[go: up one dir, main page]

PT2994528T - Organoides compreendendo células renais isoladas e utilizações dos mesmos - Google Patents

Organoides compreendendo células renais isoladas e utilizações dos mesmos

Info

Publication number
PT2994528T
PT2994528T PT147303234T PT14730323T PT2994528T PT 2994528 T PT2994528 T PT 2994528T PT 147303234 T PT147303234 T PT 147303234T PT 14730323 T PT14730323 T PT 14730323T PT 2994528 T PT2994528 T PT 2994528T
Authority
PT
Portugal
Prior art keywords
organoids
renal cells
isolated renal
isolated
cells
Prior art date
Application number
PT147303234T
Other languages
English (en)
Original Assignee
Prokidney
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Prokidney filed Critical Prokidney
Publication of PT2994528T publication Critical patent/PT2994528T/pt

Links

Classifications

    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/22Urine; Urinary tract, e.g. kidney or bladder; Intraglomerular mesangial cells; Renal mesenchymal cells; Adrenal gland
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/44Vessels; Vascular smooth muscle cells; Endothelial cells; Endothelial progenitor cells
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00Medicinal preparations characterised by special physical form
    • A61K9/0012Galenical forms characterised by the site of application
    • A61K9/0019Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/12Drugs for disorders of the urinary system of the kidneys
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0602Vertebrate cells
    • C12N5/0684Cells of the urinary tract or kidneys
    • C12N5/0686Kidney cells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/06Animal cells or tissues; Human cells or tissues
    • C12N5/0697Artificial constructs associating cells of different lineages, e.g. tissue equivalents
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00Coculture with; Conditioned medium produced by
    • C12N2502/25Urinary tract cells, renal cells
    • C12N2502/256Renal cells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2502/00Coculture with; Conditioned medium produced by
    • C12N2502/28Vascular endothelial cells
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2513/003D culture
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2533/00Supports or coatings for cell culture, characterised by material
    • C12N2533/50Proteins
    • C12N2533/54Collagen; Gelatin

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Chemical & Material Sciences (AREA)
  • Cell Biology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Genetics & Genomics (AREA)
  • Wood Science & Technology (AREA)
  • Urology & Nephrology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Virology (AREA)
  • Developmental Biology & Embryology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Vascular Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Dermatology (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicinal Preparation (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Materials For Medical Uses (AREA)
PT147303234T 2013-05-08 2014-05-08 Organoides compreendendo células renais isoladas e utilizações dos mesmos PT2994528T (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201361855146P 2013-05-08 2013-05-08
US201361855152P 2013-05-09 2013-05-09

Publications (1)

Publication Number Publication Date
PT2994528T true PT2994528T (pt) 2024-02-13

Family

ID=50942860

Family Applications (1)

Application Number Title Priority Date Filing Date
PT147303234T PT2994528T (pt) 2013-05-08 2014-05-08 Organoides compreendendo células renais isoladas e utilizações dos mesmos

Country Status (18)

Country Link
US (2) US20160101133A1 (pt)
EP (2) EP2994528B1 (pt)
JP (4) JP6490669B2 (pt)
KR (8) KR102618557B1 (pt)
CN (1) CN105378062A (pt)
AU (3) AU2014262670B2 (pt)
BR (1) BR112015027996A8 (pt)
CA (1) CA2911291A1 (pt)
DK (1) DK2994528T3 (pt)
ES (1) ES2970230T3 (pt)
FI (1) FI2994528T3 (pt)
HR (1) HRP20240170T1 (pt)
HU (1) HUE065125T2 (pt)
PL (1) PL2994528T3 (pt)
PT (1) PT2994528T (pt)
RU (1) RU2722361C2 (pt)
SI (1) SI2994528T1 (pt)
WO (1) WO2014182885A2 (pt)

