PT3159409T - Ácido nucleico anti-sentido para utilização no tratamento da distrofia muscular de duchenne - Google Patents

Ácido nucleico anti-sentido para utilização no tratamento da distrofia muscular de duchenne

Info

Publication number: PT3159409T
Authority: PT; Portugal
Prior art keywords: treatment; nucleic acid; muscular dystrophy; duchenne muscular; direction nucleic
Prior art date: 2014-06-17

Application number

PT158100974T

Other languages

English (en)

Original Assignee

Nippon Shinyaku Co Ltd

Nat Center Neurology & Psychiatry

Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)

2014-06-17

Filing date

2015-06-16

Publication date

2020-01-21

2015-06-16 Application filed by Nippon Shinyaku Co Ltd, Nat Center Neurology & Psychiatry filed Critical Nippon Shinyaku Co Ltd

2020-01-21 Publication of PT3159409T publication Critical patent/PT3159409T/pt

Classifications

- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/712—Nucleic acids or oligonucleotides having modified sugars, i.e. other than ribose or 2'-deoxyribose
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/70—Carbohydrates; Sugars; Derivatives thereof
- A61K31/7088—Compounds having three or more nucleosides or nucleotides
- A61K31/7125—Nucleic acids or oligonucleotides having modified internucleoside linkage, i.e. other than 3'-5' phosphodiesters
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K48/00—Medicinal preparations containing genetic material which is inserted into cells of the living body to treat genetic diseases; Gene therapy
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P21/00—Drugs for disorders of the muscular or neuromuscular system
- A61P21/04—Drugs for disorders of the muscular or neuromuscular system for myasthenia gravis
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/10—Type of nucleic acid
- C12N2310/11—Antisense
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2310/00—Structure or type of the nucleic acid
- C12N2310/30—Chemical structure
- C12N2310/32—Chemical structure of the sugar
- C12N2310/323—Chemical structure of the sugar modified ring structure
- C12N2310/3233—Morpholino-type ring
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/10—Applications; Uses in screening processes
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2320/00—Applications; Uses
- C12N2320/30—Special therapeutic applications
- C12N2320/33—Alteration of splicing
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2330/00—Production
- C12N2330/30—Production chemically synthesised
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/136—Screening for pharmacological compounds
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/178—Oligonucleotides characterized by their use miRNA, siRNA or ncRNA

Landscapes

Health & Medical Sciences (AREA)
Life Sciences & Earth Sciences (AREA)
Chemical & Material Sciences (AREA)
Engineering & Computer Science (AREA)
Genetics & Genomics (AREA)
Molecular Biology (AREA)
General Health & Medical Sciences (AREA)
Organic Chemistry (AREA)
Biotechnology (AREA)
Biochemistry (AREA)
Zoology (AREA)
Wood Science & Technology (AREA)
Biomedical Technology (AREA)
Medicinal Chemistry (AREA)
Pharmacology & Pharmacy (AREA)
Public Health (AREA)
Veterinary Medicine (AREA)
Animal Behavior & Ethology (AREA)
Epidemiology (AREA)
Bioinformatics & Cheminformatics (AREA)
General Engineering & Computer Science (AREA)
Proteomics, Peptides & Aminoacids (AREA)
Physics & Mathematics (AREA)
Biophysics (AREA)
Microbiology (AREA)
Analytical Chemistry (AREA)
Plant Pathology (AREA)
Immunology (AREA)
Physical Education & Sports Medicine (AREA)
Orthopedic Medicine & Surgery (AREA)
Chemical Kinetics & Catalysis (AREA)
Neurology (AREA)
General Chemical & Material Sciences (AREA)
Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
Medicinal Preparation (AREA)

PT158100974T 2014-06-17 2015-06-16 Ácido nucleico anti-sentido para utilização no tratamento da distrofia muscular de duchenne PT3159409T (pt)

Applications Claiming Priority (1)

Application Number	Priority Date	Filing Date	Title
JP2014124157		2014-06-17

Publications (1)

Publication Number	Publication Date
PT3159409T true PT3159409T (pt)	2020-01-21

Family

ID=54935505

Family Applications (1)

