	TW198720B (pt)
WO (1)	WO1991017156A1 (pt)
YU (1)	YU48528B (pt)
ZA (1)	ZA913494B (pt)

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FR2688504B1 (fr) *	1992-03-13	1995-05-05	Synthelabo	Derives de 2-(piperidin-1-yl)ethanol, leur preparation et leur application en therapeutique.
US5319096A (en) *	1992-04-03	1994-06-07	Hoechst-Roussel Pharmaceuticals Inc.	(1H-indol-1-yl)-2-(amino) acetamides and related (1H-indol-1-yl)-(aminoalkyl)amides, pharmaceutical composition and use
US6255322B1 (en)	1992-06-19	2001-07-03	Pfizer Inc.	2-(4-hydroxypiperidino)-1-alkanol derivatives as antiischemic agents
US5436255A (en) *	1992-07-23	1995-07-25	Pfizer Inc.	Method of treating diseases susceptable to treatment by blocking NMDA-receptors
EP0666854B1 (en) *	1992-10-30	1997-03-26	Pfizer Inc.	Neuroprotective 3,4-dihydro-2(1h)-quinolone compounds
US5498610A (en) *	1992-11-06	1996-03-12	Pfizer Inc.	Neuroprotective indolone and related derivatives
CN1151130C (zh) *	1994-08-18	2004-05-26	辉瑞大药厂	神经保护的3-(哌啶基-1)-苯并二氢吡喃-4,7-二醇和1-(4-氢化苯基)-2-(哌啶基-1)链烷醇衍生物
GB9510459D0 (en) *	1995-05-24	1995-07-19	Zeneca Ltd	Bicyclic amines
ZA9610745B (en) *	1995-12-22	1997-06-24	Warner Lambert Co	4-Subsituted piperidine analogs and their use as subtype selective nmda receptor antagonists
ZA9610741B (en)	1995-12-22	1997-06-24	Warner Lambert Co	4-Substituted piperidine analogs and their use as subtype selective nmda receptor antagonists
ZA9610736B (en) *	1995-12-22	1997-06-27	Warner Lambert Co	2-Substituted piperidine analogs and their use as subtypeselective nmda receptor antagonists
ZA9610738B (en) *	1995-12-22	1997-06-24	Warner Lambert Co	Subtype selective nmda receptor ligands and the use thereof
TW427978B (en) *	1996-02-03	2001-04-01	Hoffmann La Roche	Tetrahydroisoquinoline derivatives
ATE263765T1 (de) *	1996-05-13	2004-04-15	Syngenta Ltd	Bicyclische amine als insektizide
GB9623944D0 (en) *	1996-11-15	1997-01-08	Zeneca Ltd	Bicyclic amine derivatives
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GB9624611D0 (en) *	1996-11-26	1997-01-15	Zeneca Ltd	Bicyclic amine compounds
EP0944627B1 (en)	1996-11-26	2004-02-18	Syngenta Limited	8-azabicyclo 3.2.1]octane-, 8-azabicyclo 3.2.1]oct-6-ene-, 9-azabicyclo 3.3.1]nonane-, 9-aza-3-oxabicyclo 3.3.1]nonane- and 9-aza-3-thiabicyclo 3.3.1]nonane derivatives, their preparation and their use as insecticides
EP0846683B1 (en) *	1996-12-03	2001-09-19	F. Hoffmann-La Roche Ag	4-Hydroxy-piperidine derivatives
CA2220649C (en)	1996-12-03	2007-02-13	F. Hoffmann-La Roche Ag	4-hydroxy-piperidine derivatives
AU4556800A (en) *	1999-04-27	2000-11-10	Smithkline Beecham Plc	Novel treatment
US6476041B1 (en)	1999-10-29	2002-11-05	Merck & Co., Inc.	1,4 substituted piperidinyl NMDA/NR2B antagonists
US6489477B1 (en)	1999-10-29	2002-12-03	Merck & Co., Inc.	2-aza-bicyclo[2.2.2]octane NMDA/NR2B antigonists
US6495561B2 (en)	1999-10-29	2002-12-17	Merck & Co., Inc.	2-cyclohexyl imidazopyridine NMDA/NR2B antagonists
US6291499B1 (en)	1999-10-29	2001-09-18	Merck & Co., Inc.	2-cyclohexyl benzimidazole NMDA/NR2B antagonists
US6316474B1 (en)	1999-10-29	2001-11-13	Merck & Co., Inc.	2-benzyl and 2-heteroaryl benzimidazole NMDA/NR2B antagonists
US6432976B1 (en)	1999-10-29	2002-08-13	Merck & Co., Inc.	8-aza-bicyclo[3.2.1]octane NMDA/NR2B antagonists