Families Citing this family (32)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9719068B2 (en) 2010-05-06 2017-08-01 Children's Hospital Medical Center Methods and systems for converting precursor cells into intestinal tissues through directed differentiation
NZ741724A (en) 2012-10-24 2020-02-28 Inregen Renal cell populations and uses thereof
EA035413B1 (ru) 2013-06-13 2020-06-10 Ордженисис Лтд. Популяции клеток, способы трансдифференцировки и способы их применения
CN113249297A (zh) 2014-05-28 2021-08-13 儿童医院医疗中心 用于经由定向分化将前体细胞转化为胃组织的方法和系统
CA2963704A1 (en) 2014-10-17 2016-04-21 Children's Hospital Medical Center In vivo model of human small intestine using pluripotent stem cells and methods of making and using same
CA2969592C (en) 2014-12-05 2023-02-14 University Of Florida Research Foundation, Inc. 3d printing using phase changing materials as support
MA41296A (fr) 2014-12-30 2017-11-07 Orgenesis Ltd Procédés de transdifférenciation et procédés d'utilisation de ceux-ci
WO2016130953A1 (en) 2015-02-13 2016-08-18 University Of Florida Research Foundation, Inc. High speed 3d printing system for wound and tissue replacement
US11390835B2 (en) 2015-05-08 2022-07-19 University Of Florida Research Foundation, Inc. Growth media for three-dimensional cell culture
WO2017040981A1 (en) 2015-09-03 2017-03-09 University Of Florida Research Foundation, Inc. Valve incorporating temporary phase change material
AU2016318114B2 (en) * 2015-09-03 2023-04-20 The Brigham And Women's Hospital, Inc. Three-dimensional differentiation of epiblast spheroids to kidney organoids models stage-specific epithelial physiology, morphogenesis, and disease
US20180258382A1 (en) * 2015-09-18 2018-09-13 University Of Florida Research Foundation, Incorporated Apparatus for culturing and interacting with a three-dimensional cell culture
WO2017096263A1 (en) 2015-12-04 2017-06-08 University Of Florida Research Foundation, Incorporated Crosslinkable or functionalizable polymers for 3d printing of soft materials
EP4177335A1 (en) 2016-05-05 2023-05-10 Children's Hospital Medical Center Methods for the in vitro manufacture of gastric fundus tissue and compositions related to same
JP7367951B2 (ja) 2016-05-18 2023-10-24 慶應義塾 オルガノイド培養用細胞培養培地
US11124644B2 (en) 2016-09-01 2021-09-21 University Of Florida Research Foundation, Inc. Organic microgel system for 3D printing of silicone structures
KR20230110839A (ko) 2016-12-05 2023-07-25 칠드런즈 호스피탈 메디칼 센터 결장 유사장기 및 이를 제조 및 사용하는 방법
US10767164B2 (en) 2017-03-30 2020-09-08 The Research Foundation For The State University Of New York Microenvironments for self-assembly of islet organoids from stem cells differentiation
EP3635106A4 (en) 2017-05-08 2021-01-06 Orgenesis Ltd. POPULATIONS OF TRANSDIFFERENTIATED CELLS AND THEIR METHODS OF USE
WO2018220623A1 (en) * 2017-05-29 2018-12-06 Orgenesis Ltd. Compositions and methods for providing cell replacement therapy
WO2019006127A1 (en) * 2017-06-28 2019-01-03 Rutgers, The State University Of New Jersey ORGANOIDS DERIVED FROM A SINGLE RENAL CELL
JP2019196342A (ja) * 2018-05-10 2019-11-14 学校法人大阪医科薬科大学 スタチン封入ナノ粒子製剤、それを含有する歯髄由来幹細胞及びそれを含む細胞製剤。
KR102094929B1 (ko) * 2018-07-06 2020-03-30 한국생명공학연구원 신장 스페로이드 및 그의 제조 방법
US20210386786A1 (en) * 2018-08-31 2021-12-16 Timothy A. Bertram Compositions comprising cell-delivered vesicles and uses thereof
KR102118807B1 (ko) 2018-11-26 2020-06-03 숭실대학교산학협력단 3차원 오가노이드 제조용 형상변화형 하이드로젤 몰드 조성물 및 이를 통해 제조된 몰드
KR20200065892A (ko) * 2018-11-30 2020-06-09 오가노이드사이언스 주식회사 오가노이드의 생체 이식용 조성물
AU2020271121B2 (en) 2019-04-11 2024-04-11 University Of Pittsburgh-Of The Commonwealth System Of Higher Education Minimally invasive cell transplant procedure to induce the development of in vivo organogenesis
WO2021113924A1 (en) * 2019-12-12 2021-06-17 The Walter And Eliza Hall Institute Of Medical Research Organoid cultures
KR20230007766A (ko) * 2021-07-06 2023-01-13 서강대학교산학협력단 혈관화된 신장 오가노이드 형성을 위한 세포기질의 최적화 및 오가노이드 칩 개발
CN114507642B (zh) * 2022-03-17 2024-02-02 上海纽仁生物医药科技有限公司 一种动物神经系统周细胞单细胞的分离方法
CN114732832A (zh) * 2022-04-08 2022-07-12 宁夏医科大学总医院 一种防宫腔粘连的可植入物
CN116159182B (zh) * 2023-02-02 2024-09-24 中国科学院苏州纳米技术与纳米仿生研究所 用于治疗脊髓损伤的神经类器官-水凝胶体系及制备方法