Application Number	Title	Priority Date	Filing Date
PT158100974T PT3159409T (pt)	2014-06-17	2015-06-16	Ácido nucleico anti-sentido para utilização no tratamento da distrofia muscular de duchenne

Country Status (30)

Country	Link
US (4)	US9840706B2 (pt)
EP (3)	EP3660154B1 (pt)
JP (6)	JP6208349B2 (pt)
KR (1)	KR102335810B1 (pt)
CN (2)	CN106661577B (pt)
AU (3)	AU2015277924B2 (pt)
BR (2)	BR112016029369B1 (pt)
CA (1)	CA2951221A1 (pt)
CO (1)	CO2017000357A2 (pt)
CY (1)	CY1122462T1 (pt)
DK (1)	DK3159409T3 (pt)
ES (2)	ES2765463T3 (pt)
HR (1)	HRP20200042T1 (pt)
HU (1)	HUE047502T2 (pt)
IL (1)	IL249574B (pt)
LT (1)	LT3159409T (pt)
MX (2)	MX373052B (pt)
MY (2)	MY202674A (pt)
PH (1)	PH12016502501A1 (pt)
PL (2)	PL3660154T3 (pt)
PT (1)	PT3159409T (pt)
RS (1)	RS59764B1 (pt)
RU (1)	RU2695430C2 (pt)
SG (2)	SG11201610130VA (pt)
SI (1)	SI3159409T1 (pt)
SM (1)	SMT202000006T1 (pt)
TW (2)	TWI721461B (pt)
UA (1)	UA121117C2 (pt)
WO (1)	WO2015194520A1 (pt)
ZA (1)	ZA201700142B (pt)