CA2386441A1 (en)	1999-10-29	2001-05-03	Merck Sharp & Dohme Limited	Method to treat pain utilizing benzimidazole nmda/nr2b antagonists
US6369076B1 (en)	1999-10-29	2002-04-09	Merck & Co. Inc.	5-benzyl-octahydroindole and 6-benzyl-decahydroquinoline NMDA/NR2B antagonists
US6380205B1 (en)	1999-10-29	2002-04-30	Merck & Co., Inc.	2-cyclohexyl quinazoline NMDA/NR2B antagonists
ATE324371T1 (de)	2001-02-23	2006-05-15	Merck & Co Inc	N-substituierte heterocyclische nichtaryl- nmda/nr2b-antagonisten
JP2005511478A (ja) *	2001-04-03	2005-04-28	メルク　エンド　カムパニー　インコーポレーテッド	Ｎ−置換非アリール複素環アミジル系ｎｍｄａ／ｎｒ２ｂ拮抗薬
WO2003062235A1 (en) *	2002-01-17	2003-07-31	Eli Lilly And Company	Modulators of acetylcholine receptors
US6713490B2 (en)	2002-04-26	2004-03-30	Pfizer, Inc.	3,4-dihydroquinolin-2(1H)-one compounds as NR2B receptor antagonists
BRPI0415113A (pt) *	2003-10-08	2006-11-28	Pfizer	compostos de lactama condensados
WO2006075004A2 (en) *	2005-01-13	2006-07-20	Neurosearch A/S	3, 8 - substituted 8-aza-bicyclo[3.2.1] octane derivatives and their use as monoamine neurotransmitter re-uptake inhibitors
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JPS57142972A (en) *	1981-02-27	1982-09-03	Otsuka Pharmaceut Co Ltd	Carbostyril derivative
FR2534580A1 (fr) *	1982-10-13	1984-04-20	Synthelabo	Derives de phenyl-1 piperidino-2 propanol, leur preparation, et medicaments qui les contiennent
FR2546166B1 (fr) *	1983-05-19	1985-10-25	Synthelabo	Enantiomeres du erythro (benzyl-4 piperidino)-2 (hydroxy-4 ou benzyloxy-4 phenyl)-1 propanol, leur preparation et leur application en therapeutique
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FR2640266B2 (fr) *	1988-07-12	1992-07-10	Synthelabo	Derives de (hydroxy-1 piperidinyl-2 alkyl) indolones-2, quinoleinones-2, benzo(b)azepinones-2 et benzimidazolones-2, leur preparation et leur application en therapeutique
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1991
- 1991-03-04 EP EP91905608A patent/EP0554247B1/en not_active Expired - Lifetime
- 1991-03-04 RU RU9192016415A patent/RU2068414C1/ru not_active IP Right Cessation
- 1991-03-04 DK DK91905608T patent/DK0554247T3/da active
- 1991-03-04 JP JP3505475A patent/JPH0699423B2/ja not_active Expired - Fee Related
- 1991-03-04 AU AU74565/91A patent/AU642994B2/en not_active Ceased
- 1991-03-04 PL PL91296711A patent/PL169267B1/pl not_active IP Right Cessation
- 1991-03-04 AT AT91905608T patent/ATE192149T1/de not_active IP Right Cessation
- 1991-03-04 BR BR919106432A patent/BR9106432A/pt not_active Application Discontinuation
- 1991-03-04 WO PCT/US1991/001470 patent/WO1991017156A1/en active IP Right Grant
- 1991-03-04 US US07/941,118 patent/US5306723A/en not_active Expired - Fee Related
- 1991-03-04 ES ES91905608T patent/ES2146578T3/es not_active Expired - Lifetime
- 1991-03-04 KR KR1019920702794A patent/KR0163355B1/ko not_active Expired - Fee Related
- 1991-03-04 DE DE69132141T patent/DE69132141T2/de not_active Expired - Fee Related
- 1991-03-04 HU HU9203515A patent/HU221193B1/hu not_active IP Right Cessation
- 1991-03-04 CA CA002080475A patent/CA2080475C/en not_active Expired - Fee Related
- 1991-04-02 TW TW080102540A patent/TW198720B/zh active