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5965125A (en) * 1995-10-25 1999-10-12 Transkaryotic Therapies, Inc. Hybrid matrix implants and explants
US6224893B1 (en) 1997-04-11 2001-05-01 Massachusetts Institute Of Technology Semi-interpenetrating or interpenetrating polymer networks for drug delivery and tissue engineering
US6886568B2 (en) * 1998-04-08 2005-05-03 The Johns Hopkins University Method for fabricating cell-containing implants
US7326570B2 (en) * 2000-06-16 2008-02-05 The Regents Of The University Of California Induction of tubular morphogenesis using pleiotrophin
CN100341496C (zh) 2002-03-22 2007-10-10 橘生药品工业株式会社 预防或治疗肾脏疾病的药剂
US20040101884A1 (en) * 2002-03-29 2004-05-27 Lu Dyung Aina M Molecules for disease detection and treatment
US8361781B2 (en) * 2006-01-24 2013-01-29 Brown University Cell aggregation and encapsulation device and method
WO2007095193A2 (en) 2006-02-10 2007-08-23 Tengion, Inc. Scaffolds for organ reconstruction and augmentation
AU2007335753B2 (en) * 2006-12-18 2013-12-05 Ben Gurion University Of The Negev Scaffolding for tissue regeneration or repair
JP5974233B2 (ja) * 2008-11-12 2016-08-24 リージェンメド(ケイマン)エルティーディー. 単離した腎細胞およびその使用
GB201111244D0 (en) * 2011-06-30 2011-08-17 Konink Nl Akademie Van Wetenschappen Knaw Culture media for stem cells
JP5974215B2 (ja) * 2010-05-12 2016-08-24 リージェンメド(ケイマン)エルティーディー. 生理活性腎臓細胞
WO2011156642A1 (en) * 2010-06-11 2011-12-15 Tengion, Inc. Erythropoietin-expressing adipose cell populations
EP2637711B1 (en) * 2010-11-10 2024-03-27 ProKidney Injectable formulations for organ augmentation
CN110511901A (zh) * 2011-05-27 2019-11-29 德普伊新特斯产品有限责任公司 生物人工近端小管系统及使用方法
CN102366713A (zh) * 2011-09-02 2012-03-07 华中科技大学 一种具有生理功能的透析膜材料及其制备方法
WO2013063588A1 (en) * 2011-10-28 2013-05-02 The Board Of Trustees Of The Leland Stanford Junior University Ex vivo culture, proliferation and expansion of primary tissue organoids