Families Citing this family (41)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
ES2765463T3 (es)	2014-06-17	2020-06-09	Nippon Shinyaku Co Ltd	Acido nucleico antisentido para usar en el tratamiento de la distrofia muscular de Duchenne
RU2724554C2 (ru)	2015-09-15	2020-06-23	Ниппон Синяку Ко., Лтд.	Антисмысловая нуклеиновая кислота
WO2017047741A1 (ja) *	2015-09-16	2017-03-23	日本新薬株式会社	筋萎縮症治療用アンチセンス核酸
KR20180056766A (ko)	2015-10-09	2018-05-29	웨이브 라이프 사이언시스 리미티드	뉴클레오티드 조성물 및 이의 방법
MA45328A (fr)	2016-04-01	2019-02-06	Avidity Biosciences Llc	Compositions acide nucléique-polypeptide et utilisations de celles-ci
MA45618A (fr)	2016-06-30	2019-05-08	Sarepta Therapeutics Inc	Sauts d'exons oligomères pour la dystrophie musculaire
MD3554552T2 (ro)	2016-12-19	2022-12-31	Sarepta Therapeutics Inc	Conjugați oligomeri de omitere a exonilor pentru distrofie musculară
MD3554554T2 (ro)	2016-12-19	2022-12-31	Sarepta Therapeutics Inc	Conjugați de oligomeri de omitere a exonului, pentru distrofie musculară
DK3554553T3 (da)	2016-12-19	2022-09-19	Sarepta Therapeutics Inc	Exon-overspringnings-oligomerkonjugat til muskeldystrofi
SG10202107429WA (en)	2017-01-06	2021-08-30	Avidity Biosciences Inc	Nucleic acid-polypeptide compositions and methods of inducing exon skipping
GB201711809D0 (en)	2017-07-21	2017-09-06	Governors Of The Univ Of Alberta	Antisense oligonucleotide
KR102805405B1 (ko) *	2017-09-22	2025-05-12	어비디티 바이오사이언시스 인크.	핵산-폴리펩티드 조성물 및 엑손 스키핑을 유도하는 방법
EA201991450A1 (ru)	2017-09-22	2019-12-30	Сарепта Терапьютикс, Инк.	Конъюгаты олигомеров для пропуска экзона при мышечной дистрофии
WO2019113393A1 (en)	2017-12-06	2019-06-13	Avidity Biosciences Llc	Compositions and methods of treating muscle atrophy and myotonic dystrophy
US10758629B2 (en)	2018-05-29	2020-09-01	Sarepta Therapeutics, Inc.	Exon skipping oligomer conjugates for muscular dystrophy
WO2020028832A1 (en)	2018-08-02	2020-02-06	Dyne Therapeutics, Inc.	Muscle targeting complexes and uses thereof for treating dystrophinopathies
US11168141B2 (en)	2018-08-02	2021-11-09	Dyne Therapeutics, Inc.	Muscle targeting complexes and uses thereof for treating dystrophinopathies
US12018087B2 (en)	2018-08-02	2024-06-25	Dyne Therapeutics, Inc.	Muscle-targeting complexes comprising an anti-transferrin receptor antibody linked to an oligonucleotide and methods of delivering oligonucleotide to a subject
MX2021001284A (es)	2018-08-02	2021-07-15	Dyne Therapeutics Inc	Complejos dirigidos al musculo y sus usos para el tratamiento de distrofia muscular facioescapulohumeral.
US12331293B2 (en) *	2018-11-02	2025-06-17	Biomarin Technologies B.V.	Bispecific antisense oligonucleotides for dystrophin exon skipping
US12497615B2 (en)	2019-04-25	2025-12-16	Avidity Biosciences, Inc.	Nucleic acid compositions and methods of multi-exon skipping
CA3149488A1 (en) *	2019-08-02	2021-02-11	Research Institute At Nationwide Children's Hospital	Exon 44-targeted nucleic acids and recombinant adeno-associated virus comprising said nucleic acids for treatment of dystrophin-based myopathies
BR112022017066A2 (pt) *	2020-02-28	2022-11-16	Nippon Shinyaku Co Ltd	Ácido nucleico antissentido indutor de salto do éxon 51
CA3172111A1 (en)	2020-03-19	2021-09-23	Barbora MALECOVA	Compositions and methods of treating facioscapulohumeral muscular dystrophy
CA3176735A1 (en)	2020-03-20	2021-09-23	Keros Therapeutics, Inc.	Activin receptor type ii chimeras and methods of use thereof
EP4121088A4 (en)	2020-03-20	2024-07-03	Keros Therapeutics, Inc.	Methods of using activin receptor type iib variants
JP2024519451A (ja)	2021-04-30	2024-05-14	サレプタセラピューティクス，インコーポレイテッド	筋ジストロフィーのための治療法
US11638761B2 (en)	2021-07-09	2023-05-02	Dyne Therapeutics, Inc.	Muscle targeting complexes and uses thereof for treating Facioscapulohumeral muscular dystrophy
US11969475B2 (en)	2021-07-09	2024-04-30	Dyne Therapeutics, Inc.	Muscle targeting complexes and uses thereof for treating facioscapulohumeral muscular dystrophy
US11771776B2 (en)	2021-07-09	2023-10-03	Dyne Therapeutics, Inc.	Muscle targeting complexes and uses thereof for treating dystrophinopathies
KR20240035825A (ko)	2021-07-09	2024-03-18	다인 세라퓨틱스, 인크.	디스트로핀병증을 치료하기 위한 근육 표적화 복합체 및 제제
EP4389893A4 (en)	2021-08-21	2025-09-10	Takeda Pharmaceuticals Co	PEPTIDE-DRUG CONJUGATE BINDING HUMAN TRANSFERRIN RECEPTOR
JPWO2023027125A1 (pt)	2021-08-24	2023-03-02
CN118265544A (zh)	2021-09-16	2024-06-28	艾维迪提生物科学公司	治疗面肩肱型肌营养不良的组合物和方法
WO2023127918A1 (ja)	2021-12-27	2023-07-06	日本新薬株式会社	オリゴ核酸化合物の製造方法
EP4215614A1 (en)	2022-01-24	2023-07-26	Dynacure	Combination therapy for dystrophin-related diseases
EP4230196A1 (en)	2022-02-21	2023-08-23	Som Innovation Biotech, S.A.	Compounds for use in the treatment of dystrophinopathies
WO2023168427A1 (en)	2022-03-03	2023-09-07	Yale University	Compositions and methods for delivering therapeutic polynucleotides for exon skipping
JP2025509438A (ja)	2022-03-17	2025-04-11	サレプタセラピューティクス，インコーポレイテッド	ホスホロジアミデートモルホリノオリゴマーコンジュゲート
US12071621B2 (en)	2022-04-05	2024-08-27	Avidity Biosciences, Inc.	Anti-transferrin receptor antibody-PMO conjugates for inducing DMD exon 44 skipping
WO2025174995A1 (en) *	2024-02-13	2025-08-21	Keros Therapeutics, Inc.	Methods of using activin a and myostatin signaling inhibitors

