PT95983A - Processo de preparacao de novos derivados de iso-indolona - Google Patents

Processo de preparacao de novos derivados de iso-indolona

Info

Publication number: PT95983A
Authority: PT; Portugal
Prior art keywords: preparation; derivatives; indolone derivatives; new iso; radicals
Prior art date: 1989-11-23

Application number

PT95983A

Other languages

English (en)

Other versions

PT95983B (pt

Inventor

Marie-Christine Dubroeucq

Claude Moutonnier

Jean-Francois Peyronel

Michel Tabart

Alain Truchon

Original Assignee

Rhone Poulenc Sante

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

1989-11-23

Filing date

1990-11-23

Publication date

1991-09-13

1990-11-23 Application filed by Rhone Poulenc Sante filed Critical Rhone Poulenc Sante

1991-09-13 Publication of PT95983A publication Critical patent/PT95983A/pt

1998-01-30 Publication of PT95983B publication Critical patent/PT95983B/pt

Classifications

- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/44—Iso-indoles; Hydrogenated iso-indoles
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D209/00—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom
- C07D209/02—Heterocyclic compounds containing five-membered rings, condensed with other rings, with one nitrogen atom as the only ring hetero atom condensed with one carbocyclic ring
- C07D209/04—Indoles; Hydrogenated indoles
- C07D209/30—Indoles; Hydrogenated indoles with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to carbon atoms of the hetero ring
- C07D209/32—Oxygen atoms
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/04—Centrally acting analgesics, e.g. opioids
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/08—Antiepileptics; Anticonvulsants
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P27/00—Drugs for disorders of the senses
- A61P27/02—Ophthalmic agents
- A61P27/14—Decongestants or antiallergics
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/08—Antiallergic agents
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/02—Non-specific cardiovascular stimulants, e.g. drugs for syncope, antihypotensives

Landscapes

Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Chemical & Material Sciences (AREA)
Bioinformatics & Cheminformatics (AREA)
Engineering & Computer Science (AREA)
Veterinary Medicine (AREA)
Medicinal Chemistry (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
General Chemical & Material Sciences (AREA)
Pharmacology & Pharmacy (AREA)
Life Sciences & Earth Sciences (AREA)
Animal Behavior & Ethology (AREA)
General Health & Medical Sciences (AREA)
Public Health (AREA)
Chemical Kinetics & Catalysis (AREA)
Biomedical Technology (AREA)
Cardiology (AREA)
Heart & Thoracic Surgery (AREA)
Neurology (AREA)
Neurosurgery (AREA)
Immunology (AREA)
Ophthalmology & Optometry (AREA)
Pain & Pain Management (AREA)
Pulmonology (AREA)
Indole Compounds (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Nitrogen Condensed Heterocyclic Rings (AREA)
Plural Heterocyclic Compounds (AREA)

PT95983A 1989-11-23 1990-11-23 Processo de preparacao de novos derivados de iso-indolona PT95983B (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
FR8915407A FR2654726B1 (fr)	1989-11-23	1989-11-23	Nouveaux derives de l'isoindolone et leur preparation.

Publications (2)

Publication Number	Publication Date
PT95983A true PT95983A (pt)	1991-09-13
PT95983B PT95983B (pt)	1998-01-30

Family

ID=9387708

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT95983A PT95983B (pt)	1989-11-23	1990-11-23	Processo de preparacao de novos derivados de iso-indolona

Country Status (23)

Country	Link
US (1)	US5112988A (pt)
EP (1)	EP0430771B1 (pt)
JP (1)	JPH03176468A (pt)
KR (1)	KR910009660A (pt)
AT (1)	ATE108774T1 (pt)
AU (1)	AU635984B2 (pt)
CA (1)	CA2030570A1 (pt)
DE (1)	DE69010851T2 (pt)
DK (1)	DK0430771T3 (pt)
ES (1)	ES2057488T3 (pt)
FI (1)	FI94627C (pt)
FR (1)	FR2654726B1 (pt)
HU (1)	HU214574B (pt)
IE (1)	IE64737B1 (pt)
IL (1)	IL96447A (pt)
NO (1)	NO174148C (pt)
NZ (1)	NZ236175A (pt)
PL (2)	PL164955B1 (pt)
PT (1)	PT95983B (pt)
RU (1)	RU2104269C1 (pt)
SK (1)	SK580690A3 (pt)
YU (1)	YU47437B (pt)
ZA (1)	ZA909370B (pt)