- 1991-04-24 PH PH42344A patent/PH29902A/en unknown
- 1991-05-03 IL IL9805691A patent/IL98056A/en not_active IP Right Cessation
- 1991-05-08 CZ CS911354A patent/CZ280560B6/cs not_active IP Right Cessation
- 1991-05-08 EG EG27191A patent/EG19647A/xx active
- 1991-05-08 SK SK1354-91A patent/SK280833B6/sk unknown
- 1991-05-08 PT PT97602A patent/PT97602B/pt active IP Right Grant
- 1991-05-08 ZA ZA913494A patent/ZA913494B/xx unknown
- 1991-05-08 MY MYPI91000778A patent/MY107799A/en unknown
- 1991-05-09 YU YU81091A patent/YU48528B/sh unknown
- 1991-05-09 CN CN91103022A patent/CN1037439C/zh not_active Expired - Fee Related
- 1991-05-09 IE IE156991A patent/IE911569A1/en not_active IP Right Cessation
1992
- 1992-11-09 NO NO924310A patent/NO301979B1/no not_active IP Right Cessation
- 1992-11-09 FI FI925069A patent/FI109121B/fi not_active IP Right Cessation
2000
- 2000-07-24 GR GR20000401691T patent/GR3034005T3/el not_active IP Right Cessation

Also Published As

Publication number	Publication date
WO1991017156A1 (en)	1991-11-14
SK280833B6 (sk)	2000-08-14
CA2080475C (en)	2001-04-17
CN1037439C (zh)	1998-02-18
CZ280560B6 (cs)	1996-02-14
US5306723A (en)	1994-04-26
CA2080475A1 (en)	1991-11-11
PL169267B1 (pl)	1996-06-28
TW198720B (pt)	1993-01-21
AU7456591A (en)	1991-11-27
GR3034005T3 (en)	2000-11-30
EP0554247B1 (en)	2000-04-26
NO924310L (no)	1992-11-09
HU9203515D0 (en)	1993-01-28
JPH05506433A (ja)	1993-09-22
ZA913494B (en)	1992-12-30
DE69132141D1 (de)	2000-05-31
JPH0699423B2 (ja)	1994-12-07
PT97602B (pt)	1998-08-31
FI925069A0 (fi)	1992-11-09
CS135491A3 (en)	1992-05-13
IE911569A1 (en)	1991-11-20
PT97602A (pt)	1992-02-28
KR0163355B1 (ko)	1998-12-01
NO301979B1 (no)	1998-01-05
YU81091A (sh)	1993-11-16
NO924310D0 (no)	1992-11-09
RU2068414C1 (ru)	1996-10-27
FI109121B (fi)	2002-05-31
ES2146578T3 (es)	2000-08-16
BR9106432A (pt)	1993-05-04
DE69132141T2 (de)	2000-09-21
CN1056497A (zh)	1991-11-27
EP0554247A1 (en)	1993-08-11
HUT62879A (en)	1993-06-28
MY107799A (en)	1996-06-29
PH29902A (en)	1996-09-16
DK0554247T3 (da)	2000-08-07
ATE192149T1 (de)	2000-05-15
KR930700482A (ko)	1993-03-15
FI925069L (fi)	1992-11-09
IL98056A (en)	1995-11-27
IL98056A0 (en)	1992-06-21
YU48528B (sh)	1998-11-05
HU221193B1 (en)	2002-08-28
AU642994B2 (en)	1993-11-04

Publication	Publication Date	Title
EG19647A (en)	1995-08-30	Neuroprotective indolone and related derivatives
IL111861A0 (en)	1995-03-15	N-substituted azabicycloalkane derivatives
EP0786995A4 (pt)	1997-08-20
IL114600A0 (en)	1995-11-27	Thiazole and thiadiazole compounds their preparation and pharmaceutical composition containing them
IL76456A (en)	1990-01-18	1-substituted tetralin derivatives,their preparation and pharmaceutical compositions containing them
ZA949593B (en)	1996-06-03	N-substituted azabicycloheptane derivatives their preparation and use
HUT61971A (en)	1993-03-29	Process for producing new derivative of beta-phenylisoserine
GR3021736T3 (en)	1997-02-28	N-substitued 3-azabicyclo 3.2.0]heptane derivatives useful as neuroleptic agents etc.
ES2095058T3 (es)	1997-02-01	Derivados del 3-azabiciclo(3.2.0)heptano substituidos como productos intermedios.
ZA921866B (en)	1993-09-13	Novel 1-aryl-4-piperazinylcyclohexanecarbonitriles, the preparation and use thereof.