Family Cites Families (23)

* Cited by examiner, † Cited by third party
Publication number	Priority date	Publication date	Assignee	Title
JP3398378B2 (ja)	1989-12-20	2003-04-21	アンチビラルス・インコーポレイテツド	リン含有キラルインターサブユニットリンケージを有する非電荷モルホリノ―基体ポリマー
JP2924179B2 (ja)	1993-02-19	1999-07-26	日本新薬株式会社	グリセロール誘導体，デバイス及び医薬組成物
FR2705361B1 (fr) *	1993-05-18	1995-08-04	Centre Nat Rech Scient	Vecteurs viraux et utilisation en thérapie génique.
EP2374885A3 (en)	2002-11-25	2012-02-15	Masafumi Matsuo	ENA nucleic acid drugs modifying splicing in mRNA precursor
WO2004083432A1 (en) *	2003-03-21	2004-09-30	Academisch Ziekenhuis Leiden	Modulation of exon recognition in pre-mrna by interfering with the secondary rna structure
DK1766010T3 (da) *	2004-06-28	2011-06-06	Univ Western Australia	Antisense-oligonukleotider til induktion af exon-skipping og fremgangsmåder til anvendelse deraf
EP1857548A1 (en)	2006-05-19	2007-11-21	Academisch Ziekenhuis Leiden	Means and method for inducing exon-skipping
JP5143450B2 (ja) *	2007-03-14	2013-02-13	斉大戸	Ｈｌａ−ｂローカスにおける新規アリル
ES2639852T3 (es) *	2007-10-26	2017-10-30	Academisch Ziekenhuis Leiden	Medios y métodos para contrarrestar los trastornos musculares
EP2207779B1 (en)	2007-11-15	2014-04-09	Sarepta Therapeutics, Inc.	Method of synthesis of morpholino oligomers
EP2119783A1 (en)	2008-05-14	2009-11-18	Prosensa Technologies B.V.	Method for efficient exon (44) skipping in Duchenne Muscular Dystrophy and associated means
US8084601B2 (en)	2008-09-11	2011-12-27	Royal Holloway And Bedford New College Royal Holloway, University Of London	Oligomers
IL313162A (en)	2008-10-24	2024-07-01	Sarepta Therapeutics Inc	Antisense compounds for inducing axon termination and preparations containing them for the treatment of muscular dystrophy
JP2012524540A (ja) *	2009-04-24	2012-10-18	プロセンサテクノロジーズビー．ブイ．	Ｄｍｄを処置するためのイノシンを含むオリゴヌクレオチド
KR20230137491A (ko) *	2009-11-12	2023-10-04	더 유니버시티 오브 웨스턴 오스트레일리아	안티센스 분자 및 이를 이용한 질환 치료방법
TWI541024B (zh) *	2010-09-01	2016-07-11	日本新藥股份有限公司	反義核酸
CA2826836A1 (en)	2011-02-08	2012-08-16	The Charlotte-Mecklenburg Hospital Authority D/B/A Carolinas Medical Center	Antisense oligonucleotides
CA2861247C (en) *	2011-12-28	2021-11-16	Nippon Shinyaku Co., Ltd.	Antisense nucleic acids
CN118581086A (zh) *	2012-01-27	2024-09-03	比奥马林技术公司	用于治疗杜兴型肌营养不良症和贝克型肌营养不良症的具有改善特性的rna调节性寡核苷酸
EP3608407A1 (en)	2012-07-03	2020-02-12	BioMarin Technologies B.V.	Oligonucleotide for the treatment of muscular dystrophy patients
JP2014124157A (ja)	2012-12-27	2014-07-07	Nihon Cornstarch Corp	コーヒー飲料
MY193708A (en)	2014-03-12	2022-10-26	Nippon Shinyaku Co Ltd	Antisense nucleic acids
ES2765463T3 (es) *	2014-06-17	2020-06-09	Nippon Shinyaku Co Ltd	Acido nucleico antisentido para usar en el tratamiento de la distrofia muscular de Duchenne