Families Citing this family (54)

* Cited by examiner, † Cited by third party
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FR2676442B1 (fr) *	1991-05-17	1993-08-06	Rhone Poulenc Rorer Sa	Nouveau derives de perhydroisoindole, leur preparation et les compositions pharmaceutiques qui les contiennent.
FR2688219B1 (fr)	1992-03-03	1994-07-08	Sanofi Elf	Sels d'ammonium quaternaires de composes aromatiques amines, leur preparation et compositions pharmaceutiques les contenant.
FR2689889B1 (fr) *	1992-04-10	1994-06-10	Rhone Poulenc Rorer Sa	Nouveaux derives de perhydroisoindole, et leur preparation.
US5830854A (en) *	1992-12-14	1998-11-03	Merck Sharp & Dohme, Limited	Method of treating cystic fibrosis using a tachykinin receptor antagonist
FR2703679B1 (fr) *	1993-04-05	1995-06-23	Rhone Poulenc Rorer Sa	Nouveaux derives de perhydroisoindole, leur preparation et les compositions pharmaceutiques qui les contiennent.
FR2709752B1 (fr) *	1993-07-30	1995-10-06	Rhone Poulenc Rorer Sa	Nouveaux dérivés de perhydroisoindole, leur préparation et les compositions pharmaceutiques qui les contiennent.
TW365603B (en) *	1993-07-30	1999-08-01	Rhone Poulenc Rorer Sa	Novel perhydroisoindole derivatives, their preparation and pharmaceutical compositions which contain them
FR2710913B1 (fr) *	1993-10-07	1995-11-24	Rhone Poulenc Rorer Sa	Nouveaux dérivés de perhydroisoindole, leur préparation et les compositions pharmaceutiques qui les contiennent.
US5543530A (en) *	1993-12-23	1996-08-06	Ortho Pharmaceutical Corporation	4-arylisoindole analgesics
FR2728166A1 (fr)	1994-12-19	1996-06-21	Oreal	Composition topique contenant un antagoniste de substance p
FR2728169A1 (fr)	1994-12-19	1996-06-21	Oreal	Utilisation d'un antagoniste de substance p pour le traitement des prurits et des dysesthesies oculaires ou palpebrales
FR2728165A1 (fr)	1994-12-19	1996-06-21	Oreal	Utilisation d'un antagoniste de substance p pour le traitement des rougeurs cutanees d'origine neurogene
FR2729954B1 (fr)	1995-01-30	1997-08-01	Sanofi Sa	Composes heterocycliques substitues, procede pour leur preparation et compositions pharmaceutiques les contenant
FR2741262B1 (fr)	1995-11-20	1999-03-05	Oreal	Utilisation d'un antagoniste de tnf-alpha pour le traitement des rougeurs cutanees d'origine neurogene
FR2755013B1 (fr) *	1996-10-29	1998-11-27	Rhone Poulenc Rorer Sa	Nouvelle application therapeutique des antagonistes de la substance p
BR0015320A (pt)	1999-11-03	2002-07-09	Albany Molecular Res Inc	Composto, composição, métodos de tratamento de um distúrbio que e criado pela, ou é dependente da, disponibilidade diminuìda de serotonina, norepinefrina ou dopamina, para inibir a captação da serotonina, da dopamina e de norepinefrina sinápticas em um paciente em necessidade destes, e, kit
US7163949B1 (en)	1999-11-03	2007-01-16	Amr Technology, Inc.	4-phenyl substituted tetrahydroisoquinolines and use thereof
CN100430401C (zh)	2000-07-11	2008-11-05	Amr科技公司	新的4-苯基取代的四氢异喹啉类化合物及其治疗用途
UA91341C2 (ru)	2004-07-15	2010-07-26	Амр Текнолоджи, Інк.	Арил- и гетероарилзамещенные тетрагидроизохинолины и их применение для блокирования обратного захвата норэпинефрина, допамина и серотонина
US8362075B2 (en)	2005-05-17	2013-01-29	Merck Sharp & Dohme Corp.	Cyclohexyl sulphones for treatment of cancer
JP5258561B2 (ja)	2005-07-15	2013-08-07	アルバニーモレキュラーリサーチ，インコーポレイテッド	アリール置換およびヘテロアリール置換テトラヒドロベンズアゼピンならびにノルエピネフリン、ドーパミンおよびセロトニンの再取り込みを遮断するためのその使用
GB0603041D0 (en)	2006-02-15	2006-03-29	Angeletti P Ist Richerche Bio	Therapeutic compounds
US20110218176A1 (en)	2006-11-01	2011-09-08	Barbara Brooke Jennings-Spring	Compounds, methods, and treatments for abnormal signaling pathways for prenatal and postnatal development
JP4611444B2 (ja)	2007-01-10	2011-01-12	イステイチユート・デイ・リチエルケ・デイ・ビオロジア・モレコラーレ・ピ・アンジエレツテイ・エツセ・ピー・アー	ポリ（ａｄｐ−リボース）ポリメラーゼ（ｐａｒｐ）阻害剤としてのアミド置換インダゾール