Also Published As

Publication number Publication date
HRP20240170T1 (hr) 2024-04-12
BR112015027996A2 (pt) 2017-09-12
RU2015152257A (ru) 2017-06-09
AU2023206151A1 (en) 2023-08-10
JP2016519930A (ja) 2016-07-11
FI2994528T3 (fi) 2024-02-07
JP6490669B2 (ja) 2019-03-27
KR20160005037A (ko) 2016-01-13
AU2020203860B2 (en) 2023-04-27
KR20210094671A (ko) 2021-07-29
JP2024105523A (ja) 2024-08-06
US20220249569A1 (en) 2022-08-11
AU2014262670B2 (en) 2020-07-09
CA2911291A1 (en) 2014-11-13
EP2994528B1 (en) 2023-11-08
NZ752702A (en) 2021-11-26
KR20240144472A (ko) 2024-10-02
KR102668827B1 (ko) 2024-05-27
KR102281921B1 (ko) 2021-07-28
EP4299721A2 (en) 2024-01-03
JP7062605B2 (ja) 2022-05-06
PL2994528T3 (pl) 2024-04-22
EP2994528A2 (en) 2016-03-16
JP7493252B2 (ja) 2024-05-31
JP2022071069A (ja) 2022-05-13
KR20230110834A (ko) 2023-07-25
KR102710014B1 (ko) 2024-09-26
KR102349183B1 (ko) 2022-01-07
JP2019122381A (ja) 2019-07-25
KR102618557B1 (ko) 2023-12-28
DK2994528T3 (da) 2024-02-05
KR102757386B1 (ko) 2025-01-21
SI2994528T1 (sl) 2024-04-30
KR20210029285A (ko) 2021-03-15
AU2020203860A1 (en) 2020-07-02
BR112015027996A8 (pt) 2017-09-26
WO2014182885A2 (en) 2014-11-13
US20160101133A1 (en) 2016-04-14
EP4299721A3 (en) 2024-04-24
KR20240090622A (ko) 2024-06-21
ES2970230T3 (es) 2024-05-27
AU2014262670A1 (en) 2015-11-26
KR20240001290A (ko) 2024-01-03
RU2722361C2 (ru) 2020-05-29
KR102556951B1 (ko) 2023-07-18
NZ713875A (en) 2021-11-26
KR102225312B1 (ko) 2021-03-10
WO2014182885A3 (en) 2015-04-16
KR20220005636A (ko) 2022-01-13
HUE065125T2 (hu) 2024-05-28
CN105378062A (zh) 2016-03-02

Similar Documents

Publication Publication Date Title
PT2994528T (pt) Organoides compreendendo células renais isoladas e utilizações dos mesmos
IL261743B (en) and their uses 33–il antibodies against
IL261547B (en) Antibodies against pesidine and their uses
HK1223553A1 (zh) 細胞
IL243974A0 (en) Antibodies against -prlr and uses
ZA201508896B (en) Anti-c10orf54 antibodies and uses thereof
ZA201504537B (en) Anti-pdgfr-beta antibodies and uses thereof
EP2940753A4 (en) BATTERY CELL WITH ROUNDED CORNER
SG11201509116VA (en) Anti-tweakr antibodies and uses thereof
GB201310031D0 (en) Cell
GB201312332D0 (en) Cell locations
GB201306814D0 (en) Improvements in lithium-containing materials
GB201320632D0 (en) Electrochemical cells and components thereof
GB201317589D0 (en) Cell
AU2013901567A0 (en) Immune cell markers and uses thereof
AU2013901559A0 (en) Immune cell markers and uses thereof
GB201320573D0 (en) T Cell
GB201319932D0 (en) Electrochemical materials and their manufacture
AU2013901558A0 (en) Immunce cell markers and uses thereof