2015
- 2015-06-16 ES ES15810097T patent/ES2765463T3/es active Active
- 2015-06-16 KR KR1020167036291A patent/KR102335810B1/ko active Active
- 2015-06-16 TW TW108121749A patent/TWI721461B/zh active
- 2015-06-16 UA UAA201700424A patent/UA121117C2/uk unknown
- 2015-06-16 EP EP19208809.4A patent/EP3660154B1/en active Active
- 2015-06-16 MY MYPI2022005307A patent/MY202674A/en unknown
- 2015-06-16 TW TW104119378A patent/TWI666317B/zh active
- 2015-06-16 BR BR112016029369-0A patent/BR112016029369B1/pt active IP Right Grant
- 2015-06-16 SG SG11201610130VA patent/SG11201610130VA/en unknown
- 2015-06-16 EP EP15810097.4A patent/EP3159409B1/en active Active
- 2015-06-16 CN CN201580037016.2A patent/CN106661577B/zh active Active
- 2015-06-16 MX MX2016016526A patent/MX373052B/es active IP Right Grant
- 2015-06-16 HU HUE15810097A patent/HUE047502T2/hu unknown
- 2015-06-16 EP EP25170049.8A patent/EP4596047A3/en active Pending
- 2015-06-16 CA CA2951221A patent/CA2951221A1/en active Pending
- 2015-06-16 PL PL19208809.4T patent/PL3660154T3/pl unknown
- 2015-06-16 RS RS20200002A patent/RS59764B1/sr unknown
- 2015-06-16 MY MYPI2016704648A patent/MY194170A/en unknown
- 2015-06-16 PT PT158100974T patent/PT3159409T/pt unknown
- 2015-06-16 CN CN202010289118.6A patent/CN111575282B/zh active Active
- 2015-06-16 ES ES19208809T patent/ES3027057T3/es active Active
- 2015-06-16 RU RU2017101172A patent/RU2695430C2/ru active
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2016
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2017
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2020
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2021
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2023
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2024
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Also Published As

Publication number	Publication date
MX420315B (es)	2025-02-10
MY194170A (en)	2022-11-16
MX2020004417A (es)	2020-08-06
AU2024201290A1 (en)	2024-03-21
RU2695430C2 (ru)	2019-07-23
EP3660154A1 (en)	2020-06-03
EP3660154B1 (en)	2025-04-16
IL249574B (en)	2021-02-28
TW201936922A (zh)	2019-09-16
AU2015277924B2 (en)	2021-02-25
PH12016502501A1 (en)	2017-03-22
BR112016029369B1 (pt)	2020-12-08
CN111575282A (zh)	2020-08-25
ES2765463T3 (es)	2020-06-09
RU2017101172A (ru)	2018-07-17
CY1122462T1 (el)	2021-01-27
LT3159409T (lt)	2020-01-27
TW201625274A (zh)	2016-07-16
US20170204410A1 (en)	2017-07-20
US11193125B2 (en)	2021-12-07
BR112016029369A2 (pt)	2018-01-09
SG11201610130VA (en)	2017-01-27
US12060556B2 (en)	2024-08-13
TWI666317B (zh)	2019-07-21
RU2019121781A (ru)	2019-07-22
EP4596047A2 (en)	2025-08-06
US20180044675A1 (en)	2018-02-15
CN111575282B (zh)	2024-05-14
AU2015277924A1 (en)	2017-02-02
MX2016016526A (es)	2017-04-04
CA2951221A1 (en)	2015-12-23
MY202674A (en)	2024-05-14
JP2020182459A (ja)	2020-11-12
JP2022082539A (ja)	2022-06-02
WO2015194520A1 (ja)	2015-12-23
CN106661577A (zh)	2017-05-10
TWI721461B (zh)	2021-03-11
CN106661577B (zh)	2020-05-12
NZ728103A (en)	2021-11-26
EP4596047A3 (en)	2025-10-22
JP2018027087A (ja)	2018-02-22
BR122020020864B1 (pt)	2022-06-21
RU2017101172A3 (pt)	2018-12-24
SI3159409T1 (sl)	2020-02-28
PL3660154T3 (pl)	2025-07-28
US9840706B2 (en)	2017-12-12
EP3159409A4 (en)	2018-01-10
KR20170017939A (ko)	2017-02-15
NZ765451A (en)	2024-04-26
JP7041879B2 (ja)	2022-03-25
AU2021203383A1 (en)	2021-06-24
RS59764B1 (sr)	2020-02-28
ZA201700142B (en)	2020-05-27
EP3159409B1 (en)	2019-12-04
SG10201912858VA (en)	2020-02-27
JP2024023899A (ja)	2024-02-21
EP3660154C0 (en)	2025-04-16
US20250084412A1 (en)	2025-03-13
PL3159409T3 (pl)	2020-05-18
ES3027057T3 (en)	2025-06-12
HRP20200042T1 (hr)	2020-03-20
HUE047502T2 (hu)	2020-04-28
MX373052B (es)	2020-05-11
UA121117C2 (uk)	2020-04-10
CO2017000357A2 (es)	2017-06-09
JP6208349B2 (ja)	2017-10-04
JPWO2015194520A1 (ja)	2017-04-20
US20220049257A1 (en)	2022-02-17
KR102335810B1 (ko)	2021-12-03
SMT202000006T1 (it)	2020-03-13
EP3159409A1 (en)	2017-04-26
DK3159409T3 (da)	2020-01-27
JP6701139B2 (ja)	2020-05-27
JP2026010142A (ja)	2026-01-21
AU2021203383B2 (en)	2023-11-30
IL249574A0 (en)	2017-02-28