AU2008269154B2 (en)	2007-06-27	2014-06-12	Merck Sharp & Dohme Llc	4-carboxybenzylamino derivatives as histone deacetylase inhibitors
US9156812B2 (en)	2008-06-04	2015-10-13	Bristol-Myers Squibb Company	Crystalline form of 6-[(4S)-2-methyl-4-(2-naphthyl)-1,2,3,4-tetrahydroisoquinolin-7-yl]pyridazin-3-amine
AR071997A1 (es)	2008-06-04	2010-07-28	Bristol Myers Squibb Co	Forma cristalina de 6-((4s)-2-metil-4-(2-naftil)-1,2,3,4-tetrahidroisoquinolin-7-il)piridazin-3-amina
US8691825B2 (en)	2009-04-01	2014-04-08	Merck Sharp & Dohme Corp.	Inhibitors of AKT activity
EP2429296B1 (en)	2009-05-12	2017-12-27	Albany Molecular Research, Inc.	7-([1,2,4,]triazolo[1,5,-a]pyridin-6-yl)-4-(3,4-dichlorophenyl)-1,2,3,4- tetrahydroisoquinoline and use thereof
AU2010247849B2 (en)	2009-05-12	2015-11-19	Albany Molecular Research, Inc.	Aryl, heteroaryl, and heterocycle substituted tetrahydroisoquinolines and use thereof
US8815894B2 (en)	2009-05-12	2014-08-26	Bristol-Myers Squibb Company	Crystalline forms of (S)-7-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-4-(3,4-dichlorophenyl)-1,2,3,4-tetrahydroisoquinoline and use thereof
JP5099731B1 (ja)	2009-10-14	2012-12-19	メルク・シャープ・アンド・ドーム・コーポレーション	ｐ５３活性を増大する置換ピペリジン及びその使用
CA2788155C (en) *	2010-01-27	2018-04-24	AB Pharma Ltd.	Polyheterocyclic compounds highly potent as hcv inhibitors
US8518907B2 (en)	2010-08-02	2013-08-27	Merck Sharp & Dohme Corp.	RNA interference mediated inhibition of catenin (cadherin-associated protein), beta 1 (CTNNB1) gene expression using short interfering nucleic acid (siNA)
US9029341B2 (en)	2010-08-17	2015-05-12	Sirna Therapeutics, Inc.	RNA interference mediated inhibition of hepatitis B virus (HBV) gene expression using short interfering nucleic acid (siNA)
WO2012027236A1 (en)	2010-08-23	2012-03-01	Schering Corporation	NOVEL PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS
EP2613782B1 (en)	2010-09-01	2016-11-02	Merck Sharp & Dohme Corp.	Indazole derivatives useful as erk inhibitors
EP2615916B1 (en)	2010-09-16	2017-01-04	Merck Sharp & Dohme Corp.	Fused pyrazole derivatives as novel erk inhibitors
US9260471B2 (en)	2010-10-29	2016-02-16	Sirna Therapeutics, Inc.	RNA interference mediated inhibition of gene expression using short interfering nucleic acids (siNA)
US9351965B2 (en)	2010-12-21	2016-05-31	Merck Sharp & Dohme Corp.	Indazole derivatives useful as ERK inhibitors
US20140045832A1 (en)	2011-04-21	2014-02-13	Piramal Enterprises Limited	Insulin-Like Growth Factor-1 Receptor Inhibitors
EP2770987B1 (en)	2011-10-27	2018-04-04	Merck Sharp & Dohme Corp.	Novel compounds that are erk inhibitors
EP2844261B1 (en)	2012-05-02	2018-10-17	Sirna Therapeutics, Inc.	SHORT INTERFERING NUCLEIC ACID (siNA) COMPOSITIONS
CA2882950A1 (en)	2012-09-28	2014-04-03	Merck Sharp & Dohme Corp.	Novel compounds that are erk inhibitors
MX363243B (es)	2012-11-28	2019-03-14	Merck Sharp & Dohme	Composiciones para tratar cáncer y usos de dichas composiciones.
TW201429969A (zh)	2012-12-20	2014-08-01	Merck Sharp & Dohme	作爲ｈｄｍ２抑制劑之經取代咪唑吡啶
EP2951180B1 (en)	2013-01-30	2018-05-02	Merck Sharp & Dohme Corp.	2,6,7,8 substituted purines as hdm2 inhibitors
WO2015034925A1 (en)	2013-09-03	2015-03-12	Moderna Therapeutics, Inc.	Circular polynucleotides
EP3525785A4 (en)	2016-10-12	2020-03-25	Merck Sharp & Dohme Corp.	KDM5 INHIBITORS
US10947234B2 (en)	2017-11-08	2021-03-16	Merck Sharp & Dohme Corp.	PRMT5 inhibitors
WO2019094312A1 (en)	2017-11-08	2019-05-16	Merck Sharp & Dohme Corp.	Prmt5 inhibitors
US11981701B2 (en)	2018-08-07	2024-05-14	Merck Sharp & Dohme Llc	PRMT5 inhibitors
WO2020033282A1 (en)	2018-08-07	2020-02-13	Merck Sharp & Dohme Corp.	Prmt5 inhibitors
CN112805006B (zh)	2018-08-07	2024-09-24	默沙东有限责任公司	Prmt5抑制剂