Publication	Publication Date	Title
PT3159409T (pt)	2020-01-21	Ácido nucleico anti-sentido para utilização no tratamento da distrofia muscular de duchenne
SG11201704681QA (en)	2017-07-28	Artificial nucleic acid molecules
SG10201913629VA (en)	2020-03-30	Artificial nucleic acid molecules
EP3157573A4 (en)	2018-02-21	Alternative nucleic acid molecules and uses thereof
EP3157572A4 (en)	2018-02-14	Alternative nucleic acid molecules and uses thereof
HRP20190235T1 (hr)	2019-05-03	Antisensna nukleinska kiselina
IL251390B (en)	2022-01-01	Polysaccharide and nucleic acid formulations that include viscosity-reducing agents
PL3094731T3 (pl)	2019-10-31	Cząsteczki kwasu nukleinowego zmodyfikowane sacharydem
BR112017006622A2 (pt)	2018-07-03	derivados de ácido borônico
ZA201801947B (en)	2022-08-31	Compounds as dna probes, methods and applications thereof
SG11201608296PA (en)	2016-11-29	Small molecular probes, processes and use thereof
GB201403216D0 (en)	2014-04-09	Nucleic acid sample preparation
GB201408841D0 (en)	2014-07-02	Nucleic acid processing
IL250112B (en)	2022-10-01	Aqueous formulation comprising paracetamol and ibuprofen
HUE053432T2 (hu)	2021-07-28	Kitozán-tartalmú hõsterilizált készítmény és annak elõállítási eljárása
GB201413318D0 (en)	2014-09-10	Nucleic acid sample preparation
DK3125867T3 (da)	2021-12-06	Hyperosmolær hyaluronsyresammensætning
EP3124622A4 (en)	2017-12-13	Fluorescent labeled single-stranded nucleic acid and use thereof
IL255081B (en)	2020-10-29	Identification of nucleic acid molecules
IL253773B (en)	2021-09-30	Treatment of dystrophy of the facial, back and arm muscles
DK2975004T3 (da)	2017-11-20	Syrespildevandsbehandling
LT3015109T (lt)	2019-12-27	Biologinis barjeras su simetikonu, skirtas panaudoti nosies-ryklės-vamzdelių infekcijų gydymui
BR112017021414A2 (pt)	2018-07-03	anticorpos anti-flt-1 para o tratamento da distrofia muscular de duchenne.
ES1133355Y (es)	2015-02-09	Camilla de transferencia
GB201406580D0 (en)	2014-05-28	Nucleic Acid Sample preparation