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
US2858314A (en) *	1954-06-07	1958-10-28	Georgian Vlasios	Hydrocarbazolenines
US4042707A (en) *	1976-02-19	1977-08-16	E. I. Du Pont De Nemours And Company	3α-Arylhydroisoindoles
US4494547A (en) *	1981-03-30	1985-01-22	North Carolina Central University	2H-isoindolediones, their synthesis and use as radiosensitizers

1989
- 1989-11-23 FR FR8915407A patent/FR2654726B1/fr not_active Expired - Lifetime
1990
- 1990-11-20 US US07/616,044 patent/US5112988A/en not_active Expired - Fee Related
- 1990-11-21 NZ NZ236175A patent/NZ236175A/xx unknown
- 1990-11-22 KR KR1019900019099A patent/KR910009660A/ko not_active Abandoned
- 1990-11-22 CA CA002030570A patent/CA2030570A1/fr not_active Abandoned
- 1990-11-22 AU AU66828/90A patent/AU635984B2/en not_active Ceased
- 1990-11-22 ES ES90403300T patent/ES2057488T3/es not_active Expired - Lifetime
- 1990-11-22 AT AT90403300T patent/ATE108774T1/de not_active IP Right Cessation
- 1990-11-22 NO NO905067A patent/NO174148C/no unknown
- 1990-11-22 HU HU907249A patent/HU214574B/hu not_active IP Right Cessation
- 1990-11-22 IE IE423490A patent/IE64737B1/en not_active IP Right Cessation
- 1990-11-22 DE DE69010851T patent/DE69010851T2/de not_active Expired - Fee Related
- 1990-11-22 ZA ZA909370A patent/ZA909370B/xx unknown
- 1990-11-22 EP EP90403300A patent/EP0430771B1/fr not_active Expired - Lifetime
- 1990-11-22 JP JP2320570A patent/JPH03176468A/ja active Pending
- 1990-11-22 DK DK90403300.8T patent/DK0430771T3/da active
- 1990-11-22 FI FI905770A patent/FI94627C/fi not_active IP Right Cessation
- 1990-11-22 IL IL9644790A patent/IL96447A/en not_active IP Right Cessation
- 1990-11-22 SK SK5806-90A patent/SK580690A3/sk unknown
- 1990-11-23 PL PL90301462A patent/PL164955B1/pl unknown
- 1990-11-23 PT PT95983A patent/PT95983B/pt not_active IP Right Cessation
- 1990-11-23 YU YU223590A patent/YU47437B/sh unknown
- 1990-11-23 PL PL90287908A patent/PL164973B1/pl unknown
1992
- 1992-12-01 RU RU92004482A patent/RU2104269C1/ru active

Also Published As

Publication number	Publication date
HU907249D0 (en)	1991-05-28
SK278474B6 (en)	1997-07-09
HUT55756A (en)	1991-06-28
PT95983B (pt)	1998-01-30
YU223590A (sh)	1993-05-28
DE69010851D1 (de)	1994-08-25
EP0430771A1 (fr)	1991-06-05
SK580690A3 (en)	1997-07-09
IE64737B1 (en)	1995-09-06
NZ236175A (en)	1993-03-26
KR910009660A (ko)	1991-06-28
IE904234A1 (en)	1991-06-05
NO174148C (no)	1994-03-23
IL96447A (en)	1995-03-15
FI905770A0 (fi)	1990-11-22
YU47437B (sh)	1995-03-27
RU2104269C1 (ru)	1998-02-10
IL96447A0 (en)	1991-08-16
PL287908A1 (en)	1991-12-02
JPH03176468A (ja)	1991-07-31
PL164973B1 (pl)	1994-10-31
FI94627B (fi)	1995-06-30
FR2654726B1 (fr)	1992-02-14
NO905067D0 (no)	1990-11-22
CA2030570A1 (fr)	1991-05-24
ZA909370B (en)	1991-10-30
US5112988A (en)	1992-05-12
PL164955B1 (en)	1994-10-31
FR2654726A1 (fr)	1991-05-24
DK0430771T3 (da)	1994-08-29
FI905770L (fi)	1991-05-24
NO174148B (no)	1993-12-13
ES2057488T3 (es)	1994-10-16
ATE108774T1 (de)	1994-08-15
EP0430771B1 (fr)	1994-07-20
HU214574B (hu)	1998-04-28
FI94627C (fi)	1995-10-10
AU635984B2 (en)	1993-04-08
NO905067L (no)	1991-05-24
DE69010851T2 (de)	1994-11-24
AU6682890A (en)	1991-05-30

Publication	Publication Date	Title
PT95983A (pt)	1991-09-13	Processo de preparacao de novos derivados de iso-indolona
RU92004482A (ru)	1995-06-19	Производные изоиндола
MX9301986A (es)	1994-05-31	Derivados de perhidroisoindol, procedimiento para su preparacion y composiciones farmaceuticas que los contienen.
GR900100380A (el)	1991-10-10	Μέ?οδος παρασκευής αντι-φλεγμονωδών παραγώγων αμινοφενόλης.
PT82945B (pt)	1988-07-01	Processo para a preparacao de novos derivados de 2,3-dihidro-benzofurano
ES545728A0 (es)	1987-08-01	Procedimiento para preparar 5h,11h-pirrolo (2,1c)-(1,4)ben- zoxazepinas sustituidas en posicion 11
FI893901A0 (fi)	1989-08-18	Menetelmä tetrasyklisten masennuslääkkeiden valmistamiseksi
FI861324A0 (fi)	1986-03-26	Nya (4.2.0) bicyclooktanderivat, som har vaerdefulla terapeutiska egenskaper.
DK228086D0 (da)	1986-05-16	Substituerede isoxazol-derivater med antiviral virkning og fremgangsmaade af saadanne derivater
HUT36469A (en)	1985-09-30	Process for producing 2-/n-pyrrolidino/-3-isobuthyloxy-n-/substituted phenyl/-n-benzyl-propyl-amines and acid additional salts thereof
ES531318A0 (es)	1985-05-16	Procedimiento para la obtencion de derivados quinolinicos
ES2042727T3 (es)	1993-12-16	Acidos 1,3,4,9-tetrahidropirano(3,4-b)indol-1-acetico.
NO842345L (no)	1984-12-27	Heksahydropyrrolo(2,1-a)isoquinolin-derivater.
PT92494A (pt)	1990-06-29	Processo para a preparacao de novos derivados do indol
ATE154345T1 (de)	1997-06-15	Indol-sulfonamide als antitumormittel
DK0424248T3 (da)	1996-03-04	20,21-dinoreburnamein med substitution i 15-stillingen, fremgangsmåde til deres fremstilling samt mellemprodukter til brug derved, deres anvendelse som lægemidler og præparater med indhold deraf
DK1264836T3 (da)	2005-03-07	Fremgangsmåde til fremstilling af indolopyrrolocarbaxolderivater
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